GONUTS is under stress! The website is currently experiencing long-wait times and frequent time-outs due to the record number of students, groups, and annotations related to CACAO this semester. We are currently working on increasing performance -- please accept our apologies for the technical difficulties.
You can help reduce stress on the server by:
- not reloading pages frequently - this just adds
- opening links in new windows (so you can read the old page)
FB:E(spl)
Contents |
| Species (Taxon ID) | Drosophila melanogaster (fruit fly) (taxon:7227) | |
| Gene Name(s) | E(spl) ( synonyms: CG8365, E(Spl), E(spl) m8, E(spl)-C, E(spl)-m8, E(spl)M8, E(spl)bHLH, E(spl)m8, En(spl), En(spl)-C, Enhancer of Split, Enhancer of split m8, Enhancer-of-split, Espl, HLHm8, Hes, M8, Su(H)((m8)), anon-EST:Liang-1.71, bHLHb36, clone 1.71, e(spl), enhancer of split, enhancer-of-split-m8, l(3)96Fd, m8 ) | |
| Protein Name(s) | Enhancer of split, | |
| External Links | ||
| FB | FBgn0000591 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
FB:FBrf0105495 |
ISS: Inferred from Sequence or Structural Similarity |
MGI:MGI:104853 |
P |
From FB |
||
| GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
FB:FBrf0123568 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0001078 |
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription |
FB:FBrf0076959 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0003677 |
DNA binding |
FB:FBrf0123568 |
NAS: Non-traceable Author Statement |
F |
From FB |
|||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
FB:FBrf0129916 |
TAS: Traceable Author Statement |
F |
From FB |
|||
| GO:0005634 |
nucleus |
FB:FBrf0123568 |
NAS: Non-traceable Author Statement |
C |
From FB |
|||
| GO:0007173 |
epidermal growth factor receptor signaling pathway |
FB:FBrf0144824 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0007219 |
Notch signaling pathway |
FB:FBrf0144824 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0007398 |
ectoderm development |
FB:FBrf0053362 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007422 |
peripheral nervous system development |
FB:FBrf0131381 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007498 |
mesoderm development |
FB:FBrf0053362 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008587 |
imaginal disc-derived wing margin morphogenesis |
FB:FBrf0093584 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0010629 |
negative regulation of gene expression |
FB:FBrf0155707 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0016360 |
sensory organ precursor cell fate determination |
FB:FBrf0187452 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0042803 |
protein homodimerization activity |
FB:FBrf0076959 |
IPI: Inferred from Physical Interaction |
FB:FBgn0000591 |
F |
From FB |
||
| GO:0043565 |
sequence-specific DNA binding |
FB:FBrf0108816 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0045165 |
cell fate commitment |
FB:FBrf0123568 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0045468 |
regulation of R8 cell spacing in compound eye |
FB:FBrf0144824 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0046982 |
protein heterodimerization activity |
FB:FBrf0076959 |
IPI: Inferred from Physical Interaction |
FB:FBgn0002631 |
F |
From FB |
||
| GO:0048666 |
neuron development |
FB:FBrf0190556 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0048749 |
compound eye development |
FB:FBrf0129916 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0048749 |
compound eye development |
FB:FBrf0193054 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0048813 |
dendrite morphogenesis |
FB:FBrf0190556 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Oellers N et al. (1994) bHLH proteins encoded by the Enhancer of split complex of Drosophila negatively interfere with transcriptional activation mediated by proneural genes. Mol Gen Genet 244: 465-73 PubMed GONUTS page
- ↑ 2.0 2.1 Kumar JP & Moses K (2000) Cell fate specification in the Drosophila retina. Results Probl Cell Differ 31: 93-114 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Frankfort BJ & Mardon G (2002) R8 development in the Drosophila eye: a paradigm for neural selection and differentiation. Development 129: 1295-306 PubMed GONUTS page
- ↑ 4.0 4.1 Corbin V et al. (1991) A role for the Drosophila neurogenic genes in mesoderm differentiation. Cell 67: 311-23 PubMed GONUTS page
- ↑ Prokopenko SN et al. (2000) Mutations affecting the development of the peripheral nervous system in Drosophila: a molecular screen for novel proteins. Genetics 156: 1691-715 PubMed GONUTS page
- ↑ Majumdar A et al. (1997) strawberry notch encodes a conserved nuclear protein that functions downstream of Notch and regulates gene expression along the developing wing margin of Drosophila. Genes Dev 11: 1341-53 PubMed GONUTS page
- ↑ Giagtzoglou N et al. (2003) Two modes of recruitment of E(spl) repressors onto target genes. Development 130: 259-70 PubMed GONUTS page
- ↑ Castro B et al. (2005) Lateral inhibition in proneural clusters: cis-regulatory logic and default repression by Suppressor of Hairless. Development 132: 3333-44 PubMed GONUTS page
- ↑ Jennings BH et al. (1999) Target specificities of Drosophila enhancer of split basic helix-loop-helix proteins. Mol Cell Biol 19: 4600-10 PubMed GONUTS page
- ↑ 10.0 10.1 Parrish JZ et al. (2006) Genome-wide analyses identify transcription factors required for proper morphogenesis of Drosophila sensory neuron dendrites. Genes Dev 20: 820-35 PubMed GONUTS page
- ↑ Bose A et al. (2006) Drosophila CK2 regulates lateral-inhibition during eye and bristle development. Mech Dev 123: 649-64 PubMed GONUTS page
