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FB:Dl

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Contents

Species (Taxon ID) Drosophila melanogaster (fruit fly) (taxon:7227)
Gene Name(s) Dl ( synonyms: 0495/20, 0926/11, 1053/14, 1119/09, 1304/03, 1423/11, 1440/11, 1485/04, C1, CG3619, CT12133, Complementation group 1, D, DL, E(ls)2, Overflow, anon-WO0118547.269, delta, delta D1, dmDelta, l(3)05151, l(3)92Ab, l(3)j8C3 )
Protein Name(s) Delta,
External Links
FB FBgn0000463

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0001708

cell fate specification

FB:FBrf0103246
PMID:9642168[1]

TAS: Traceable Author Statement

P

From FB

GO:0001708

cell fate specification

FB:FBrf0141762
PMID:11735386[2]

TAS: Traceable Author Statement

P

From FB

GO:0001736

establishment of planar polarity

FB:FBrf0156094
PMID:12414186[3]

NAS: Non-traceable Author Statement

P

From FB

GO:0005102

receptor binding

FB:FBrf0159232
PMID:12612640[4]

NAS: Non-traceable Author Statement

F

From FB

GO:0005112

Notch binding

FB:FBrf0051377
PMID:2185893[5]

IDA: Inferred from Direct Assay

F

From FB

GO:0005112

Notch binding

FB:FBrf0076038
PMID:7954795[6]

TAS: Traceable Author Statement

F

From FB

GO:0005112

Notch binding

FB:FBrf0144824
PMID:11880339[7]

NAS: Non-traceable Author Statement

F

From FB

GO:0005112

Notch binding

FB:FBrf0160750
PMID:12879448[8]

TAS: Traceable Author Statement

F

From FB

GO:0005112

Notch binding

FB:FBrf0210603
PMID:20203305[9]

IPI: Inferred from Physical Interaction

FB:FBgn0004647

F

From FB

GO:0005509

calcium ion binding

FB:FBrf0174215

IEA: Inferred from Electronic Annotation

InterPro:IPR001881
InterPro:IPR018097

F

From FB

GO:0005886

plasma membrane

FB:FBrf0051377
PMID:2185893[5]

IDA: Inferred from Direct Assay

C

From FB

GO:0005886

plasma membrane

FB:FBrf0099033
PMID:9367444[10]

IDA: Inferred from Direct Assay

C

From FB

GO:0005886

plasma membrane

FB:FBrf0193514
PMID:17065551[11]

IDA: Inferred from Direct Assay

C

From FB

GO:0005912

adherens junction

FB:FBrf0099033
PMID:9367444[10]

IDA: Inferred from Direct Assay

C

From FB

GO:0005912

adherens junction

FB:FBrf0192755
PMID:17212657[12]

IDA: Inferred from Direct Assay

C

From FB

GO:0007015

actin filament organization

FB:FBrf0187471
PMID:16049109[13]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007155

cell adhesion

FB:FBrf0129916
PMID:10929403[14]

TAS: Traceable Author Statement

P

From FB

GO:0007219

Notch signaling pathway

FB:FBrf0076038
PMID:7954795[6]

TAS: Traceable Author Statement

P

From FB

GO:0007219

Notch signaling pathway

FB:FBrf0144824
PMID:11880339[7]

NAS: Non-traceable Author Statement

P

From FB

GO:0007219

Notch signaling pathway

FB:FBrf0187479
PMID:16093323[15]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007219

Notch signaling pathway

FB:FBrf0190498
PMID:16326033[16]

IGI: Inferred from Genetic Interaction

FB:FBgn0002643

P

From FB

GO:0007298

border follicle cell migration

FB:FBrf0191839
PMID:17010965[17]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007314

oocyte anterior/posterior axis specification

FB:FBrf0160750
PMID:12879448[8]

TAS: Traceable Author Statement

P

From FB

GO:0007398

ectoderm development

FB:FBrf0053362
PMID:1913825[18]

TAS: Traceable Author Statement

P

From FB

GO:0007398

ectoderm development

FB:FBrf0123498

NAS: Non-traceable Author Statement

P

From FB

GO:0007399

nervous system development

FB:FBrf0129916
PMID:10929403[14]

NAS: Non-traceable Author Statement

P

From FB

GO:0007417

central nervous system development

FB:FBrf0123498

NAS: Non-traceable Author Statement

P

From FB

GO:0007419

ventral cord development

FB:FBrf0158840
PMID:12593977[19]

