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FB:InR

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Contents

Species (Taxon ID) Drosophila melanogaster (fruit fly) (taxon:7227)
Gene Name(s) InR ( synonyms: 18402, CG18402, DIHR, DILR, DIR, DIRH, DIRbeta, DInR, DInr, Dir-a, Dir-b, INR, INS, IR, Inr, Inr-alpha, Inr-beta, InsR, Insulin, Insulin Receptor, Insulin receptor, Insulin-like Receptor, dINR, dIR, dIRH, dInR, dInr, dInsR, dinr, dir, er10, inr, insulin receptor, insulin receptor homolog, insulin receptor homologue, insulin-like receptor, insulin-receptor, insulin/insulin-like growth factor receptor, l(3)05545, l(3)93Dj, l(3)er10, lethal(3)93Dj )
Protein Name(s) Insulin-like receptor,
External Links
FB FBgn0013984

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0001700

embryonic development via the syncytial blastoderm

FB:FBrf0042914
PMID:3934169[1]

IEP: Inferred from Expression Pattern

P

From FB

GO:0001700

embryonic development via the syncytial blastoderm

FB:FBrf0134820
PMID:11179818[2]

TAS: Traceable Author Statement

P

From FB

GO:0004713

protein tyrosine kinase activity

FB:FBrf0123484

NAS: Non-traceable Author Statement

F

From FB

GO:0004713

protein tyrosine kinase activity

FB:FBrf0132098
PMID:10908587[3]

NAS: Non-traceable Author Statement

F

From FB

GO:0005009

insulin-activated receptor activity

FB:FBrf0042914
PMID:3934169[1]

IDA: Inferred from Direct Assay

F

From FB

GO:0005009

insulin-activated receptor activity

FB:FBrf0045261
PMID:3014506[4]

IDA: Inferred from Direct Assay

F

From FB

GO:0005009

insulin-activated receptor activity

FB:FBrf0045261
PMID:3014506[4]

ISS: Inferred from Sequence or Structural Similarity

F

From FB

GO:0005009

insulin-activated receptor activity

FB:FBrf0081989
PMID:7628438[5]

IDA: Inferred from Direct Assay

F

From FB

GO:0005009

insulin-activated receptor activity

FB:FBrf0105495

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P06213

F

From FB

GO:0005520

insulin-like growth factor binding

FB:FBrf0123484

NAS: Non-traceable Author Statement

F

From FB

GO:0005524

ATP binding

FB:FBrf0132098
PMID:10908587[3]

IC: Inferred by Curator

GO:0004713

F

From FB

GO:0005524

ATP binding

FB:FBrf0174215

IEA: Inferred from Electronic Annotation

InterPro:IPR000719
InterPro:IPR002011
InterPro:IPR006211
InterPro:IPR017441

F

From FB

GO:0005886

plasma membrane

FB:FBrf0045261
PMID:3014506[4]

ISS: Inferred from Sequence or Structural Similarity

C

From FB

GO:0005886

plasma membrane

FB:FBrf0081989
PMID:7628438[5]

ISS: Inferred from Sequence or Structural Similarity

HGNC:5465

C

From FB

GO:0005886

plasma membrane

FB:FBrf0081989
PMID:7628438[5]

ISS: Inferred from Sequence or Structural Similarity

HGNC:6091

C

From FB

GO:0005887

integral to plasma membrane

FB:FBrf0123484

NAS: Non-traceable Author Statement

C

From FB

GO:0005899

insulin receptor complex

FB:FBrf0042914
PMID:3934169[1]

IDA: Inferred from Direct Assay

C

From FB

GO:0005899

insulin receptor complex

FB:FBrf0081989
PMID:7628438[5]

IDA: Inferred from Direct Assay

C

From FB

GO:0005911

cell-cell junction

FB:FBrf0058920
PMID:8366341[6]

IDA: Inferred from Direct Assay

C

From FB

GO:0006468

protein phosphorylation

FB:FBrf0132098
PMID:10908587[3]

NAS: Non-traceable Author Statement

P

From FB

GO:0006974

response to DNA damage stimulus

FB:FBrf0208272
PMID:19543366[7]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007285

primary spermatocyte growth

FB:FBrf0208094
PMID:19384053[8]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007296

vitellogenesis

FB:FBrf0156191
PMID:11897402[9]

TAS: Traceable Author Statement

P

From FB

GO:0007390

germ-band shortening

FB:FBrf0111406
PMID:10491260[10]

IGI: Inferred from Genetic Interaction

FB:FBgn0003053

P

From FB

GO:0007390

germ-band shortening

FB:FBrf0111406
PMID:10491260[10]

