FB:Arr2

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Species (Taxon ID)	Drosophila melanogaster (fruit fly) (taxon:7227)
Gene Name(s)	Arr2 ( synonyms: 49, 49kD Arrestin homolog, AH, ARR2, Arr, Arr-2, ArrB, ArrB-ml, Arrestin B, Arrestin-2, Beta-Arrestin, CG5962, DAII, Dro.-Arr.II, PRI, Phosrestin I, arr, arr2, arrestin, arrestin 2, arrestin-2, arrestin-like protein, arrestin2, phosrestin I, phosrestin-1 )
Protein Name(s)	Arrestin 2,
External Links
FB	FBgn0000121

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0005515	protein binding	FB:FBrf0174855 PMID:15014127^[1]	IPI: Inferred from Physical Interaction	FB:FBgn0002940	F	From FB
	GO:0005624	membrane fraction	FB:FBrf0108568 PMID:10339543^[2]	IDA: Inferred from Direct Assay		C	From FB
	GO:0005625	soluble fraction	FB:FBrf0108568 PMID:10339543^[2]	IDA: Inferred from Direct Assay		C	From FB
	GO:0005737	cytoplasm	FB:FBrf0190043 PMID:16213818^[3]	IDA: Inferred from Direct Assay		C	From FB
	GO:0007602	phototransduction	FB:FBrf0105495	NAS: Non-traceable Author Statement		P	From FB
	GO:0007602	phototransduction	FB:FBrf0123703	NAS: Non-traceable Author Statement		P	From FB
	GO:0016028	rhabdomere	FB:FBrf0059339 PMID:8316831^[4]	IDA: Inferred from Direct Assay		C	From FB
	GO:0016028	rhabdomere	FB:FBrf0190043 PMID:16213818^[3]	IDA: Inferred from Direct Assay		C	From FB
	GO:0016028	rhabdomere	FB:FBrf0211901 PMID:20869596^[5]	IDA: Inferred from Direct Assay		C	From FB
	GO:0016029	subrhabdomeral cisterna	FB:FBrf0211901 PMID:20869596^[5]	IDA: Inferred from Direct Assay		C	From FB
	GO:0016030	metarhodopsin binding	FB:FBrf0108568 PMID:10339543^[2]	TAS: Traceable Author Statement		F	From FB
	GO:0016059	deactivation of rhodopsin mediated signaling	FB:FBrf0059339 PMID:8316831^[4]	IGI: Inferred from Genetic Interaction	FB:FBgn0000120	P	From FB
	GO:0016059	deactivation of rhodopsin mediated signaling	FB:FBrf0059339 PMID:8316831^[4]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0016059	deactivation of rhodopsin mediated signaling	FB:FBrf0108568 PMID:10339543^[2]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0016059	deactivation of rhodopsin mediated signaling	FB:FBrf0123143 PMID:10611962^[6]	TAS: Traceable Author Statement		P	From FB
	GO:0016059	deactivation of rhodopsin mediated signaling	FB:FBrf0141625 PMID:11707492^[7]	TAS: Traceable Author Statement		P	From FB
	GO:0016060	metarhodopsin inactivation	FB:FBrf0059339 PMID:8316831^[4]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0016060	metarhodopsin inactivation	FB:FBrf0082507 PMID:7781061^[8]	IGI: Inferred from Genetic Interaction	FB:FBgn0000120	P	From FB
	GO:0016060	metarhodopsin inactivation	FB:FBrf0082507 PMID:7781061^[8]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0016060	metarhodopsin inactivation	FB:FBrf0086225 PMID:8570597^[9]	NAS: Non-traceable Author Statement		P	From FB
	GO:0016062	adaptation of rhodopsin mediated signaling	FB:FBrf0160726 PMID:12848937^[10]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0045494	photoreceptor cell maintenance	FB:FBrf0191981 PMID:16835270^[11]	IMP: Inferred from Mutant Phenotype		P	From FB
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Iakhine R et al. (2004) Novel dominant rhodopsin mutation triggers two mechanisms of retinal degeneration and photoreceptor desensitization. J Neurosci 24: 2516-26 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Alloway PG & Dolph PJ (1999) A role for the light-dependent phosphorylation of visual arrestin. Proc Natl Acad Sci U S A 96: 6072-7 PubMed GONUTS page
↑ ^3.0 ^3.1 Satoh AK & Ready DF (2005) Arrestin1 mediates light-dependent rhodopsin endocytosis and cell survival. Curr Biol 15: 1722-33 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Dolph PJ et al. (1993) Arrestin function in inactivation of G protein-coupled receptor rhodopsin in vivo. Science 260: 1910-6 PubMed GONUTS page
↑ ^5.0 ^5.1 Satoh AK et al. (2010) Arrestin translocation is stoichiometric to rhodopsin isomerization and accelerated by phototransduction in Drosophila photoreceptors. Neuron 67: 997-1008 PubMed GONUTS page
↑ Montell C (1999) Visual transduction in Drosophila. Annu Rev Cell Dev Biol 15: 231-68 PubMed GONUTS page
↑ Hardie RC (2001) Phototransduction in Drosophila melanogaster. J Exp Biol 204: 3403-9 PubMed GONUTS page
↑ ^8.0 ^8.1 Ranganathan R & Stevens CF (1995) Arrestin binding determines the rate of inactivation of the G protein-coupled receptor rhodopsin in vivo. Cell 81: 841-8 PubMed GONUTS page
↑ Zuker CS (1996) The biology of vision of Drosophila. Proc Natl Acad Sci U S A 93: 571-6 PubMed GONUTS page
↑ Lee SJ et al. (2003) Light adaptation through phosphoinositide-regulated translocation of Drosophila visual arrestin. Neuron 39: 121-32 PubMed GONUTS page
↑ Orem NR et al. (2006) An essential role for endocytosis of rhodopsin through interaction of visual arrestin with the AP-2 adaptor. J Cell Sci 119: 3141-8 PubMed GONUTS page