NAS: Non-traceable Author Statement

P

From FB

GO:0007422

peripheral nervous system development

FB:FBrf0083410
PMID:8060613[20]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007422

peripheral nervous system development

FB:FBrf0131381
PMID:11102367[21]

TAS: Traceable Author Statement

P

From FB

GO:0007423

sensory organ development

FB:FBrf0187479
PMID:16093323[15]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007424

open tracheal system development

FB:FBrf0125237
PMID:10684581[22]

NAS: Non-traceable Author Statement

P

From FB

GO:0007451

dorsal/ventral lineage restriction, imaginal disc

FB:FBrf0141064
PMID:11253649[23]

TAS: Traceable Author Statement

P

From FB

GO:0007460

R8 cell fate commitment

FB:FBrf0129916
PMID:10929403[14]

TAS: Traceable Author Statement

P

From FB

GO:0007464

R3/R4 cell fate commitment

FB:FBrf0156094
PMID:12414186[3]

NAS: Non-traceable Author Statement

P

From FB

GO:0007474

imaginal disc-derived wing vein specification

FB:FBrf0158727
PMID:12717815[24]

NAS: Non-traceable Author Statement

P

From FB

GO:0007475

apposition of dorsal and ventral imaginal disc-derived wing surfaces

FB:FBrf0093664
PMID:9136017[25]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007476

imaginal disc-derived wing morphogenesis

FB:FBrf0187469
PMID:15829515[26]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007480

imaginal disc-derived leg morphogenesis

FB:FBrf0137014
PMID:11429287[27]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007498

mesoderm development

FB:FBrf0053362
PMID:1913825[18]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0008284

positive regulation of cell proliferation

FB:FBrf0187403
PMID:15809035[28]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0008347

glial cell migration

FB:FBrf0191976
PMID:17157832[29]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0008356

asymmetric cell division

FB:FBrf0174511
PMID:15018932[30]

TAS: Traceable Author Statement

P

From FB

GO:0008407

chaeta morphogenesis

FB:FBrf0190182
PMID:16168983[31]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0008586

imaginal disc-derived wing vein morphogenesis

FB:FBrf0182589

TAS: Traceable Author Statement

P

From FB

GO:0009986

cell surface

FB:FBrf0210603
PMID:20203305[9]

IDA: Inferred from Direct Assay

C

From FB

GO:0016021

integral to membrane

FB:FBrf0123498

NAS: Non-traceable Author Statement

C

From FB

GO:0016021

integral to membrane

FB:FBrf0129916
PMID:10929403[14]

TAS: Traceable Author Statement

C

From FB

GO:0016021

integral to membrane

FB:FBrf0159232
PMID:12612640[4]

NAS: Non-traceable Author Statement

C

From FB

GO:0016021

integral to membrane

FB:FBrf0174215

IEA: Inferred from Electronic Annotation

InterPro:IPR011651

C

From FB

GO:0016318

ommatidial rotation

FB:FBrf0149002
PMID:12000787[32]

NAS: Non-traceable Author Statement

P

From FB

GO:0016330

second mitotic wave involved in compound eye morphogenesis

FB:FBrf0187403
PMID:15809035[28]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0030139

endocytic vesicle

FB:FBrf0193509
PMID:17028337[33]

IDA: Inferred from Direct Assay

C

From FB

GO:0030707

ovarian follicle cell development

FB:FBrf0103246
PMID:9642168[1]

TAS: Traceable Author Statement

P

From FB

GO:0030707

ovarian follicle cell development

FB:FBrf0128450
PMID:10822261[34]

TAS: Traceable Author Statement

P

From FB

GO:0030707

ovarian follicle cell development

FB:FBrf0189756
PMID:16542414[35]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0030713

ovarian follicle cell stalk formation

FB:FBrf0167471
PMID:14536057[36]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0030713

ovarian follicle cell stalk formation

FB:FBrf0195377
PMID:17332535[37]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0030718

germ-line stem cell maintenance

FB:FBrf0194773
PMID:17070683[38]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0030718

germ-line stem cell maintenance

FB:FBrf0201538
PMID:17287246[39]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0030720

oocyte localization involved in germarium-derived egg chamber formation

FB:FBrf0167471
PMID:14536057[36]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0031410

cytoplasmic vesicle

FB:FBrf0099033
PMID:9367444[10]

IDA: Inferred from Direct Assay

C

From FB

GO:0031410

cytoplasmic vesicle

FB:FBrf0193514
PMID:17065551[11]

