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FB:EcR
Contents |
| Species (Taxon ID) | Drosophila melanogaster (fruit fly) (taxon:7227) | |
| Gene Name(s) | EcR ( synonyms: CG1765, CG8347, DEcR, Dhr23, DmEcR, ECR, ECR-C, EcR-A, EcR-B, EcR-B1, EcRB-1, EcRB1, EcdR, Ecdysone Receptor, Ecr, NR1H1, anon-WO0229075.1, dECR, dmEcR, ecdysone receptor, ecdysone receptor complex, ecdysteroid receptor, ecdysterone receptor, ecr, lie, long island expressway, male sterile(2)42A, ms(2)06410, ms(2)42A, snaggletooth, snt ) | |
| Protein Name(s) | Ecdysone receptor, | |
| External Links | ||
| FB | FBgn0000546 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001077 |
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription |
FB:FBrf0053385 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0003677 |
DNA binding |
FB:FBrf0129910 |
NAS: Non-traceable Author Statement |
F |
From FB |
|||
| GO:0003677 |
DNA binding |
FB:FBrf0156734 |
NAS: Non-traceable Author Statement |
F |
From FB |
|||
| GO:0004879 |
ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity |
FB:FBrf0137174 |
TAS: Traceable Author Statement |
F |
From FB |
|||
| GO:0004879 |
ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity |
FB:FBrf0138424 |
NAS: Non-traceable Author Statement |
F |
From FB |
|||
| GO:0004884 |
ecdysteroid hormone receptor activity |
FB:FBrf0053385 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0004884 |
ecdysteroid hormone receptor activity |
FB:FBrf0057897 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0004884 |
ecdysteroid hormone receptor activity |
FB:FBrf0156734 |
NAS: Non-traceable Author Statement |
F |
From FB |
|||
| GO:0005496 |
steroid binding |
FB:FBrf0129910 |
NAS: Non-traceable Author Statement |
F |
From FB |
|||
| GO:0005496 |
steroid binding |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
F |
From FB |
|||
| GO:0005515 |
protein binding |
FB:FBrf0167527 |
IPI: Inferred from Physical Interaction |
FB:FBgn0250850 |
F |
From FB |
||
| GO:0005634 |
nucleus |
FB:FBrf0053385 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005634 |
nucleus |
FB:FBrf0057897 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005634 |
nucleus |
FB:FBrf0105495 |
NAS: Non-traceable Author Statement |
C |
From FB |
|||
| GO:0005634 |
nucleus |
FB:FBrf0126781 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005634 |
nucleus |
FB:FBrf0156734 |
NAS: Non-traceable Author Statement |
C |
From FB |
|||
| GO:0005700 |
polytene chromosome |
FB:FBrf0129910 |
NAS: Non-traceable Author Statement |
C |
From FB |
|||
| GO:0005737 |
cytoplasm |
FB:FBrf0131261 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0006357 |
regulation of transcription from RNA polymerase II promoter |
FB:FBrf0127048 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0006914 |
autophagy |
FB:FBrf0180118 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007155 |
cell adhesion |
FB:FBrf0127048 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007281 |
germ cell development |
FB:FBrf0213531 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007286 |
spermatid development |
FB:FBrf0064394 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007291 |
sperm individualization |
FB:FBrf0102829 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007298 |
border follicle cell migration |
FB:FBrf0132259 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007298 |
border follicle cell migration |
FB:FBrf0187473 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007298 |
border follicle cell migration |
FB:FBrf0207765 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007390 |
germ-band shortening |
FB:FBrf0162290 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007409 |
axonogenesis |
FB:FBrf0190279 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007422 |
peripheral nervous system development |
FB:FBrf0190319 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007443 |
Malpighian tubule morphogenesis |
FB:FBrf0210168 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007468 |
regulation of rhodopsin gene expression |
FB:FBrf0207191 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007476 |
imaginal disc-derived wing morphogenesis |
FB:FBrf0127048 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0001250 |
P |
From FB |
||
| GO:0007476 |
imaginal disc-derived wing morphogenesis |
FB:FBrf0127048 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0004657 |
P |
From FB |
||
| GO:0007476 |
imaginal disc-derived wing morphogenesis |
FB:FBrf0127048 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007488 |
histoblast morphogenesis |
