GONUTS is under stress! The website is currently experiencing long-wait times and frequent time-outs due to the record number of students, groups, and annotations related to CACAO this semester. We are currently working on increasing performance -- please accept our apologies for the technical difficulties.
You can help reduce stress on the server by:
- not reloading pages frequently - this just adds
- opening links in new windows (so you can read the old page)
FB:Dhc64C
Contents |
| Species (Taxon ID) | Drosophila melanogaster (fruit fly) (taxon:7227) | |
| Gene Name(s) | Dhc64C ( synonyms: CD, CG7507, Cdhc, Cytoplasmic dynein, Cytoplasmic dynein heavy chain, DHC, DHC64C, Dhc, Dhc46C, Dhc64, Dhc64c, Dynein, Dynein heavy chain, Dynein heavy-chain, Female sterile(3)Laborc, Fs(3)Lab, Fs(3)Laborc, Fs(3)Sz18, HMW MAP, Lab, Laborc, Su(Gl)77, Suppressor of Glued 77, cDhc, cDhc64C, cytoplasmic Dynein heavy chain, cytoplasmic dynein, cytoplasmic dynein heavy chain, cytoplasmic dynenin, dhc, dhc64C, dynein, dynein HC, dynein heavy chain, dynein heavy chain 64C, dynein heavy chain at 64C, dynein heavy-chain, l(3)64Ca ) | |
| Protein Name(s) | Dynein heavy chain 64C, | |
| External Links | ||
| FB | FBgn0261797 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000776 |
kinetochore |
FB:FBrf0200141 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0003774 |
motor activity |
FB:FBrf0105495 |
ISS: Inferred from Sequence or Structural Similarity |
EMBL:N39708 |
F |
From FB |
||
| GO:0003777 |
microtubule motor activity |
FB:FBrf0073309 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0005524 |
ATP binding |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
F |
From FB |
|||
| GO:0005737 |
cytoplasm |
FB:FBrf0156706 |
NAS: Non-traceable Author Statement |
C |
From FB |
|||
| GO:0005737 |
cytoplasm |
FB:FBrf0188148 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005794 |
Golgi apparatus |
FB:FBrf0188148 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005868 |
cytoplasmic dynein complex |
FB:FBrf0105495 |
ISS: Inferred from Sequence or Structural Similarity |
EMBL:N39708 |
C |
From FB |
||
| GO:0005868 |
cytoplasmic dynein complex |
FB:FBrf0132100 |
ISS: Inferred from Sequence or Structural Similarity |
C |
From FB |
|||
| GO:0005875 |
microtubule associated complex |
FB:FBrf0073309 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005875 |
microtubule associated complex |
FB:FBrf0119403 |
NAS: Non-traceable Author Statement |
C |
From FB |
|||
| GO:0005875 |
microtubule associated complex |
FB:FBrf0204649 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005938 |
cell cortex |
FB:FBrf0112050 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0006886 |
intracellular protein transport |
FB:FBrf0191164 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007018 |
microtubule-based movement |
FB:FBrf0073309 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0007018 |
microtubule-based movement |
FB:FBrf0132100 |
ISS: Inferred from Sequence or Structural Similarity |
P |
From FB |
|||
| GO:0007018 |
microtubule-based movement |
FB:FBrf0156706 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0007051 |
spindle organization |
FB:FBrf0188049 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007052 |
mitotic spindle organization |
FB:FBrf0180379 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007052 |
mitotic spindle organization |
FB:FBrf0200397 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007067 |
mitosis |
FB:FBrf0180379 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007098 |
centrosome cycle |
FB:FBrf0134518 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007279 |
pole cell formation |
FB:FBrf0213255 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007282 |
cystoblast division |
FB:FBrf0180502 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007294 |
germarium-derived oocyte fate determination |
FB:FBrf0095713 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007294 |
germarium-derived oocyte fate determination |
FB:FBrf0132360 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007301 |
female germline ring canal formation |
FB:FBrf0132360 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007312 |
oocyte nucleus migration involved in oocyte dorsal/ventral axis specification |
FB:FBrf0158831 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007349 |
cellularization |
