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FB:Iswi

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Contents

Species (Taxon ID) Drosophila melanogaster (fruit fly) (taxon:7227)
Gene Name(s) Iswi ( synonyms: ACF, CG8625, CHRAC, ISW, ISWI, ISWI ATPase, Imitation SW, NURF, NURF-140, Nucleosome remodeling factor, Nucleosome remodeling factor - 140kD, Nurf-140, SWI, anon-EP1279744.124, dCHRAC, dISWI, dNURF, imitation SWI, imitation switch, imitation-SWI, iswi, p140, p140/ISWI )
Protein Name(s) Imitation SWI,
External Links
FB FBgn0011604

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000166

nucleotide binding

FB:FBrf0095281
PMID:9230310[1]

TAS: Traceable Author Statement

F

From FB

GO:0003677

DNA binding

FB:FBrf0174215

IEA: Inferred from Electronic Annotation

InterPro:IPR000330
InterPro:IPR001005

F

From FB

GO:0003678

DNA helicase activity

FB:FBrf0129739
PMID:10944116[2]

TAS: Traceable Author Statement

F

From FB

GO:0004386

helicase activity

FB:FBrf0174215

IEA: Inferred from Electronic Annotation

InterPro:IPR001650

F

From FB

GO:0005515

protein binding

FB:FBrf0129776
PMID:10856248[3]

IPI: Inferred from Physical Interaction

FB:FBgn0043002

F

From FB

GO:0005515

protein binding

FB:FBrf0129776
PMID:10856248[3]

IPI: Inferred from Physical Interaction

FB:FBgn0043002
FB:FBgn0043001

F

From FB

GO:0005515

protein binding

FB:FBrf0159374
PMID:12192034[4]

IPI: Inferred from Physical Interaction

FB:FBgn0027620

F

From FB

GO:0005515

protein binding

FB:FBrf0187487
PMID:16141224[5]

IPI: Inferred from Physical Interaction

FB:FBgn0013764

F

From FB

GO:0005515

protein binding

FB:FBrf0187487
PMID:16141224[5]

IPI: Inferred from Physical Interaction

FB:FBgn0033636

F

From FB

GO:0005524

ATP binding

FB:FBrf0086062
PMID:8521502[6]

ISS: Inferred from Sequence or Structural Similarity

SGD:S0005816

F

From FB

GO:0005634

nucleus

FB:FBrf0086062
PMID:8521502[6]

IDA: Inferred from Direct Assay

C

From FB

GO:0005667

transcription factor complex

FB:FBrf0155489
PMID:12459787[7]

IPI: Inferred from Physical Interaction

FB:FBgn0261793

C

From FB

GO:0005700

polytene chromosome

FB:FBrf0210332
PMID:18454204[8]

IDA: Inferred from Direct Assay

C

From FB

GO:0005700

polytene chromosome

FB:FBrf0211659
PMID:18535655[9]

IDA: Inferred from Direct Assay

C

From FB

GO:0006325

chromatin organization

FB:FBrf0202257
PMID:17760505[10]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0006333

chromatin assembly or disassembly

FB:FBrf0102150
PMID:9659911[11]

IDA: Inferred from Direct Assay

P

From FB

GO:0006333

chromatin assembly or disassembly

FB:FBrf0173283
PMID:14635254[12]

TAS: Traceable Author Statement

P

From FB

GO:0006334

nucleosome assembly

FB:FBrf0095281
PMID:9230310[1]

IDA: Inferred from Direct Assay

P

From FB

GO:0006334

nucleosome assembly

FB:FBrf0109981
PMID:10385622[13]

IDA: Inferred from Direct Assay

P

From FB

GO:0006338

chromatin remodeling

FB:FBrf0068480
PMID:7908117[14]

ISS: Inferred from Sequence or Structural Similarity

SGD:S0005816

P

From FB

GO:0006338

chromatin remodeling

FB:FBrf0124303

NAS: Non-traceable Author Statement

P

From FB

GO:0006338

chromatin remodeling

FB:FBrf0129739
PMID:10944116[2]

TAS: Traceable Author Statement

P

From FB

GO:0006338

chromatin remodeling

FB:FBrf0173283
PMID:14635254[12]

TAS: Traceable Author Statement

P

From FB

GO:0006351

transcription, DNA-dependent

FB:FBrf0135834
PMID:11279013[15]

