FB:Abl

From GONUTS

Species (Taxon ID)	Drosophila melanogaster (fruit fly) (taxon:7227)
Gene Name(s)	Abl ( synonyms: 4674, ABL, Abelson, Abelson Kinase, Abelson tyrosine kinase, Abl oncogene, Abl1, AblK, Ableson, Am ABL, C-abl, CG4032, D-abelson, D-abl, D-ash, DAbl, DROTKABL3, Dabl, Dash, Ddash/abl, Dsrc7, abelson, abl, abl kinase, abl1, c-abl, cAbl, dAbl, l(3)04674, l(3)73Ba, l(3)c-abl )
Protein Name(s)	Abl tyrosine kinase,
External Links
FB	FBgn0000017

Annotations

Qualifier	GO ID	GO term name	Reference(s)	Evidence Code	with/from	Aspect	Notes
	GO:0000287	magnesium ion binding	FB:FBrf0174215	IEA: Inferred from Electronic Annotation	InterPro:IPR020700	F	From FB
	GO:0002009	morphogenesis of an epithelium	FB:FBrf0151280 PMID:12147138^[1]	NAS: Non-traceable Author Statement		P	From FB
	GO:0004713	protein tyrosine kinase activity	FB:FBrf0048684 PMID:2832740^[2]	IDA: Inferred from Direct Assay		F	From FB
	GO:0004713	protein tyrosine kinase activity	FB:FBrf0048684 PMID:2832740^[2]	ISS: Inferred from Sequence or Structural Similarity		F	From FB
	GO:0004713	protein tyrosine kinase activity	FB:FBrf0123321	NAS: Non-traceable Author Statement		F	From FB
	GO:0004713	protein tyrosine kinase activity	FB:FBrf0128391 PMID:10892742^[3]	IDA: Inferred from Direct Assay		F	From FB
	GO:0004713	protein tyrosine kinase activity	FB:FBrf0132098 PMID:10908587^[4]	NAS: Non-traceable Author Statement		F	From FB
	GO:0004713	protein tyrosine kinase activity	FB:FBrf0201419 PMID:17804420^[5]	IMP: Inferred from Mutant Phenotype		F	From FB
	GO:0004715	non-membrane spanning protein tyrosine kinase activity	FB:FBrf0126931	ISS: Inferred from Sequence or Structural Similarity		F	From FB
	GO:0004715	non-membrane spanning protein tyrosine kinase activity	FB:FBrf0174215	IEA: Inferred from Electronic Annotation	InterPro:IPR015015 InterPro:IPR020700	F	From FB
	GO:0005515	protein binding	FB:FBrf0111395 PMID:10498863^[6]	IPI: Inferred from Physical Interaction	FB:FBgn0020510	F	From FB
	GO:0005524	ATP binding	FB:FBrf0123321	NAS: Non-traceable Author Statement		F	From FB
	GO:0005524	ATP binding	FB:FBrf0174215	IEA: Inferred from Electronic Annotation	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008266 InterPro:IPR015015 InterPro:IPR017441 InterPro:IPR020700	F	From FB
	GO:0005737	cytoplasm	FB:FBrf0055913 PMID:1295746^[7]	IDA: Inferred from Direct Assay		C	From FB
	GO:0005737	cytoplasm	FB:FBrf0123321	NAS: Non-traceable Author Statement		C	From FB
	GO:0005829	cytosol	FB:FBrf0201419 PMID:17804420^[5]	IDA: Inferred from Direct Assay		C	From FB
	GO:0005911	cell-cell junction	FB:FBrf0055913 PMID:1295746^[7]	IDA: Inferred from Direct Assay		C	From FB
	GO:0005912	adherens junction	FB:FBrf0123321	NAS: Non-traceable Author Statement		C	From FB
	GO:0005912	adherens junction	FB:FBrf0151280 PMID:12147138^[1]	TAS: Traceable Author Statement		C	From FB
	GO:0005927	muscle tendon junction	FB:FBrf0055913 PMID:1295746^[7]	IDA: Inferred from Direct Assay		C	From FB
	GO:0006468	protein amino acid phosphorylation	FB:FBrf0132098 PMID:10908587^[4]	NAS: Non-traceable Author Statement		P	From FB
	GO:0007165	signal transduction	FB:FBrf0174215	IEA: Inferred from Electronic Annotation	InterPro:IPR020700	P	From FB
	GO:0007303	cytoplasmic transport, nurse cell to oocyte	FB:FBrf0208541 PMID:19576200^[8]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0007370	ventral furrow formation	FB:FBrf0195363 PMID:17202187^[9]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0007391	dorsal closure	FB:FBrf0141596 PMID:11756472^[10]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0007391	dorsal closure	FB:FBrf0151280 PMID:12147138^[1]	NAS: Non-traceable Author Statement		P	From FB
	GO:0007411	axon guidance	FB:FBrf0051382 PMID:2406026^[11]	IGI: Inferred from Genetic Interaction	FB:FBgn0000634	P	From FB
	GO:0007411	axon guidance	FB:FBrf0127511 PMID:10798396^[12]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0007411	axon guidance	FB:FBrf0128391 PMID:10892742^[3]	IGI: Inferred from Genetic Interaction	FB:FBgn0005631	P	From FB
	GO:0007411	axon guidance	FB:FBrf0128391 PMID:10892742^[3]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0007411	axon guidance	FB:FBrf0159717 PMID:12781136^[13]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0007417	central nervous system development	FB:FBrf0049327 PMID:2502313^[14]	IGI: Inferred from Genetic Interaction	FB:FBgn0004108	P	From FB