IDA: Inferred from Direct Assay

C

From FB

GO:0035003

subapical complex

FB:FBrf0192755
PMID:17212657[12]

IDA: Inferred from Direct Assay

C

From FB

GO:0035155

negative regulation of terminal cell fate specification, open tracheal system

FB:FBrf0125237
PMID:10684581[22]

NAS: Non-traceable Author Statement

P

From FB

GO:0035157

negative regulation of fusion cell fate specification

FB:FBrf0125237
PMID:10684581[22]

NAS: Non-traceable Author Statement

P

From FB

GO:0036011

imaginal disc-derived leg segmentation

FB:FBrf0109019
PMID:10357895[40]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0042067

establishment of ommatidial planar polarity

FB:FBrf0151712
PMID:12121634[41]

TAS: Traceable Author Statement

P

From FB

GO:0042676

compound eye cone cell fate commitment

FB:FBrf0151870
PMID:12419199[42]

TAS: Traceable Author Statement

P

From FB

GO:0045465

R8 cell differentiation

FB:FBrf0144824
PMID:11880339[7]

NAS: Non-traceable Author Statement

P

From FB

GO:0045468

regulation of R8 cell spacing in compound eye

FB:FBrf0144824
PMID:11880339[7]

NAS: Non-traceable Author Statement

P

From FB

GO:0045931

positive regulation of mitotic cell cycle

FB:FBrf0187403
PMID:15809035[28]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0046331

lateral inhibition

FB:FBrf0151530
PMID:11932008[43]

TAS: Traceable Author Statement

P

From FB

GO:0046331

lateral inhibition

FB:FBrf0158840
PMID:12593977[19]

NAS: Non-traceable Author Statement

P

From FB

GO:0046331

lateral inhibition

FB:FBrf0160550
PMID:12879451[44]

TAS: Traceable Author Statement

P

From FB

GO:0046331

lateral inhibition

FB:FBrf0160750
PMID:12879448[8]

TAS: Traceable Author Statement

P

From FB

GO:0046331

lateral inhibition

FB:FBrf0187479
PMID:16093323[15]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0046331

lateral inhibition

FB:FBrf0214518

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0046667

compound eye retinal cell programmed cell death

FB:FBrf0147184
PMID:12006672[45]

TAS: Traceable Author Statement

P

From FB

GO:0048190

wing disc dorsal/ventral pattern formation

FB:FBrf0187471
PMID:16049109[13]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0048477

oogenesis

FB:FBrf0139618
PMID:11591336[46]

TAS: Traceable Author Statement

P

From FB

GO:0048477

oogenesis

FB:FBrf0167471
PMID:14536057[36]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0048749

compound eye development

FB:FBrf0129916
PMID:10929403[14]

TAS: Traceable Author Statement

P

From FB

GO:0048800

antennal morphogenesis

FB:FBrf0137014
PMID:11429287[27]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0048863

stem cell differentiation

FB:FBrf0194773
PMID:17070683[38]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0050768

negative regulation of neurogenesis

FB:FBrf0190498
PMID:16326033[16]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0050768

negative regulation of neurogenesis

FB:FBrf0199183
PMID:15452147[47]

IMP: Inferred from Mutant Phenotype

P

From FB

colocalizes_with

GO:0031410

cytoplasmic vesicle

FB:FBrf0190204
PMID:16137928[48]

