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FB:Lrrk

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Species (Taxon ID) Drosophila melanogaster (fruit fly) (taxon:7227)
Gene Name(s) Lrrk ( synonyms: CG5483, CT17358, LRRK, LRRK2, dLRRK, lrrk )
Protein Name(s) Leucine-rich repeat kinase,
External Links
FB FBgn0038816

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0004672

protein kinase activity

FB:FBrf0105495

ISS: Inferred from Sequence or Structural Similarity

SGD:S0000072

F

From FB

GO:0004672

protein kinase activity

FB:FBrf0207127
PMID:18701920[1]

IDA: Inferred from Direct Assay

F

From FB

GO:0004674

protein serine/threonine kinase activity

FB:FBrf0207127
PMID:18701920[1]

IMP: Inferred from Mutant Phenotype

F

From FB

GO:0004674

protein serine/threonine kinase activity

FB:FBrf0211787
PMID:20624856[2]

IDA: Inferred from Direct Assay

F

From FB

GO:0005524

ATP binding

FB:FBrf0174215

IEA: Inferred from Electronic Annotation

InterPro:IPR000719
InterPro:IPR017441

F

From FB

GO:0005525

GTP binding

FB:FBrf0174215

IEA: Inferred from Electronic Annotation

InterPro:IPR001806
InterPro:IPR013684

F

From FB

GO:0005622

intracellular

FB:FBrf0174215

IEA: Inferred from Electronic Annotation

InterPro:IPR013684

C

From FB

GO:0006468

protein phosphorylation

FB:FBrf0174215

IEA: Inferred from Electronic Annotation

InterPro:IPR000719
InterPro:IPR008271

P

From FB

GO:0007264

small GTPase mediated signal transduction

FB:FBrf0174215

IEA: Inferred from Electronic Annotation

InterPro:IPR001806
InterPro:IPR013684

P

From FB

GO:0050808

synapse organization

FB:FBrf0212570
PMID:21159966[3]

IMP: Inferred from Mutant Phenotype

P

From FB


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 Imai, Y et al. (2008) Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila. EMBO J. 27 2432-43 PubMed GONUTS page
  2. Kanao, T et al. (2010) Activation of FoxO by LRRK2 induces expression of proapoptotic proteins and alters survival of postmitotic dopaminergic neuron in Drosophila. Hum. Mol. Genet. 19 3747-58 PubMed GONUTS page
  3. Lee, S et al. (2010) LRRK2 kinase regulates synaptic morphology through distinct substrates at the presynaptic and postsynaptic compartments of the Drosophila neuromuscular junction. J. Neurosci. 30 16959-69 PubMed GONUTS page
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