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FB:Dif
Contents |
| Species (Taxon ID) | Drosophila melanogaster (fruit fly) (taxon:7227) | |
| Gene Name(s) | Dif ( synonyms: 6794, CG6794, DIF, Dorsal related immunity factor, Dorsal-like immunity factor, dif, dorsal-related immunity factor ) | |
| Protein Name(s) | Dorsal-related immunity factor, | |
| External Links | ||
| FB | FBgn0011274 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001077 |
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription |
FB:FBrf0194397 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0002781 |
antifungal peptide production |
FB:FBrf0128630 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0003677 |
DNA binding |
FB:FBrf0064521 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0003677 |
DNA binding |
FB:FBrf0128630 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
FB:FBrf0082476 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
FB:FBrf0133282 |
NAS: Non-traceable Author Statement |
F |
From FB |
|||
| GO:0005515 |
protein binding |
FB:FBrf0155963 |
IPI: Inferred from Physical Interaction |
FB:FBgn0038578 |
F |
From FB |
||
| GO:0005634 |
nucleus |
FB:FBrf0100747 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005634 |
nucleus |
FB:FBrf0110270 |
TAS: Traceable Author Statement |
C |
From FB |
|||
| GO:0005634 |
nucleus |
FB:FBrf0141184 |
NAS: Non-traceable Author Statement |
C |
From FB |
|||
| GO:0005634 |
nucleus |
FB:FBrf0147014 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005634 |
nucleus |
FB:FBrf0155963 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005634 |
nucleus |
FB:FBrf0167884 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005634 |
nucleus |
FB:FBrf0179043 |
TAS: Traceable Author Statement |
C |
From FB |
|||
| GO:0005737 |
cytoplasm |
FB:FBrf0100747 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005737 |
cytoplasm |
FB:FBrf0110270 |
TAS: Traceable Author Statement |
C |
From FB |
|||
| GO:0005737 |
cytoplasm |
FB:FBrf0141184 |
NAS: Non-traceable Author Statement |
C |
From FB |
|||
| GO:0005737 |
cytoplasm |
FB:FBrf0147014 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005737 |
cytoplasm |
FB:FBrf0167884 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0006952 |
defense response |
FB:FBrf0099002 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0006952 |
defense response |
FB:FBrf0133282 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0006955 |
immune response |
FB:FBrf0127230 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0006955 |
immune response |
FB:FBrf0128774 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0006955 |
immune response |
FB:FBrf0141184 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0006955 |
immune response |
FB:FBrf0179043 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0006967 |
positive regulation of antifungal peptide biosynthetic process |
FB:FBrf0174342 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0006967 |
positive regulation of antifungal peptide biosynthetic process |
FB:FBrf0179457 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0006974 |
response to DNA damage stimulus |
FB:FBrf0208272 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008063 |
Toll signaling pathway |
FB:FBrf0133282 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0008063 |
Toll signaling pathway |
FB:FBrf0141068 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0008063 |
Toll signaling pathway |
FB:FBrf0155459 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0008063 |
Toll signaling pathway |
FB:FBrf0155688 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0008063 |
Toll signaling pathway |
FB:FBrf0179043 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0009620 |
response to fungus |
FB:FBrf0132053 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0009620 |
response to fungus |
FB:FBrf0141068 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0010628 |
positive regulation of gene expression |
FB:FBrf0206693 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0014018 |
P |
From FB |
||
| GO:0035070 |
salivary gland histolysis |
FB:FBrf0146921 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0035171 |
lamellocyte differentiation |
FB:FBrf0187386 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0035206 |
regulation of hemocyte proliferation |
FB:FBrf0193396 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0042387 |
plasmatocyte differentiation |
FB:FBrf0187386 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0043565 |
sequence-specific DNA binding |
FB:FBrf0201799 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0045087 |
innate immune response |
FB:FBrf0159908 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0045087 |
innate immune response |
FB:FBrf0188361 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
FB:FBrf0155963 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0048935 |