FB:FBrf0194691 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007517 |
muscle organ development |
FB:FBrf0190556 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007552 |
metamorphosis |
FB:FBrf0128551 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007561 |
imaginal disc eversion |
FB:FBrf0137174 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007616 |
long-term memory |
FB:FBrf0207826 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008230 |
ecdysone receptor holocomplex |
FB:FBrf0086205 |
IPI: Inferred from Physical Interaction |
FB:FBgn0003964 |
C |
From FB |
||
| GO:0008230 |
ecdysone receptor holocomplex |
FB:FBrf0133206 |
TAS: Traceable Author Statement |
C |
From FB |
|||
| GO:0008231 |
repressor ecdysone receptor complex |
FB:FBrf0108335 |
IPI: Inferred from Physical Interaction |
FB:FBgn0013746 |
C |
From FB |
||
| GO:0008258 |
head involution |
FB:FBrf0162290 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008270 |
zinc ion binding |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
F |
From FB |
|||
| GO:0008340 |
determination of adult lifespan |
FB:FBrf0157215 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008362 |
chitin-based embryonic cuticle biosynthetic process |
FB:FBrf0162290 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008544 |
epidermis development |
FB:FBrf0194691 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0010002 |
cardioblast differentiation |
FB:FBrf0190311 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0016319 |
mushroom body development |
FB:FBrf0155597 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0011300 |
P |
From FB |
||
| GO:0016319 |
mushroom body development |
FB:FBrf0155597 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0025800 |
P |
From FB |
||
| GO:0016322 |
neuron remodeling |
FB:FBrf0132434 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0016322 |
neuron remodeling |
FB:FBrf0174492 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0016322 |
neuron remodeling |
FB:FBrf0205432 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0018990 |
ecdysis, chitin-based cuticle |
FB:FBrf0128551 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0030425 |
dendrite |
FB:FBrf0191447 |
IMP: Inferred from Mutant Phenotype |
C |
From FB |
|||
| GO:0035053 |
dorsal vessel heart proper cell fate commitment |
FB:FBrf0190311 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0035072 |
ecdysone-mediated induction of salivary gland cell autophagic cell death |
FB:FBrf0133206 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0035073 |
pupariation |
FB:FBrf0128551 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0035073 |
pupariation |
FB:FBrf0187381 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0035076 |
ecdysone receptor-mediated signaling pathway |
FB:FBrf0128551 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0035180 |
larval wandering behavior |
FB:FBrf0187381 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0035188 |
hatching |
FB:FBrf0128551 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0035193 |
larval central nervous system remodeling |
FB:FBrf0128665 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0035193 |
larval central nervous system remodeling |
FB:FBrf0155299 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0035193 |
larval central nervous system remodeling |
FB:FBrf0209119 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0035297 |
regulation of Malpighian tubule diameter |
FB:FBrf0210168 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0040034 |
regulation of development, heterochronic |
FB:FBrf0141454 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0042220 |
response to cocaine |
FB:FBrf0193254 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0013984 |
P |
From FB |
||
| GO:0043065 |
positive regulation of apoptotic process |
FB:FBrf0207191 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0043401 |
steroid hormone mediated signaling pathway |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
P |
From FB |
|||
| GO:0043565 |
sequence-specific DNA binding |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
F |
From FB |
|||
| GO:0044130 |
negative regulation of growth of symbiont in host |
FB:FBrf0202775 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0045892 |
negative regulation of transcription, DNA-dependent |
FB:FBrf0129910 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0045938 |
positive regulation of circadian sleep/wake cycle, sleep |
FB:FBrf0210911 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0046982 |
protein heterodimerization activity |
FB:FBrf0086205 |
