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FB:Dscam
Contents |
| Species (Taxon ID) | Drosophila melanogaster (fruit fly) (taxon:7227) | |
| Gene Name(s) | Dscam ( synonyms: 43Bc, CG17800, CT39257, DSCAM, DScam, DmDscam, Dm_2R:13612, Down Syndrome Cell Adhesion Molecule, Down Syndrome cell adhesion molecule, Down syndrome cell-adhesion molecule, Down's syndrome Cell Adhesion Molecule, Drosophila Down syndrome cell adhesion molecule, Drosophila Down syndrome cell adhesion molecule 1, Dscam1, FBgn0033159, Neu1, dScam, dscam, l(2)05518, l(2)43Bc, lethal(2)43Bc, p270 ) | |
| Protein Name(s) | Down syndrome cell adhesion molecule, | |
| External Links | ||
| FB | FBgn0033159 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0005887 |
integral to plasma membrane |
FB:FBrf0128634 |
ISS: Inferred from Sequence or Structural Similarity |
C |
From FB |
|||
| GO:0005887 |
integral to plasma membrane |
FB:FBrf0202429 |
ISM: Inferred from Sequence Model |
C |
From FB |
|||
| GO:0006909 |
phagocytosis |
FB:FBrf0188335 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007411 |
axon guidance |
FB:FBrf0128634 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0010583 |
P |
From FB |
||
| GO:0007411 |
axon guidance |
FB:FBrf0128634 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007411 |
axon guidance |
FB:FBrf0136755 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007411 |
axon guidance |
FB:FBrf0145178 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007411 |
axon guidance |
FB:FBrf0179899 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007411 |
axon guidance |
FB:FBrf0180020 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007411 |
axon guidance |
FB:FBrf0189904 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007411 |
axon guidance |
FB:FBrf0206236 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007413 |
axonal fasciculation |
FB:FBrf0180574 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007422 |
peripheral nervous system development |
FB:FBrf0156018 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008046 |
axon guidance receptor activity |
FB:FBrf0129495 |
NAS: Non-traceable Author Statement |
F |
From FB |
|||
| GO:0008046 |
axon guidance receptor activity |
FB:FBrf0180020 |
IMP: Inferred from Mutant Phenotype |
F |
From FB |
|||
| GO:0016319 |
mushroom body development |
FB:FBrf0180573 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0016319 |
mushroom body development |
FB:FBrf0180574 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0016319 |
mushroom body development |
FB:FBrf0205027 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0016319 |
mushroom body development |
FB:FBrf0206032 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0021551 |
central nervous system morphogenesis |
FB:FBrf0205027 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0030424 |
axon |
FB:FBrf0200892 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0030425 |
dendrite |
FB:FBrf0200892 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0042802 |
identical protein binding |
FB:FBrf0201331 |
IPI: Inferred from Physical Interaction |
FB:FBgn0033159 |
F |
From FB |
||
| GO:0042803 |
protein homodimerization activity |
FB:FBrf0206032 |
IPI: Inferred from Physical Interaction |
FB:FBgn0033159 |
F |
From FB |
||
| GO:0043025 |
neuronal cell body |
FB:FBrf0200892 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0048666 |
neuron development |
FB:FBrf0193609 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0048846 |
axon extension involved in axon guidance |
FB:FBrf0206032 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0051635 |
bacterial cell surface binding |
FB:FBrf0188335 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0070593 |
dendrite self-avoidance |
FB:FBrf0200892 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0070593 |
dendrite self-avoidance |
FB:FBrf0205027 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Schmucker D et al. (2000) Drosophila Dscam is an axon guidance receptor exhibiting extraordinary molecular diversity. Cell 101: 671-84 PubMed GONUTS page
- ↑ Millard SS et al. (2007) Dscam2 mediates axonal tiling in the Drosophila visual system. Nature 447: 720-4 PubMed GONUTS page
- ↑ 3.0 3.1 Watson FL et al. (2005) Extensive diversity of Ig-superfamily proteins in the immune system of insects. Science 309: 1874-8 PubMed GONUTS page
- ↑ Bateman J & Van Vactor D (2001) The Trio family of guanine-nucleotide-exchange factors: regulators of axon guidance. J Cell Sci 114: 1973-80 PubMed GONUTS page
- ↑ Wang J et al. (2002) Drosophila Dscam is required for divergent segregation of sister branches and suppresses ectopic bifurcation of axons. Neuron 33: 559-71 PubMed GONUTS page
- ↑ Hallem EA & Carlson JR (2004) The odor coding system of Drosophila. Trends Genet 20: 453-9 PubMed GONUTS page
- ↑ 7.0 7.1 Wojtowicz WM et al. (2004) Alternative splicing of Drosophila Dscam generates axon guidance receptors that exhibit isoform-specific homophilic binding. Cell 118: 619-33 PubMed GONUTS page
- ↑ Chen BE et al. (2006) The molecular diversity of Dscam is functionally required for neuronal wiring specificity in Drosophila. Cell 125: 607-20 PubMed GONUTS page
- ↑ Andrews GL et al. (2008) Dscam guides embryonic axons by Netrin-dependent and -independent functions. Development 135: 3839-48 PubMed GONUTS page
- ↑ 10.0 10.1 Zhan XL et al. (2004) Analysis of Dscam diversity in regulating axon guidance in Drosophila mushroom bodies. Neuron 43: 673-86 PubMed GONUTS page
- ↑ Hummel T et al. (2003) Axonal targeting of olfactory receptor neurons in Drosophila is controlled by Dscam. Neuron 37: 221-31 PubMed GONUTS page
- ↑ Wang J et al. (2004) Transmembrane/juxtamembrane domain-dependent Dscam distribution and function during mushroom body neuronal morphogenesis. Neuron 43: 663-72 PubMed GONUTS page
- ↑ 13.0 13.1 13.2 Hattori D et al. (2007) Dscam diversity is essential for neuronal wiring and self-recognition. Nature 449: 223-7 PubMed GONUTS page
- ↑ 14.0 14.1 14.2 Sawaya MR et al. (2008) A double S shape provides the structural basis for the extraordinary binding specificity of Dscam isoforms. Cell 134: 1007-18 PubMed GONUTS page
- ↑ 15.0 15.1 15.2 15.3 Matthews BJ et al. (2007) Dendrite self-avoidance is controlled by Dscam. Cell 129: 593-604 PubMed GONUTS page
- ↑ Wojtowicz WM et al. (2007) A vast repertoire of Dscam binding specificities arises from modular interactions of variable Ig domains. Cell 130: 1134-45 PubMed GONUTS page
- ↑ Keene AC et al. (2006) Drosophila dorsal paired medial neurons provide a general mechanism for memory consolidation. Curr Biol 16: 1524-30 PubMed GONUTS page
