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FB:Ark
Contents |
| Species (Taxon ID) | Drosophila melanogaster (fruit fly) (taxon:7227) | |
| Gene Name(s) | Ark ( synonyms: APAF1, ARK, Apaf-1, Apaf-1 related, Apaf-1 related killer, Apaf-1-Related Killer, Apaf-1-related killer, Apaf1, CG6829, D-Apaf-1, DARK, Dapaf-1, Dapaf-1/HAC-1, Dark, Dark/Apaf-I, Dark/Dapaf-1/HAC1, Dark/Hac-1/dApaf-1, Dark/Hac-1/dApaf1, Drosophila Apaf-1-related killer, Hac-1, Hac-1/Dark, Hac1, T1, Transcription unit 1, anon-53Fa, apaf-1, apaf1, arc, ark, dAPAF-1, dApaf-1, dApaf-1/DARK/HAC-1, dApaf1, dArk, dapaf, dapaf-1, dapaf-1L, dapaf-1S, dark, dark/dapaf-1/hac-1, dark/hac-1/dapaf-1, hac-1, hac1, l(2)SH0173, lethal (2) SH0173 ) | |
| Protein Name(s) | Apaf-1-related-killer, | |
| External Links | ||
| FB | FBgn0263864 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0006915 |
apoptotic process |
FB:FBrf0134503 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0006915 |
apoptotic process |
FB:FBrf0167429 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0006915 |
apoptotic process |
FB:FBrf0173268 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0006917 |
induction of apoptosis |
FB:FBrf0147184 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0006919 |
activation of cysteine-type endopeptidase activity involved in apoptotic process |
FB:FBrf0111320 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0006919 |
activation of cysteine-type endopeptidase activity involved in apoptotic process |
FB:FBrf0123073 |
ISS: Inferred from Sequence or Structural Similarity |
HGNC:576 |
P |
From FB |
||
| GO:0006919 |
activation of cysteine-type endopeptidase activity involved in apoptotic process |
FB:FBrf0123073 |
ISS: Inferred from Sequence or Structural Similarity |
WP:CE01203 |
P |
From FB |
||
| GO:0006919 |
activation of cysteine-type endopeptidase activity involved in apoptotic process |
FB:FBrf0123261 |
IPI: Inferred from Physical Interaction |
FB:FBgn0020381 |
P |
From FB |
||
| GO:0006919 |
activation of cysteine-type endopeptidase activity involved in apoptotic process |
FB:FBrf0123261 |
ISS: Inferred from Sequence or Structural Similarity |
HGNC:576 |
P |
From FB |
||
| GO:0006919 |
activation of cysteine-type endopeptidase activity involved in apoptotic process |
FB:FBrf0134503 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0006919 |
activation of cysteine-type endopeptidase activity involved in apoptotic process |
FB:FBrf0147184 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0006974 |
response to DNA damage stimulus |
FB:FBrf0147184 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007291 |
sperm individualization |
FB:FBrf0167989 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007291 |
sperm individualization |
FB:FBrf0190354 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007423 |
sensory organ development |
FB:FBrf0190361 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007559 |
histolysis |
FB:FBrf0194101 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008635 |
activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c |
FB:FBrf0123073 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008635 |
activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c |
FB:FBrf0130139 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0008656 |
cysteine-type endopeptidase activator activity involved in apoptotic process |
FB:FBrf0123073 |
ISS: Inferred from Sequence or Structural Similarity |
HGNC:576 |
F |
From FB |
||
| GO:0008656 |
cysteine-type endopeptidase activator activity involved in apoptotic process |
FB:FBrf0147184 |
TAS: Traceable Author Statement |
F |
From FB |
|||
| GO:0010332 |
response to gamma radiation |
FB:FBrf0190939 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0012501 |
programmed cell death |
FB:FBrf0132215 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0012501 |
programmed cell death |
