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FB:Mef2

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Contents

Species (Taxon ID) Drosophila melanogaster (fruit fly) (taxon:7227)
Gene Name(s) Mef2 ( synonyms: 22.21, BEST:SD04091, C, CG1429, Complementation group C, D-MEF2, D-Mef2, D-mef2, DMEF-2, DMEF2, DMedf2, DMef-2, DMef2, Dmef, Dmef-2, Dmef2, Drosophila myocyte-specific enhancer factor 2, Drosophila-myocyte enhancer factor 2, Group C, MEF-2, MEF2, Mef, Mef-2, Myocyte Enhancer Factor-2, Myocyte Enhancing Factor 2, Myocyte enhancer factor-2, Myocyte enhancing factor 2, Myocyte-enhancer factor-2, Myocyte-specific enhancer factor 2, SD04091, dMEF2, dMef2, dmef2, l(2)46CFr, mb247, mef, mef-2, mef2, mef2c, myocyte enhancer factor 2, myocyte enhancer factor-2 )
Protein Name(s) Myocyte enhancer factor 2,
External Links
FB FBgn0011656

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0001077

RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription

FB:FBrf0204428
PMID:18160709[1]

IDA: Inferred from Direct Assay

F

From FB

GO:0003677

DNA binding

FB:FBrf0174215

IEA: Inferred from Electronic Annotation

InterPro:IPR002100

F

From FB

GO:0003700

sequence-specific DNA binding transcription factor activity

FB:FBrf0123981

NAS: Non-traceable Author Statement

F

From FB

GO:0005634

nucleus

FB:FBrf0079902
PMID:7729689[2]

IDA: Inferred from Direct Assay

C

From FB

GO:0005634

nucleus

FB:FBrf0080216
PMID:7839146[3]

IDA: Inferred from Direct Assay

C

From FB

GO:0005634

nucleus

FB:FBrf0105495

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q02078

C

From FB

GO:0005634

nucleus

FB:FBrf0123981

NAS: Non-traceable Author Statement

C

From FB

GO:0006355

regulation of transcription, DNA-dependent

FB:FBrf0123981

NAS: Non-traceable Author Statement

P

From FB

GO:0006366

transcription from RNA polymerase II promoter

FB:FBrf0105495

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q02078

P

From FB

GO:0007496

anterior midgut development

FB:FBrf0190174
PMID:16171793[4]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007498

mesoderm development

FB:FBrf0079902
PMID:7729689[2]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007498

mesoderm development

FB:FBrf0138533
PMID:11486054[5]

IEP: Inferred from Expression Pattern

P

From FB

GO:0007507

heart development

FB:FBrf0151249
PMID:12027431[6]

TAS: Traceable Author Statement

P

From FB

GO:0007519

skeletal muscle tissue development

FB:FBrf0079902
PMID:7729689[2]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007520

myoblast fusion

FB:FBrf0187819
PMID:15955848[7]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0010468

regulation of gene expression

FB:FBrf0202755
PMID:18198273[8]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0016202

regulation of striated muscle tissue development

FB:FBrf0108595
PMID:10218153[9]

TAS: Traceable Author Statement

P

From FB

GO:0030707

ovarian follicle cell development

FB:FBrf0128450
PMID:10822261[10]

TAS: Traceable Author Statement

P

From FB

GO:0032968

positive regulation of transcription elongation from RNA polymerase II promoter

FB:FBrf0204428
PMID:18160709[1]

IDA: Inferred from Direct Assay

P

From FB

GO:0045475

locomotor rhythm

FB:FBrf0210652
PMID:20427646[11]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0046983

protein dimerization activity

FB:FBrf0174215

IEA: Inferred from Electronic Annotation

InterPro:IPR002100

F

From FB

GO:0048747

muscle fiber development

FB:FBrf0190139
PMID:16325168[12]

IMP: Inferred from Mutant Phenotype

P

From FB


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 Tanaka KK et al. (2008) Myocyte enhancer factor 2 and chorion factor 2 collaborate in activation of the myogenic program in Drosophila. Mol Cell Biol 28: 1616-29 PubMed GONUTS page
  2. 2.0 2.1 2.2 Bour BA et al. (1995) Drosophila MEF2, a transcription factor that is essential for myogenesis. Genes Dev 9: 730-41 PubMed GONUTS page
  3. Lilly B et al. (1995) Requirement of MADS domain transcription factor D-MEF2 for muscle formation in Drosophila. Science 267: 688-93 PubMed GONUTS page
  4. Vining MS et al. (2005) Organ positioning in Drosophila requires complex tissue-tissue interactions. Dev Biol 287: 19-34 PubMed GONUTS page
  5. Furlong EE et al. (2001) Patterns of gene expression during Drosophila mesoderm development. Science 293: 1629-33 PubMed GONUTS page
  6. Cripps RM & Olson EN (2002) Control of cardiac development by an evolutionarily conserved transcriptional network. Dev Biol 246: 14-28 PubMed GONUTS page
  7. Menon SD et al. (2005) A positive feedback loop between Dumbfounded and Rolling pebbles leads to myotube enlargement in Drosophila. J Cell Biol 169: 909-20 PubMed GONUTS page
  8. Elgar SJ et al. (2008) mef2 activity levels differentially affect gene expression during Drosophila muscle development. Proc Natl Acad Sci U S A 105: 918-23 PubMed GONUTS page
  9. Bate M et al. (1999) Development of larval body wall muscles. Int Rev Neurobiol 43: 25-44 PubMed GONUTS page
  10. Dobens LL & Raftery LA (2000) Integration of epithelial patterning and morphogenesis in Drosophila ovarian follicle cells. Dev Dyn 218: 80-93 PubMed GONUTS page
  11. Blanchard FJ et al. (2010) The transcription factor Mef2 is required for normal circadian behavior in Drosophila. J Neurosci 30: 5855-65 PubMed GONUTS page
  12. Lovato TL et al. (2005) Transcription of Myocyte enhancer factor-2 in adult Drosophila myoblasts is induced by the steroid hormone ecdysone. Dev Biol 288: 612-21 PubMed GONUTS page
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