IDA: Inferred from Direct Assay

P

From FB

GO:0006355

regulation of transcription, DNA-dependent

FB:FBrf0095281
PMID:9230310[1]

IDA: Inferred from Direct Assay

P

From FB

GO:0006355

regulation of transcription, DNA-dependent

FB:FBrf0202257
PMID:17760505[10]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007517

muscle organ development

FB:FBrf0190556
PMID:16547170[16]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0008094

DNA-dependent ATPase activity

FB:FBrf0094778
PMID:9303316[17]

IDA: Inferred from Direct Assay

F

From FB

GO:0008094

DNA-dependent ATPase activity

FB:FBrf0094778
PMID:9303316[17]

IGI: Inferred from Genetic Interaction

FB:FBgn0001199

F

From FB

GO:0008094

DNA-dependent ATPase activity

FB:FBrf0094778
PMID:9303316[17]

IGI: Inferred from Genetic Interaction

FB:FBgn0001200

F

From FB

GO:0008094

DNA-dependent ATPase activity

FB:FBrf0097684
PMID:9252192[18]

IDA: Inferred from Direct Assay

F

From FB

GO:0008094

DNA-dependent ATPase activity

FB:FBrf0108784
PMID:10399912[19]

IDA: Inferred from Direct Assay

F

From FB

GO:0008094

DNA-dependent ATPase activity

FB:FBrf0159374
PMID:12192034[4]

IDA: Inferred from Direct Assay

F

From FB

GO:0008134

transcription factor binding

FB:FBrf0187487
PMID:16141224[5]

IPI: Inferred from Physical Interaction

FB:FBgn0003117

F

From FB

GO:0008623

chromatin accessibility complex

FB:FBrf0097684
PMID:9252192[18]

IDA: Inferred from Direct Assay

C

From FB

GO:0008623

chromatin accessibility complex

FB:FBrf0124303

NAS: Non-traceable Author Statement

C

From FB

GO:0008623

chromatin accessibility complex

FB:FBrf0138380
PMID:11447119[20]

IDA: Inferred from Direct Assay

C

From FB

GO:0008623

chromatin accessibility complex

FB:FBrf0155786
PMID:12502740[21]

TAS: Traceable Author Statement

C

From FB

GO:0008623

chromatin accessibility complex

FB:FBrf0173283
PMID:14635254[12]

NAS: Non-traceable Author Statement

C

From FB

GO:0016584

nucleosome positioning

FB:FBrf0095281
PMID:9230310[1]

IDA: Inferred from Direct Assay

P

From FB

GO:0016584

nucleosome positioning

FB:FBrf0097684
PMID:9252192[18]

IDA: Inferred from Direct Assay

P

From FB

GO:0016585

chromatin remodeling complex

FB:FBrf0105495

ISS: Inferred from Sequence or Structural Similarity

SGD:S0005816

C

From FB

GO:0016589

NURF complex

FB:FBrf0086062
PMID:8521502[6]

IDA: Inferred from Direct Assay

C

From FB

GO:0016589

NURF complex

FB:FBrf0095281
PMID:9230310[1]

TAS: Traceable Author Statement

C

From FB

GO:0016589

NURF complex

FB:FBrf0105229
PMID:9784495[22]

TAS: Traceable Author Statement

C

From FB

GO:0016589

NURF complex

FB:FBrf0124303

NAS: Non-traceable Author Statement

C

From FB

GO:0016589

NURF complex

FB:FBrf0155786
PMID:12502740[21]

TAS: Traceable Author Statement

C

From FB

GO:0016589

NURF complex

FB:FBrf0173283
PMID:14635254[12]

TAS: Traceable Author Statement

C

From FB

GO:0016590

ACF complex

FB:FBrf0095281
PMID:9230310[1]

IDA: Inferred from Direct Assay

C

From FB

GO:0016590

ACF complex

FB:FBrf0109981
PMID:10385622[13]

IDA: Inferred from Direct Assay

C

From FB

GO:0016590

ACF complex

FB:FBrf0124303

NAS: Non-traceable Author Statement

C

From FB

GO:0016590

ACF complex

FB:FBrf0155786
PMID:12502740[21]

TAS: Traceable Author Statement

C

From FB

GO:0016590

ACF complex

FB:FBrf0173283
PMID:14635254[12]

