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FB:Khc
Contents |
| Species (Taxon ID) | Drosophila melanogaster (fruit fly) (taxon:7227) | |
| Gene Name(s) | Khc ( synonyms: CG7765, DK, DKH, DmK, DmKHC, Dmkin, KHC, KIF5A, KIN, Kin, Kinesin, Kinesin-1, Kinesin-1 heavy chain, conventional kinesin, khc, kin, kinesin, kinesin 1, kinesin I, kinesin alpha subunit, kinesin alpha-chain, kinesin heavy chain, kinesin heavy chain I, kinesin-1, kinesin-1 heavy chain, l(2)W12, l(2)k13219, l(2)k13314, l(2R)W12, partagas, pgs ) | |
| Protein Name(s) | Kinesin heavy chain, | |
| External Links | ||
| FB | FBgn0001308 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001754 |
eye photoreceptor cell differentiation |
FB:FBrf0180149 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0001108 |
P |
From FB |
||
| GO:0003774 |
motor activity |
FB:FBrf0059140 |
NAS: Non-traceable Author Statement |
F |
From FB |
|||
| GO:0003777 |
microtubule motor activity |
FB:FBrf0105495 |
ISS: Inferred from Sequence or Structural Similarity |
EMBL:AF067180 |
F |
From FB |
||
| GO:0003777 |
microtubule motor activity |
FB:FBrf0123648 |
NAS: Non-traceable Author Statement |
F |
From FB |
|||
| GO:0003777 |
microtubule motor activity |
FB:FBrf0132100 |
ISS: Inferred from Sequence or Structural Similarity |
F |
From FB |
|||
| GO:0003777 |
microtubule motor activity |
FB:FBrf0205157 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0003777 |
microtubule motor activity |
FB:FBrf0210395 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0005524 |
ATP binding |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
F |
From FB |
|||
| GO:0005871 |
kinesin complex |
FB:FBrf0059140 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005871 |
kinesin complex |
FB:FBrf0105495 |
ISS: Inferred from Sequence or Structural Similarity |
EMBL:AF067180 |
C |
From FB |
||
| GO:0005871 |
kinesin complex |
FB:FBrf0123648 |
NAS: Non-traceable Author Statement |
C |
From FB |
|||
| GO:0005871 |
kinesin complex |
FB:FBrf0132100 |
ISS: Inferred from Sequence or Structural Similarity |
C |
From FB |
|||
| GO:0005875 |
microtubule associated complex |
FB:FBrf0204649 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0006886 |
intracellular protein transport |
FB:FBrf0216511 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007018 |
microtubule-based movement |
FB:FBrf0105495 |
ISS: Inferred from Sequence or Structural Similarity |
EMBL:AF067180 |
P |
From FB |
||
| GO:0007018 |
microtubule-based movement |
FB:FBrf0123648 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0007018 |
microtubule-based movement |
FB:FBrf0132100 |
ISS: Inferred from Sequence or Structural Similarity |
P |
From FB |
|||
| GO:0007018 |
microtubule-based movement |
FB:FBrf0205157 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0007269 |
neurotransmitter secretion |
FB:FBrf0123648 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0007303 |
cytoplasmic transport, nurse cell to oocyte |
FB:FBrf0155474 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007310 |
oocyte dorsal/ventral axis specification |
FB:FBrf0151843 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007315 |
pole plasm assembly |
FB:FBrf0151439 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007317 |
regulation of pole plasm oskar mRNA localization |
FB:FBrf0129740 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007317 |
regulation of pole plasm oskar mRNA localization |
FB:FBrf0156097 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007409 |
axonogenesis |
FB:FBrf0207048 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007411 |
axon guidance |
FB:FBrf0210319 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008017 |
microtubule binding |
FB:FBrf0059140 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0008017 |
microtubule binding |
FB:FBrf0105495 |
ISS: Inferred from Sequence or Structural Similarity |
EMBL:AF067180 |
F |
From FB |
||
| GO:0008088 |
axon cargo transport |
FB:FBrf0162237 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008103 |
oocyte microtubule cytoskeleton polarization |
FB:FBrf0192117 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008574 |
plus-end-directed microtubule motor activity |
FB:FBrf0129740 |
TAS: Traceable Author Statement |
F |
From FB |
