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FB:Caf1

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Contents

Species (Taxon ID) Drosophila melanogaster (fruit fly) (taxon:7227)
Gene Name(s) Caf1 ( synonyms: 154659_at, 55, CAF-1, CAF1, CAF1-55, CAF1p55, CG4236, Caf-1, Caf1/p55, Caf1p55, Chromatin Assembly Factor 1, Chromatin Assembly Factor-1, Chromatin associated factor-1 subunit, MSI1/RbAp48/CAC3/LIN-53, NURF, NURF-55, NURF55, Nucleosome remodeling factor, Nucleosome remodeling factor - 55kD, Nurf, Nurf 55, Nurf-55, Nurf55, Nurf55/CAF1, P55, RbAp48, S(ls)3, caf-1, caf1, caf1 p55, chromatin assembly factor 1, d-CAF1, dCAF-1, dCAF-1 p55, dNURF, p55, p55 CAF1, p55,CAF1, p55/NURF-55, p55CAF1 )
Protein Name(s) Chromatin assembly factor 1 subunit,
External Links
FB FBgn0263979

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000122

negative regulation of transcription from RNA polymerase II promoter

FB:FBrf0180259
PMID:15545624[1]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0000910

cytokinesis

FB:FBrf0180064
PMID:15380073[2]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0003682

chromatin binding

FB:FBrf0124325

NAS: Non-traceable Author Statement

F

From FB

GO:0005515

protein binding

FB:FBrf0179964
PMID:15516265[3]

IPI: Inferred from Physical Interaction

FB:FBgn0027950

F

From FB

GO:0005634

nucleus

FB:FBrf0090840
PMID:8887645[4]

IDA: Inferred from Direct Assay

C

From FB

GO:0005634

nucleus

FB:FBrf0100153
PMID:9419341[5]

IDA: Inferred from Direct Assay

C

From FB

GO:0005634

nucleus

FB:FBrf0124325

NAS: Non-traceable Author Statement

C

From FB

GO:0005634

nucleus

FB:FBrf0132295
PMID:11124122[6]

IDA: Inferred from Direct Assay

C

From FB

GO:0005634

nucleus

FB:FBrf0151814
PMID:12408863[7]

IDA: Inferred from Direct Assay

C

From FB

GO:0005667

transcription factor complex

FB:FBrf0155489
PMID:12459787[8]

IPI: Inferred from Physical Interaction

FB:FBgn0261793

C

From FB

GO:0005678

chromatin assembly complex

FB:FBrf0105495

NAS: Non-traceable Author Statement

C

From FB

GO:0005678

chromatin assembly complex

FB:FBrf0124325

NAS: Non-traceable Author Statement

C

From FB

GO:0005700

polytene chromosome

FB:FBrf0100153
PMID:9419341[5]

IDA: Inferred from Direct Assay

C

From FB

GO:0006281

DNA repair

FB:FBrf0095281
PMID:9230310[9]

TAS: Traceable Author Statement

P

From FB

GO:0006334

nucleosome assembly

FB:FBrf0095281
PMID:9230310[9]

IDA: Inferred from Direct Assay

P

From FB

GO:0006334

nucleosome assembly

FB:FBrf0105495

NAS: Non-traceable Author Statement

P

From FB

GO:0006334

nucleosome assembly

FB:FBrf0124995
PMID:10591219[10]

IDA: Inferred from Direct Assay

P

From FB

GO:0006335

DNA replication-dependent nucleosome assembly

FB:FBrf0124325

NAS: Non-traceable Author Statement

P

From FB

GO:0006342

chromatin silencing

FB:FBrf0132295
PMID:11124122[6]

IPI: Inferred from Physical Interaction

FB:FBgn0000588

P

From FB

GO:0006342

chromatin silencing

FB:FBrf0132295
PMID:11124122[6]

IPI: Inferred from Physical Interaction

FB:FBgn0000629

P

From FB

GO:0006351

transcription, DNA-dependent

FB:FBrf0135834
PMID:11279013[11]

IDA: Inferred from Direct Assay

P

From FB

GO:0007307

eggshell chorion gene amplification

FB:FBrf0155469
PMID:12490953[12]

