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FB:CadN

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Contents

Species (Taxon ID) Drosophila melanogaster (fruit fly) (taxon:7227)
Gene Name(s) CadN ( synonyms: B, CG7100, CT21941, CadherinN, D-cad, DN, DN cadherin, DN-CAD, DN-CADHERIN, DN-Cad, DN-Cadherin, DN-cad, DN-cadherin, DN-cadherin1, DNCad, DNcad, Drosophila neuronal cadherin, N-Cad, N-Cadh, N-Cadherin, N-cad, N-cadherin, NCAD, NCad, Ncad, S(DmcycE(JP))2.12, anon-EST:CL32, cad1, cadN, l(2)36Da, l(2)Bld, lethal(2)36Da, ncad )
Protein Name(s) Cadherin-N,
External Links
FB FBgn0015609

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0004872

receptor activity

FB:FBrf0129868
PMID:10908592[1]

ISS: Inferred from Sequence or Structural Similarity

F

From FB

GO:0005509

calcium ion binding

FB:FBrf0174215

IEA: Inferred from Electronic Annotation

InterPro:IPR001881
InterPro:IPR002126
InterPro:IPR015919

F

From FB

GO:0005886

plasma membrane

FB:FBrf0095287
PMID:9247265[2]

ISS: Inferred from Sequence or Structural Similarity

FB:FBgn0003391

C

From FB

GO:0005886

plasma membrane

FB:FBrf0108154
PMID:10218152[3]

TAS: Traceable Author Statement

C

From FB

GO:0005886

plasma membrane

FB:FBrf0210975

IDA: Inferred from Direct Assay

C

From FB

GO:0005887

integral to plasma membrane

FB:FBrf0129868
PMID:10908592[1]

ISS: Inferred from Sequence or Structural Similarity

C

From FB

GO:0005887

integral to plasma membrane

FB:FBrf0132105
PMID:10908592[1]

ISS: Inferred from Sequence or Structural Similarity

C

From FB

GO:0005911

cell-cell junction

FB:FBrf0095287
PMID:9247265[2]

IDA: Inferred from Direct Assay

C

From FB

GO:0007155

cell adhesion

FB:FBrf0136602

NAS: Non-traceable Author Statement

P

From FB

GO:0007156

homophilic cell adhesion

FB:FBrf0095287
PMID:9247265[2]

IDA: Inferred from Direct Assay

P

From FB

GO:0007156

homophilic cell adhesion

FB:FBrf0129868
PMID:10908592[1]

ISS: Inferred from Sequence or Structural Similarity

P

From FB

GO:0007411

axon guidance

FB:FBrf0155635
PMID:11891122[4]

NAS: Non-traceable Author Statement

P

From FB

GO:0007411

axon guidance

FB:FBrf0209258
PMID:19766621[5]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007411

axon guidance

FB:FBrf0210319
PMID:18516287[6]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007411

axon guidance

FB:FBrf0212620
PMID:21117153[7]

IGI: Inferred from Genetic Interaction

FB:FBgn0004055

P

From FB

GO:0007411

axon guidance

FB:FBrf0214681
PMID:21835342[8]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007412

axon target recognition

FB:FBrf0137065
PMID:11395005[9]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007413

axonal fasciculation

FB:FBrf0108154
PMID:10218152[3]

TAS: Traceable Author Statement

P

From FB

GO:0008013

beta-catenin binding

FB:FBrf0146675
PMID:11253370[10]

NAS: Non-traceable Author Statement

F

From FB

GO:0016021

integral to membrane

FB:FBrf0095287
PMID:9247265[2]

ISS: Inferred from Sequence or Structural Similarity

MGI:MGI:88355

C

From FB

GO:0016318

ommatidial rotation

FB:FBrf0191998
PMID:16887833[11]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0016339

calcium-dependent cell-cell adhesion

FB:FBrf0095287
PMID:9247265[2]

IPI: Inferred from Physical Interaction

FB:FBgn0000117

P

From FB

GO:0016339

calcium-dependent cell-cell adhesion

FB:FBrf0095287
PMID:9247265[2]

IPI: Inferred from Physical Interaction

FB:FBgn0010215

P

From FB

GO:0016339

calcium-dependent cell-cell adhesion

FB:FBrf0095287
PMID:9247265[2]

ISS: Inferred from Sequence or Structural Similarity

FB:FBgn0003391

P

From FB

GO:0016339

calcium-dependent cell-cell adhesion

FB:FBrf0095287
PMID:9247265[2]

