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FB:Lis-1
Contents |
| Species (Taxon ID) | Drosophila melanogaster (fruit fly) (taxon:7227) | |
| Gene Name(s) | Lis-1 ( synonyms: CG8440, D-Lis1, DLIS-1, DLIS1, DLis-1, DLis1, Dlis-1, Dlis1, DmLIS1, LIS-1, Lis 1, Lis1, Paf-AHbeta, dLis1, l(2)k13209, l(2R)W8, lis-1, lis1, lissencephaly-1, n(2)k11702, platelet-activating factor acetylhydrolase Ib beta-subunit homolog ) | |
| Protein Name(s) | Lissencephaly-1, | |
| External Links | ||
| FB | FBgn0015754 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000776 |
kinetochore |
FB:FBrf0191164 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005828 |
kinetochore microtubule |
FB:FBrf0191164 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005869 |
dynactin complex |
FB:FBrf0191164 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005938 |
cell cortex |
FB:FBrf0112050 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0006886 |
intracellular protein transport |
FB:FBrf0191164 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007018 |
microtubule-based movement |
FB:FBrf0132100 |
ISS: Inferred from Sequence or Structural Similarity |
P |
From FB |
|||
| GO:0007093 |
mitotic cell cycle checkpoint |
FB:FBrf0191164 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0003268 |
P |
From FB |
||
| GO:0007093 |
mitotic cell cycle checkpoint |
FB:FBrf0191164 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007294 |
germarium-derived oocyte fate determination |
FB:FBrf0112050 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007303 |
cytoplasmic transport, nurse cell to oocyte |
FB:FBrf0112050 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007312 |
oocyte nucleus migration involved in oocyte dorsal/ventral axis specification |
FB:FBrf0129938 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007405 |
neuroblast proliferation |
FB:FBrf0131351 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008088 |
axon cargo transport |
FB:FBrf0131351 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008104 |
protein localization |
FB:FBrf0112050 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0261797 |
P |
From FB |
||
| GO:0008104 |
protein localization |
FB:FBrf0129938 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008298 |
intracellular mRNA localization |
FB:FBrf0129938 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0016319 |
mushroom body development |
FB:FBrf0131351 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0019827 |
stem cell maintenance |
FB:FBrf0212350 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0030234 |
enzyme regulator activity |
FB:FBrf0111489 |
ISS: Inferred from Sequence or Structural Similarity |
F |
From FB |
|||
| GO:0030286 |
dynein complex |
FB:FBrf0132100 |
ISS: Inferred from Sequence or Structural Similarity |
C |
From FB |
|||
| GO:0030286 |
dynein complex |
FB:FBrf0191164 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0030381 |
chorion-containing eggshell pattern formation |
FB:FBrf0129938 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0030424 |
axon |
FB:FBrf0131351 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0030425 |
dendrite |
FB:FBrf0131351 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0030473 |
nuclear migration along microtubule |
FB:FBrf0129938 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0001108 |
P |
From FB |
||
| GO:0030473 |
nuclear migration along microtubule |
FB:FBrf0129938 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0261797 |
P |
From FB |
||
| GO:0030510 |
regulation of BMP signaling pathway |
FB:FBrf0212350 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0030706 |
germarium-derived oocyte differentiation |
FB:FBrf0111416 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0030716 |
oocyte fate determination |
FB:FBrf0112050 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0000183 |
P |
From FB |
||
| GO:0031616 |
spindle pole centrosome |
FB:FBrf0191164 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0042623 |
ATPase activity, coupled |
FB:FBrf0132100 |
ISS: Inferred from Sequence or Structural Similarity |
F |
From FB |
|||
| GO:0043025 |
neuronal cell body |
FB:FBrf0131351 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0045478 |
fusome organization |
FB:FBrf0111416 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0045502 |
dynein binding |
FB:FBrf0128643 |
ISS: Inferred from Sequence or Structural Similarity |
F |
From FB |
|||
| GO:0048135 |
female germ-line cyst formation |
FB:FBrf0111416 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0048477 |
oogenesis |
FB:FBrf0111416 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0048477 |
oogenesis |
FB:FBrf0112050 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0048813 |
dendrite morphogenesis |
FB:FBrf0131351 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0048813 |
dendrite morphogenesis |
FB:FBrf0207048 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0048814 |
regulation of dendrite morphogenesis |
FB:FBrf0206898 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0050790 |
regulation of catalytic activity |
FB:FBrf0111489 |
ISS: Inferred from Sequence or Structural Similarity |
P |
From FB |
|||
| GO:0051225 |
spindle assembly |
FB:FBrf0191164 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0051299 |
centrosome separation |
FB:FBrf0191164 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0051383 |
kinetochore organization |
FB:FBrf0191164 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0051647 |
nucleus localization |
FB:FBrf0112050 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 Siller KH et al. (2005) Live imaging of Drosophila brain neuroblasts reveals a role for Lis1/dynactin in spindle assembly and mitotic checkpoint control. Mol Biol Cell 16: 5127-40 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Swan A et al. (1999) Drosophila Lissencephaly-1 functions with Bic-D and dynein in oocyte determination and nuclear positioning. Nat Cell Biol 1: 444-9 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Goldstein LS & Gunawardena S (2000) Flying through the drosophila cytoskeletal genome. J Cell Biol 150: F63-8 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 Lei Y & Warrior R (2000) The Drosophila Lissencephaly1 (DLis1) gene is required for nuclear migration. Dev Biol 226: 57-72 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 Liu Z et al. (2000) Drosophila Lis1 is required for neuroblast proliferation, dendritic elaboration and axonal transport. Nat Cell Biol 2: 776-83 PubMed GONUTS page
- ↑ 6.0 6.1 Chen S et al. (2010) Lissencephaly-1 controls germline stem cell self-renewal through modulating bone morphogenetic protein signaling and niche adhesion. Proc Natl Acad Sci U S A 107: 19939-44 PubMed GONUTS page
- ↑ 7.0 7.1 Spradling AC et al. (1999) The Berkeley Drosophila Genome Project gene disruption project: Single P-element insertions mutating 25% of vital Drosophila genes. Genetics 153: 135-77 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 8.3 Liu Z et al. (1999) Lis1, the Drosophila homolog of a human lissencephaly disease gene, is required for germline cell division and oocyte differentiation. Development 126: 4477-88 PubMed GONUTS page
- ↑ Sheffield PJ et al. (2000) Homologs of the alpha- and beta-subunits of mammalian brain platelet-activating factor acetylhydrolase Ib in the Drosophila melanogaster genome. Proteins 39: 1-8 PubMed GONUTS page
- ↑ Satoh D et al. (2008) Spatial control of branching within dendritic arbors by dynein-dependent transport of Rab5-endosomes. Nat Cell Biol 10: 1164-71 PubMed GONUTS page
- ↑ Zheng Y et al. (2008) Dynein is required for polarized dendritic transport and uniform microtubule orientation in axons. Nat Cell Biol 10: 1172-80 PubMed GONUTS page