FB:FBrf0188148 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007405 |
neuroblast proliferation |
FB:FBrf0131351 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008088 |
axon cargo transport |
FB:FBrf0131351 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008298 |
intracellular mRNA localization |
FB:FBrf0155474 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0016319 |
mushroom body development |
FB:FBrf0131351 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0030071 |
regulation of mitotic metaphase/anaphase transition |
FB:FBrf0200141 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0030286 |
dynein complex |
FB:FBrf0207048 |
IPI: Inferred from Physical Interaction |
FB:FBgn0030276 |
C |
From FB |
||
| GO:0030529 |
ribonucleoprotein complex |
FB:FBrf0205196 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0030723 |
ovarian fusome organization |
FB:FBrf0180502 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0040001 |
establishment of mitotic spindle localization |
FB:FBrf0158833 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0040003 |
chitin-based cuticle development |
FB:FBrf0202671 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0261873 |
P |
From FB |
||
| GO:0042623 |
ATPase activity, coupled |
FB:FBrf0073309 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0042623 |
ATPase activity, coupled |
FB:FBrf0132100 |
ISS: Inferred from Sequence or Structural Similarity |
F |
From FB |
|||
| GO:0042623 |
ATPase activity, coupled |
FB:FBrf0156706 |
NAS: Non-traceable Author Statement |
F |
From FB |
|||
| GO:0043148 |
mitotic spindle stabilization |
FB:FBrf0180379 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0045169 |
fusome |
FB:FBrf0108992 |
TAS: Traceable Author Statement |
C |
From FB |
|||
| GO:0045169 |
fusome |
FB:FBrf0132360 |
TAS: Traceable Author Statement |
C |
From FB |
|||
| GO:0045172 |
germline ring canal |
FB:FBrf0132360 |
TAS: Traceable Author Statement |
C |
From FB |
|||
| GO:0045197 |
establishment or maintenance of epithelial cell apical/basal polarity |
FB:FBrf0202671 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0045198 |
establishment of epithelial cell apical/basal polarity |
FB:FBrf0202884 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0045478 |
fusome organization |
FB:FBrf0108992 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0045478 |
fusome organization |
FB:FBrf0132360 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0046604 |
positive regulation of mitotic centrosome separation |
FB:FBrf0180379 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0047497 |
mitochondrion transport along microtubule |
FB:FBrf0191163 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0048134 |
germ-line cyst formation |
FB:FBrf0108992 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0048134 |
germ-line cyst formation |
FB:FBrf0132360 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0048311 |
mitochondrion distribution |
FB:FBrf0192257 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0048477 |
oogenesis |
FB:FBrf0078998 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0048477 |
oogenesis |
FB:FBrf0095713 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0048813 |
dendrite morphogenesis |
FB:FBrf0131351 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0050658 |
RNA transport |
FB:FBrf0201524 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0051237 |
maintenance of RNA location |
FB:FBrf0187222 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0051642 |
centrosome localization |
FB:FBrf0180379 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0051642 |
centrosome localization |
FB:FBrf0188049 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0051683 |
establishment of Golgi localization |
FB:FBrf0188148 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
|
colocalizes_with |
GO:0005739 |
mitochondrion |
FB:FBrf0191163 |
IDA: Inferred from Direct Assay |
C |
From FB |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Griffis ER et al. (2007) Spindly, a novel protein essential for silencing the spindle assembly checkpoint, recruits dynein to the kinetochore. J Cell Biol 177: 1005-15 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Hays TS et al. (1994) A cytoplasmic dynein motor in Drosophila: identification and localization during embryogenesis. J Cell Sci 107 ( Pt 6): 1557-69 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Papoulas O et al. (2005) The golgin Lava lamp mediates dynein-based Golgi movements during Drosophila cellularization. Nat Cell Biol 7: 612-8 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Goldstein LS & Gunawardena S (2000) Flying through the drosophila cytoskeletal genome. J Cell Biol 150: F63-8 PubMed GONUTS page