TAS: Traceable Author Statement

P

From FB

GO:0007391

dorsal closure

FB:FBrf0151280
PMID:12147138[11]

TAS: Traceable Author Statement

P

From FB

GO:0007411

axon guidance

FB:FBrf0159325
PMID:12702863[12]

TAS: Traceable Author Statement

P

From FB

GO:0007411

axon guidance

FB:FBrf0159327
PMID:12702880[13]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007446

imaginal disc growth

FB:FBrf0086349
PMID:8603594[14]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007568

aging

FB:FBrf0135947
PMID:11292875[15]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007584

response to nutrient

FB:FBrf0156191
PMID:11897402[9]

TAS: Traceable Author Statement

P

From FB

GO:0007626

locomotory behavior

FB:FBrf0192310
PMID:17264888[16]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0008284

positive regulation of cell proliferation

FB:FBrf0134520
PMID:11250149[17]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0008286

insulin receptor signaling pathway

FB:FBrf0045261
PMID:3014506[4]

ISS: Inferred from Sequence or Structural Similarity

P

From FB

GO:0008286

insulin receptor signaling pathway

FB:FBrf0080497
PMID:7711018[18]

IDA: Inferred from Direct Assay

P

From FB

GO:0008286

insulin receptor signaling pathway

FB:FBrf0105495

ISS: Inferred from Sequence or Structural Similarity

MGI:MGI:96575

P

From FB

GO:0008286

insulin receptor signaling pathway

FB:FBrf0123484

NAS: Non-traceable Author Statement

P

From FB

GO:0008286

insulin receptor signaling pathway

FB:FBrf0141377
PMID:11782950[19]

NAS: Non-traceable Author Statement

P

From FB

GO:0008286

insulin receptor signaling pathway

FB:FBrf0156191
PMID:11897402[9]

TAS: Traceable Author Statement

P

From FB

GO:0008340

determination of adult lifespan

FB:FBrf0155558
PMID:12539239[20]

TAS: Traceable Author Statement

P

From FB

GO:0008340

determination of adult lifespan

FB:FBrf0155931
PMID:12470891[21]

TAS: Traceable Author Statement

P

From FB

GO:0008340

determination of adult lifespan

FB:FBrf0156109
PMID:11998690[22]

TAS: Traceable Author Statement

P

From FB

GO:0008340

determination of adult lifespan

FB:FBrf0156191
PMID:11897402[9]

TAS: Traceable Author Statement

P

From FB

GO:0008340

determination of adult lifespan

FB:FBrf0167266
PMID:14616064[23]

TAS: Traceable Author Statement

P

From FB

GO:0008340

determination of adult lifespan

FB:FBrf0208962
PMID:19692410[24]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0008361

regulation of cell size

FB:FBrf0134520
PMID:11250149[17]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0008361

regulation of cell size

FB:FBrf0156191
PMID:11897402[9]

NAS: Non-traceable Author Statement

P

From FB

GO:0009790

embryo development

FB:FBrf0048653
PMID:2454394[25]

IEP: Inferred from Expression Pattern

P

From FB

GO:0016049

cell growth

FB:FBrf0134520
PMID:11250149[17]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0016049

cell growth

FB:FBrf0209639
PMID:19910925[26]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0030307

positive regulation of cell growth

FB:FBrf0141377
PMID:11782950[19]

NAS: Non-traceable Author Statement

P

From FB

GO:0034059

response to anoxia

FB:FBrf0207966
PMID:19412543[27]

IDA: Inferred from Direct Assay

P

From FB

GO:0040007

growth

FB:FBrf0130003
PMID:11128988[28]

TAS: Traceable Author Statement

P

From FB

GO:0040007

growth

FB:FBrf0134820
PMID:11179818[2]

TAS: Traceable Author Statement

P

From FB

GO:0040014

regulation of multicellular organism growth

FB:FBrf0086349
PMID:8603594[14]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0040014

regulation of multicellular organism growth

FB:FBrf0156191
PMID:11897402[9]

TAS: Traceable Author Statement

P

From FB

GO:0040014

regulation of multicellular organism growth

FB:FBrf0188217
PMID:16086608[29]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0040014

regulation of multicellular organism growth

FB:FBrf0190035
PMID:16182527[30]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0040018

positive regulation of multicellular organism growth

FB:FBrf0156084
PMID:12559758[31]

TAS: Traceable Author Statement

P

From FB

GO:0042127

regulation of cell proliferation

FB:FBrf0086349
PMID:8603594[14]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0042220

response to cocaine

FB:FBrf0193254
PMID:16730347[32]

