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FB:E(z)

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Contents

Species (Taxon ID) Drosophila melanogaster (fruit fly) (taxon:7227)
Gene Name(s) E(z) ( synonyms: CG6502, E(Z), E(z)1, EZ, E(z), Enhancer of Zeste, Enhancer-of-Zeste, Enhancer-of-zeste, Ez, Su(z)301, enhancer of zeste, enhancer-of-zeste, l(3)1902, l(3)67Fa, l(3)B12, l(3)SG17, l(3)ds12, pco, pco/E(z), polycombeotic )
Protein Name(s) Enhancer of zeste,
External Links
FB FBgn0000629

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0003677

DNA binding

FB:FBrf0174215

IEA: Inferred from Electronic Annotation

InterPro:IPR001005

F

From FB

GO:0005515

protein binding

FB:FBrf0159213
PMID:12697833[1]

IPI: Inferred from Physical Interaction

FB:FBgn0003044

F

From FB

GO:0005515

protein binding

FB:FBrf0160909
PMID:12771214[2]

IPI: Inferred from Physical Interaction

UniProtKB:P41046

F

From FB

GO:0005634

nucleus

FB:FBrf0124012

NAS: Non-traceable Author Statement

C

From FB

GO:0005634

nucleus

FB:FBrf0132295
PMID:11124122[3]

IDA: Inferred from Direct Assay

C

From FB

GO:0005634

nucleus

FB:FBrf0151814
PMID:12408863[4]

IDA: Inferred from Direct Assay

C

From FB

GO:0006342

chromatin silencing

FB:FBrf0124012

NAS: Non-traceable Author Statement

P

From FB

GO:0006723

cuticle hydrocarbon biosynthetic process

FB:FBrf0125446
PMID:10663138[5]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007411

axon guidance

FB:FBrf0190330
PMID:16495309[6]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007517

muscle organ development

FB:FBrf0190556
PMID:16547170[7]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0016571

histone methylation

FB:FBrf0151814
PMID:12408863[4]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0016571

histone methylation

FB:FBrf0151815
PMID:12408864[8]

IDA: Inferred from Direct Assay

P

From FB

GO:0016571

histone methylation

FB:FBrf0151815
PMID:12408864[8]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0016571

histone methylation

FB:FBrf0173275

TAS: Traceable Author Statement

P

From FB

GO:0016571

histone methylation

FB:FBrf0179020

TAS: Traceable Author Statement

P

From FB

GO:0022008

neurogenesis

FB:FBrf0202325
PMID:17287254[9]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0035097

histone methyltransferase complex

FB:FBrf0188105
PMID:16055700[10]

IDA: Inferred from Direct Assay

C

From FB

GO:0035098

ESC/E(Z) complex

FB:FBrf0151814
PMID:12408863[4]

IDA: Inferred from Direct Assay

C

From FB

GO:0035098

ESC/E(Z) complex

FB:FBrf0151815
PMID:12408864[8]

IDA: Inferred from Direct Assay

C

From FB

GO:0035098

ESC/E(Z) complex

FB:FBrf0205395
PMID:18276122[11]

IDA: Inferred from Direct Assay

C

From FB

GO:0035186

syncytial blastoderm mitotic cell cycle

FB:FBrf0190149
PMID:16388795[12]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0042054

histone methyltransferase activity

FB:FBrf0151814
PMID:12408863[4]

IMP: Inferred from Mutant Phenotype

F

From FB

GO:0042054

histone methyltransferase activity

FB:FBrf0206913
PMID:18693240[13]

IDA: Inferred from Direct Assay

F

From FB

GO:0042810

pheromone metabolic process

FB:FBrf0083517

NAS: Non-traceable Author Statement

P

From FB

GO:0046974

histone methyltransferase activity (H3-K9 specific)

FB:FBrf0151814
PMID:12408863[4]

IDA: Inferred from Direct Assay

F

From FB

GO:0046976

histone methyltransferase activity (H3-K27 specific)

FB:FBrf0151814
PMID:12408863[4]

IDA: Inferred from Direct Assay

F

From FB

GO:0046976

histone methyltransferase activity (H3-K27 specific)

FB:FBrf0151815
PMID:12408864[8]

IDA: Inferred from Direct Assay

F

From FB

GO:0046976

histone methyltransferase activity (H3-K27 specific)