IPI: Inferred from Physical Interaction |
FB:FBgn0003964 |
F |
From FB |
||
| GO:0046982 |
protein heterodimerization activity |
FB:FBrf0206889 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0048477 |
oogenesis |
FB:FBrf0126781 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0048477 |
oogenesis |
FB:FBrf0129910 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0048666 |
neuron development |
FB:FBrf0190556 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0048738 |
cardiac muscle tissue development |
FB:FBrf0190311 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0048813 |
dendrite morphogenesis |
FB:FBrf0174512 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0048813 |
dendrite morphogenesis |
FB:FBrf0190556 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0070491 |
repressing transcription factor binding |
FB:FBrf0108335 |
IPI: Inferred from Physical Interaction |
FB:FBgn0013746 |
F |
From FB |
||
|
contributes_to |
GO:0001077 |
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription |
FB:FBrf0086205 |
IPI: Inferred from Physical Interaction |
FB:FBgn0003964 |
F |
From FB |
|
|
contributes_to |
GO:0004884 |
ecdysteroid hormone receptor activity |
FB:FBrf0086205 |
IPI: Inferred from Physical Interaction |
FB:FBgn0003964 |
F |
From FB |
|
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Koelle MR et al. (1991) The Drosophila EcR gene encodes an ecdysone receptor, a new member of the steroid receptor superfamily. Cell 67: 59-77 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 Kozlova T & Thummel CS (2000) Steroid regulation of postembryonic development and reproduction in Drosophila. Trends Endocrinol Metab 11: 276-80 PubMed GONUTS page
- ↑ 3.0 3.1 Gibson MC & Schubiger G (2001) Drosophila peripodial cells, more than meets the eye? Bioessays 23: 691-7 PubMed GONUTS page
- ↑ Maglich JM et al. (2001) Comparison of complete nuclear receptor sets from the human, Caenorhabditis elegans and Drosophila genomes. Genome Biol 2: RESEARCH0029 PubMed GONUTS page
- ↑ 5.0 5.1 Talbot WS et al. (1993) Drosophila tissues with different metamorphic responses to ecdysone express different ecdysone receptor isoforms. Cell 73: 1323-37 PubMed GONUTS page
- ↑ Gates J et al. (2004) rigor mortis encodes a novel nuclear receptor interacting protein required for ecdysone signaling during Drosophila larval development. Development 131: 25-36 PubMed GONUTS page
- ↑ 7.0 7.1 Carney GE & Bender M (2000) The Drosophila ecdysone receptor (EcR) gene is required maternally for normal oogenesis. Genetics 154: 1203-11 PubMed GONUTS page
- ↑ Brennan CA et al. (2001) Broad-complex, but not ecdysone receptor, is required for progression of the morphogenetic furrow in the Drosophila eye. Development 128: 1-11 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 9.3 9.4 D'Avino PP & Thummel CS (2000) The ecdysone regulatory pathway controls wing morphogenesis and integrin expression during Drosophila metamorphosis. Dev Biol 220: 211-24 PubMed GONUTS page
- ↑ Rusten TE et al. (2004) Programmed autophagy in the Drosophila fat body is induced by ecdysone through regulation of the PI3K pathway. Dev Cell 7: 179-92 PubMed GONUTS page
- ↑ König A et al. (2011) Ecdysteroids affect Drosophila ovarian stem cell niche formation and early germline differentiation. EMBO J 30: 1549-62 PubMed GONUTS page
- ↑ Castrillon DH et al. (1993) Toward a molecular genetic analysis of spermatogenesis in Drosophila melanogaster: characterization of male-sterile mutants generated by single P element mutagenesis. Genetics 135: 489-505 PubMed GONUTS page
- ↑ Fabrizio JJ et al. (1998) Genetic dissection of sperm individualization in Drosophila melanogaster. Development 125: 1833-43 PubMed GONUTS page
- ↑ Bai J et al. (2000) Regulation of invasive cell behavior by taiman, a Drosophila protein related to AIB1, a steroid receptor coactivator amplified in breast cancer. Cell 103: 1047-58 PubMed GONUTS page
- ↑ Medioni C & Noselli S (2005) Dynamics of the basement membrane in invasive epithelial clusters in Drosophila. Development 132: 3069-77 PubMed GONUTS page
- ↑ Jang AC et al. (2009) Border-cell migration requires integration of spatial and temporal signals by the BTB protein Abrupt. Nat Cell Biol 11: 569-79 PubMed GONUTS page
- ↑ 17.0 17.1 17.2 Kozlova T & Thummel CS (2003) Essential roles for ecdysone signaling during Drosophila mid-embryonic development. Science 301: 1911-4 PubMed GONUTS page
- ↑ Brown HL et al. (2006) Use of time-lapse imaging and dominant negative receptors to dissect the steroid receptor control of neuronal remodeling in Drosophila. Development 133: 275-85 PubMed GONUTS page