ISS: Inferred from Sequence or Structural Similarity

MGI:MGI:88355

P

From FB

GO:0016339

calcium-dependent cell-cell adhesion

FB:FBrf0129868
PMID:10908592[1]

ISS: Inferred from Sequence or Structural Similarity

P

From FB

GO:0016339

calcium-dependent cell-cell adhesion

FB:FBrf0132105
PMID:10908592[1]

ISS: Inferred from Sequence or Structural Similarity

P

From FB

GO:0031290

retinal ganglion cell axon guidance

FB:FBrf0195369
PMID:16864799[12]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0045463

R8 cell development

FB:FBrf0204173
PMID:18400161[13]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0045467

R7 cell development

FB:FBrf0204173
PMID:18400161[13]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0045467

R7 cell development

FB:FBrf0214681
PMID:21835342[8]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0048676

axon extension involved in development

FB:FBrf0209258
PMID:19766621[5]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0048814

regulation of dendrite morphogenesis

FB:FBrf0213020
PMID:21303851[14]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0048841

regulation of axon extension involved in axon guidance

FB:FBrf0209258
PMID:19766621[5]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0048846

axon extension involved in axon guidance

FB:FBrf0184200
PMID:15735641[15]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0050774

negative regulation of dendrite morphogenesis

FB:FBrf0175027
PMID:15066265[16]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0050839

cell adhesion molecule binding

FB:FBrf0129868
PMID:10908592[1]

ISS: Inferred from Sequence or Structural Similarity

F

From FB


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Hynes RO & Zhao Q (2000) The evolution of cell adhesion. J Cell Biol 150: F89-96 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 Iwai Y et al. (1997) Axon patterning requires DN-cadherin, a novel neuronal adhesion receptor, in the Drosophila embryonic CNS. Neuron 19: 77-89 PubMed GONUTS page
  3. 3.0 3.1 Chiba A (1999) Early development of the Drosophila neuromuscular junction: a model for studying neuronal networks in development. Int Rev Neurobiol 43: 1-24 PubMed GONUTS page
  4. Patel BN & Van Vactor DL (2002) Axon guidance: the cytoplasmic tail. Curr Opin Cell Biol 14: 221-9 PubMed GONUTS page
  5. 5.0 5.1 5.2 Prakash S et al. (2009) Complex interactions amongst N-cadherin, DLAR, and Liprin-alpha regulate Drosophila photoreceptor axon targeting. Dev Biol 336: 10-9 PubMed GONUTS page
  6. Berger J et al. (2008) Systematic identification of genes that regulate neuronal wiring in the Drosophila visual system. PLoS Genet 4: e1000085 PubMed GONUTS page
  7. Ding ZY et al. (2011) Glial cell adhesive molecule unzipped mediates axon guidance in Drosophila. Dev Dyn 240: 122-34 PubMed GONUTS page
  8. 8.0 8.1 Tong C et al. (2011) Rich regulates target specificity of photoreceptor cells and N-cadherin trafficking in the Drosophila visual system via Rab6. Neuron 71: 447-59 PubMed GONUTS page
  9. Lee CH et al. (2001) N-cadherin regulates target specificity in the Drosophila visual system. Neuron 30: 437-50 PubMed GONUTS page
  10. Tepass U et al. (2000) Cadherins in embryonic and neural morphogenesis. Nat Rev Mol Cell Biol 1: 91-100 PubMed GONUTS page
  11. Mirkovic I & Mlodzik M (2006) Cooperative activities of drosophila DE-cadherin and DN-cadherin regulate the cell motility process of ommatidial rotation. Development 133: 3283-93 PubMed GONUTS page
  12. Choe KM et al. (2006) Liprin-alpha is required for photoreceptor target selection in Drosophila. Proc Natl Acad Sci U S A 103: 11601-6 PubMed GONUTS page
  13. 13.0 13.1 Nern A et al. (2008) Local N-cadherin interactions mediate distinct steps in the targeting of lamina neurons. Neuron 58: 34-41 PubMed GONUTS page
  14. Hasegawa E et al. (2011) Concentric zones, cell migration and neuronal circuits in the Drosophila visual center. Development 138: 983-93 PubMed GONUTS page
  15. Prakash S et al. (2005) Drosophila N-cadherin mediates an attractive interaction between photoreceptor axons and their targets. Nat Neurosci 8: 443-50 PubMed GONUTS page
  16. Zhu H & Luo L (2004) Diverse functions of N-cadherin in dendritic and axonal terminal arborization of olfactory projection neurons. Neuron 42: 63-75 PubMed GONUTS page
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