[PMID:15014127-0] Iakhine R et al. (2004) Novel dominant rhodopsin mutation triggers two mechanisms of retinal degeneration and photoreceptor desensitization. J Neurosci 24: 2516-26 PubMed GONUTS page

[PMID:10339543-1] 2.0 ^2.1 ^2.2 ^2.3 Alloway PG & Dolph PJ (1999) A role for the light-dependent phosphorylation of visual arrestin. Proc Natl Acad Sci U S A 96: 6072-7 PubMed GONUTS page

[PMID:16213818-2] 3.0 ^3.1 Satoh AK & Ready DF (2005) Arrestin1 mediates light-dependent rhodopsin endocytosis and cell survival. Curr Biol 15: 1722-33 PubMed GONUTS page

[PMID:8316831-3] 4.0 ^4.1 ^4.2 ^4.3 Dolph PJ et al. (1993) Arrestin function in inactivation of G protein-coupled receptor rhodopsin in vivo. Science 260: 1910-6 PubMed GONUTS page

[PMID:20869596-4] 5.0 ^5.1 Satoh AK et al. (2010) Arrestin translocation is stoichiometric to rhodopsin isomerization and accelerated by phototransduction in Drosophila photoreceptors. Neuron 67: 997-1008 PubMed GONUTS page

[PMID:10611962-5] Montell C (1999) Visual transduction in Drosophila. Annu Rev Cell Dev Biol 15: 231-68 PubMed GONUTS page

[PMID:11707492-6] Hardie RC (2001) Phototransduction in Drosophila melanogaster. J Exp Biol 204: 3403-9 PubMed GONUTS page

[PMID:7781061-7] 8.0 ^8.1 Ranganathan R & Stevens CF (1995) Arrestin binding determines the rate of inactivation of the G protein-coupled receptor rhodopsin in vivo. Cell 81: 841-8 PubMed GONUTS page

[PMID:8570597-8] Zuker CS (1996) The biology of vision of Drosophila. Proc Natl Acad Sci U S A 93: 571-6 PubMed GONUTS page

[PMID:12848937-9] Lee SJ et al. (2003) Light adaptation through phosphoinositide-regulated translocation of Drosophila visual arrestin. Neuron 39: 121-32 PubMed GONUTS page

[PMID:16835270-10] Orem NR et al. (2006) An essential role for endocytosis of rhodopsin through interaction of visual arrestin with the AP-2 adaptor. J Cell Sci 119: 3141-8 PubMed GONUTS page

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FB:Arr2

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