	GO:0008064	regulation of actin polymerization or depolymerization	FB:FBrf0151872 PMID:12231351^[15]	TAS: Traceable Author Statement		P	From FB
	GO:0008360	regulation of cell shape	FB:FBrf0151280 PMID:12147138^[1]	NAS: Non-traceable Author Statement		P	From FB
	GO:0008360	regulation of cell shape	FB:FBrf0167741 PMID:14527345^[16]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0008360	regulation of cell shape	FB:FBrf0195363 PMID:17202187^[9]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0018108	peptidyl-tyrosine phosphorylation	FB:FBrf0201419 PMID:17804420^[5]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0019897	extrinsic to plasma membrane	FB:FBrf0055913 PMID:1295746^[7]	IDA: Inferred from Direct Assay		C	From FB
	GO:0030145	manganese ion binding	FB:FBrf0174215	IEA: Inferred from Electronic Annotation	InterPro:IPR020700	F	From FB
	GO:0031647	regulation of protein stability	FB:FBrf0201419 PMID:17804420^[5]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0032880	regulation of protein localization	FB:FBrf0201419 PMID:17804420^[5]	IDA: Inferred from Direct Assay		P	From FB
	GO:0045179	apical cortex	FB:FBrf0195363 PMID:17202187^[9]	IDA: Inferred from Direct Assay		C	From FB
	GO:0045886	negative regulation of synaptic growth at neuromuscular junction	FB:FBrf0208583 PMID:19675132^[17]	IMP: Inferred from Mutant Phenotype		P	From FB
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Harden N (2002) Signaling pathways directing the movement and fusion of epithelial sheets: lessons from dorsal closure in Drosophila. Differentiation 70: 181-203 PubMed GONUTS page
↑ ^2.0 ^2.1 Henkemeyer MJ et al. (1988) DNA sequence, structure, and tyrosine kinase activity of the Drosophila melanogaster Abelson proto-oncogene homolog. Mol Cell Biol 8: 843-53 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Bashaw GJ et al. (2000) Repulsive axon guidance: Abelson and Enabled play opposing roles downstream of the roundabout receptor. Cell 101: 703-15 PubMed GONUTS page
↑ ^4.0 ^4.1 Morrison DK et al. (2000) Protein kinases and phosphatases in the Drosophila genome. J Cell Biol 150: F57-62 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 Huang CH et al. (2007) The involvement of Abl and PTP61F in the regulation of Abi protein localization and stability and lamella formation in Drosophila S2 cells. J Biol Chem 282: 32442-52 PubMed GONUTS page
↑ Juang JL & Hoffmann FM (1999) Drosophila abelson interacting protein (dAbi) is a positive regulator of abelson tyrosine kinase activity. Oncogene 18: 5138-47 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Bennett RL & Hoffmann FM (1992) Increased levels of the Drosophila Abelson tyrosine kinase in nerves and muscles: subcellular localization and mutant phenotypes imply a role in cell-cell interactions. Development 116: 953-66 PubMed GONUTS page
↑ Gates J et al. (2009) Enabled and Capping protein play important roles in shaping cell behavior during Drosophila oogenesis. Dev Biol 333: 90-107 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Fox DT & Peifer M (2007) Abelson kinase (Abl) and RhoGEF2 regulate actin organization during cell constriction in Drosophila. Development 134: 567-78 PubMed GONUTS page
↑ Grevengoed EE et al. (2001) Abelson kinase regulates epithelial morphogenesis in Drosophila. J Cell Biol 155: 1185-98 PubMed GONUTS page
↑ Elkins T et al. (1990) Genetic analysis of a Drosophila neural cell adhesion molecule: interaction of fasciclin I and Abelson tyrosine kinase mutations. Cell 60: 565-75 PubMed GONUTS page
↑ Liebl EC et al. (2000) Dosage-sensitive, reciprocal genetic interactions between the Abl tyrosine kinase and the putative GEF trio reveal trio's role in axon pathfinding. Neuron 26: 107-18 PubMed GONUTS page
↑ Crowner D et al. (2003) Notch steers Drosophila ISNb motor axons by regulating the Abl signaling pathway. Curr Biol 13: 967-72 PubMed GONUTS page
↑ Gertler FB et al. (1989) Drosophila abl tyrosine kinase in embryonic CNS axons: a role in axonogenesis is revealed through dosage-sensitive interactions with disabled. Cell 58: 103-13 PubMed GONUTS page
↑ Martin P & Wood W (2002) Epithelial fusions in the embryo. Curr Opin Cell Biol 14: 569-74 PubMed GONUTS page
↑ Kiger AA et al. (2003) A functional genomic analysis of cell morphology using RNA interference. J Biol 2: 27 PubMed GONUTS page
↑ Lin TY et al. (2009) Abi plays an opposing role to Abl in Drosophila axonogenesis and synaptogenesis. Development 136: 3099-107 PubMed GONUTS page

