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FB:Apc2
Contents |
| Species (Taxon ID) | Drosophila melanogaster (fruit fly) (taxon:7227) | |
| Gene Name(s) | Apc2 ( synonyms: APC, APC2, Adenomatous Polyposis Coli 2, Adenomatous polyposis coli 2, CG6193, D-APC2, Dm APC2, E-APC, E-APC dAPC2, Epithelial Adenomatous Polyposis Coli, adenomatous polyposis coli 2, apc2, d-APC2, dAPC2, dAPC2/E-APC, dApc2 ) | |
| Protein Name(s) | Adenomatous polyposis coli tumor suppressor homolog 2, | |
| External Links | ||
| FB | FBgn0026598 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000910 |
cytokinesis |
FB:FBrf0141377 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0005515 |
protein binding |
FB:FBrf0111426 |
IPI: Inferred from Physical Interaction |
FB:FBgn0000117 |
F |
From FB |
||
| GO:0005515 |
protein binding |
FB:FBrf0207596 |
IPI: Inferred from Physical Interaction |
FB:FBgn0000117 |
F |
From FB |
||
| GO:0005515 |
protein binding |
FB:FBrf0207596 |
IPI: Inferred from Physical Interaction |
FB:FBgn0011202 |
F |
From FB |
||
| GO:0005515 |
protein binding |
FB:FBrf0207596 |
IPI: Inferred from Physical Interaction |
FB:FBgn0028421 |
F |
From FB |
||
| GO:0005634 |
nucleus |
FB:FBrf0151433 |
TAS: Traceable Author Statement |
C |
From FB |
|||
| GO:0005737 |
cytoplasm |
FB:FBrf0151433 |
TAS: Traceable Author Statement |
C |
From FB |
|||
| GO:0005875 |
microtubule associated complex |
FB:FBrf0132100 |
ISS: Inferred from Sequence or Structural Similarity |
C |
From FB |
|||
| GO:0005912 |
adherens junction |
FB:FBrf0141377 |
TAS: Traceable Author Statement |
C |
From FB |
|||
| GO:0005912 |
adherens junction |
FB:FBrf0151433 |
TAS: Traceable Author Statement |
C |
From FB |
|||
| GO:0005938 |
cell cortex |
FB:FBrf0151885 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005938 |
cell cortex |
FB:FBrf0192526 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0007017 |
microtubule-based process |
FB:FBrf0132100 |
ISS: Inferred from Sequence or Structural Similarity |
P |
From FB |
|||
| GO:0007017 |
microtubule-based process |
FB:FBrf0151433 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007155 |
cell adhesion |
FB:FBrf0145163 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007155 |
cell adhesion |
FB:FBrf0151433 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0007405 |
neuroblast proliferation |
FB:FBrf0151885 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0015589 |
P |
From FB |
||
| GO:0007411 |
axon guidance |
FB:FBrf0200173 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0015589 |
P |
From FB |
||
| GO:0007420 |
brain development |
FB:FBrf0151885 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0015589 |
P |
From FB |
||
| GO:0007447 |
imaginal disc pattern formation |
FB:FBrf0151886 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0015589 |
P |
From FB |
||
| GO:0008013 |
beta-catenin binding |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
F |
From FB |
|||
| GO:0008017 |
microtubule binding |
FB:FBrf0132100 |
ISS: Inferred from Sequence or Structural Similarity |
F |
From FB |
|||
| GO:0008258 |
head involution |
FB:FBrf0151886 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0015589 |
P |
From FB |
||
| GO:0008362 |
chitin-based embryonic cuticle biosynthetic process |
FB:FBrf0192526 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0016055 |
Wnt receptor signaling pathway |
FB:FBrf0149011 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0016327 |
apicolateral plasma membrane |
FB:FBrf0141282 |
TAS: Traceable Author Statement |
C |
From FB |
|||
| GO:0016327 |
apicolateral plasma membrane |
FB:FBrf0151433 |
TAS: Traceable Author Statement |
C |
From FB |
|||
| GO:0016337 |
cell-cell adhesion |
FB:FBrf0200173 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0015589 |
P |
From FB |
||
| GO:0021550 |
medulla oblongata development |
FB:FBrf0200173 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0015589 |
P |
From FB |
||
| GO:0030111 |
regulation of Wnt receptor signaling pathway |
FB:FBrf0146980 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0015589 |
P |
From FB |
||
| GO:0030111 |
regulation of Wnt receptor signaling pathway |
FB:FBrf0146980 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0030111 |
regulation of Wnt receptor signaling pathway |
FB:FBrf0151886 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0015589 |
P |
From FB |
||
| GO:0030178 |
negative regulation of Wnt receptor signaling pathway |
FB:FBrf0111426 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0004009 |
P |
From FB |
||
| GO:0030178 |
negative regulation of Wnt receptor signaling pathway |
FB:FBrf0200173 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0015589 |
P |
From FB |
||
| GO:0030425 |
dendrite |
