FB:Abl

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Species (Taxon ID)	Drosophila melanogaster (fruit fly) (taxon:7227)
Gene Name(s)	Abl ( synonyms: 4674, ABL, Abelson, Abelson Kinase, Abelson cytoplasmic tyrosine kinase, Abelson kinase, Abelson tyrosine kinase, Abl oncogene, Abl1, AblK, Ableson, Am ABL, C-abl, CG4032, D-abelson, D-abl, D-ash, DAbl, DROTKABL3, Dabl, Dash, Ddash/abl, Dsrc7, abelson, abl, abl kinase, abl1, c-abl, cAbl, dAbl, l(3)04674, l(3)73Ba, l(3)c-abl )
Protein Name(s)	Abl tyrosine kinase,
External Links
FB	FBgn0000017

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0016301	kinase activity	PMID:6203030^[1]	IEP: Inferred from Expression Pattern		F	ABL expression is reduced in embryo as time passes after egg laying. RNA blot fig 2	complete
	GO:0004713	protein tyrosine kinase activity	PMID:2832740^[2]	ISA: Inferred from Sequence Alignment	UniProtKB:P00519	F	tyrosine kinase activity inferred from sequence similarity to human abl tyrosine kinase. kinase activity observed from expression products of transformed e.coli with Drosophila abl	complete
	GO:0002009	morphogenesis of an epithelium	FB:FBrf0151280 PMID:12147138^[3]	NAS: Non-traceable Author Statement		P	From FB
	GO:0004713	protein tyrosine kinase activity	FB:FBrf0048684 PMID:2832740^[2]	IDA: Inferred from Direct Assay		F	From FB
	GO:0004713	protein tyrosine kinase activity	FB:FBrf0048684 PMID:2832740^[2]	ISS: Inferred from Sequence or Structural Similarity		F	From FB
	GO:0004713	protein tyrosine kinase activity	FB:FBrf0123321	NAS: Non-traceable Author Statement		F	From FB
	GO:0004713	protein tyrosine kinase activity	FB:FBrf0128391 PMID:10892742^[4]	IDA: Inferred from Direct Assay		F	From FB
	GO:0004713	protein tyrosine kinase activity	FB:FBrf0132098 PMID:10908587^[5]	NAS: Non-traceable Author Statement		F	From FB
	GO:0004713	protein tyrosine kinase activity	FB:FBrf0201419 PMID:17804420^[6]	IMP: Inferred from Mutant Phenotype		F	From FB
	GO:0004715	non-membrane spanning protein tyrosine kinase activity	FB:FBrf0126931	ISS: Inferred from Sequence or Structural Similarity		F	From FB
	GO:0004715	non-membrane spanning protein tyrosine kinase activity	FB:FBrf0174215	IEA: Inferred from Electronic Annotation	InterPro:IPR015015	F	From FB
	GO:0005515	protein binding	FB:FBrf0111395 PMID:10498863^[7]	IPI: Inferred from Physical Interaction	FB:FBgn0020510	F	From FB
	GO:0005524	ATP binding	FB:FBrf0123321	NAS: Non-traceable Author Statement		F	From FB
	GO:0005524	ATP binding	FB:FBrf0174215	IEA: Inferred from Electronic Annotation	InterPro:IPR000719 InterPro:IPR015015 InterPro:IPR017441	F	From FB
	GO:0005737	cytoplasm	FB:FBrf0055913 PMID:1295746^[8]	IDA: Inferred from Direct Assay		C	From FB
	GO:0005737	cytoplasm	FB:FBrf0123321	NAS: Non-traceable Author Statement		C	From FB
	GO:0005829	cytosol	FB:FBrf0201419 PMID:17804420^[6]	IDA: Inferred from Direct Assay		C	From FB
	GO:0005911	cell-cell junction	FB:FBrf0055913 PMID:1295746^[8]	IDA: Inferred from Direct Assay		C	From FB
	GO:0005912	adherens junction	FB:FBrf0123321	NAS: Non-traceable Author Statement		C	From FB
	GO:0005912	adherens junction	FB:FBrf0151280 PMID:12147138^[3]	TAS: Traceable Author Statement		C	From FB
	GO:0005927	muscle tendon junction	FB:FBrf0055913 PMID:1295746^[8]	IDA: Inferred from Direct Assay		C	From FB
	GO:0006468	protein phosphorylation	FB:FBrf0132098 PMID:10908587^[5]	NAS: Non-traceable Author Statement		P	From FB
	GO:0007303	cytoplasmic transport, nurse cell to oocyte	FB:FBrf0208541 PMID:19576200^[9]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0007370	ventral furrow formation	FB:FBrf0195363 PMID:17202187^[10]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0007391	dorsal closure	FB:FBrf0141596 PMID:11756472^[11]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0007391	dorsal closure	FB:FBrf0151280 PMID:12147138^[3]	NAS: Non-traceable Author Statement		P	From FB
	GO:0007411	axon guidance	FB:FBrf0051382 PMID:2406026^[12]	IGI: Inferred from Genetic Interaction	FB:FBgn0262742	P	From FB
	GO:0007411	axon guidance	FB:FBrf0127511 PMID:10798396^[13]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0007411	axon guidance	FB:FBrf0128391 PMID:10892742^[4]	IGI: Inferred from Genetic Interaction	FB:FBgn0005631	P	From FB
	GO:0007411	axon guidance	FB:FBrf0128391 PMID:10892742^[4]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0007411	axon guidance	FB:FBrf0159717 PMID:12781136^[14]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0007411	axon guidance	FB:FBrf0211499 PMID:20498300^[15]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0007417	central nervous system development	FB:FBrf0049327 PMID:2502313^[16]	IGI: Inferred from Genetic Interaction	FB:FBgn0004108	P	From FB
