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FB:Atpalpha

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Contents

Species (Taxon ID) Drosophila melanogaster (fruit fly) (taxon:7227)
Gene Name(s) Atpalpha ( synonyms: (Na(+) + K(+))-ATPase alpha-subunit, (Na(+),K(+))ATPase alpha subunit, ATPBagr, ATPa, ATPalpha, ATPase alpha, ATPase alpha subunit, Atp a, Atpa, CG5670, Da-47, JY, Na+,K+ ATPase alpha-subunit, Na+-K+-ATPase, Na+/K+ ATPase alpha subunit, Na, K ATPase a subunit, Na, K ATPase alpha, Na,K ATPase, Na,K ATPase alpha subunit, Na,K-ATPase, Na,K-ATPase alpha subunit, Na,K-ATPase alpha-subunit, Na-p, Na/K-ATPase, Na/K-ATPase alpha-subunit, NaK, NaK ATPase, Na(+) pump alpha subunit, Na(+), K(+) -ATPase, Na(+),K(+) ATPase alpha subunit, Na(+),K(+)-ATPase, Na(+),K(+)-ATPase alpha subunit, Na(+),K(+)-ATPase alpha-subunit, Na(+)-K(+) ATPase, Na(+)-K(+)-ATPase alpha((5))-subunit, Na(+)/K(+) ATPase, Na(+)/K(+) ATPase (alpha subunit), Na(+)/K(+) ATPase alpha subunit, Na(+)/K(+)-ATPase, Na(+)/K(+)ATPase, Na(+)K(+) ATPase, Na(+)K(+)ATPase, Sodium pump alpha subunit, alpha-subunit of ATPase, dnATPase, l(3)01164, l(3)01453, l(3)04492, l(3)j3B2, l(3)j3B7, l(3)j6A4, l(3)rM454, l(3)ry136, sodium pump alpha-subunit, sodium/potassium transporting ATPase alpha )
Protein Name(s) Na pump alpha subunit,
External Links
FB FBgn0002921

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0001700

embryonic development via the syncytial blastoderm

FB:FBrf0091142
PMID:8978055[1]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0001894

tissue homeostasis

FB:FBrf0159062
PMID:12598616[2]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0005391

sodium:potassium-exchanging ATPase activity

FB:FBrf0049610
PMID:2540956[3]

ISS: Inferred from Sequence or Structural Similarity

RGD:2167

F

From FB

GO:0005391

sodium:potassium-exchanging ATPase activity

FB:FBrf0068678
PMID:8110464[4]

IMP: Inferred from Mutant Phenotype

F

From FB

GO:0005391

sodium:potassium-exchanging ATPase activity

FB:FBrf0100024
PMID:9680312[5]

IMP: Inferred from Mutant Phenotype

F

From FB

GO:0005391

sodium:potassium-exchanging ATPase activity

FB:FBrf0105495

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q64436

F

From FB

GO:0005391

sodium:potassium-exchanging ATPase activity

FB:FBrf0123584

NAS: Non-traceable Author Statement

F

From FB

GO:0005524

ATP binding

FB:FBrf0174215

IEA: Inferred from Electronic Annotation

InterPro:IPR001757
InterPro:IPR005775
InterPro:IPR018303

F

From FB

GO:0005634

nucleus

FB:FBrf0068678
PMID:8110464[4]

IDA: Inferred from Direct Assay

C

From FB

GO:0005886

plasma membrane

FB:FBrf0068678
PMID:8110464[4]

IDA: Inferred from Direct Assay

C

From FB

GO:0005886

plasma membrane

FB:FBrf0105495

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q64436

C

From FB

GO:0005886

plasma membrane

FB:FBrf0167641
PMID:14668392[6]

IDA: Inferred from Direct Assay

C

From FB

GO:0005886

plasma membrane

FB:FBrf0210975

IDA: Inferred from Direct Assay

C

From FB

GO:0005890

sodium:potassium-exchanging ATPase complex

FB:FBrf0103046
PMID:9648860[7]

IC: Inferred by Curator

GO:0005391

C

From FB

GO:0005890

sodium:potassium-exchanging ATPase complex

FB:FBrf0105495

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q64436

C

From FB

GO:0005890

sodium:potassium-exchanging ATPase complex

FB:FBrf0123584

NAS: Non-traceable Author Statement

C

From FB

GO:0005918

septate junction

FB:FBrf0160546
PMID:12782686[8]

IDA: Inferred from Direct Assay

C

From FB

GO:0005918

septate junction

FB:FBrf0162083
PMID:12930776[9]

IDA: Inferred from Direct Assay

C

From FB

GO:0006754

ATP biosynthetic process

FB:FBrf0174215

IEA: Inferred from Electronic Annotation

InterPro:IPR005775
InterPro:IPR006069

P

From FB

GO:0006812

cation transport

FB:FBrf0100024
PMID:9680312[5]

IDA: Inferred from Direct Assay

P

From FB

GO:0006812

cation transport

FB:FBrf0103046
PMID:9648860[7]

IDA: Inferred from Direct Assay

P

From FB

GO:0006812

cation transport

FB:FBrf0123584

NAS: Non-traceable Author Statement

P

From FB

GO:0007268

synaptic transmission

FB:FBrf0179487
PMID:15281071[10]