IC: Inferred by Curator

GO:0031523

P

From FB

GO:0007346

regulation of mitotic cell cycle

FB:FBrf0149111
PMID:12077326[13]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007379

segment specification

FB:FBrf0213580
PMID:21490066[14]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007517

muscle organ development

FB:FBrf0190556
PMID:16547170[15]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0016571

histone methylation

FB:FBrf0151814
PMID:12408863[7]

IDA: Inferred from Direct Assay

P

From FB

GO:0016571

histone methylation

FB:FBrf0151815
PMID:12408864[16]

IDA: Inferred from Direct Assay

P

From FB

GO:0016573

histone acetylation

FB:FBrf0100153
PMID:9419341[5]

IDA: Inferred from Direct Assay

P

From FB

GO:0016573

histone acetylation

FB:FBrf0100153
PMID:9419341[5]

ISS: Inferred from Sequence or Structural Similarity

SGD:S0000782

P

From FB

GO:0016581

NuRD complex

FB:FBrf0179964
PMID:15516265[3]

IDA: Inferred from Direct Assay

C

From FB

GO:0016581

NuRD complex

FB:FBrf0212010
PMID:20733004[17]

IDA: Inferred from Direct Assay

C

From FB

GO:0016584

nucleosome positioning

FB:FBrf0084814
PMID:8524837[18]

IDA: Inferred from Direct Assay

P

From FB

GO:0016585

chromatin remodeling complex

FB:FBrf0124325

NAS: Non-traceable Author Statement

C

From FB

GO:0016589

NURF complex

FB:FBrf0100153
PMID:9419341[5]

IPI: Inferred from Physical Interaction

FB:FBgn0011604

C

From FB

GO:0016589

NURF complex

FB:FBrf0105229
PMID:9784495[19]

TAS: Traceable Author Statement

C

From FB

GO:0016589

NURF complex

FB:FBrf0124325

NAS: Non-traceable Author Statement

C

From FB

GO:0016589

NURF complex

FB:FBrf0155786
PMID:12502740[20]

TAS: Traceable Author Statement

C

From FB

GO:0031497

chromatin assembly

FB:FBrf0090840
PMID:8887645[4]

IDA: Inferred from Direct Assay

P

From FB

GO:0031497

chromatin assembly

FB:FBrf0187164
PMID:15896722[21]

ISS: Inferred from Sequence or Structural Similarity

HGNC:9887

P

From FB

GO:0031497

chromatin assembly

FB:FBrf0187164
PMID:15896722[21]

ISS: Inferred from Sequence or Structural Similarity

HGNC:9890

P

From FB

GO:0031523

Myb complex

FB:FBrf0155469
PMID:12490953[12]

IDA: Inferred from Direct Assay

C

From FB

GO:0031523

Myb complex

FB:FBrf0180022
PMID:15479636[22]

IDA: Inferred from Direct Assay

C

From FB

GO:0031523

Myb complex

FB:FBrf0180259
PMID:15545624[1]

IDA: Inferred from Direct Assay

C

From FB

GO:0033186

CAF-1 complex

FB:FBrf0090840
PMID:8887645[4]

IDA: Inferred from Direct Assay

C

From FB

GO:0035035

histone acetyltransferase binding

FB:FBrf0100153
PMID:9419341[5]

IPI: Inferred from Physical Interaction

FB:FBgn0019981

F

From FB

GO:0035035

histone acetyltransferase binding

FB:FBrf0100153
PMID:9419341[5]

ISS: Inferred from Sequence or Structural Similarity

SGD:S0000782

F

From FB

GO:0035097

histone methyltransferase complex

FB:FBrf0188105
PMID:16055700[23]

IDA: Inferred from Direct Assay

C

From FB

GO:0035098

ESC/E(Z) complex

FB:FBrf0151814
PMID:12408863[7]

IDA: Inferred from Direct Assay

C

From FB

GO:0035098

ESC/E(Z) complex

FB:FBrf0151815
PMID:12408864[16]

IDA: Inferred from Direct Assay

C

From FB

GO:0035098

ESC/E(Z) complex

FB:FBrf0205395
PMID:18276122[24]