NAS: Non-traceable Author Statement

C

From FB

GO:0016887

ATPase activity

FB:FBrf0124303

NAS: Non-traceable Author Statement

F

From FB

GO:0031213

RSF complex

FB:FBrf0210332
PMID:18454204[8]

IPI: Inferred from Physical Interaction

FB:FBgn0026577

C

From FB

GO:0031491

nucleosome binding

FB:FBrf0174215

IEA: Inferred from Electronic Annotation

InterPro:IPR015194

F

From FB

GO:0035063

nuclear speck organization

FB:FBrf0213856
PMID:21637796[23]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0035076

ecdysone receptor-mediated signaling pathway

FB:FBrf0190536
PMID:16264191[24]

IGI: Inferred from Genetic Interaction

FB:FBgn0000546

P

From FB

GO:0042752

regulation of circadian rhythm

FB:FBrf0201156
PMID:17578908[25]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0042766

nucleosome mobilization

FB:FBrf0108784
PMID:10399912[19]

IDA: Inferred from Direct Assay

P

From FB

GO:0042766

nucleosome mobilization

FB:FBrf0138380
PMID:11447119[20]

IDA: Inferred from Direct Assay

P

From FB

GO:0042766

nucleosome mobilization

FB:FBrf0149692
PMID:11741543[26]

IDA: Inferred from Direct Assay

P

From FB

GO:0042766

nucleosome mobilization

FB:FBrf0173283
PMID:14635254[12]

TAS: Traceable Author Statement

P

From FB

GO:0043044

ATP-dependent chromatin remodeling

FB:FBrf0174215

IEA: Inferred from Electronic Annotation

InterPro:IPR015194

P

From FB

GO:0045892

negative regulation of transcription, DNA-dependent

FB:FBrf0206995
PMID:18786525[27]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0045893

positive regulation of transcription, DNA-dependent

FB:FBrf0155786
PMID:12502740[21]

TAS: Traceable Author Statement

P

From FB

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

FB:FBrf0187487
PMID:16141224[5]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0048813

dendrite morphogenesis

FB:FBrf0190556
PMID:16547170[16]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0070615

nucleosome-dependent ATPase activity

FB:FBrf0211659
PMID:18535655[9]

IDA: Inferred from Direct Assay

F

From FB

NOT

GO:0035060

brahma complex

FB:FBrf0127148
PMID:10809665[28]