FB:FBrf0209884 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0030589 |
pseudocleavage involved in syncytial blastoderm formation |
FB:FBrf0207596 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0030720 |
oocyte localization involved in germarium-derived egg chamber formation |
FB:FBrf0145163 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0015589 |
P |
From FB |
||
| GO:0030720 |
oocyte localization involved in germarium-derived egg chamber formation |
FB:FBrf0145163 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0030951 |
establishment or maintenance of microtubule cytoskeleton polarity |
FB:FBrf0212550 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0032154 |
cleavage furrow |
FB:FBrf0151885 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0035190 |
syncytial nuclear migration |
FB:FBrf0192526 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0035293 |
chitin-based larval cuticle pattern formation |
FB:FBrf0151886 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0015589 |
P |
From FB |
||
| GO:0040001 |
establishment of mitotic spindle localization |
FB:FBrf0151433 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0040001 |
establishment of mitotic spindle localization |
FB:FBrf0156078 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0043025 |
neuronal cell body |
FB:FBrf0209884 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0043234 |
protein complex |
FB:FBrf0207596 |
IPI: Inferred from Physical Interaction |
FB:FBgn0011202 |
C |
From FB |
||
| GO:0045179 |
apical cortex |
FB:FBrf0151886 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0045862 |
positive regulation of proteolysis |
FB:FBrf0151433 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0045892 |
negative regulation of transcription, DNA-dependent |
FB:FBrf0151433 |
TAS: Traceable Author Statement |
P |
From FB |
|||
|
colocalizes_with |
GO:0005884 |
actin filament |
FB:FBrf0207596 |
IDA: Inferred from Direct Assay |
C |
From FB |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Johnston LA & Gallant P (2002) Control of growth and organ size in Drosophila. Bioessays 24: 54-64 PubMed GONUTS page
- ↑ 2.0 2.1 McCartney BM et al. (1999) Drosophila APC2 is a cytoskeletally-associated protein that regulates wingless signaling in the embryonic epidermis. J Cell Biol 146: 1303-18 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 Webb RL et al. (2009) A novel role for an APC2-Diaphanous complex in regulating actin organization in Drosophila. Development 136: 1283-93 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 4.7 4.8 Bienz M (2002) The subcellular destinations of APC proteins. Nat Rev Mol Cell Biol 3: 328-38 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Goldstein LS & Gunawardena S (2000) Flying through the drosophila cytoskeletal genome. J Cell Biol 150: F63-8 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 Akong K et al. (2002) Drosophila APC2 and APC1 have overlapping roles in the larval brain despite their distinct intracellular localizations. Dev Biol 250: 71-90 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 McCartney BM et al. (2006) Testing hypotheses for the functions of APC family proteins using null and truncation alleles in Drosophila. Development 133: 2407-18 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 Hamada F & Bienz M (2002) A Drosophila APC tumour suppressor homologue functions in cellular adhesion. Nat Cell Biol 4: 208-13 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 9.3 Hayden MA et al. (2007) Novel roles for APC family members and Wingless/Wnt signaling during Drosophila brain development. Dev Biol 305: 358-76 PubMed GONUTS page
- ↑ 10.0 10.1 10.2 10.3 10.4 Akong K et al. (2002) Drosophila APC2 and APC1 play overlapping roles in wingless signaling in the embryo and imaginal discs. Dev Biol 250: 91-100 PubMed GONUTS page
- ↑ Ostrowski S et al. (2002) Genetic control of cuticle formation during embryonic development of Drosophila melanogaster. Genetics 161: 171-82 PubMed GONUTS page
- ↑ Tepass U et al. (2001) Epithelial cell polarity and cell junctions in Drosophila. Annu Rev Genet 35: 747-84 PubMed GONUTS page
- ↑ 13.0 13.1 Ahmed Y et al. (2002) Drosophila Apc1 and Apc2 regulate Wingless transduction throughout development. Development 129: 1751-62 PubMed GONUTS page
- ↑ 14.0 14.1 Rolls MM et al. (2007) Polarity and intracellular compartmentalization of Drosophila neurons. Neural Dev 2: 7 PubMed GONUTS page
- ↑ Mattie FJ et al. (2010) Directed microtubule growth, +TIPs, and kinesin-2 are required for uniform microtubule polarity in dendrites. Curr Biol 20: 2169-77 PubMed GONUTS page
- ↑ Gönczy P (2002) Mechanisms of spindle positioning: focus on flies and worms. Trends Cell Biol 12: 332-9 PubMed GONUTS page
