GONUTS is under stress! The website is currently experiencing long-wait times and frequent time-outs due to the record number of students, groups, and annotations related to CACAO this semester. We are currently working on increasing performance -- please accept our apologies for the technical difficulties.
You can help reduce stress on the server by:
- not reloading pages frequently - this just adds
- opening links in new windows (so you can read the old page)
FB:B52
Contents |
| Species (Taxon ID) | Drosophila melanogaster (fruit fly) (taxon:7227) | |
| Gene Name(s) | B52 ( synonyms: B52/SRp55, B52/dSRp55, CG10851, E(Dfd), E726, Enhancer of Deformed, MabB52, Monoclonal-antibody-B52, RNA-binding protein 8, RRM8, RSp55, Rbp8, SR55, SRp55, Serine/arginine rich protein 55, Splicing factor B52, dSRp55, l(3)s2249, rrm8, serine-arginine protein 55 ) | |
| Protein Name(s) | B52, | |
| External Links | ||
| FB | FBgn0004587 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000166 |
nucleotide binding |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
F |
From FB |
|||
| GO:0000381 |
regulation of alternative nuclear mRNA splicing, via spliceosome |
FB:FBrf0180650 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0000398 |
nuclear mRNA splicing, via spliceosome |
FB:FBrf0101500 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0000398 |
nuclear mRNA splicing, via spliceosome |
FB:FBrf0123052 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0000398 |
nuclear mRNA splicing, via spliceosome |
FB:FBrf0207172 |
IC: Inferred by Curator |
GO:0071011 GO:0071013 |
P |
From FB |
||
| GO:0003676 |
nucleic acid binding |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
F |
From FB |
|||
| GO:0003729 |
mRNA binding |
FB:FBrf0116886 |
NAS: Non-traceable Author Statement |
F |
From FB |
|||
| GO:0003729 |
mRNA binding |
FB:FBrf0123883 |
NAS: Non-traceable Author Statement |
F |
From FB |
|||
| GO:0003729 |
mRNA binding |
FB:FBrf0129923 |
ISS: Inferred from Sequence or Structural Similarity |
F |
From FB |
|||
| GO:0005515 |
protein binding |
FB:FBrf0151413 |
IPI: Inferred from Physical Interaction |
FB:FBgn0031456 |
F |
From FB |
||
| GO:0005634 |
nucleus |
FB:FBrf0123883 |
NAS: Non-traceable Author Statement |
C |
From FB |
|||
| GO:0005634 |
nucleus |
FB:FBrf0151413 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005634 |
nucleus |
FB:FBrf0180650 |
IC: Inferred by Curator |
GO:0000381 |
C |
From FB |
||
| GO:0005700 |
polytene chromosome |
FB:FBrf0211891 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0006376 |
mRNA splice site selection |
FB:FBrf0129982 |
ISS: Inferred from Sequence or Structural Similarity |
NCBI_NP:005617 |
P |
From FB |
||
| GO:0007067 |
mitosis |
FB:FBrf0207149 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0016607 |
nuclear speck |
FB:FBrf0130032 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0035327 |
transcriptionally active chromatin |
FB:FBrf0054035 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0048024 |
regulation of nuclear mRNA splicing, via spliceosome |
FB:FBrf0187590 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0071011 |
precatalytic spliceosome |
FB:FBrf0207172 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0071013 |
catalytic step 2 spliceosome |
FB:FBrf0207172 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
|
NOT |
GO:0035062 |
omega speckle |
FB:FBrf0130032 |
IDA: Inferred from Direct Assay |
C |
From FB |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Park JW et al. (2004) Identification of alternative splicing regulators by RNA interference in Drosophila. Proc Natl Acad Sci U S A 101: 15974-9 PubMed GONUTS page
- ↑ Hoffman BE & Lis JT (2000) Pre-mRNA splicing by the essential Drosophila protein B52: tissue and target specificity. Mol Cell Biol 20: 181-6 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Herold N et al. (2009) Conservation of the protein composition and electron microscopy structure of Drosophila melanogaster and human spliceosomal complexes. Mol Cell Biol 29: 281-301 PubMed GONUTS page
- ↑ Lasko P (2000) The drosophila melanogaster genome: translation factors and RNA binding proteins. J Cell Biol 150: F51-6 PubMed GONUTS page
- ↑ 5.0 5.1 Allemand E et al. (2002) A conserved Drosophila transportin-serine/arginine-rich (SR) protein permits nuclear import of Drosophila SR protein splicing factors and their antagonist repressor splicing factor 1. Mol Biol Cell 13: 2436-47 PubMed GONUTS page
- ↑ Juge F et al. (2010) The SR protein B52/SRp55 is required for DNA topoisomerase I recruitment to chromatin, mRNA release and transcription shutdown. PLoS Genet 6: PubMed GONUTS page
- ↑ Mount SM & Salz HK (2000) Pre-messenger RNA processing factors in the Drosophila genome. J Cell Biol 150: F37-44 PubMed GONUTS page
- ↑ Ducat D et al. (2008) Regulation of microtubule assembly and organization in mitosis by the AAA+ ATPase Pontin. Mol Biol Cell 19: 3097-110 PubMed GONUTS page
- ↑ 9.0 9.1 Prasanth KV et al. (2000) Omega speckles - a novel class of nuclear speckles containing hnRNPs associated with noncoding hsr-omega RNA in Drosophila. J Cell Sci 113 Pt 19: 3485-97 PubMed GONUTS page
- ↑ Champlin DT et al. (1991) Characterization of a Drosophila protein associated with boundaries of transcriptionally active chromatin. Genes Dev 5: 1611-21 PubMed GONUTS page
- ↑ Blanchette M et al. (2005) Global analysis of positive and negative pre-mRNA splicing regulators in Drosophila. Genes Dev 19: 1306-14 PubMed GONUTS page