	GO:0008064	regulation of actin polymerization or depolymerization	FB:FBrf0151872 PMID:12231351^[17]	TAS: Traceable Author Statement		P	From FB
	GO:0008360	regulation of cell shape	FB:FBrf0151280 PMID:12147138^[3]	NAS: Non-traceable Author Statement		P	From FB
	GO:0008360	regulation of cell shape	FB:FBrf0167741 PMID:14527345^[18]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0008360	regulation of cell shape	FB:FBrf0195363 PMID:17202187^[10]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0018108	peptidyl-tyrosine phosphorylation	FB:FBrf0201419 PMID:17804420^[6]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0019897	extrinsic to plasma membrane	FB:FBrf0055913 PMID:1295746^[8]	IDA: Inferred from Direct Assay		C	From FB
	GO:0031647	regulation of protein stability	FB:FBrf0201419 PMID:17804420^[6]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0032880	regulation of protein localization	FB:FBrf0201419 PMID:17804420^[6]	IDA: Inferred from Direct Assay		P	From FB
	GO:0045179	apical cortex	FB:FBrf0195363 PMID:17202187^[10]	IDA: Inferred from Direct Assay		C	From FB
	GO:0045886	negative regulation of synaptic growth at neuromuscular junction	FB:FBrf0208583 PMID:19675132^[19]	IMP: Inferred from Mutant Phenotype		P	From FB
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Lev Z et al. (1984) Expression of the src and abl cellular oncogenes during development of Drosophila melanogaster. Mol Cell Biol 4: 982-4 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Henkemeyer MJ et al. (1988) DNA sequence, structure, and tyrosine kinase activity of the Drosophila melanogaster Abelson proto-oncogene homolog. Mol Cell Biol 8: 843-53 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Harden N (2002) Signaling pathways directing the movement and fusion of epithelial sheets: lessons from dorsal closure in Drosophila. Differentiation 70: 181-203 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Bashaw GJ et al. (2000) Repulsive axon guidance: Abelson and Enabled play opposing roles downstream of the roundabout receptor. Cell 101: 703-15 PubMed GONUTS page
↑ ^5.0 ^5.1 Morrison DK et al. (2000) Protein kinases and phosphatases in the Drosophila genome. J Cell Biol 150: F57-62 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 Huang CH et al. (2007) The involvement of Abl and PTP61F in the regulation of Abi protein localization and stability and lamella formation in Drosophila S2 cells. J Biol Chem 282: 32442-52 PubMed GONUTS page
↑ Juang JL & Hoffmann FM (1999) Drosophila abelson interacting protein (dAbi) is a positive regulator of abelson tyrosine kinase activity. Oncogene 18: 5138-47 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Bennett RL & Hoffmann FM (1992) Increased levels of the Drosophila Abelson tyrosine kinase in nerves and muscles: subcellular localization and mutant phenotypes imply a role in cell-cell interactions. Development 116: 953-66 PubMed GONUTS page
↑ Gates J et al. (2009) Enabled and Capping protein play important roles in shaping cell behavior during Drosophila oogenesis. Dev Biol 333: 90-107 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Fox DT & Peifer M (2007) Abelson kinase (Abl) and RhoGEF2 regulate actin organization during cell constriction in Drosophila. Development 134: 567-78 PubMed GONUTS page
↑ Grevengoed EE et al. (2001) Abelson kinase regulates epithelial morphogenesis in Drosophila. J Cell Biol 155: 1185-98 PubMed GONUTS page
↑ Elkins T et al. (1990) Genetic analysis of a Drosophila neural cell adhesion molecule: interaction of fasciclin I and Abelson tyrosine kinase mutations. Cell 60: 565-75 PubMed GONUTS page
↑ Liebl EC et al. (2000) Dosage-sensitive, reciprocal genetic interactions between the Abl tyrosine kinase and the putative GEF trio reveal trio's role in axon pathfinding. Neuron 26: 107-18 PubMed GONUTS page
↑ Crowner D et al. (2003) Notch steers Drosophila ISNb motor axons by regulating the Abl signaling pathway. Curr Biol 13: 967-72 PubMed GONUTS page
↑ Lowery LA et al. (2010) Parallel genetic and proteomic screens identify Msps as a CLASP-Abl pathway interactor in Drosophila. Genetics 185: 1311-25 PubMed GONUTS page
↑ Gertler FB et al. (1989) Drosophila abl tyrosine kinase in embryonic CNS axons: a role in axonogenesis is revealed through dosage-sensitive interactions with disabled. Cell 58: 103-13 PubMed GONUTS page
↑ Martin P & Wood W (2002) Epithelial fusions in the embryo. Curr Opin Cell Biol 14: 569-74 PubMed GONUTS page
↑ Kiger AA et al. (2003) A functional genomic analysis of cell morphology using RNA interference. J Biol 2: 27 PubMed GONUTS page
↑ Lin TY et al. (2009) Abi plays an opposing role to Abl in Drosophila axonogenesis and synaptogenesis. Development 136: 3099-107 PubMed GONUTS page