IGI: Inferred from Genetic Interaction

FB:FBgn0000546

P

From FB

GO:0045793

positive regulation of cell size

FB:FBrf0136845
PMID:11377964[33]

NAS: Non-traceable Author Statement

P

From FB

GO:0045793

positive regulation of cell size

FB:FBrf0156084
PMID:12559758[31]

TAS: Traceable Author Statement

P

From FB

GO:0046620

regulation of organ growth

FB:FBrf0156191
PMID:11897402[9]

NAS: Non-traceable Author Statement

P

From FB

GO:0046620

regulation of organ growth

FB:FBrf0188217
PMID:16086608[29]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0046622

positive regulation of organ growth

FB:FBrf0125443
PMID:10679387[34]

TAS: Traceable Author Statement

P

From FB

GO:0046622

positive regulation of organ growth

FB:FBrf0136845
PMID:11377964[33]

NAS: Non-traceable Author Statement

P

From FB

GO:0046622

positive regulation of organ growth

FB:FBrf0156084
PMID:12559758[31]

TAS: Traceable Author Statement

P

From FB

GO:0046777

protein autophosphorylation

FB:FBrf0159327
PMID:12702880[13]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0048132

female germ-line stem cell division

FB:FBrf0207811
PMID:19336466[35]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0048133

male germ-line stem cell division

FB:FBrf0208094
PMID:19384053[8]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0048589

developmental growth

FB:FBrf0188217
PMID:16086608[29]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0060180

female mating behavior

FB:FBrf0212666
PMID:20739318[36]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0060250

germ-line stem-cell niche homeostasis

FB:FBrf0206962
PMID:19136634[37]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:2000377

regulation of reactive oxygen species metabolic process

FB:FBrf0210161
PMID:20203043[38]

