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FB:Cdc42

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Contents

Species (Taxon ID) Drosophila melanogaster (fruit fly) (taxon:7227)
Gene Name(s) Cdc42 ( synonyms: CDC42, CG12530, Cdc42-like, Cdc42Dm, D-CDC42, D-Cdc42, D-cdc42, DCDC42, DCdc42, Dcdc42, Dm Cdc42, DmCDC42, Dmcdc42, cdc42 )
Protein Name(s) Cdc42,
External Links
FB FBgn0010341

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0003924

GTPase activity

FB:FBrf0105495

ISS: Inferred from Sequence or Structural Similarity

SGD:S0004219

F

From FB

GO:0003924

GTPase activity

FB:FBrf0110443
PMID:10449347[1]

NAS: Non-traceable Author Statement

F

From FB

GO:0003924

GTPase activity

FB:FBrf0123983

NAS: Non-traceable Author Statement

F

From FB

GO:0003924

GTPase activity

FB:FBrf0128589
PMID:10847683[2]

TAS: Traceable Author Statement

F

From FB

GO:0003924

GTPase activity

FB:FBrf0173281
PMID:14579253[3]

ISS: Inferred from Sequence or Structural Similarity

F

From FB

GO:0005515

protein binding

FB:FBrf0208460
PMID:19633175[4]

IPI: Inferred from Physical Interaction

FB:FBgn0037750

F

From FB

GO:0005525

GTP binding

FB:FBrf0174215

IEA: Inferred from Electronic Annotation

InterPro:IPR001806
InterPro:IPR003578
InterPro:IPR005225

F

From FB

GO:0005634

nucleus

FB:FBrf0208229
PMID:19498173[5]

IDA: Inferred from Direct Assay

C

From FB

GO:0005737

cytoplasm

FB:FBrf0208229
PMID:19498173[5]

IDA: Inferred from Direct Assay

C

From FB

GO:0006911

phagocytosis, engulfment

FB:FBrf0191376
PMID:16336044[6]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007010

cytoskeleton organization

FB:FBrf0149002
PMID:12000787[7]

NAS: Non-traceable Author Statement

P

From FB

GO:0007015

actin filament organization

FB:FBrf0167741
PMID:14527345[8]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007179

transforming growth factor beta receptor signaling pathway

FB:FBrf0151280
PMID:12147138[9]

TAS: Traceable Author Statement

P

From FB

GO:0007254

JNK cascade

FB:FBrf0110443
PMID:10449347[1]

TAS: Traceable Author Statement

P

From FB

GO:0007264

small GTPase mediated signal transduction

FB:FBrf0174215

IEA: Inferred from Electronic Annotation

InterPro:IPR001806
InterPro:IPR003578

P

From FB

GO:0007274

neuromuscular synaptic transmission

FB:FBrf0212767
PMID:21228159[10]

IGI: Inferred from Genetic Interaction

FB:FBgn0086901

P

From FB

GO:0007274

neuromuscular synaptic transmission

FB:FBrf0212767
PMID:21228159[10]

IGI: Inferred from Genetic Interaction

FB:FBgn0260003

P

From FB

GO:0007349

cellularization

FB:FBrf0151773
PMID:12386932[11]

TAS: Traceable Author Statement

P

From FB

GO:0007391

dorsal closure

FB:FBrf0090759
PMID:8946916[12]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007391

dorsal closure

FB:FBrf0110443
PMID:10449347[1]

TAS: Traceable Author Statement

P

From FB

GO:0007391

dorsal closure

FB:FBrf0149002
PMID:12000787[7]

TAS: Traceable Author Statement

P

From FB

GO:0007391

dorsal closure

FB:FBrf0151280
PMID:12147138[9]

TAS: Traceable Author Statement

P

From FB

GO:0007396

suture of dorsal opening

FB:FBrf0149002
PMID:12000787[7]

TAS: Traceable Author Statement

P

From FB

GO:0007409

axonogenesis

FB:FBrf0111874
PMID:10521399[13]

TAS: Traceable Author Statement

P

From FB

GO:0007411

axon guidance

FB:FBrf0144971
PMID:11880508[14]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007411

axon guidance

FB:FBrf0155484
PMID:12453459[15]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0008045

motor axon guidance

FB:FBrf0200818
PMID:17568577[16]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0008360

regulation of cell shape

FB:FBrf0167406
PMID:14588242[17]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0008360

regulation of cell shape

FB:FBrf0167741
PMID:14527345[8]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0008582

regulation of synaptic growth at neuromuscular junction

FB:FBrf0205746
PMID:18701694[18]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0008582

regulation of synaptic growth at neuromuscular junction

FB:FBrf0211075
PMID:20554864[19]

IDA: Inferred from Direct Assay

P

From FB

GO:0016028

rhabdomere

FB:FBrf0167774
PMID:14744998[20]

