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FB:Dys

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Contents

Species (Taxon ID) Drosophila melanogaster (fruit fly) (taxon:7227)
Gene Name(s) Dys ( synonyms: CG17750, CG31175, CG34157, CG7240, CG7243, CG7344, DLP, DLP1, DLP186, DLP2, DLP3, DmDLP, DmDYS, Dp117, Dp186, Dp205, Dystrophin Dp186, Dystrophin-like protein 1, Dystrophin-like protein 186, Dystrophin-like protein 2, Dystrophin-like protein 3, GI3046716, IDLP, det, detached, dmDLP, dmDp186, dmDys, dys, dystrophin )
Protein Name(s) Dystrophin,
External Links
FB FBgn0260003

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0003779

actin binding

FB:FBrf0152121
PMID:12376554[1]

ISS: Inferred from Sequence or Structural Similarity

F

From FB

GO:0003779

actin binding

FB:FBrf0178372

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P11532

F

From FB

GO:0003779

actin binding

FB:FBrf0178373

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P11532

F

From FB

GO:0005198

structural molecule activity

FB:FBrf0129830
PMID:10908588[2]

ISS: Inferred from Sequence or Structural Similarity

F

From FB

GO:0005200

structural constituent of cytoskeleton

FB:FBrf0178372

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P11532

F

From FB

GO:0005200

structural constituent of cytoskeleton

FB:FBrf0178373

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P11532

F

From FB

GO:0005509

calcium ion binding

FB:FBrf0174215

IEA: Inferred from Electronic Annotation

InterPro:IPR011992

F

From FB

GO:0005856

cytoskeleton

FB:FBrf0129830
PMID:10908588[2]

ISS: Inferred from Sequence or Structural Similarity

C

From FB

GO:0005856

cytoskeleton

FB:FBrf0178372

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P11532

C

From FB

GO:0005856

cytoskeleton

FB:FBrf0178373

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P11532

C

From FB

GO:0007274

neuromuscular synaptic transmission

FB:FBrf0191057
PMID:16399704[3]

IDA: Inferred from Direct Assay

P

From FB

GO:0007474

imaginal disc-derived wing vein specification

FB:FBrf0203132
PMID:18093579[4]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007517

muscle organ development

FB:FBrf0178372

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P11532

P

From FB

GO:0007517

muscle organ development

FB:FBrf0178373

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P11532

P

From FB

GO:0008092

cytoskeletal protein binding

FB:FBrf0132100
PMID:10908588[2]

ISS: Inferred from Sequence or Structural Similarity

F

From FB

GO:0008270

zinc ion binding

FB:FBrf0174215

IEA: Inferred from Electronic Annotation

InterPro:IPR000433

F

From FB

GO:0008307

structural constituent of muscle

FB:FBrf0129834
PMID:11018515[5]

ISS: Inferred from Sequence or Structural Similarity

HGNC:12635

F

From FB

GO:0008307

structural constituent of muscle

FB:FBrf0129834
PMID:11018515[5]

ISS: Inferred from Sequence or Structural Similarity

HGNC:2928

F

From FB

GO:0008307

structural constituent of muscle

FB:FBrf0129834
PMID:11018515[5]

ISS: Inferred from Sequence or Structural Similarity

HGNC:3032

F

From FB

GO:0008307

structural constituent of muscle

FB:FBrf0178372

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P11532

F

From FB

GO:0008307

structural constituent of muscle

FB:FBrf0178373

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P11532

F

From FB

GO:0008586

imaginal disc-derived wing vein morphogenesis

FB:FBrf0076146
PMID:7720583[6]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0008586

imaginal disc-derived wing vein morphogenesis

FB:FBrf0212767
PMID:21228159[7]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0016010

dystrophin-associated glycoprotein complex

FB:FBrf0129834
PMID:11018515[5]

ISS: Inferred from Sequence or Structural Similarity

HGNC:12635

C

From FB

GO:0016010

dystrophin-associated glycoprotein complex

FB:FBrf0129834
PMID:11018515[5]

