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FB:Iap2
Contents |
| Species (Taxon ID) | Drosophila melanogaster (fruit fly) (taxon:7227) | |
| Gene Name(s) | Iap2 ( synonyms: CG8293, D-IAP2, D-iap2, DIAP, DIAP-2, DIAP2, DIAPII, DIHA, Diap, Diap2, Diha, Drosophila inhibitor of apoptosis 2, Drosophila melanogaster inhibitor of apoptosis 2, IAP, IAP-like protein, IAP2, Ilp, Inhibitor of Apoptosis Protein 2, dIAP, dIAP2, dILP, diap2, inhibitor of apoptosis 2 ) | |
| Protein Name(s) | Inhibitor of apoptosis 2, | |
| External Links | ||
| FB | FBgn0015247 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0005622 |
intracellular |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
C |
From FB |
|||
| GO:0006916 |
anti-apoptosis |
FB:FBrf0089151 |
ISS: Inferred from Sequence or Structural Similarity |
P |
From FB |
|||
| GO:0006916 |
anti-apoptosis |
FB:FBrf0104543 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0006916 |
anti-apoptosis |
FB:FBrf0105495 |
ISS: Inferred from Sequence or Structural Similarity |
P |
From FB |
|||
| GO:0006916 |
anti-apoptosis |
FB:FBrf0111320 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0006916 |
anti-apoptosis |
FB:FBrf0124291 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0006916 |
anti-apoptosis |
FB:FBrf0132215 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0006916 |
anti-apoptosis |
FB:FBrf0147184 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0006916 |
anti-apoptosis |
FB:FBrf0149068 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0006964 |
positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria |
FB:FBrf0190362 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007423 |
sensory organ development |
FB:FBrf0190361 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008270 |
zinc ion binding |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
F |
From FB |
|||
| GO:0033160 |
positive regulation of protein import into nucleus, translocation |
FB:FBrf0190362 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0043066 |
negative regulation of apoptotic process |
FB:FBrf0201142 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0043154 |
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process |
FB:FBrf0201142 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0043281 |
regulation of cysteine-type endopeptidase activity involved in apoptotic process |
FB:FBrf0192581 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0050829 |
defense response to Gram-negative bacterium |
FB:FBrf0192381 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0050829 |
defense response to Gram-negative bacterium |
FB:FBrf0192423 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0061057 |
peptidoglycan recognition protein signaling pathway |
FB:FBrf0190362 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Uren AG et al. (1996) Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors. Proc Natl Acad Sci U S A 93: 4974-8 PubMed GONUTS page
- ↑ Hawkins CJ et al. (1998) Anti-apoptotic potential of insect cellular and viral IAPs in mammalian cells. Cell Death Differ 5: 569-76 PubMed GONUTS page
- ↑ Abrams JM (1999) An emerging blueprint for apoptosis in Drosophila. Trends Cell Biol 9: 435-40 PubMed GONUTS page
- ↑ Tittel JN & Steller H (2000) A comparison of programmed cell death between species. Genome Biol 1: REVIEWS0003 PubMed GONUTS page
- ↑ Gorski S & Marra M (2002) Programmed cell death takes flight: genetic and genomic approaches to gene discovery in Drosophila. Physiol Genomics 9: 59-69 PubMed GONUTS page
- ↑ Richardson H & Kumar S (2002) Death to flies: Drosophila as a model system to study programmed cell death. J Immunol Methods 265: 21-38 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 Kleino A et al. (2005) Inhibitor of apoptosis 2 and TAK1-binding protein are components of the Drosophila Imd pathway. EMBO J 24: 3423-34 PubMed GONUTS page
- ↑ Kanuka H et al. (2005) Drosophila caspase transduces Shaggy/GSK-3beta kinase activity in neural precursor development. EMBO J 24: 3793-806 PubMed GONUTS page
- ↑ 9.0 9.1 Ribeiro PS et al. (2007) DIAP2 functions as a mechanism-based regulator of drICE that contributes to the caspase activity threshold in living cells. J Cell Biol 179: 1467-80 PubMed GONUTS page
- ↑ Leulier F et al. (2006) Systematic in vivo RNAi analysis of putative components of the Drosophila cell death machinery. Cell Death Differ 13: 1663-74 PubMed GONUTS page
- ↑ Leulier F et al. (2006) The Drosophila inhibitor of apoptosis protein DIAP2 functions in innate immunity and is essential to resist gram-negative bacterial infection. Mol Cell Biol 26: 7821-31 PubMed GONUTS page
- ↑ Huh JR et al. (2007) The Drosophila inhibitor of apoptosis (IAP) DIAP2 is dispensable for cell survival, required for the innate immune response to gram-negative bacterial infection, and can be negatively regulated by the reaper/hid/grim family of IAP-binding apoptosis inducers. J Biol Chem 282: 2056-68 PubMed GONUTS page
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