IDA: Inferred from Direct Assay

P

From FB

GO:0007626

locomotory behavior

FB:FBrf0139615
PMID:11691629[11]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0008340

determination of adult lifespan

FB:FBrf0159062
PMID:12598616[2]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0008340

determination of adult lifespan

FB:FBrf0190718
PMID:16272407[12]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0008344

adult locomotory behavior

FB:FBrf0159062
PMID:12598616[2]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0008360

regulation of cell shape

FB:FBrf0155706
PMID:12466193[13]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0009266

response to temperature stimulus

FB:FBrf0100024
PMID:9680312[5]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0009266

response to temperature stimulus

FB:FBrf0159062
PMID:12598616[2]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0009612

response to mechanical stimulus

FB:FBrf0068678
PMID:8110464[4]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0009612

response to mechanical stimulus

FB:FBrf0139615
PMID:11691629[11]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0009612

response to mechanical stimulus

FB:FBrf0159062
PMID:12598616[2]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0015672

monovalent inorganic cation transport

FB:FBrf0174215

IEA: Inferred from Electronic Annotation

InterPro:IPR005775

P

From FB

GO:0019991

septate junction assembly

FB:FBrf0162083
PMID:12930776[9]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0035152

regulation of tube architecture, open tracheal system

FB:FBrf0167264
PMID:14570584[14]

TAS: Traceable Author Statement

P

From FB

GO:0035158

regulation of tube diameter, open tracheal system

FB:FBrf0155706
PMID:12466193[13]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0035158

regulation of tube diameter, open tracheal system

FB:FBrf0162083
PMID:12930776[9]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0035159

regulation of tube length, open tracheal system

FB:FBrf0155706
PMID:12466193[13]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0035159

regulation of tube length, open tracheal system

FB:FBrf0162083
PMID:12930776[9]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0046872

metal ion binding

FB:FBrf0174215

IEA: Inferred from Electronic Annotation

InterPro:IPR008250

F

From FB

GO:0050905

neuromuscular process

FB:FBrf0159062
PMID:12598616[2]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0051124

synaptic growth at neuromuscular junction

FB:FBrf0179487
PMID:15281071[10]

IMP: Inferred from Mutant Phenotype

P

From FB

contributes_to

GO:0005391

sodium:potassium-exchanging ATPase activity

FB:FBrf0103046
PMID:9648860[7]

IMP: Inferred from Mutant Phenotype

F

From FB

contributes_to

GO:0008324

cation transmembrane transporter activity

FB:FBrf0103046
PMID:9648860[7]

IDA: Inferred from Direct Assay

F

From FB


Notes

References

See Help:References for how to manage references in GONUTS.
  1. Perrimon N et al. (1996) Zygotic lethal mutations with maternal effect phenotypes in Drosophila melanogaster. II. Loci on the second and third chromosomes identified by P-element-induced mutations. Genetics 144: 1681-92 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 Palladino MJ et al. (2003) Neural dysfunction and neurodegeneration in Drosophila Na+/K+ ATPase alpha subunit mutants. J Neurosci 23: 1276-86 PubMed GONUTS page
  3. Lebovitz RM et al. (1989) Molecular characterization and expression of the (Na+ + K+)-ATPase alpha-subunit in Drosophila melanogaster. EMBO J 8: 193-202 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 Schubiger M et al. (1994) A mutation of the Drosophila sodium pump alpha subunit gene results in bang-sensitive paralysis. Neuron 12: 373-81 PubMed GONUTS page
  5. 5.0 5.1 5.2 Feng Y et al. (1997) The Drosophila Na,K-ATPase alpha-subunit gene: gene structure, promoter function and analysis of a cold-sensitive recessive-lethal mutation. Genes Funct 1: 99-117 PubMed GONUTS page
  6. Clyne PJ et al. (2003) Green fluorescent protein tagging Drosophila proteins at their native genomic loci with small P elements. Genetics 165: 1433-41 PubMed GONUTS page
  7. 7.0 7.1 7.2 7.3 Sun B et al. (1998) Functional analysis and tissue-specific expression of Drosophila Na+,K+-ATPase subunits. J Neurochem 71: 142-51 PubMed GONUTS page
  8. Genova JL & Fehon RG (2003) Neuroglian, Gliotactin, and the Na+/K+ ATPase are essential for septate junction function in Drosophila. J Cell Biol 161: 979-89 PubMed GONUTS page
  9. 9.0 9.1 9.2 9.3 Paul SM et al. (2003) The Na+/K+ ATPase is required for septate junction function and epithelial tube-size control in the Drosophila tracheal system. Development 130: 4963-74 PubMed GONUTS page
  10. 10.0 10.1 Trotta N et al. (2004) Cellular bases of activity-dependent paralysis in Drosophila stress-sensitive mutants. J Neurobiol 60: 328-47 PubMed GONUTS page
  11. 11.0 11.1 Sun B et al. (2001) In vivo modification of Na(+),K(+)-ATPase activity in Drosophila. Comp Biochem Physiol B Biochem Mol Biol 130: 521-36 PubMed GONUTS page
  12. Fergestad T et al. (2006) Neuropathology in Drosophila membrane excitability mutants. Genetics 172: 1031-42 PubMed GONUTS page
  13. 13.0 13.1 13.2 Hemphälä J et al. (2003) Grainy head controls apical membrane growth and tube elongation in response to Branchless/FGF signalling. Development 130: 249-58 PubMed GONUTS page
  14. Ghabrial A et al. (2003) Branching morphogenesis of the Drosophila tracheal system. Annu Rev Cell Dev Biol 19: 623-47 PubMed GONUTS page
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