IMP: Inferred from Mutant Phenotype

P

From FB


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Notes

References

See Help:References for how to manage references in GONUTS.
  1. ↑ 1.0 1.1 1.2 Petruzzelli L et al. (1985) Acquisition of insulin-dependent protein tyrosine kinase activity during Drosophila embryogenesis. J Biol Chem 260: 16072-5 PubMed GONUTS page
  2. ↑ 2.0 2.1 Vanden Broeck J (2001) Neuropeptides and their precursors in the fruitfly, Drosophila melanogaster. Peptides 22: 241-54 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 Morrison DK et al. (2000) Protein kinases and phosphatases in the Drosophila genome. J Cell Biol 150: F57-62 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 Petruzzelli L et al. (1986) Isolation of a Drosophila genomic sequence homologous to the kinase domain of the human insulin receptor and detection of the phosphorylated Drosophila receptor with an anti-peptide antibody. Proc Natl Acad Sci U S A 83: 4710-4 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 Fernandez R et al. (1995) The Drosophila insulin receptor homolog: a gene essential for embryonic development encodes two receptor isoforms with different signaling potential. EMBO J 14: 3373-84 PubMed GONUTS page
  6. ↑ Gorczyca M et al. (1993) Insulin-like receptor and insulin-like peptide are localized at neuromuscular junctions in Drosophila. J Neurosci 13: 3692-704 PubMed GONUTS page
  7. ↑ Ravi D et al. (2009) A network of conserved damage survival pathways revealed by a genomic RNAi screen. PLoS Genet 5: e1000527 PubMed GONUTS page
  8. ↑ 8.0 8.1 Ueishi S et al. (2009) Male germline stem cell division and spermatocyte growth require insulin signaling in Drosophila. Cell Struct Funct 34: 61-9 PubMed GONUTS page
  9. ↑ 9.0 9.1 9.2 9.3 9.4 9.5 9.6 Claeys I et al. (2002) Insulin-related peptides and their conserved signal transduction pathway. Peptides 23: 807-16 PubMed GONUTS page
  10. ↑ 10.0 10.1 Lamka ML & Lipshitz HD (1999) Role of the amnioserosa in germ band retraction of the Drosophila melanogaster embryo. Dev Biol 214: 102-12 PubMed GONUTS page
  11. ↑ Harden N (2002) Signaling pathways directing the movement and fusion of epithelial sheets: lessons from dorsal closure in Drosophila. Differentiation 70: 181-203 PubMed GONUTS page
  12. ↑ Dickson BJ (2003) Development. Wiring the brain with insulin. Science 300: 440-1 PubMed GONUTS page
  13. ↑ 13.0 13.1 Song J et al. (2003) Axons guided by insulin receptor in Drosophila visual system. Science 300: 502-5 PubMed GONUTS page
  14. ↑ 14.0 14.1 14.2 Chen C et al. (1996) The Drosophila insulin receptor is required for normal growth. Endocrinology 137: 846-56 PubMed GONUTS page
  15. ↑ Tatar M et al. (2001) A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function. Science 292: 107-10 PubMed GONUTS page
  16. ↑ Belgacem YH & Martin JR (2007) Hmgcr in the corpus allatum controls sexual dimorphism of locomotor activity and body size via the insulin pathway in Drosophila. PLoS One 2: e187 PubMed GONUTS page
  17. ↑ 17.0 17.1 17.2 Brogiolo W et al. (2001) An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control. Curr Biol 11: 213-21 PubMed GONUTS page
  18. ↑ Yamaguchi T et al. (1995) Comparison of the signaling abilities of the Drosophila and human insulin receptors in mammalian cells. Biochemistry 34: 4962-8 PubMed GONUTS page
  19. ↑ 19.0 19.1 Johnston LA & Gallant P (2002) Control of growth and organ size in Drosophila. Bioessays 24: 54-64 PubMed GONUTS page
  20. ↑ Helfand SL & Rogina B (2003) Molecular genetics of aging in the fly: is this the end of the beginning? Bioessays 25: 134-41 PubMed GONUTS page
  21. ↑ Aigaki T et al. (2002) Longevity determination genes in Drosophila melanogaster. Mech Ageing Dev 123: 1531-41 PubMed GONUTS page
  22. ↑ Wolkow CA (2002) Life span: getting the signal from the nervous system. Trends Neurosci 25: 212-6 PubMed GONUTS page
  23. ↑ Helfand SL & Rogina B (2003) Genetics of aging in the fruit fly, Drosophila melanogaster. Annu Rev Genet 37: 329-48 PubMed GONUTS page
  24. ↑ Ikeya T et al. (2009) The endosymbiont Wolbachia increases insulin/IGF-like signalling in Drosophila. Proc Biol Sci 276: 3799-807 PubMed GONUTS page
  25. ↑ Garofalo RS & Rosen OM (1988) Tissue localization of Drosophila melanogaster insulin receptor transcripts during development. Mol Cell Biol 8: 1638-47 PubMed GONUTS page
  26. ↑ Tiefenböck SK et al. (2010) The Drosophila PGC-1 homologue Spargel coordinates mitochondrial activity to insulin signalling. EMBO J 29: 171-83 PubMed GONUTS page
  27. ↑ Vigne P et al. (2009) Strong dietary restrictions protect Drosophila against anoxia/reoxygenation injuries. PLoS One 4: e5422 PubMed GONUTS page
  28. ↑ Oldham S et al. (2000) Genetic control of size in Drosophila. Philos Trans R Soc Lond B Biol Sci 355: 945-52 PubMed GONUTS page
  29. ↑ 29.0 29.1 29.2 Shingleton AW et al. (2005) The temporal requirements for insulin signaling during development in Drosophila. PLoS Biol 3: e289 PubMed GONUTS page
  30. ↑ Mirth C et al. (2005) The role of the prothoracic gland in determining critical weight for metamorphosis in Drosophila melanogaster. Curr Biol 15: 1796-807 PubMed GONUTS page
  31. ↑ 31.0 31.1 31.2 Oldham S & Hafen E (2003) Insulin/IGF and target of rapamycin signaling: a TOR de force in growth control. Trends Cell Biol 13: 79-85 PubMed GONUTS page
  32. ↑ Willard SS et al. (2006) Chronic cocaine exposure in Drosophila: life, cell death and oogenesis. Dev Biol 296: 150-63 PubMed GONUTS page
  33. ↑ 33.0 33.1 Potter CJ & Xu T (2001) Mechanisms of size control. Curr Opin Genet Dev 11: 279-86 PubMed GONUTS page
  34. ↑ Weinkove D & Leevers SJ (2000) The genetic control of organ growth: insights from Drosophila. Curr Opin Genet Dev 10: 75-80 PubMed GONUTS page
  35. ↑ Yu JY et al. (2009) Dicer-1-dependent Dacapo suppression acts downstream of Insulin receptor in regulating cell division of Drosophila germline stem cells. Development 136: 1497-507 PubMed GONUTS page
  36. ↑ Wigby S et al. (2011) Insulin signalling regulates remating in female Drosophila. Proc Biol Sci 278: 424-31 PubMed GONUTS page
  37. ↑ Hsu HJ & Drummond-Barbosa D (2009) Insulin levels control female germline stem cell maintenance via the niche in Drosophila. Proc Natl Acad Sci U S A 106: 1117-21 PubMed GONUTS page
  38. ↑ Lee JH et al. (2010) Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies. Science 327: 1223-8 PubMed GONUTS page
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