- ↑ Schubiger M et al. (2005) Ligand-dependent de-repression via EcR/USP acts as a gate to coordinate the differentiation of sensory neurons in the Drosophila wing. Development 132: 5239-48 PubMed GONUTS page
- ↑ 20.0 20.1 Gautam NK & Tapadia MG (2010) Ecdysone signaling is required for proper organization and fluid secretion of stellate cells in the Malpighian tubules of Drosophila melanogaster. Int J Dev Biol 54: 635-42 PubMed GONUTS page
- ↑ 21.0 21.1 Sprecher SG & Desplan C (2008) Switch of rhodopsin expression in terminally differentiated Drosophila sensory neurons. Nature 454: 533-7 PubMed GONUTS page
- ↑ 22.0 22.1 Ninov N et al. (2007) Extrinsic and intrinsic mechanisms directing epithelial cell sheet replacement during Drosophila metamorphosis. Development 134: 367-79 PubMed GONUTS page
- ↑ 23.0 23.1 23.2 Parrish JZ et al. (2006) Genome-wide analyses identify transcription factors required for proper morphogenesis of Drosophila sensory neuron dendrites. Genes Dev 20: 820-35 PubMed GONUTS page
- ↑ 24.0 24.1 24.2 24.3 24.4 Li T & Bender M (2000) A conditional rescue system reveals essential functions for the ecdysone receptor (EcR) gene during molting and metamorphosis in Drosophila. Development 127: 2897-905 PubMed GONUTS page
- ↑ Ishimoto H et al. (2009) Ecdysone signaling regulates the formation of long-term courtship memory in adult Drosophila melanogaster. Proc Natl Acad Sci U S A 106: 6381-6 PubMed GONUTS page
- ↑ 26.0 26.1 26.2 26.3 Zelhof AC et al. (1995) Seven-up inhibits ultraspiracle-based signaling pathways in vitro and in vivo. Mol Cell Biol 15: 6736-45 PubMed GONUTS page
- ↑ 27.0 27.1 Buszczak M & Segraves WA (2000) Insect metamorphosis: out with the old, in with the new. Curr Biol 10: R830-3 PubMed GONUTS page
- ↑ 28.0 28.1 Dressel U et al. (1999) Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily. Mol Cell Biol 19: 3383-94 PubMed GONUTS page
- ↑ Simon AF et al. (2003) Steroid control of longevity in Drosophila melanogaster. Science 299: 1407-10 PubMed GONUTS page
- ↑ 30.0 30.1 30.2 Monier B et al. (2005) Steroid-dependent modification of Hox function drives myocyte reprogramming in the Drosophila heart. Development 132: 5283-93 PubMed GONUTS page
- ↑ 31.0 31.1 Zheng X et al. (2003) TGF-beta signaling activates steroid hormone receptor expression during neuronal remodeling in the Drosophila brain. Cell 112: 303-15 PubMed GONUTS page
- ↑ Lee T et al. (2000) Cell-autonomous requirement of the USP/EcR-B ecdysone receptor for mushroom body neuronal remodeling in Drosophila. Neuron 28: 807-18 PubMed GONUTS page
- ↑ Awasaki T & Ito K (2004) Engulfing action of glial cells is required for programmed axon pruning during Drosophila metamorphosis. Curr Biol 14: 668-77 PubMed GONUTS page
- ↑ Roy B et al. (2007) Metamorphosis of an identified serotonergic neuron in the Drosophila olfactory system. Neural Dev 2: 20 PubMed GONUTS page
- ↑ Kuo CT et al. (2005) Dendrite-specific remodeling of Drosophila sensory neurons requires matrix metalloproteases, ubiquitin-proteasome, and ecdysone signaling. Proc Natl Acad Sci U S A 102: 15230-5 PubMed GONUTS page
- ↑ 36.0 36.1 Davis MB et al. (2005) Phenotypic analysis of EcR-A mutants suggests that EcR isoforms have unique functions during Drosophila development. Dev Biol 282: 385-96 PubMed GONUTS page
- ↑ Tissot M & Stocker RF (2000) Metamorphosis in drosophila and other insects: the fate of neurons throughout the stages. Prog Neurobiol 62: 89-111 PubMed GONUTS page
- ↑ Brown HL & Truman JW (2009) Fine-tuning of secondary arbor development: the effects of the ecdysone receptor on the adult neuronal lineages of the Drosophila thoracic CNS. Development 136: 3247-56 PubMed GONUTS page
- ↑ Thummel CS (2001) Molecular mechanisms of developmental timing in C. elegans and Drosophila. Dev Cell 1: 453-65 PubMed GONUTS page
- ↑ Willard SS et al. (2006) Chronic cocaine exposure in Drosophila: life, cell death and oogenesis. Dev Biol 296: 150-63 PubMed GONUTS page
- ↑ Koo IC et al. (2008) Role for lysosomal enzyme beta-hexosaminidase in the control of mycobacteria infection. Proc Natl Acad Sci U S A 105: 710-5 PubMed GONUTS page
- ↑ Ishimoto H & Kitamoto T (2010) The steroid molting hormone Ecdysone regulates sleep in adult Drosophila melanogaster. Genetics 185: 269-81 PubMed GONUTS page
- ↑ Bitra K & Palli SR (2009) Interaction of proteins involved in ecdysone and juvenile hormone signal transduction. Arch Insect Biochem Physiol 70: 90-105 PubMed GONUTS page
- ↑ Grueber WB & Jan YN (2004) Dendritic development: lessons from Drosophila and related branches. Curr Opin Neurobiol 14: 74-82 PubMed GONUTS page