IDA: Inferred from Direct Assay

C

From FB

GO:0042393

histone binding

FB:FBrf0095281
PMID:9230310[9]

TAS: Traceable Author Statement

F

From FB

GO:0042393

histone binding

FB:FBrf0105495

NAS: Non-traceable Author Statement

F

From FB

GO:0042393

histone binding

FB:FBrf0213994
PMID:21550984[25]

IDA: Inferred from Direct Assay

F

From FB

GO:0042766

nucleosome mobilization

FB:FBrf0108784
PMID:10399912[26]

IDA: Inferred from Direct Assay

P

From FB

GO:0042803

protein homodimerization activity

FB:FBrf0179964
PMID:15516265[3]

IPI: Inferred from Physical Interaction

FB:FBgn0263347

F

From FB

GO:0042826

histone deacetylase binding

FB:FBrf0090840
PMID:8887645[4]

IDA: Inferred from Direct Assay

F

From FB

GO:0042826

histone deacetylase binding

FB:FBrf0090840
PMID:8887645[4]

ISS: Inferred from Sequence or Structural Similarity

HGNC:9887

F

From FB

GO:0048666

neuron development

FB:FBrf0190556
PMID:16547170[15]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0048813

dendrite morphogenesis

FB:FBrf0190556
PMID:16547170[15]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0070822

Sin3-type complex

FB:FBrf0211588
PMID:20566628[27]

IDA: Inferred from Direct Assay

C

From FB

NOT

GO:0016590

ACF complex

FB:FBrf0095281
PMID:9230310[9]

IDA: Inferred from Direct Assay

C

From FB

contributes_to

GO:0042054

histone methyltransferase activity

FB:FBrf0188105
PMID:16055700[23]

IDA: Inferred from Direct Assay

F

From FB

contributes_to

GO:0042054

histone methyltransferase activity

FB:FBrf0205395
PMID:18276122[24]

IDA: Inferred from Direct Assay

F

From FB

contributes_to

GO:0046974

histone methyltransferase activity (H3-K9 specific)

FB:FBrf0151814
PMID:12408863[7]

IC: Inferred by Curator

GO:0035098

F

From FB

contributes_to

GO:0046976

histone methyltransferase activity (H3-K27 specific)

FB:FBrf0151814
PMID:12408863[7]

IC: Inferred by Curator

GO:0035098

F

From FB

contributes_to

GO:0046976

histone methyltransferase activity (H3-K27 specific)

FB:FBrf0151815
PMID:12408864[16]