FB:FBrf0173275

TAS: Traceable Author Statement

F

From FB

GO:0046976

histone methyltransferase activity (H3-K27 specific)

FB:FBrf0179020

TAS: Traceable Author Statement

F

From FB

GO:0046976

histone methyltransferase activity (H3-K27 specific)

FB:FBrf0206913
PMID:18693240[13]

IMP: Inferred from Mutant Phenotype

F

From FB

GO:0048813

dendrite morphogenesis

FB:FBrf0190556
PMID:16547170[7]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0051567

histone H3-K9 methylation

FB:FBrf0151814
PMID:12408863[4]

IDA: Inferred from Direct Assay

P

From FB

GO:0070734

histone H3-K27 methylation

FB:FBrf0151814
PMID:12408863[4]

IDA: Inferred from Direct Assay

P

From FB

GO:0070734

histone H3-K27 methylation

FB:FBrf0206913
PMID:18693240[13]

IMP: Inferred from Mutant Phenotype

P

From FB

contributes_to

GO:0042054

histone methyltransferase activity

FB:FBrf0188105
PMID:16055700[10]

IDA: Inferred from Direct Assay

F

From FB

contributes_to

GO:0042054

histone methyltransferase activity

FB:FBrf0205395
PMID:18276122[11]

IDA: Inferred from Direct Assay

F

From FB

contributes_to

GO:0046976

histone methyltransferase activity (H3-K27 specific)

FB:FBrf0188105
PMID:16055700[10]

IMP: Inferred from Mutant Phenotype

F

From FB


Notes

References

See Help:References for how to manage references in GONUTS.
  1. Tie F et al. (2003) A 1-megadalton ESC/E(Z) complex from Drosophila that contains polycomblike and RPD3. Mol Cell Biol 23: 3352-62 PubMed GONUTS page
  2. Salvaing J et al. (2003) The Drosophila Corto protein interacts with Polycomb-group proteins and the GAGA factor. Nucleic Acids Res 31: 2873-82 PubMed GONUTS page
  3. Tie F et al. (2001) The Drosophila Polycomb Group proteins ESC and E(Z) are present in a complex containing the histone-binding protein p55 and the histone deacetylase RPD3. Development 128: 275-86 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 4.4 4.5 4.6 4.7 Czermin B et al. (2002) Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites. Cell 111: 185-96 PubMed GONUTS page
  5. Wicker-Thomas C & Jallon J (2000) Role of Enhancer of zeste on the production of Drosophila melanogaster pheromonal hydrocarbons. Naturwissenschaften 87: 76-9 PubMed GONUTS page
  6. Wang J et al. (2006) Steroid hormone-dependent transformation of polyhomeotic mutant neurons in the Drosophila brain. Development 133: 1231-40 PubMed GONUTS page
  7. 7.0 7.1 Parrish JZ et al. (2006) Genome-wide analyses identify transcription factors required for proper morphogenesis of Drosophila sensory neuron dendrites. Genes Dev 20: 820-35 PubMed GONUTS page
  8. 8.0 8.1 8.2 8.3 Müller J et al. (2002) Histone methyltransferase activity of a Drosophila Polycomb group repressor complex. Cell 111: 197-208 PubMed GONUTS page
  9. Bello B et al. (2007) Polycomb group genes are required for neural stem cell survival in postembryonic neurogenesis of Drosophila. Development 134: 1091-9 PubMed GONUTS page
  10. 10.0 10.1 10.2 Ketel CS et al. (2005) Subunit contributions to histone methyltransferase activities of fly and worm polycomb group complexes. Mol Cell Biol 25: 6857-68 PubMed GONUTS page
  11. 11.0 11.1 Ohno K et al. (2008) ESC, ESCL and their roles in Polycomb Group mechanisms. Mech Dev 125: 527-41 PubMed GONUTS page
  12. O'Dor E et al. (2006) Polycomb group mutants exhibit mitotic defects in syncytial cell cycles of Drosophila embryos. Dev Biol 290: 312-22 PubMed GONUTS page
  13. 13.0 13.1 13.2 Joshi P et al. (2008) Dominant alleles identify SET domain residues required for histone methyltransferase of Polycomb repressive complex 2. J Biol Chem 283: 27757-66 PubMed GONUTS page
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