IMP: Inferred from Mutant Phenotype

C

From FB

GO:0030011

maintenance of cell polarity

FB:FBrf0184064
PMID:15699212[21]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0030031

cell projection assembly

FB:FBrf0167406
PMID:14588242[17]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0030036

actin cytoskeleton organization

FB:FBrf0141280
PMID:11700288[22]

TAS: Traceable Author Statement

P

From FB

GO:0030041

actin filament polymerization

FB:FBrf0090541
PMID:8947551[23]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0030041

actin filament polymerization

FB:FBrf0149002
PMID:12000787[7]

TAS: Traceable Author Statement

P

From FB

GO:0030424

axon

FB:FBrf0208229
PMID:19498173[5]

IDA: Inferred from Direct Assay

C

From FB

GO:0030426

growth cone

FB:FBrf0144971
PMID:11880508[14]

IDA: Inferred from Direct Assay

C

From FB

GO:0030707

ovarian follicle cell development

FB:FBrf0128450
PMID:10822261[24]

TAS: Traceable Author Statement

P

From FB

GO:0030833

regulation of actin filament polymerization

FB:FBrf0205746
PMID:18701694[18]

IDA: Inferred from Direct Assay

P

From FB

GO:0030866

cortical actin cytoskeleton organization

FB:FBrf0167406
PMID:14588242[17]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0031175

neuron projection development

FB:FBrf0132411
PMID:11124895[25]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0035099

hemocyte migration

FB:FBrf0184064
PMID:15699212[21]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0035318

imaginal disc-derived wing hair outgrowth

FB:FBrf0090541
PMID:8947551[23]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0042060

wound healing

FB:FBrf0152249
PMID:12402048[26]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0045200

establishment of neuroblast polarity

FB:FBrf0200720
PMID:17726059[27]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0046843

dorsal appendage formation

FB:FBrf0138279
PMID:11543614[28]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0048477

oogenesis

FB:FBrf0151280
PMID:12147138[9]

TAS: Traceable Author Statement

P

From FB

GO:0048813

dendrite morphogenesis

FB:FBrf0111874
PMID:10521399[13]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0048813

dendrite morphogenesis

FB:FBrf0159064
PMID:12716918[29]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0048813

dendrite morphogenesis

FB:FBrf0190157
PMID:16223476[30]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0048813

dendrite morphogenesis

FB:FBrf0208229
PMID:19498173[5]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0050770

regulation of axonogenesis

FB:FBrf0180582
PMID:15572110[31]

IGI: Inferred from Genetic Interaction

FB:FBgn0041203

P

From FB

GO:0060446

branching involved in open tracheal system development

FB:FBrf0215238
PMID:21750259[32]

IMP: Inferred from Mutant Phenotype

P

From FB

NOT

GO:0046664

dorsal closure, amnioserosa morphology change

FB:FBrf0147105
PMID:11973353[33]