[PMID:12147138-0] 1.0 ^1.1 ^1.2 ^1.3 Harden N (2002) Signaling pathways directing the movement and fusion of epithelial sheets: lessons from dorsal closure in Drosophila. Differentiation 70: 181-203 PubMed GONUTS page

[PMID:2832740-1] 2.0 ^2.1 Henkemeyer MJ et al. (1988) DNA sequence, structure, and tyrosine kinase activity of the Drosophila melanogaster Abelson proto-oncogene homolog. Mol Cell Biol 8: 843-53 PubMed GONUTS page

[PMID:10892742-2] 3.0 ^3.1 ^3.2 Bashaw GJ et al. (2000) Repulsive axon guidance: Abelson and Enabled play opposing roles downstream of the roundabout receptor. Cell 101: 703-15 PubMed GONUTS page

[PMID:10908587-3] 4.0 ^4.1 Morrison DK et al. (2000) Protein kinases and phosphatases in the Drosophila genome. J Cell Biol 150: F57-62 PubMed GONUTS page

[PMID:17804420-4] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 Huang CH et al. (2007) The involvement of Abl and PTP61F in the regulation of Abi protein localization and stability and lamella formation in Drosophila S2 cells. J Biol Chem 282: 32442-52 PubMed GONUTS page

[PMID:10498863-5] Juang JL & Hoffmann FM (1999) Drosophila abelson interacting protein (dAbi) is a positive regulator of abelson tyrosine kinase activity. Oncogene 18: 5138-47 PubMed GONUTS page

[PMID:1295746-6] 7.0 ^7.1 ^7.2 ^7.3 Bennett RL & Hoffmann FM (1992) Increased levels of the Drosophila Abelson tyrosine kinase in nerves and muscles: subcellular localization and mutant phenotypes imply a role in cell-cell interactions. Development 116: 953-66 PubMed GONUTS page

[PMID:19576200-7] Gates J et al. (2009) Enabled and Capping protein play important roles in shaping cell behavior during Drosophila oogenesis. Dev Biol 333: 90-107 PubMed GONUTS page

[PMID:17202187-8] 9.0 ^9.1 ^9.2 Fox DT & Peifer M (2007) Abelson kinase (Abl) and RhoGEF2 regulate actin organization during cell constriction in Drosophila. Development 134: 567-78 PubMed GONUTS page

[PMID:11756472-9] Grevengoed EE et al. (2001) Abelson kinase regulates epithelial morphogenesis in Drosophila. J Cell Biol 155: 1185-98 PubMed GONUTS page

[PMID:2406026-10] Elkins T et al. (1990) Genetic analysis of a Drosophila neural cell adhesion molecule: interaction of fasciclin I and Abelson tyrosine kinase mutations. Cell 60: 565-75 PubMed GONUTS page

[PMID:10798396-11] Liebl EC et al. (2000) Dosage-sensitive, reciprocal genetic interactions between the Abl tyrosine kinase and the putative GEF trio reveal trio's role in axon pathfinding. Neuron 26: 107-18 PubMed GONUTS page

[PMID:12781136-12] Crowner D et al. (2003) Notch steers Drosophila ISNb motor axons by regulating the Abl signaling pathway. Curr Biol 13: 967-72 PubMed GONUTS page

[PMID:2502313-13] Gertler FB et al. (1989) Drosophila abl tyrosine kinase in embryonic CNS axons: a role in axonogenesis is revealed through dosage-sensitive interactions with disabled. Cell 58: 103-13 PubMed GONUTS page

[PMID:12231351-14] Martin P & Wood W (2002) Epithelial fusions in the embryo. Curr Opin Cell Biol 14: 569-74 PubMed GONUTS page

[PMID:14527345-15] Kiger AA et al. (2003) A functional genomic analysis of cell morphology using RNA interference. J Biol 2: 27 PubMed GONUTS page

[PMID:19675132-16] Lin TY et al. (2009) Abi plays an opposing role to Abl in Drosophila axonogenesis and synaptogenesis. Development 136: 3099-107 PubMed GONUTS page

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FB:Abl

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