IDA: Inferred from Direct Assay

C

From FB


edit table

Notes

References

See Help:References for how to manage references in GONUTS.
  1. ↑ 1.0 1.1 Cooperstock RL & Lipshitz HD (1997) Control of mRNA stability and translation during Drosophila development. Semin Cell Dev Biol 8: 541-9 PubMed GONUTS page
  2. ↑ Baker NE (2001) Cell proliferation, survival, and death in the Drosophila eye. Semin Cell Dev Biol 12: 499-507 PubMed GONUTS page
  3. ↑ 3.0 3.1 Mlodzik M (2002) Planar cell polarization: do the same mechanisms regulate Drosophila tissue polarity and vertebrate gastrulation? Trends Genet 18: 564-71 PubMed GONUTS page
  4. ↑ 4.0 4.1 González-Gaitán M (2003) Signal dispersal and transduction through the endocytic pathway. Nat Rev Mol Cell Biol 4: 213-24 PubMed GONUTS page
  5. ↑ 5.0 5.1 Fehon RG et al. (1990) Molecular interactions between the protein products of the neurogenic loci Notch and Delta, two EGF-homologous genes in Drosophila. Cell 61: 523-34 PubMed GONUTS page
  6. ↑ 6.0 6.1 Fortini ME & Artavanis-Tsakonas S (1994) The suppressor of hairless protein participates in notch receptor signaling. Cell 79: 273-82 PubMed GONUTS page
  7. ↑ 7.0 7.1 7.2 7.3 Frankfort BJ & Mardon G (2002) R8 development in the Drosophila eye: a paradigm for neural selection and differentiation. Development 129: 1295-306 PubMed GONUTS page
  8. ↑ 8.0 8.1 8.2 López-Schier H (2003) The polarisation of the anteroposterior axis in Drosophila. Bioessays 25: 781-91 PubMed GONUTS page
  9. ↑ 9.0 9.1 Kim IM et al. (2010) Gene deletion screen for cardiomyopathy in adult Drosophila identifies a new notch ligand. Circ Res 106: 1233-43 PubMed GONUTS page
  10. ↑ 10.0 10.1 10.2 Doherty D et al. (1997) The Drosophila neurogenic gene big brain, which encodes a membrane-associated protein, acts cell autonomously and can act synergistically with Notch and Delta. Development 124: 3881-93 PubMed GONUTS page
  11. ↑ 11.0 11.1 Commisso C & Boulianne GL (2007) The NHR1 domain of Neuralized binds Delta and mediates Delta trafficking and Notch signaling. Mol Biol Cell 18: 1-13 PubMed GONUTS page
  12. ↑ 12.0 12.1 Sasaki N et al. (2007) Polarized exocytosis and transcytosis of Notch during its apical localization in Drosophila epithelial cells. Genes Cells 12: 89-103 PubMed GONUTS page
  13. ↑ 13.0 13.1 Major RJ & Irvine KD (2005) Influence of Notch on dorsoventral compartmentalization and actin organization in the Drosophila wing. Development 132: 3823-33 PubMed GONUTS page
  14. ↑ 14.0 14.1 14.2 14.3 14.4 Kumar JP & Moses K (2000) Cell fate specification in the Drosophila retina. Results Probl Cell Differ 31: 93-114 PubMed GONUTS page
  15. ↑ 15.0 15.1 15.2 Pitsouli C & Delidakis C (2005) The interplay between DSL proteins and ubiquitin ligases in Notch signaling. Development 132: 4041-50 PubMed GONUTS page
  16. ↑ 16.0 16.1 Alexander SJ et al. (2006) Insertional inactivation of the L13a ribosomal protein gene of Drosophila melanogaster identifies a new Minute locus. Gene 368: 46-52 PubMed GONUTS page
  17. ↑ Wang X et al. (2007) Spatially localized Kuzbanian required for specific activation of Notch during border cell migration. Dev Biol 301: 532-40 PubMed GONUTS page
  18. ↑ 18.0 18.1 Corbin V et al. (1991) A role for the Drosophila neurogenic genes in mesoderm differentiation. Cell 67: 311-23 PubMed GONUTS page
  19. ↑ 19.0 19.1 Skeath JB & Thor S (2003) Genetic control of Drosophila nerve cord development. Curr Opin Neurobiol 13: 8-15 PubMed GONUTS page
  20. ↑ Salzberg A et al. (1994) Mutations affecting the pattern of the PNS in Drosophila reveal novel aspects of neuronal development. Neuron 13: 269-87 PubMed GONUTS page
  21. ↑ Prokopenko SN et al. (2000) Mutations affecting the development of the peripheral nervous system in Drosophila: a molecular screen for novel proteins. Genetics 156: 1691-715 PubMed GONUTS page
  22. ↑ 22.0 22.1 22.2 Zelzer E & Shilo BZ (2000) Cell fate choices in Drosophila tracheal morphogenesis. Bioessays 22: 219-26 PubMed GONUTS page
  23. ↑ McNeill H (2000) Sticking together and sorting things out: adhesion as a force in development. Nat Rev Genet 1: 100-8 PubMed GONUTS page