IMP: Inferred from Mutant Phenotype

P

From FB


edit table

Notes

References

See Help:References for how to manage references in GONUTS.
  1. ↑ 1.0 1.1 1.2 Noselli S & Agnès F (1999) Roles of the JNK signaling pathway in Drosophila morphogenesis. Curr Opin Genet Dev 9: 466-72 PubMed GONUTS page
  2. ↑ Newsome TP et al. (2000) Trio combines with dock to regulate Pak activity during photoreceptor axon pathfinding in Drosophila. Cell 101: 283-94 PubMed GONUTS page
  3. ↑ Jékely G (2003) Small GTPases and the evolution of the eukaryotic cell. Bioessays 25: 1129-38 PubMed GONUTS page
  4. ↑ Liu R et al. (2009) Wash functions downstream of Rho and links linear and branched actin nucleation factors. Development 136: 2849-60 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 Kamiyama D & Chiba A (2009) Endogenous activation patterns of Cdc42 GTPase within Drosophila embryos. Science 324: 1338-40 PubMed GONUTS page
  6. ↑ Stroschein-Stevenson SL et al. (2006) Identification of Drosophila gene products required for phagocytosis of Candida albicans. PLoS Biol 4: e4 PubMed GONUTS page
  7. ↑ 7.0 7.1 7.2 7.3 Van Aelst L & Symons M (2002) Role of Rho family GTPases in epithelial morphogenesis. Genes Dev 16: 1032-54 PubMed GONUTS page
  8. ↑ 8.0 8.1 Kiger AA et al. (2003) A functional genomic analysis of cell morphology using RNA interference. J Biol 2: 27 PubMed GONUTS page
  9. ↑ 9.0 9.1 9.2 Harden N (2002) Signaling pathways directing the movement and fusion of epithelial sheets: lessons from dorsal closure in Drosophila. Differentiation 70: 181-203 PubMed GONUTS page
  10. ↑ 10.0 10.1 Pilgram GS et al. (2011) The RhoGAP crossveinless-c interacts with Dystrophin and is required for synaptic homeostasis at the Drosophila neuromuscular junction. J Neurosci 31: 492-500 PubMed GONUTS page
  11. ↑ Mazumdar A & Mazumdar M (2002) How one becomes many: blastoderm cellularization in Drosophila melanogaster. Bioessays 24: 1012-22 PubMed GONUTS page
  12. ↑ Riesgo-Escovar JR et al. (1996) The Drosophila Jun-N-terminal kinase is required for cell morphogenesis but not for DJun-dependent cell fate specification in the eye. Genes Dev 10: 2759-68 PubMed GONUTS page
  13. ↑ 13.0 13.1 Gao FB et al. (1999) Genes regulating dendritic outgrowth, branching, and routing in Drosophila. Genes Dev 13: 2549-61 PubMed GONUTS page
  14. ↑ 14.0 14.1 Kim MD et al. (2002) Growth cone pathfinding and filopodial dynamics are mediated separately by Cdc42 activation. J Neurosci 22: 1794-806 PubMed GONUTS page
  15. ↑ Fritz JL & VanBerkum MF (2002) Regulation of rho family GTPases is required to prevent axons from crossing the midline. Dev Biol 252: 46-58 PubMed GONUTS page
  16. ↑ Dorsten JN et al. (2007) Frazzled regulation of myosin II activity in the Drosophila embryonic CNS. Dev Biol 308: 120-32 PubMed GONUTS page
  17. ↑ 17.0 17.1 17.2 Kunda P et al. (2003) Abi, Sra1, and Kette control the stability and localization of SCAR/WAVE to regulate the formation of actin-based protrusions. Curr Biol 13: 1867-75 PubMed GONUTS page
  18. ↑ 18.0 18.1 Rodal AA et al. (2008) Nervous wreck and Cdc42 cooperate to regulate endocytic actin assembly during synaptic growth. J Neurosci 28: 8316-25 PubMed GONUTS page
  19. ↑ Nahm M et al. (2010) dCIP4 (Drosophila Cdc42-interacting protein 4) restrains synaptic growth by inhibiting the secretion of the retrograde Glass bottom boat signal. J Neurosci 30: 8138-50 PubMed GONUTS page
  20. ↑ Zelhof AC & Hardy RW (2004) WASp is required for the correct temporal morphogenesis of rhabdomere microvilli. J Cell Biol 164: 417-26 PubMed GONUTS page
  21. ↑ 21.0 21.1 Stramer B et al. (2005) Live imaging of wound inflammation in Drosophila embryos reveals key roles for small GTPases during in vivo cell migration. J Cell Biol 168: 567-73 PubMed GONUTS page
  22. ↑ Johnstone O & Lasko P (2001) Translational regulation and RNA localization in Drosophila oocytes and embryos. Annu Rev Genet 35: 365-406 PubMed GONUTS page
  23. ↑ 23.0 23.1 Eaton S et al. (1996) Roles for Rac1 and Cdc42 in planar polarization and hair outgrowth in the wing of Drosophila. J Cell Biol 135: 1277-89 PubMed GONUTS page
  24. ↑ Dobens LL & Raftery LA (2000) Integration of epithelial patterning and morphogenesis in Drosophila ovarian follicle cells. Dev Dyn 218: 80-93 PubMed GONUTS page
  25. ↑ Allen MJ et al. (2000) A role for Drosophila Drac1 in neurite outgrowth and synaptogenesis in the giant fiber system. Mol Cell Neurosci 16: 754-65 PubMed GONUTS page
  26. ↑ Wood W et al. (2002) Wound healing recapitulates morphogenesis in Drosophila embryos. Nat Cell Biol 4: 907-12 PubMed GONUTS page
  27. ↑ Atwood SX et al. (2007) Cdc42 acts downstream of Bazooka to regulate neuroblast polarity through Par-6 aPKC. J Cell Sci 120: 3200-6 PubMed GONUTS page
  28. ↑ Suzanne M et al. (2001) The Drosophila JNK pathway controls the morphogenesis of the egg dorsal appendages and micropyle. Dev Biol 237: 282-94 PubMed GONUTS page
  29. ↑ Scott EK et al. (2003) Small GTPase Cdc42 is required for multiple aspects of dendritic morphogenesis. J Neurosci 23: 3118-23 PubMed GONUTS page
  30. ↑ Sánchez-Soriano N et al. (2005) Are dendrites in Drosophila homologous to vertebrate dendrites? Dev Biol 288: 126-38 PubMed GONUTS page
  31. ↑ Ng J & Luo L (2004) Rho GTPases regulate axon growth through convergent and divergent signaling pathways. Neuron 44: 779-93 PubMed GONUTS page
  32. ↑ Jones TA & Metzstein MM (2011) A novel function for the PAR complex in subcellular morphogenesis of tracheal terminal cells in Drosophila melanogaster. Genetics 189: 153-64 PubMed GONUTS page
  33. ↑ Harden N et al. (2002) Drac1 and Crumbs participate in amnioserosa morphogenesis during dorsal closure in Drosophila. J Cell Sci 115: 2119-29 PubMed GONUTS page
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