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FB:Mad
Contents |
| Species (Taxon ID) | Drosophila melanogaster (fruit fly) (taxon:7227) | |
| Gene Name(s) | Mad ( synonyms: 2/23, CG12399, E(zen)2, En(vvl), MAD, Mat, Mother against decapentaplegic, Mothers Against Decapentaplegic, Mothers Against Dpp, Mothers against DPP, Mothers against Decapentaplegic, Mothers against Dpp, Mothers against decapentaplegic, P-Mad, P-mad, PMad, Smad, Smad1, apang, apg, c28, dMad, l(2)K00237, l(2)k00237, mad, mothers against decapentaplegi, mothers against decapentaplegic, mothers against dpp, p-Mad, pMAD, pMad, pSmad, phospho-Smad, phosphoSmad, phosphorylated Smad ) | |
| Protein Name(s) | Mothers against dpp, | |
| External Links | ||
| FB | FBgn0011648 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000980 |
RNA polymerase II distal enhancer sequence-specific DNA binding |
FB:FBrf0103397 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0001102 |
RNA polymerase II activating transcription factor binding |
FB:FBrf0131280 |
IPI: Inferred from Physical Interaction |
FB:FBgn0003396 |
F |
From FB |
||
| GO:0001105 |
RNA polymerase II transcription coactivator activity |
FB:FBrf0131280 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0001745 |
compound eye morphogenesis |
FB:FBrf0200828 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0003677 |
DNA binding |
FB:FBrf0108831 |
TAS: Traceable Author Statement |
F |
From FB |
|||
| GO:0003705 |
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity |
FB:FBrf0095428 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0005515 |
protein binding |
FB:FBrf0102610 |
IPI: Inferred from Physical Interaction |
FB:FBgn0011655 |
F |
From FB |
||
| GO:0005515 |
protein binding |
FB:FBrf0141457 |
IPI: Inferred from Physical Interaction |
F |
From FB |
|||
| GO:0005515 |
protein binding |
FB:FBrf0160739 |
IPI: Inferred from Physical Interaction |
F |
From FB |
|||
| GO:0005515 |
protein binding |
FB:FBrf0167890 |
IPI: Inferred from Physical Interaction |
FB:FBgn0033748 |
F |
From FB |
||
| GO:0005634 |
nucleus |
FB:FBrf0095428 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005634 |
nucleus |
FB:FBrf0108831 |
TAS: Traceable Author Statement |
C |
From FB |
|||
| GO:0005634 |
nucleus |
FB:FBrf0136863 |
TAS: Traceable Author Statement |
C |
From FB |
|||
| GO:0005634 |
nucleus |
FB:FBrf0190539 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005667 |
transcription factor complex |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
C |
From FB |
|||
| GO:0005737 |
cytoplasm |
FB:FBrf0088659 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005737 |
cytoplasm |
FB:FBrf0108831 |
TAS: Traceable Author Statement |
C |
From FB |
|||
| GO:0005737 |
cytoplasm |
FB:FBrf0190539 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0006357 |
regulation of transcription from RNA polymerase II promoter |
FB:FBrf0136863 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0007179 |
transforming growth factor beta receptor signaling pathway |
FB:FBrf0089199 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0000490 |
P |
From FB |
||
| GO:0007179 |
transforming growth factor beta receptor signaling pathway |
FB:FBrf0089199 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0003716 |
P |
From FB |
||
| GO:0007179 |
transforming growth factor beta receptor signaling pathway |
FB:FBrf0089199 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0004009 |
P |
From FB |
||
| GO:0007179 |
transforming growth factor beta receptor signaling pathway |
FB:FBrf0124011 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0007179 |
transforming growth factor beta receptor signaling pathway |
FB:FBrf0141281 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007391 |
dorsal closure |
FB:FBrf0151280 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0007424 |
open tracheal system development |
FB:FBrf0167264 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007476 |
imaginal disc-derived wing morphogenesis |
FB:FBrf0193945 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007480 |
imaginal disc-derived leg morphogenesis |
FB:FBrf0135803 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007488 |
histoblast morphogenesis |
FB:FBrf0210385 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007507 |
heart development |
FB:FBrf0151249 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0008586 |