ISS: Inferred from Sequence or Structural Similarity

HGNC:2928

C

From FB

GO:0016010

dystrophin-associated glycoprotein complex

FB:FBrf0129834
PMID:11018515[5]

ISS: Inferred from Sequence or Structural Similarity

HGNC:3032

C

From FB

GO:0016010

dystrophin-associated glycoprotein complex

FB:FBrf0130697

NAS: Non-traceable Author Statement

C

From FB

GO:0016010

dystrophin-associated glycoprotein complex

FB:FBrf0132100
PMID:10908588[2]

ISS: Inferred from Sequence or Structural Similarity

C

From FB

GO:0016010

dystrophin-associated glycoprotein complex

FB:FBrf0178372

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P11532

C

From FB

GO:0016010

dystrophin-associated glycoprotein complex

FB:FBrf0178373

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P11532

C

From FB

GO:0016010

dystrophin-associated glycoprotein complex

FB:FBrf0191923
PMID:17355978[8]

IPI: Inferred from Physical Interaction

FB:FBgn0034072

C

From FB

GO:0030010

establishment of cell polarity

FB:FBrf0192541
PMID:17215867[9]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0046716

muscle cell homeostasis

FB:FBrf0192541
PMID:17215867[9]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0046928

regulation of neurotransmitter secretion

FB:FBrf0204668
PMID:18463264[10]

IDA: Inferred from Direct Assay

P

From FB

GO:0048172

regulation of short-term neuronal synaptic plasticity

FB:FBrf0191057
PMID:16399704[3]

IDA: Inferred from Direct Assay

P

From FB

GO:0050699

WW domain binding

FB:FBrf0192541
PMID:17215867[9]

IPI: Inferred from Physical Interaction

FB:FBgn0034072

F

From FB


Notes

References

See Help:References for how to manage references in GONUTS.
  1. Röper K et al. (2002) The 'spectraplakins': cytoskeletal giants with characteristics of both spectrin and plakin families. J Cell Sci 115: 4215-25 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 Goldstein LS & Gunawardena S (2000) Flying through the drosophila cytoskeletal genome. J Cell Biol 150: F63-8 PubMed GONUTS page
  3. 3.0 3.1 van der Plas MC et al. (2006) Dystrophin is required for appropriate retrograde control of neurotransmitter release at the Drosophila neuromuscular junction. J Neurosci 26: 333-44 PubMed GONUTS page
  4. Christoforou CP et al. (2008) The detached locus encodes Drosophila Dystrophin, which acts with other components of the Dystrophin Associated Protein Complex to influence intercellular signalling in developing wing veins. Dev Biol 313: 519-32 PubMed GONUTS page
  5. 5.0 5.1 5.2 5.3 5.4 5.5 Greener MJ & Roberts RG (2000) Conservation of components of the dystrophin complex in Drosophila. FEBS Lett 482: 13-8 PubMed GONUTS page
  6. Sturtevant MA & Bier E (1995) Analysis of the genetic hierarchy guiding wing vein development in Drosophila. Development 121: 785-801 PubMed GONUTS page
  7. Pilgram GS et al. (2011) The RhoGAP crossveinless-c interacts with Dystrophin and is required for synaptic homeostasis at the Drosophila neuromuscular junction. J Neurosci 31: 492-500 PubMed GONUTS page
  8. Yatsenko AS et al. (2007) A putative Src homology 3 domain binding motif but not the C-terminal dystrophin WW domain binding motif is required for dystroglycan function in cellular polarity in Drosophila. J Biol Chem 282: 15159-69 PubMed GONUTS page
  9. 9.0 9.1 9.2 Shcherbata HR et al. (2007) Dissecting muscle and neuronal disorders in a Drosophila model of muscular dystrophy. EMBO J 26: 481-93 PubMed GONUTS page
  10. Fradkin LG et al. (2008) The dystrophin Dp186 isoform regulates neurotransmitter release at a central synapse in Drosophila. J Neurosci 28: 5105-14 PubMed GONUTS page
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