|||
| GO:0010970 |
microtubule-based transport |
FB:FBrf0210395 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0016482 |
cytoplasmic transport |
FB:FBrf0187481 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0019227 |
neuronal action potential propagation |
FB:FBrf0123648 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0030011 |
maintenance of cell polarity |
FB:FBrf0216511 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0045451 |
pole plasm oskar mRNA localization |
FB:FBrf0155474 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0047497 |
mitochondrion transport along microtubule |
FB:FBrf0191163 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0048311 |
mitochondrion distribution |
FB:FBrf0192257 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0048812 |
neuron projection morphogenesis |
FB:FBrf0216511 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0048813 |
dendrite morphogenesis |
FB:FBrf0207048 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
|
colocalizes_with |
GO:0005739 |
mitochondrion |
FB:FBrf0191163 |
IDA: Inferred from Direct Assay |
C |
From FB |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Whited JL et al. (2004) Dynactin is required to maintain nuclear position within postmitotic Drosophila photoreceptor neurons. Development 131: 4677-86 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Harrison BC et al. (1993) Decoration of the microtubule surface by one kinesin head per tubulin heterodimer. Nature 362: 73-5 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Goldstein LS & Gunawardena S (2000) Flying through the drosophila cytoskeletal genome. J Cell Biol 150: F63-8 PubMed GONUTS page
- ↑ 4.0 4.1 Ali MY et al. (2008) Myosin V and Kinesin act as tethers to enhance each others' processivity. Proc Natl Acad Sci U S A 105: 4691-6 PubMed GONUTS page
- ↑ 5.0 5.1 Gagliano J et al. (2010) Kinesin velocity increases with the number of motors pulling against viscoelastic drag. Eur Biophys J 39: 801-13 PubMed GONUTS page
- ↑ Hughes JR et al. (2008) A microtubule interactome: complexes with roles in cell cycle and mitosis. PLoS Biol 6: e98 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 Henthorn KS et al. (2011) A role for kinesin heavy chain in controlling vesicle transport into dendrites in Drosophila. Mol Biol Cell 22: 4038-46 PubMed GONUTS page
- ↑ 8.0 8.1 Cohen RS (2002) Oocyte patterning: dynein and kinesin, inc. Curr Biol 12: R797-9 PubMed GONUTS page
- ↑ Brendza RP et al. (2002) Posterior localization of dynein and dorsal-ventral axis formation depend on kinesin in Drosophila oocytes. Curr Biol 12: 1541-5 PubMed GONUTS page
- ↑ Cha BJ et al. (2002) Kinesin I-dependent cortical exclusion restricts pole plasm to the oocyte posterior. Nat Cell Biol 4: 592-8 PubMed GONUTS page
- ↑ 11.0 11.1 Brendza RP et al. (2000) A function for kinesin I in the posterior transport of oskar mRNA and Staufen protein. Science 289: 2120-2 PubMed GONUTS page
- ↑ Tekotte H & Davis I (2002) Intracellular mRNA localization: motors move messages. Trends Genet 18: 636-42 PubMed GONUTS page
- ↑ 13.0 13.1 Satoh D et al. (2008) Spatial control of branching within dendritic arbors by dynein-dependent transport of Rab5-endosomes. Nat Cell Biol 10: 1164-71 PubMed GONUTS page
- ↑ Berger J et al. (2008) Systematic identification of genes that regulate neuronal wiring in the Drosophila visual system. PLoS Genet 4: e1000085 PubMed GONUTS page
- ↑ Gindhart JG et al. (2003) The kinesin-associated protein UNC-76 is required for axonal transport in the Drosophila nervous system. Mol Biol Cell 14: 3356-65 PubMed GONUTS page
- ↑ Zimyanin V et al. (2007) An oskar-dependent positive feedback loop maintains the polarity of the Drosophila oocyte. Curr Biol 17: 353-9 PubMed GONUTS page
- ↑ Serbus LR et al. (2005) Dynein and the actin cytoskeleton control kinesin-driven cytoplasmic streaming in Drosophila oocytes. Development 132: 3743-52 PubMed GONUTS page
- ↑ 18.0 18.1 Pilling AD et al. (2006) Kinesin-1 and Dynein are the primary motors for fast transport of mitochondria in Drosophila motor axons. Mol Biol Cell 17: 2057-68 PubMed GONUTS page
- ↑ Cox RT & Spradling AC (2006) Milton controls the early acquisition of mitochondria by Drosophila oocytes. Development 133: 3371-7 PubMed GONUTS page