imaginal disc-derived wing vein morphogenesis |
FB:FBrf0135803 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0010629 |
negative regulation of gene expression |
FB:FBrf0193889 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0030618 |
transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity |
FB:FBrf0108831 |
NAS: Non-traceable Author Statement |
F |
From FB |
|||
| GO:0030707 |
ovarian follicle cell development |
FB:FBrf0128450 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0030707 |
ovarian follicle cell development |
FB:FBrf0190209 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0030718 |
germ-line stem cell maintenance |
FB:FBrf0103396 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0035019 |
somatic stem cell maintenance |
FB:FBrf0190209 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0035290 |
trunk segmentation |
FB:FBrf0208669 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0042078 |
germ-line stem cell division |
FB:FBrf0103396 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0042078 |
germ-line stem cell division |
FB:FBrf0155987 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0043565 |
sequence-specific DNA binding |
FB:FBrf0194560 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0043565 |
sequence-specific DNA binding |
FB:FBrf0209175 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0043565 |
sequence-specific DNA binding |
FB:FBrf0209559 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0045595 |
regulation of cell differentiation |
FB:FBrf0209706 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0045705 |
negative regulation of salivary gland boundary specification |
FB:FBrf0139594 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0045749 |
negative regulation of S phase of mitotic cell cycle |
FB:FBrf0187405 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0045887 |
positive regulation of synaptic growth at neuromuscular junction |
FB:FBrf0175022 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0045887 |
positive regulation of synaptic growth at neuromuscular junction |
FB:FBrf0208030 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
FB:FBrf0095428 |
IEP: Inferred from Expression Pattern |
P |
From FB |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
FB:FBrf0103397 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
FB:FBrf0209175 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0048100 |
wing disc anterior/posterior pattern formation |
FB:FBrf0183859 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0061353 |
BMP signaling pathway involved in Malpighian tubule cell chemotaxis |
FB:FBrf0211514 |
IDA: Inferred from Direct Assay |
P |
From FB |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Xu X et al. (1998) Smad proteins act in combination with synergistic and antagonistic regulators to target Dpp responses to the Drosophila mesoderm. Genes Dev 12: 2354-70 PubMed GONUTS page
- ↑ 2.0 2.1 Dai H et al. (2000) The zinc finger protein schnurri acts as a Smad partner in mediating the transcriptional response to decapentaplegic. Dev Biol 227: 373-87 PubMed GONUTS page
- ↑ Cordero JB et al. (2007) Dynamic decapentaplegic signaling regulates patterning and adhesion in the Drosophila pupal retina. Development 134: 1861-71 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Kim J et al. (1997) Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic. Nature 388: 304-8 PubMed GONUTS page
- ↑ Wisotzkey RG et al. (1998) Medea is a Drosophila Smad4 homolog that is differentially required to potentiate DPP responses. Development 125: 1433-45 PubMed GONUTS page
- ↑ Podos SD et al. (2001) The DSmurf ubiquitin-protein ligase restricts BMP signaling spatially and temporally during Drosophila embryogenesis. Dev Cell 1: 567-78 PubMed GONUTS page
- ↑ Liang YY et al. (2003) dSmurf selectively degrades decapentaplegic-activated MAD, and its overexpression disrupts imaginal disc development. J Biol Chem 278: 26307-10 PubMed GONUTS page
- ↑ Hyman CA et al. (2003) Drosophila TGIF proteins are transcriptional activators. Mol Cell Biol 23: 9262-74 PubMed GONUTS page
- ↑ 9.0 9.1 Affolter M et al. (2001) Nuclear interpretation of Dpp signaling in Drosophila. EMBO J 20: 3298-305 PubMed GONUTS page
- ↑ 10.0 10.1 Chen HB et al. (2006) Identification of phosphatases for Smad in the BMP/DPP pathway. Genes Dev 20: 648-53 PubMed GONUTS page
