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FB:Kr

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Contents

Species (Taxon ID) Drosophila melanogaster (fruit fly) (taxon:7227)
Gene Name(s) Kr ( synonyms: CG3340, Dm-Kr, If, Irregular facets, KR, KRUPPEL, Krpple, Krueppel, Kuppel, Lruppel, kr, krueppel, kruppel )
Protein Name(s) Kruppel,
External Links
FB FBgn0001325

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000122

negative regulation of transcription from RNA polymerase II promoter

FB:FBrf0054055
PMID:1671661[1]

IDA: Inferred from Direct Assay

P

From FB

GO:0000122

negative regulation of transcription from RNA polymerase II promoter

FB:FBrf0125319
PMID:10644409[2]

IDA: Inferred from Direct Assay

P

From FB

GO:0000122

negative regulation of transcription from RNA polymerase II promoter

FB:FBrf0141797
PMID:11691830[3]

TAS: Traceable Author Statement

P

From FB

GO:0000981

sequence-specific DNA binding RNA polymerase II transcription factor activity

FB:FBrf0054055
PMID:1671661[1]

IDA: Inferred from Direct Assay

F

From FB

GO:0003682

chromatin binding

FB:FBrf0123422

NAS: Non-traceable Author Statement

F

From FB

GO:0003700

sequence-specific DNA binding transcription factor activity

FB:FBrf0105495

NAS: Non-traceable Author Statement

F

From FB

GO:0003700

sequence-specific DNA binding transcription factor activity

FB:FBrf0205197
PMID:18271625[4]

IDA: Inferred from Direct Assay

F

From FB

GO:0003705

RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity

FB:FBrf0125319
PMID:10644409[2]

IDA: Inferred from Direct Assay

F

From FB

GO:0005622

intracellular

FB:FBrf0174215

IEA: Inferred from Electronic Annotation

InterPro:IPR007087
InterPro:IPR015880

C

From FB

GO:0005634

nucleus

FB:FBrf0105495

NAS: Non-traceable Author Statement

C

From FB

GO:0005634

nucleus

FB:FBrf0123422

NAS: Non-traceable Author Statement

C

From FB

GO:0006342

chromatin silencing

FB:FBrf0206861
PMID:19049982[5]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007354

zygotic determination of anterior/posterior axis, embryo

FB:FBrf0123422

NAS: Non-traceable Author Statement

P

From FB

GO:0007354

zygotic determination of anterior/posterior axis, embryo

FB:FBrf0141797
PMID:11691830[3]

NAS: Non-traceable Author Statement

P

From FB

GO:0007354

zygotic determination of anterior/posterior axis, embryo

FB:FBrf0179912
PMID:15382142[6]

TAS: Traceable Author Statement

P

From FB

GO:0007400

neuroblast fate determination

FB:FBrf0138252
PMID:11525736[7]

IEP: Inferred from Expression Pattern

P

From FB

GO:0007400

neuroblast fate determination

FB:FBrf0138252
PMID:11525736[7]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007402

ganglion mother cell fate determination

FB:FBrf0158840
PMID:12593977[8]

TAS: Traceable Author Statement

P

From FB

GO:0007411

axon guidance

FB:FBrf0139747
PMID:11677048[9]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007419

ventral cord development

FB:FBrf0158840
PMID:12593977[8]

NAS: Non-traceable Author Statement

P

From FB

GO:0007443

Malpighian tubule morphogenesis

FB:FBrf0111439
PMID:10512197[10]

TAS: Traceable Author Statement

P

From FB

GO:0007443

Malpighian tubule morphogenesis

FB:FBrf0123422

NAS: Non-traceable Author Statement

P

From FB

GO:0007517

muscle organ development

FB:FBrf0151208
PMID:12111720[11]

TAS: Traceable Author Statement

P

From FB

GO:0008270

zinc ion binding

FB:FBrf0174215

IEA: Inferred from Electronic Annotation

InterPro:IPR007087
InterPro:IPR015880

F

From FB

GO:0010629

negative regulation of gene expression

FB:FBrf0193889
PMID:16780828[12]

IDA: Inferred from Direct Assay

P

From FB

GO:0035220

wing disc development

FB:FBrf0211594
PMID:20730086[13]

IGI: Inferred from Genetic Interaction

FB:FBgn0000242

P

From FB

GO:0035290

trunk segmentation

FB:FBrf0179912
PMID:15382142[6]

TAS: Traceable Author Statement

P

From FB

GO:0040034

regulation of development, heterochronic

FB:FBrf0144740
PMID:11835276[14]

