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FB:Med
Contents |
| Species (Taxon ID) | Drosophila melanogaster (fruit fly) (taxon:7227) | |
| Gene Name(s) | Med ( synonyms: CG1775, E(zen)3, MED, Media, SMAD4, Smad4, anon-EST:Posey121, dSmad4, l(3)11m-254, l(3)12m-137, l(3)SG36, l(3)SG70, l(3)XIIm137, lethal(3)SG36, lethal(3)SG70, med, medea ) | |
| Protein Name(s) | Medea, | |
| External Links | ||
| FB | FBgn0011655 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0003677 |
DNA binding |
FB:FBrf0108831 |
TAS: Traceable Author Statement |
F |
From FB |
|||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
F |
From FB |
|||
| GO:0005515 |
protein binding |
FB:FBrf0102610 |
IPI: Inferred from Physical Interaction |
FB:FBgn0011648 |
F |
From FB |
||
| GO:0005634 |
nucleus |
FB:FBrf0102610 |
IPI: Inferred from Physical Interaction |
FB:FBgn0011648 |
C |
From FB |
||
| GO:0005634 |
nucleus |
FB:FBrf0136863 |
TAS: Traceable Author Statement |
C |
From FB |
|||
| GO:0005667 |
transcription factor complex |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
C |
From FB |
|||
| GO:0005737 |
cytoplasm |
FB:FBrf0102610 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0006355 |
regulation of transcription, DNA-dependent |
FB:FBrf0136863 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0006355 |
regulation of transcription, DNA-dependent |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
InterPro:IPR001132 |
P |
From FB |
||
| GO:0007179 |
transforming growth factor beta receptor signaling pathway |
FB:FBrf0102608 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0000490 |
P |
From FB |
||
| GO:0007179 |
transforming growth factor beta receptor signaling pathway |
FB:FBrf0102608 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0003716 |
P |
From FB |
||
| GO:0007179 |
transforming growth factor beta receptor signaling pathway |
FB:FBrf0102608 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0004053 |
P |
From FB |
||
| GO:0007179 |
transforming growth factor beta receptor signaling pathway |
FB:FBrf0102608 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007179 |
transforming growth factor beta receptor signaling pathway |
FB:FBrf0102608 |
ISS: Inferred from Sequence or Structural Similarity |
HGNC:6770 |
P |
From FB |
||
| GO:0007179 |
transforming growth factor beta receptor signaling pathway |
FB:FBrf0102610 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0000490 |
P |
From FB |
||
| GO:0007179 |
transforming growth factor beta receptor signaling pathway |
FB:FBrf0135803 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007179 |
transforming growth factor beta receptor signaling pathway |
FB:FBrf0141281 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007476 |
imaginal disc-derived wing morphogenesis |
FB:FBrf0135803 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007480 |
imaginal disc-derived leg morphogenesis |
FB:FBrf0135803 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007507 |
heart development |
FB:FBrf0134876 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007507 |
heart development |
FB:FBrf0151249 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0008283 |
cell proliferation |
FB:FBrf0135803 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0009950 |
dorsal/ventral axis specification |
FB:FBrf0102608 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0009953 |
dorsal/ventral pattern formation |
FB:FBrf0102610 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0030509 |
BMP signaling pathway |
FB:FBrf0168049 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0030616 |
transforming growth factor beta receptor, common-partner cytoplasmic mediator activity |
FB:FBrf0108831 |
NAS: Non-traceable Author Statement |
F |
From FB |
|||
| GO:0030707 |
ovarian follicle cell development |
FB:FBrf0190209 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0030718 |
germ-line stem cell maintenance |
FB:FBrf0103396 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0031290 |
retinal ganglion cell axon guidance |
FB:FBrf0187493 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0035019 |
somatic stem cell maintenance |
FB:FBrf0190209 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0042078 |
germ-line stem cell division |
FB:FBrf0103396 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0042078 |
germ-line stem cell division |
FB:FBrf0155987 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0043565 |
sequence-specific DNA binding |
FB:FBrf0209559 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0045705 |
negative regulation of salivary gland boundary specification |
FB:FBrf0139594 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0045887 |
positive regulation of synaptic growth at neuromuscular junction |
FB:FBrf0175022 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0048666 |
neuron development |
FB:FBrf0190369 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 Wisotzkey RG et al. (1998) Medea is a Drosophila Smad4 homolog that is differentially required to potentiate DPP responses. Development 125: 1433-45 PubMed GONUTS page
- ↑ 2.0 2.1 Affolter M et al. (2001) Nuclear interpretation of Dpp signaling in Drosophila. EMBO J 20: 3298-305 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 Hudson JB et al. (1998) The Drosophila Medea gene is required downstream of dpp and encodes a functional homolog of human Smad4. Development 125: 1407-20 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Marquez RM et al. (2001) Transgenic analysis of the Smad family of TGF-beta signal transducers in Drosophila melanogaster suggests new roles and new interactions between family members. Genetics 157: 1639-48 PubMed GONUTS page
- ↑ Lall S & Patel NH (2001) Conservation and divergence in molecular mechanisms of axis formation. Annu Rev Genet 35: 407-37 PubMed GONUTS page
- ↑ Chen JN & Fishman MC (2000) Genetics of heart development. Trends Genet 16: 383-8 PubMed GONUTS page
- ↑ Cripps RM & Olson EN (2002) Control of cardiac development by an evolutionarily conserved transcriptional network. Dev Biol 246: 14-28 PubMed GONUTS page
- ↑ Raftery LA & Sutherland DJ (2003) Gradients and thresholds: BMP response gradients unveiled in Drosophila embryos. Trends Genet 19: 701-8 PubMed GONUTS page
- ↑ 9.0 9.1 Kirilly D et al. (2005) BMP signaling is required for controlling somatic stem cell self-renewal in the Drosophila ovary. Dev Cell 9: 651-62 PubMed GONUTS page
- ↑ 10.0 10.1 Xie T & Spradling AC (1998) decapentaplegic is essential for the maintenance and division of germline stem cells in the Drosophila ovary. Cell 94: 251-60 PubMed GONUTS page
- ↑ Yoshida S et al. (2005) DPP signaling controls development of the lamina glia required for retinal axon targeting in the visual system of Drosophila. Development 132: 4587-98 PubMed GONUTS page
- ↑ Lin H (2002) The stem-cell niche theory: lessons from flies. Nat Rev Genet 3: 931-40 PubMed GONUTS page
- ↑ Weiss A et al. (2010) A conserved activation element in BMP signaling during Drosophila development. Nat Struct Mol Biol 17: 69-76 PubMed GONUTS page
- ↑ Bradley PL et al. (2001) Organ formation in Drosophila: specification and morphogenesis of the salivary gland. Bioessays 23: 901-11 PubMed GONUTS page
- ↑ McCabe BD et al. (2004) Highwire regulates presynaptic BMP signaling essential for synaptic growth. Neuron 41: 891-905 PubMed GONUTS page
- ↑ Zheng X et al. (2006) Baboon/dSmad2 TGF-beta signaling is required during late larval stage for development of adult-specific neurons. EMBO J 25: 615-27 PubMed GONUTS page