- ↑ Newfeld SJ et al. (1996) Mothers against dpp encodes a conserved cytoplasmic protein required in DPP/TGF-beta responsive cells. Development 122: 2099-108 PubMed GONUTS page
- ↑ 12.0 12.1 12.2 Wiersdorff V et al. (1996) Mad acts downstream of Dpp receptors, revealing a differential requirement for dpp signaling in initiation and propagation of morphogenesis in the Drosophila eye. Development 122: 2153-62 PubMed GONUTS page
- ↑ Lall S & Patel NH (2001) Conservation and divergence in molecular mechanisms of axis formation. Annu Rev Genet 35: 407-37 PubMed GONUTS page
- ↑ Harden N (2002) Signaling pathways directing the movement and fusion of epithelial sheets: lessons from dorsal closure in Drosophila. Differentiation 70: 181-203 PubMed GONUTS page
- ↑ Ghabrial A et al. (2003) Branching morphogenesis of the Drosophila tracheal system. Annu Rev Cell Dev Biol 19: 623-47 PubMed GONUTS page
- ↑ Dworkin I & Gibson G (2006) Epidermal growth factor receptor and transforming growth factor-beta signaling contributes to variation for wing shape in Drosophila melanogaster. Genetics 173: 1417-31 PubMed GONUTS page
- ↑ 17.0 17.1 Marquez RM et al. (2001) Transgenic analysis of the Smad family of TGF-beta signal transducers in Drosophila melanogaster suggests new roles and new interactions between family members. Genetics 157: 1639-48 PubMed GONUTS page
- ↑ Ninov N et al. (2010) Dpp signaling directs cell motility and invasiveness during epithelial morphogenesis. Curr Biol 20: 513-20 PubMed GONUTS page
- ↑ Cripps RM & Olson EN (2002) Control of cardiac development by an evolutionarily conserved transcriptional network. Dev Biol 246: 14-28 PubMed GONUTS page
- ↑ Anderson J et al. (2006) Regulation of the retinal determination gene dachshund in the embryonic head and developing eye of Drosophila. Dev Biol 297: 536-49 PubMed GONUTS page
- ↑ Dobens LL & Raftery LA (2000) Integration of epithelial patterning and morphogenesis in Drosophila ovarian follicle cells. Dev Dyn 218: 80-93 PubMed GONUTS page
- ↑ 22.0 22.1 Kirilly D et al. (2005) BMP signaling is required for controlling somatic stem cell self-renewal in the Drosophila ovary. Dev Cell 9: 651-62 PubMed GONUTS page
- ↑ 23.0 23.1 Xie T & Spradling AC (1998) decapentaplegic is essential for the maintenance and division of germline stem cells in the Drosophila ovary. Cell 94: 251-60 PubMed GONUTS page
- ↑ Eivers E et al. (2009) Mad is required for wingless signaling in wing development and segment patterning in Drosophila. PLoS One 4: e6543 PubMed GONUTS page
- ↑ Lin H (2002) The stem-cell niche theory: lessons from flies. Nat Rev Genet 3: 931-40 PubMed GONUTS page
- ↑ Lin MC et al. (2006) Threshold response of C15 to the Dpp gradient in Drosophila is established by the cumulative effect of Smad and Zen activators and negative cues. Development 133: 4805-13 PubMed GONUTS page
- ↑ 27.0 27.1 Grienenberger A et al. (2003) Tgfbeta signaling acts on a Hox response element to confer specificity and diversity to Hox protein function. Development 130: 5445-55 PubMed GONUTS page
- ↑ Weiss A et al. (2010) A conserved activation element in BMP signaling during Drosophila development. Nat Struct Mol Biol 17: 69-76 PubMed GONUTS page
- ↑ Mathur D et al. (2010) A transient niche regulates the specification of Drosophila intestinal stem cells. Science 327: 210-3 PubMed GONUTS page
- ↑ Bradley PL et al. (2001) Organ formation in Drosophila: specification and morphogenesis of the salivary gland. Bioessays 23: 901-11 PubMed GONUTS page
- ↑ Firth LC & Baker NE (2005) Extracellular signals responsible for spatially regulated proliferation in the differentiating Drosophila eye. Dev Cell 8: 541-51 PubMed GONUTS page
- ↑ McCabe BD et al. (2004) Highwire regulates presynaptic BMP signaling essential for synaptic growth. Neuron 41: 891-905 PubMed GONUTS page
- ↑ Merino C et al. (2009) Nemo kinase interacts with Mad to coordinate synaptic growth at the Drosophila neuromuscular junction. J Cell Biol 185: 713-25 PubMed GONUTS page
- ↑ Shen J & Dahmann C (2005) The role of Dpp signaling in maintaining the Drosophila anteroposterior compartment boundary. Dev Biol 279: 31-43 PubMed GONUTS page
- ↑ Bunt S et al. (2010) Hemocyte-secreted type IV collagen enhances BMP signaling to guide renal tubule morphogenesis in Drosophila. Dev Cell 19: 296-306 PubMed GONUTS page