IC: Inferred by Curator

GO:0035098

F

From FB


edit table

Notes

References

See Help:References for how to manage references in GONUTS.
  1. ↑ 1.0 1.1 Lewis PW et al. (2004) Identification of a Drosophila Myb-E2F2/RBF transcriptional repressor complex. Genes Dev 18: 2929-40 PubMed GONUTS page
  2. ↑ Echard A et al. (2004) Terminal cytokinesis events uncovered after an RNAi screen. Curr Biol 14: 1685-93 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 Marhold J et al. (2004) The Drosophila methyl-DNA binding protein MBD2/3 interacts with the NuRD complex via p55 and MI-2. BMC Mol Biol 5: 20 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 4.4 Tyler JK et al. (1996) The p55 subunit of Drosophila chromatin assembly factor 1 is homologous to a histone deacetylase-associated protein. Mol Cell Biol 16: 6149-59 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 Martínez-Balbás MA et al. (1998) Drosophila NURF-55, a WD repeat protein involved in histone metabolism. Proc Natl Acad Sci U S A 95: 132-7 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 Tie F et al. (2001) The Drosophila Polycomb Group proteins ESC and E(Z) are present in a complex containing the histone-binding protein p55 and the histone deacetylase RPD3. Development 128: 275-86 PubMed GONUTS page
  7. ↑ 7.0 7.1 7.2 7.3 7.4 Czermin B et al. (2002) Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites. Cell 111: 185-96 PubMed GONUTS page
  8. ↑ Hochheimer A et al. (2002) TRF2 associates with DREF and directs promoter-selective gene expression in Drosophila. Nature 420: 439-45 PubMed GONUTS page
  9. ↑ 9.0 9.1 9.2 9.3 Ito T et al. (1997) ACF, an ISWI-containing and ATP-utilizing chromatin assembly and remodeling factor. Cell 90: 145-55 PubMed GONUTS page
  10. ↑ Tyler JK et al. (1999) The RCAF complex mediates chromatin assembly during DNA replication and repair. Nature 402: 555-60 PubMed GONUTS page
  11. ↑ Mizuguchi G et al. (2001) ATP-dependent nucleosome remodeling and histone hyperacetylation synergistically facilitate transcription of chromatin. J Biol Chem 276: 14773-83 PubMed GONUTS page
  12. ↑ 12.0 12.1 Beall EL et al. (2002) Role for a Drosophila Myb-containing protein complex in site-specific DNA replication. Nature 420: 833-7 PubMed GONUTS page
  13. ↑ Pile LA et al. (2002) The SIN3/RPD3 deacetylase complex is essential for G(2) phase cell cycle progression and regulation of SMRTER corepressor levels. Mol Cell Biol 22: 4965-76 PubMed GONUTS page
  14. ↑ Anderson AE et al. (2011) The enhancer of trithorax and polycomb gene Caf1/p55 is essential for cell survival and patterning in Drosophila development. Development 138: 1957-66 PubMed GONUTS page
  15. ↑ 15.0 15.1 15.2 Parrish JZ et al. (2006) Genome-wide analyses identify transcription factors required for proper morphogenesis of Drosophila sensory neuron dendrites. Genes Dev 20: 820-35 PubMed GONUTS page
  16. ↑ 16.0 16.1 16.2 Müller J et al. (2002) Histone methyltransferase activity of a Drosophila Polycomb group repressor complex. Cell 111: 197-208 PubMed GONUTS page
  17. ↑ Reddy BA et al. (2010) Drosophila transcription factor Tramtrack69 binds MEP1 to recruit the chromatin remodeler NuRD. Mol Cell Biol 30: 5234-44 PubMed GONUTS page
  18. ↑ Bulger M et al. (1995) Assembly of regularly spaced nucleosome arrays by Drosophila chromatin assembly factor 1 and a 56-kDa histone-binding protein. Proc Natl Acad Sci U S A 92: 11726-30 PubMed GONUTS page
  19. ↑ Gdula DA et al. (1998) Inorganic pyrophosphatase is a component of the Drosophila nucleosome remodeling factor complex. Genes Dev 12: 3206-16 PubMed GONUTS page
  20. ↑ Badenhorst P et al. (2002) Biological functions of the ISWI chromatin remodeling complex NURF. Genes Dev 16: 3186-98 PubMed GONUTS page
  21. ↑ 21.0 21.1 Tie F et al. (2005) The N-terminus of Drosophila ESC mediates its phosphorylation and dimerization. Biochem Biophys Res Commun 332: 622-32 PubMed GONUTS page
  22. ↑ Korenjak M et al. (2004) Native E2F/RBF complexes contain Myb-interacting proteins and repress transcription of developmentally controlled E2F target genes. Cell 119: 181-93 PubMed GONUTS page
  23. ↑ 23.0 23.1 Ketel CS et al. (2005) Subunit contributions to histone methyltransferase activities of fly and worm polycomb group complexes. Mol Cell Biol 25: 6857-68 PubMed GONUTS page
  24. ↑ 24.0 24.1 Ohno K et al. (2008) ESC, ESCL and their roles in Polycomb Group mechanisms. Mech Dev 125: 527-41 PubMed GONUTS page
  25. ↑ Nowak AJ et al. (2011) Chromatin-modifying complex component Nurf55/p55 associates with histones H3 and H4 and polycomb repressive complex 2 subunit Su(z)12 through partially overlapping binding sites. J Biol Chem 286: 23388-96 PubMed GONUTS page
  26. ↑ Hamiche A et al. (1999) ATP-dependent histone octamer sliding mediated by the chromatin remodeling complex NURF. Cell 97: 833-42 PubMed GONUTS page
  27. ↑ Spain MM et al. (2010) Drosophila SIN3 isoforms interact with distinct proteins and have unique biological functions. J Biol Chem 285: 27457-67 PubMed GONUTS page
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