TAS: Traceable Author Statement

P

From FB

GO:0040034

regulation of development, heterochronic

FB:FBrf0151728
PMID:12142272[15]

TAS: Traceable Author Statement

P

From FB

GO:0040034

regulation of development, heterochronic

FB:FBrf0178965
PMID:14588255[16]

NAS: Non-traceable Author Statement

P

From FB

GO:0043565

sequence-specific DNA binding

FB:FBrf0050632
PMID:2797150[17]

IDA: Inferred from Direct Assay

F

From FB

GO:0043565

sequence-specific DNA binding

FB:FBrf0054055
PMID:1671661[1]

IDA: Inferred from Direct Assay

F

From FB

GO:0048749

compound eye development

FB:FBrf0056571
PMID:1634999[18]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0048749

compound eye development

FB:FBrf0193889
PMID:16780828[12]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0061332

Malpighian tubule bud morphogenesis

FB:FBrf0192796
PMID:17190812[19]

IGI: Inferred from Genetic Interaction

FB:FBgn0004198

P

From FB


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 1.2 Zuo P et al. (1991) Activation and repression of transcription by the gap proteins hunchback and Krüppel in cultured Drosophila cells. Genes Dev 5: 254-64 PubMed GONUTS page
  2. 2.0 2.1 Shimell MJ et al. (2000) Functional analysis of repressor binding sites in the iab-2 regulatory region of the abdominal-A homeotic gene. Dev Biol 218: 38-52 PubMed GONUTS page
  3. 3.0 3.1 Courey AJ & Jia S (2001) Transcriptional repression: the long and the short of it. Genes Dev 15: 2786-96 PubMed GONUTS page
  4. Li XY et al. (2008) Transcription factors bind thousands of active and inactive regions in the Drosophila blastoderm. PLoS Biol 6: e27 PubMed GONUTS page
  5. Matyash A et al. (2009) SAP18 promotes Krüppel-dependent transcriptional repression by enhancer-specific histone deacetylation. J Biol Chem 284: 3012-20 PubMed GONUTS page
  6. 6.0 6.1 Peel A (2004) The evolution of arthropod segmentation mechanisms. Bioessays 26: 1108-16 PubMed GONUTS page
  7. 7.0 7.1 Isshiki T et al. (2001) Drosophila neuroblasts sequentially express transcription factors which specify the temporal identity of their neuronal progeny. Cell 106: 511-21 PubMed GONUTS page
  8. 8.0 8.1 Skeath JB & Thor S (2003) Genetic control of Drosophila nerve cord development. Curr Opin Neurobiol 13: 8-15 PubMed GONUTS page
  9. Abrell S & Jäckle H (2001) Axon guidance of Drosophila SNb motoneurons depends on the cooperative action of muscular Krüppel and neuronal capricious activities. Mech Dev 109: 3-12 PubMed GONUTS page
  10. Murakami R et al. (1999) Developmental genetics of the Drosophila gut: specification of primordia, subdivision and overt-differentiation. Cell Mol Biol (Noisy-le-grand) 45: 661-76 PubMed GONUTS page
  11. Dworak HA & Sink H (2002) Myoblast fusion in Drosophila. Bioessays 24: 591-601 PubMed GONUTS page
  12. 12.0 12.1 Anderson J et al. (2006) Regulation of the retinal determination gene dachshund in the embryonic head and developing eye of Drosophila. Dev Biol 297: 536-49 PubMed GONUTS page
  13. Bronstein R et al. (2010) Transcriptional regulation by CHIP/LDB complexes. PLoS Genet 6: e1001063 PubMed GONUTS page
  14. Banerjee D & Slack F (2002) Control of developmental timing by small temporal RNAs: a paradigm for RNA-mediated regulation of gene expression. Bioessays 24: 119-29 PubMed GONUTS page
  15. Pasquinelli AE & Ruvkun G (2002) Control of developmental timing by micrornas and their targets. Annu Rev Cell Dev Biol 18: 495-513 PubMed GONUTS page
  16. Abbott AL (2003) Heterochronic genes. Curr Biol 13: R824-5 PubMed GONUTS page
  17. Treisman J & Desplan C (1989) The products of the Drosophila gap genes hunchback and Krüppel bind to the hunchback promoters. Nature 341: 335-7 PubMed GONUTS page
  18. Baker NE et al. (1992) Mutations on the second chromosome affecting the Drosophila eye. J Neurogenet 8: 85-100 PubMed GONUTS page
  19. Hatton-Ellis E et al. (2007) Genetic regulation of patterned tubular branching in Drosophila. Proc Natl Acad Sci U S A 104: 169-74 PubMed GONUTS page
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