- ↑ Hughes JR et al. (2008) A microtubule interactome: complexes with roles in cell cycle and mitosis. PLoS Biol 6: e98 PubMed GONUTS page
- ↑ Swan A et al. (1999) Drosophila Lissencephaly-1 functions with Bic-D and dynein in oocyte determination and nuclear positioning. Nat Cell Biol 1: 444-9 PubMed GONUTS page
- ↑ Siller KH et al. (2005) Live imaging of Drosophila brain neuroblasts reveals a role for Lis1/dynactin in spindle assembly and mitotic checkpoint control. Mol Biol Cell 16: 5127-40 PubMed GONUTS page
- ↑ 8.0 8.1 Morales-Mulia S & Scholey JM (2005) Spindle pole organization in Drosophila S2 cells by dynein, abnormal spindle protein (Asp), and KLP10A. Mol Biol Cell 16: 3176-86 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 9.3 9.4 Maiato H et al. (2004) Kinetochore-driven formation of kinetochore fibers contributes to spindle assembly during animal mitosis. J Cell Biol 167: 831-40 PubMed GONUTS page
- ↑ Goshima G et al. (2007) Genes required for mitotic spindle assembly in Drosophila S2 cells. Science 316: 417-21 PubMed GONUTS page
- ↑ Belecz I et al. (2001) Dominant-negative mutant dynein allows spontaneous centrosome assembly, uncouples chromosome and centrosome cycles. Curr Biol 11: 136-40 PubMed GONUTS page
- ↑ Lerit DA & Gavis ER (2011) Transport of germ plasm on astral microtubules directs germ cell development in Drosophila. Curr Biol 21: 439-48 PubMed GONUTS page
- ↑ 13.0 13.1 Snapp EL et al. (2004) The fusome mediates intercellular endoplasmic reticulum connectivity in Drosophila ovarian cysts. Mol Biol Cell 15: 4512-21 PubMed GONUTS page
- ↑ 14.0 14.1 McGrail M & Hays TS (1997) The microtubule motor cytoplasmic dynein is required for spindle orientation during germline cell divisions and oocyte differentiation in Drosophila. Development 124: 2409-19 PubMed GONUTS page
- ↑ 15.0 15.1 15.2 15.3 15.4 15.5 Deng W & Lin H (2001) Asymmetric germ cell division and oocyte determination during Drosophila oogenesis. Int Rev Cytol 203: 93-138 PubMed GONUTS page
- ↑ Morris NR (2003) Nuclear positioning: the means is at the ends. Curr Opin Cell Biol 15: 54-9 PubMed GONUTS page
- ↑ 17.0 17.1 17.2 17.3 Liu Z et al. (2000) Drosophila Lis1 is required for neuroblast proliferation, dendritic elaboration and axonal transport. Nat Cell Biol 2: 776-83 PubMed GONUTS page
- ↑ Cohen RS (2002) Oocyte patterning: dynein and kinesin, inc. Curr Biol 12: R797-9 PubMed GONUTS page
- ↑ Satoh D et al. (2008) Spatial control of branching within dendritic arbors by dynein-dependent transport of Rab5-endosomes. Nat Cell Biol 10: 1164-71 PubMed GONUTS page
- ↑ Boylan KL et al. (2008) Motility screen identifies Drosophila IGF-II mRNA-binding protein--zipcode-binding protein acting in oogenesis and synaptogenesis. PLoS Genet 4: e36 PubMed GONUTS page
- ↑ Wang H et al. (2003) Cytokinesis: relative alignment of the cell division apparatus and the mitotic spindle. Curr Opin Cell Biol 15: 82-7 PubMed GONUTS page
- ↑ 22.0 22.1 Horne-Badovinac S & Bilder D (2008) Dynein regulates epithelial polarity and the apical localization of stardust A mRNA. PLoS Genet 4: e8 PubMed GONUTS page
- ↑ 23.0 23.1 23.2 Pepling ME et al. (1999) Germline cysts: a conserved phase of germ cell development? Trends Cell Biol 9: 257-62 PubMed GONUTS page
- ↑ Li Z et al. (2008) Dynein-mediated apical localization of crumbs transcripts is required for Crumbs activity in epithelial polarity. J Cell Biol 180: 31-8 PubMed GONUTS page
- ↑ 25.0 25.1 Pilling AD et al. (2006) Kinesin-1 and Dynein are the primary motors for fast transport of mitochondria in Drosophila motor axons. Mol Biol Cell 17: 2057-68 PubMed GONUTS page
- ↑ Cox RT & Spradling AC (2006) Milton controls the early acquisition of mitochondria by Drosophila oocytes. Development 133: 3371-7 PubMed GONUTS page
- ↑ Clark A et al. (2007) A Dynein-dependent shortcut rapidly delivers axis determination transcripts into the Drosophila oocyte. Development 134: 1955-65 PubMed GONUTS page
- ↑ Delanoue R & Davis I (2005) Dynein anchors its mRNA cargo after apical transport in the Drosophila blastoderm embryo. Cell 122: 97-106 PubMed GONUTS page