  24. ↑ De Celis JF (2003) Pattern formation in the Drosophila wing: The development of the veins. Bioessays 25: 443-51 PubMed GONUTS page
  25. ↑ Prout M et al. (1997) Autosomal mutations affecting adhesion between wing surfaces in Drosophila melanogaster. Genetics 146: 275-85 PubMed GONUTS page
  26. ↑ Lai EC et al. (2005) The ubiquitin ligase Drosophila Mind bomb promotes Notch signaling by regulating the localization and activity of Serrate and Delta. Development 132: 2319-32 PubMed GONUTS page
  27. ↑ 27.0 27.1 Mishra A et al. (2001) Spatial regulation of DELTA expression mediates NOTCH signalling for segmentation of Drosophila legs. Mech Dev 105: 115-27 PubMed GONUTS page
  28. ↑ 28.0 28.1 28.2 Baonza A & Freeman M (2005) Control of cell proliferation in the Drosophila eye by Notch signaling. Dev Cell 8: 529-39 PubMed GONUTS page
  29. ↑ Edenfeld G et al. (2007) Notch and Numb are required for normal migration of peripheral glia in Drosophila. Dev Biol 301: 27-37 PubMed GONUTS page
  30. ↑ Bardin AJ et al. (2004) Asymmetric localization and function of cell-fate determinants: a fly's view. Curr Opin Neurobiol 14: 6-14 PubMed GONUTS page
  31. ↑ Wildonger J & Mann RS (2005) Evidence that nervy, the Drosophila homolog of ETO/MTG8, promotes mechanosensory organ development by enhancing Notch signaling. Dev Biol 286: 507-20 PubMed GONUTS page
  32. ↑ Van Aelst L & Symons M (2002) Role of Rho family GTPases in epithelial morphogenesis. Genes Dev 16: 1032-54 PubMed GONUTS page
  33. ↑ Parks AL et al. (2006) Structure-function analysis of delta trafficking, receptor binding and signaling in Drosophila. Genetics 174: 1947-61 PubMed GONUTS page
  34. ↑ Dobens LL & Raftery LA (2000) Integration of epithelial patterning and morphogenesis in Drosophila ovarian follicle cells. Dev Dyn 218: 80-93 PubMed GONUTS page
  35. ↑ Jordan KC et al. (2006) Notch signaling through tramtrack bypasses the mitosis promoting activity of the JNK pathway in the mitotic-to-endocycle transition of Drosophila follicle cells. BMC Dev Biol 6: 16 PubMed GONUTS page
  36. ↑ 36.0 36.1 36.2 Torres IL et al. (2003) A Notch/Delta-dependent relay mechanism establishes anterior-posterior polarity in Drosophila. Dev Cell 5: 547-58 PubMed GONUTS page
  37. ↑ Assa-Kunik E et al. (2007) Drosophila follicle cells are patterned by multiple levels of Notch signaling and antagonism between the Notch and JAK/STAT pathways. Development 134: 1161-9 PubMed GONUTS page
  38. ↑ 38.0 38.1 Ward EJ et al. (2006) Stem cells signal to the niche through the Notch pathway in the Drosophila ovary. Curr Biol 16: 2352-8 PubMed GONUTS page
  39. ↑ Song X et al. (2007) Notch signaling controls germline stem cell niche formation in the Drosophila ovary. Development 134: 1071-80 PubMed GONUTS page
  40. ↑ Rauskolb C & Irvine KD (1999) Notch-mediated segmentation and growth control of the Drosophila leg. Dev Biol 210: 339-50 PubMed GONUTS page
  41. ↑ McNeill H (2002) Planar polarity: location, location, location. Curr Biol 12: R449-51 PubMed GONUTS page
  42. ↑ Lai EC (2002) Developmental signaling: shrimp and strawberries help flies make cones. Curr Biol 12: R722-4 PubMed GONUTS page
  43. ↑ Arias AM (2002) New alleles of Notch draw a blueprint for multifunctionality. Trends Genet 18: 168-70 PubMed GONUTS page
  44. ↑ Ghysen A & Thomas R (2003) The formation of sense organs in Drosophila: a logical approach. Bioessays 25: 802-7 PubMed GONUTS page
  45. ↑ Gorski S & Marra M (2002) Programmed cell death takes flight: genetic and genomic approaches to gene discovery in Drosophila. Physiol Genomics 9: 59-69 PubMed GONUTS page
  46. ↑ Roth S (2001) Drosophila oogenesis: coordinating germ line and soma. Curr Biol 11: R779-81 PubMed GONUTS page
  47. ↑ Kamimura K et al. (2004) Regulation of Notch signaling by Drosophila heparan sulfate 3-O sulfotransferase. J Cell Biol 166: 1069-79 PubMed GONUTS page
  48. ↑ Jafar-Nejad H et al. (2005) Sec15, a component of the exocyst, promotes notch signaling during the asymmetric division of Drosophila sensory organ precursors. Dev Cell 9: 351-63 PubMed GONUTS page
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