peripheral nervous system neuron development |
FB:FBrf0210269 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0050830 |
defense response to Gram-positive bacterium |
FB:FBrf0168033 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0050830 |
defense response to Gram-positive bacterium |
FB:FBrf0206693 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0050832 |
defense response to fungus |
FB:FBrf0168033 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Junell A et al. (2007) Isolation of regulators of Drosophila immune defense genes by a double interaction screen in yeast. Insect Biochem Mol Biol 37: 202-12 PubMed GONUTS page
- ↑ 2.0 2.1 Rutschmann S et al. (2000) The Rel protein DIF mediates the antifungal but not the antibacterial host defense in Drosophila. Immunity 12: 569-80 PubMed GONUTS page
- ↑ Ip YT et al. (1993) Dif, a dorsal-related gene that mediates an immune response in Drosophila. Cell 75: 753-63 PubMed GONUTS page
- ↑ Petersen UM et al. (1995) The dorsal-related immunity factor, Dif, is a sequence-specific trans-activator of Drosophila Cecropin gene expression. EMBO J 14: 3146-58 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Park JM et al. (2003) Signal-induced transcriptional activation by Dif requires the dTRAP80 mediator module. Mol Cell Biol 23: 1358-67 PubMed GONUTS page
- ↑ 6.0 6.1 Wu LP & Anderson KV (1998) Regulated nuclear import of Rel proteins in the Drosophila immune response. Nature 392: 93-7 PubMed GONUTS page
- ↑ 7.0 7.1 Manfruelli P et al. (1999) A mosaic analysis in Drosophila fat body cells of the control of antimicrobial peptide genes by the Rel proteins Dorsal and DIF. EMBO J 18: 3380-91 PubMed GONUTS page
- ↑ 8.0 8.1 Bhattacharya A & Steward R (2002) The Drosophila homolog of NTF-2, the nuclear transport factor-2, is essential for immune response. EMBO Rep 3: 378-83 PubMed GONUTS page
- ↑ 9.0 9.1 Cha GH et al. (2003) Discrete functions of TRAF1 and TRAF2 in Drosophila melanogaster mediated by c-Jun N-terminal kinase and NF-kappaB-dependent signaling pathways. Mol Cell Biol 23: 7982-91 PubMed GONUTS page
- ↑ 10.0 10.1 10.2 Leclerc V & Reichhart JM (2004) The immune response of Drosophila melanogaster. Immunol Rev 198: 59-71 PubMed GONUTS page
- ↑ Williams MJ et al. (1997) The 18-wheeler mutation reveals complex antibacterial gene regulation in Drosophila host defense. EMBO J 16: 6120-30 PubMed GONUTS page
- ↑ Meister M et al. (2000) The antimicrobial host defense of Drosophila. Curr Top Microbiol Immunol 248: 17-36 PubMed GONUTS page
- ↑ Martín-Blanco E (2000) p38 MAPK signalling cascades: ancient roles and new functions. Bioessays 22: 637-45 PubMed GONUTS page
- ↑ Brennan CA & Anderson KV (2004) Drosophila: the genetics of innate immune recognition and response. Annu Rev Immunol 22: 457-83 PubMed GONUTS page
- ↑ Steiner H (2004) Peptidoglycan recognition proteins: on and off switches for innate immunity. Immunol Rev 198: 83-96 PubMed GONUTS page
- ↑ Ravi D et al. (2009) A network of conserved damage survival pathways revealed by a genomic RNAi screen. PLoS Genet 5: e1000527 PubMed GONUTS page
- ↑ 17.0 17.1 Kimbrell DA & Beutler B (2001) The evolution and genetics of innate immunity. Nat Rev Genet 2: 256-67 PubMed GONUTS page
- ↑ Silverman N (2003) Flies kNOw how to signal. Dev Cell 4: 5-6 PubMed GONUTS page
- ↑ Medzhitov R & Janeway Jr C (2000) Fly immunity: great expectations. Genome Biol 1: REVIEWS106 PubMed GONUTS page
- ↑ 20.0 20.1 Brown AE et al. (2009) Short-term starvation of immune deficient Drosophila improves survival to gram-negative bacterial infections. PLoS One 4: e4490 PubMed GONUTS page
- ↑ Lehmann M et al. (2002) AP-1, but not NF-kappa B, is required for efficient steroid-triggered cell death in Drosophila. Cell Death Differ 9: 581-90 PubMed GONUTS page
- ↑ 22.0 22.1 Huang L et al. (2005) The lesswright mutation activates Rel-related proteins, leading to overproduction of larval hemocytes in Drosophila melanogaster. Dev Biol 280: 407-20 PubMed GONUTS page
- ↑ Matova N & Anderson KV (2006) Rel/NF-kappaB double mutants reveal that cellular immunity is central to Drosophila host defense. Proc Natl Acad Sci U S A 103: 16424-9 PubMed GONUTS page
- ↑ Copley RR et al. (2007) Functional conservation of Rel binding sites in drosophilid genomes. Genome Res 17: 1327-35 PubMed GONUTS page
- ↑ Janssens S & Beyaert R (2002) A universal role for MyD88 in TLR/IL-1R-mediated signaling. Trends Biochem Sci 27: 474-82 PubMed GONUTS page
- ↑ Kwiatkowski DP (2005) The complexity of genetic variation in a simple immune system. Trends Genet 21: 197-9 PubMed GONUTS page
- ↑ Ayyar S et al. (2007) NF-kappaB/Rel-mediated regulation of the neural fate in Drosophila. PLoS One 2: e1178 PubMed GONUTS page
- ↑ 28.0 28.1 Gobert V et al. (2003) Dual activation of the Drosophila toll pathway by two pattern recognition receptors. Science 302: 2126-30 PubMed GONUTS page