[PMID:6203030-0] Lev Z et al. (1984) Expression of the src and abl cellular oncogenes during development of Drosophila melanogaster. Mol Cell Biol 4: 982-4 PubMed GONUTS page

[PMID:2832740-1] 2.0 ^2.1 ^2.2 Henkemeyer MJ et al. (1988) DNA sequence, structure, and tyrosine kinase activity of the Drosophila melanogaster Abelson proto-oncogene homolog. Mol Cell Biol 8: 843-53 PubMed GONUTS page

[PMID:12147138-2] 3.0 ^3.1 ^3.2 ^3.3 Harden N (2002) Signaling pathways directing the movement and fusion of epithelial sheets: lessons from dorsal closure in Drosophila. Differentiation 70: 181-203 PubMed GONUTS page

[PMID:10892742-3] 4.0 ^4.1 ^4.2 Bashaw GJ et al. (2000) Repulsive axon guidance: Abelson and Enabled play opposing roles downstream of the roundabout receptor. Cell 101: 703-15 PubMed GONUTS page

[PMID:10908587-4] 5.0 ^5.1 Morrison DK et al. (2000) Protein kinases and phosphatases in the Drosophila genome. J Cell Biol 150: F57-62 PubMed GONUTS page

[PMID:17804420-5] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 Huang CH et al. (2007) The involvement of Abl and PTP61F in the regulation of Abi protein localization and stability and lamella formation in Drosophila S2 cells. J Biol Chem 282: 32442-52 PubMed GONUTS page

[PMID:10498863-6] Juang JL & Hoffmann FM (1999) Drosophila abelson interacting protein (dAbi) is a positive regulator of abelson tyrosine kinase activity. Oncogene 18: 5138-47 PubMed GONUTS page

[PMID:1295746-7] 8.0 ^8.1 ^8.2 ^8.3 Bennett RL & Hoffmann FM (1992) Increased levels of the Drosophila Abelson tyrosine kinase in nerves and muscles: subcellular localization and mutant phenotypes imply a role in cell-cell interactions. Development 116: 953-66 PubMed GONUTS page

[PMID:19576200-8] Gates J et al. (2009) Enabled and Capping protein play important roles in shaping cell behavior during Drosophila oogenesis. Dev Biol 333: 90-107 PubMed GONUTS page

[PMID:17202187-9] 10.0 ^10.1 ^10.2 Fox DT & Peifer M (2007) Abelson kinase (Abl) and RhoGEF2 regulate actin organization during cell constriction in Drosophila. Development 134: 567-78 PubMed GONUTS page

[PMID:11756472-10] Grevengoed EE et al. (2001) Abelson kinase regulates epithelial morphogenesis in Drosophila. J Cell Biol 155: 1185-98 PubMed GONUTS page

[PMID:2406026-11] Elkins T et al. (1990) Genetic analysis of a Drosophila neural cell adhesion molecule: interaction of fasciclin I and Abelson tyrosine kinase mutations. Cell 60: 565-75 PubMed GONUTS page

[PMID:10798396-12] Liebl EC et al. (2000) Dosage-sensitive, reciprocal genetic interactions between the Abl tyrosine kinase and the putative GEF trio reveal trio's role in axon pathfinding. Neuron 26: 107-18 PubMed GONUTS page

[PMID:12781136-13] Crowner D et al. (2003) Notch steers Drosophila ISNb motor axons by regulating the Abl signaling pathway. Curr Biol 13: 967-72 PubMed GONUTS page

[PMID:20498300-14] Lowery LA et al. (2010) Parallel genetic and proteomic screens identify Msps as a CLASP-Abl pathway interactor in Drosophila. Genetics 185: 1311-25 PubMed GONUTS page

[PMID:2502313-15] Gertler FB et al. (1989) Drosophila abl tyrosine kinase in embryonic CNS axons: a role in axonogenesis is revealed through dosage-sensitive interactions with disabled. Cell 58: 103-13 PubMed GONUTS page

[PMID:12231351-16] Martin P & Wood W (2002) Epithelial fusions in the embryo. Curr Opin Cell Biol 14: 569-74 PubMed GONUTS page

[PMID:14527345-17] Kiger AA et al. (2003) A functional genomic analysis of cell morphology using RNA interference. J Biol 2: 27 PubMed GONUTS page

[PMID:19675132-18] Lin TY et al. (2009) Abi plays an opposing role to Abl in Drosophila axonogenesis and synaptogenesis. Development 136: 3099-107 PubMed GONUTS page

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FB:Abl

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