GONUTS is under stress! The website is currently experiencing long-wait times and frequent time-outs due to the record number of students, groups, and annotations related to CACAO this semester. We are currently working on increasing performance -- please accept our apologies for the technical difficulties.
You can help reduce stress on the server by:
- not reloading pages frequently - this just adds
- opening links in new windows (so you can read the old page)
FB:Cbl
Contents |
| Species (Taxon ID) | Drosophila melanogaster (fruit fly) (taxon:7227) | |
| Gene Name(s) | Cbl ( synonyms: CBL, CG7037, CG7043, D-Cbl, D-Cbl L, D-cbl, D-cblL, D-cblLONG, D-cblS, D-cblSHORT, DCbl, Dcbl, Dv-Cbl, Dv-cbl, F165, anon-WO0118547.68, cable, cbl, d-cbl, dCbl ) | |
| Protein Name(s) | Cbl, | |
| External Links | ||
| FB | FBgn0020224 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001754 |
eye photoreceptor cell differentiation |
FB:FBrf0210285 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0001784 |
phosphotyrosine binding |
FB:FBrf0093510 |
ISM: Inferred from Sequence Model |
F |
From FB |
|||
| GO:0001784 |
phosphotyrosine binding |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
F |
From FB |
|||
| GO:0004842 |
ubiquitin-protein ligase activity |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
F |
From FB |
|||
| GO:0004871 |
signal transducer activity |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
F |
From FB |
|||
| GO:0005509 |
calcium ion binding |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
F |
From FB |
|||
| GO:0005515 |
protein binding |
FB:FBrf0213073 |
IPI: Inferred from Physical Interaction |
FB:FBgn0004638 |
F |
From FB |
||
| GO:0005634 |
nucleus |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
C |
From FB |
|||
| GO:0005737 |
cytoplasm |
FB:FBrf0093510 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005938 |
cell cortex |
FB:FBrf0195049 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0006508 |
proteolysis |
FB:FBrf0167264 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007173 |
epidermal growth factor receptor signaling pathway |
FB:FBrf0135878 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007175 |
negative regulation of epidermal growth factor-activated receptor activity |
FB:FBrf0131153 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007175 |
negative regulation of epidermal growth factor-activated receptor activity |
FB:FBrf0158927 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007175 |
negative regulation of epidermal growth factor-activated receptor activity |
FB:FBrf0213073 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0004638 |
P |
From FB |
||
| GO:0007298 |
border follicle cell migration |
FB:FBrf0187407 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007465 |
R7 cell fate commitment |
FB:FBrf0210285 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0007476 |
imaginal disc-derived wing morphogenesis |
FB:FBrf0193945 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008069 |
dorsal/ventral axis specification, ovarian follicular epithelium |
FB:FBrf0131153 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008270 |
zinc ion binding |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
F |
From FB |
|||
| GO:0009950 |
dorsal/ventral axis specification |
FB:FBrf0131153 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0010941 |
regulation of cell death |
FB:FBrf0210285 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0016874 |
ligase activity |
FB:FBrf0167264 |
TAS: Traceable Author Statement |
F |
From FB |
|||
| GO:0042059 |
negative regulation of epidermal growth factor receptor signaling pathway |
FB:FBrf0136839 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0042059 |
negative regulation of epidermal growth factor receptor signaling pathway |
FB:FBrf0195049 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0042127 |
regulation of cell proliferation |
FB:FBrf0208071 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0028734 |
P |
From FB |
||
| GO:0048134 |
germ-line cyst formation |
FB:FBrf0208071 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0028734 |
P |
From FB |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Wang Y et al. (2008) Drosophila cbl is essential for control of cell death and cell differentiation during eye development. PLoS One 3: e1447 PubMed GONUTS page
- ↑ 2.0 2.1 Hime GR et al. (1997) D-Cbl, the Drosophila homologue of the c-Cbl proto-oncogene, interacts with the Drosophila EGF receptor in vivo, despite lacking C-terminal adaptor binding sites. Oncogene 14: 2709-19 PubMed GONUTS page
- ↑ 3.0 3.1 Wang PY & Pai LM (2011) D-Cbl binding to Drk leads to dose-dependent down-regulation of EGFR signaling and increases receptor-ligand endocytosis. PLoS One 6: e17097 PubMed GONUTS page
- ↑ 4.0 4.1 Pai LM et al. (2006) Differential effects of Cbl isoforms on Egfr signaling in Drosophila. Mech Dev 123: 450-62 PubMed GONUTS page
- ↑ 5.0 5.1 Ghabrial A et al. (2003) Branching morphogenesis of the Drosophila tracheal system. Annu Rev Cell Dev Biol 19: 623-47 PubMed GONUTS page
- ↑ Hime GR et al. (2001) Dynamic expression of alternate splice forms of D-cbl during embryogenesis. Mech Dev 102: 235-8 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 Pai LM et al. (2000) D-cbl, a negative regulator of the Egfr pathway, is required for dorsoventral patterning in Drosophila oogenesis. Cell 103: 51-61 PubMed GONUTS page
- ↑ Shilo BZ (2003) Signaling by the Drosophila epidermal growth factor receptor pathway during development. Exp Cell Res 284: 140-9 PubMed GONUTS page
- ↑ Jékely G et al. (2005) Regulators of endocytosis maintain localized receptor tyrosine kinase signaling in guided migration. Dev Cell 9: 197-207 PubMed GONUTS page
- ↑ Dworkin I & Gibson G (2006) Epidermal growth factor receptor and transforming growth factor-beta signaling contributes to variation for wing shape in Drosophila melanogaster. Genetics 173: 1417-31 PubMed GONUTS page
- ↑ 11.0 11.1 Epstein AM et al. (2009) Drosophila Fragile X protein controls cellular proliferation by regulating cbl levels in the ovary. Dev Biol 330: 83-92 PubMed GONUTS page