FB:FBrf0190939 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0021556 |
central nervous system formation |
FB:FBrf0190939 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0034352 |
positive regulation of glial cell apoptotic process |
FB:FBrf0200411 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0035070 |
salivary gland histolysis |
FB:FBrf0192581 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0035071 |
salivary gland cell autophagic cell death |
FB:FBrf0190939 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0043065 |
positive regulation of apoptotic process |
FB:FBrf0200411 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0003997 |
P |
From FB |
||
| GO:0043531 |
ADP binding |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
F |
From FB |
|||
| GO:0046668 |
regulation of retinal cell programmed cell death |
FB:FBrf0156100 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0046672 |
positive regulation of compound eye retinal cell programmed cell death |
FB:FBrf0192581 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0048813 |
dendrite morphogenesis |
FB:FBrf0192062 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Kumar S & Doumanis J (2000) The fly caspases. Cell Death Differ 7: 1039-44 PubMed GONUTS page
- ↑ Bergmann A et al. (2003) Regulators of IAP function: coming to grips with the grim reaper. Curr Opin Cell Biol 15: 717-24 PubMed GONUTS page
- ↑ Lawen A (2003) Apoptosis-an introduction. Bioessays 25: 888-96 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Gorski S & Marra M (2002) Programmed cell death takes flight: genetic and genomic approaches to gene discovery in Drosophila. Physiol Genomics 9: 59-69 PubMed GONUTS page
- ↑ Abrams JM (1999) An emerging blueprint for apoptosis in Drosophila. Trends Cell Biol 9: 435-40 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 Kanuka H et al. (1999) Control of the cell death pathway by Dapaf-1, a Drosophila Apaf-1/CED-4-related caspase activator. Mol Cell 4: 757-69 PubMed GONUTS page
- ↑ 7.0 7.1 Zhou L et al. (1999) HAC-1, a Drosophila homolog of APAF-1 and CED-4 functions in developmental and radiation-induced apoptosis. Mol Cell 4: 745-55 PubMed GONUTS page
- ↑ Huh JR et al. (2004) Multiple apoptotic caspase cascades are required in nonapoptotic roles for Drosophila spermatid individualization. PLoS Biol 2: E15 PubMed GONUTS page
- ↑ Arama E et al. (2006) The two Drosophila cytochrome C proteins can function in both respiration and caspase activation. EMBO J 25: 232-43 PubMed GONUTS page
- ↑ Kanuka H et al. (2005) Drosophila caspase transduces Shaggy/GSK-3beta kinase activity in neural precursor development. EMBO J 24: 3793-806 PubMed GONUTS page
- ↑ Akdemir F et al. (2006) Autophagy occurs upstream or parallel to the apoptosome during histolytic cell death. Development 133: 1457-65 PubMed GONUTS page
- ↑ Vernooy SY et al. (2000) Cell death regulation in Drosophila: conservation of mechanism and unique insights. J Cell Biol 150: F69-76 PubMed GONUTS page
- ↑ 13.0 13.1 13.2 13.3 Mills K et al. (2006) The Drosophila melanogaster Apaf-1 homologue ARK is required for most, but not all, programmed cell death. J Cell Biol 172: 809-15 PubMed GONUTS page
- ↑ Tittel JN & Steller H (2000) A comparison of programmed cell death between species. Genome Biol 1: REVIEWS0003 PubMed GONUTS page
- ↑ 15.0 15.1 Srivastava M et al. (2007) ARK, the Apaf-1 related killer in Drosophila, requires diverse domains for its apoptotic activity. Cell Death Differ 14: 92-102 PubMed GONUTS page
- ↑ 16.0 16.1 Leulier F et al. (2006) Systematic in vivo RNAi analysis of putative components of the Drosophila cell death machinery. Cell Death Differ 13: 1663-74 PubMed GONUTS page
- ↑ Brachmann CB & Cagan RL (2003) Patterning the fly eye: the role of apoptosis. Trends Genet 19: 91-6 PubMed GONUTS page
- ↑ Williams DW et al. (2006) Local caspase activity directs engulfment of dendrites during pruning. Nat Neurosci 9: 1234-6 PubMed GONUTS page