IDA: Inferred from Direct Assay

C

From FB


edit table

Notes

References

See Help:References for how to manage references in GONUTS.
  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Ito T et al. (1997) ACF, an ISWI-containing and ATP-utilizing chromatin assembly and remodeling factor. Cell 90: 145-55 PubMed GONUTS page
  2. ↑ 2.0 2.1 Brehm A et al. (2000) dMi-2 and ISWI chromatin remodelling factors have distinct nucleosome binding and mobilization properties. EMBO J 19: 4332-41 PubMed GONUTS page
  3. ↑ 3.0 3.1 Corona DF et al. (2000) Two histone fold proteins, CHRAC-14 and CHRAC-16, are developmentally regulated subunits of chromatin accessibility complex (CHRAC). EMBO J 19: 3049-59 PubMed GONUTS page
  4. ↑ 4.0 4.1 Fyodorov DV & Kadonaga JT (2002) Binding of Acf1 to DNA involves a WAC motif and is important for ACF-mediated chromatin assembly. Mol Cell Biol 22: 6344-53 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 Vanolst L et al. (2005) Toutatis, a TIP5-related protein, positively regulates Pannier function during Drosophila neural development. Development 132: 4327-38 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 Tsukiyama T et al. (1995) ISWI, a member of the SWI2/SNF2 ATPase family, encodes the 140 kDa subunit of the nucleosome remodeling factor. Cell 83: 1021-6 PubMed GONUTS page
  7. ↑ Hochheimer A et al. (2002) TRF2 associates with DREF and directs promoter-selective gene expression in Drosophila. Nature 420: 439-45 PubMed GONUTS page
  8. ↑ 8.0 8.1 Hanai K et al. (2008) RSF governs silent chromatin formation via histone H2Av replacement. PLoS Genet 4: e1000011 PubMed GONUTS page
  9. ↑ 9.0 9.1 Burgio G et al. (2008) Genetic identification of a network of factors that functionally interact with the nucleosome remodeling ATPase ISWI. PLoS Genet 4: e1000089 PubMed GONUTS page
  10. ↑ 10.0 10.1 Corona DF et al. (2007) ISWI regulates higher-order chromatin structure and histone H1 assembly in vivo. PLoS Biol 5: e232 PubMed GONUTS page
  11. ↑ Mizuguchi G et al. (1997) Role of nucleosome remodeling factor NURF in transcriptional activation of chromatin. Mol Cell 1: 141-50 PubMed GONUTS page
  12. ↑ 12.0 12.1 12.2 12.3 12.4 12.5 Lusser A & Kadonaga JT (2003) Chromatin remodeling by ATP-dependent molecular machines. Bioessays 25: 1192-200 PubMed GONUTS page
  13. ↑ 13.0 13.1 Ito T et al. (1999) ACF consists of two subunits, Acf1 and ISWI, that function cooperatively in the ATP-dependent catalysis of chromatin assembly. Genes Dev 13: 1529-39 PubMed GONUTS page
  14. ↑ Elfring LK et al. (1994) Identification and characterization of Drosophila relatives of the yeast transcriptional activator SNF2/SWI2. Mol Cell Biol 14: 2225-34 PubMed GONUTS page
  15. ↑ Mizuguchi G et al. (2001) ATP-dependent nucleosome remodeling and histone hyperacetylation synergistically facilitate transcription of chromatin. J Biol Chem 276: 14773-83 PubMed GONUTS page
  16. ↑ 16.0 16.1 Parrish JZ et al. (2006) Genome-wide analyses identify transcription factors required for proper morphogenesis of Drosophila sensory neuron dendrites. Genes Dev 20: 820-35 PubMed GONUTS page
  17. ↑ 17.0 17.1 17.2 Georgel PT et al. (1997) Role of histone tails in nucleosome remodeling by Drosophila NURF. EMBO J 16: 4717-26 PubMed GONUTS page
  18. ↑ 18.0 18.1 18.2 Varga-Weisz PD et al. (1997) Chromatin-remodelling factor CHRAC contains the ATPases ISWI and topoisomerase II. Nature 388: 598-602 PubMed GONUTS page
  19. ↑ 19.0 19.1 Hamiche A et al. (1999) ATP-dependent histone octamer sliding mediated by the chromatin remodeling complex NURF. Cell 97: 833-42 PubMed GONUTS page
  20. ↑ 20.0 20.1 Eberharter A et al. (2001) Acf1, the largest subunit of CHRAC, regulates ISWI-induced nucleosome remodelling. EMBO J 20: 3781-8 PubMed GONUTS page
  21. ↑ 21.0 21.1 21.2 21.3 Badenhorst P et al. (2002) Biological functions of the ISWI chromatin remodeling complex NURF. Genes Dev 16: 3186-98 PubMed GONUTS page
  22. ↑ Gdula DA et al. (1998) Inorganic pyrophosphatase is a component of the Drosophila nucleosome remodeling factor complex. Genes Dev 12: 3206-16 PubMed GONUTS page
  23. ↑ Onorati MC et al. (2011) The ISWI chromatin remodeler organizes the hsrω ncRNA-containing omega speckle nuclear compartments. PLoS Genet 7: e1002096 PubMed GONUTS page
  24. ↑ Badenhorst P et al. (2005) The Drosophila nucleosome remodeling factor NURF is required for Ecdysteroid signaling and metamorphosis. Genes Dev 19: 2540-5 PubMed GONUTS page
  25. ↑ Matsumoto A et al. (2007) A functional genomics strategy reveals clockwork orange as a transcriptional regulator in the Drosophila circadian clock. Genes Dev 21: 1687-700 PubMed GONUTS page
  26. ↑ Längst G & Becker PB (2001) ISWI induces nucleosome sliding on nicked DNA. Mol Cell 8: 1085-92 PubMed GONUTS page
  27. ↑ Liu YI et al. (2008) The chromatin remodelers ISWI and ACF1 directly repress Wingless transcriptional targets. Dev Biol 323: 41-52 PubMed GONUTS page
  28. ↑ Kal AJ et al. (2000) The Drosophila brahma complex is an essential coactivator for the trithorax group protein zeste. Genes Dev 14: 1058-71 PubMed GONUTS page
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