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FB:AGO1
Contents |
| Species (Taxon ID) | Drosophila melanogaster (fruit fly) (taxon:7227) | |
| Gene Name(s) | AGO1 ( synonyms: ARGONAUTE-1, Ago, Ago-1, Ago1, Argonaute, Argonaute 1, Argonaute protein 1, Argonaute1, CG6671, Dm Ago1, MRE20, ago1, ago1-1, anon-WO0257455.29, argonaute 1, argonaute-1, dAGO1, dAgo1, l(2)04845, l(2)4845, l(2)k00208, l(2)k08121, mRNA-like ncRNA in embryogenesis 20 ) | |
| Protein Name(s) | Argonaute-1, | |
| External Links | ||
| FB | FBgn0262739 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0003743 |
translation initiation factor activity |
FB:FBrf0105495 |
ISS: Inferred from Sequence or Structural Similarity |
F |
From FB |
|||
| GO:0005515 |
protein binding |
FB:FBrf0194224 |
IPI: Inferred from Physical Interaction |
FB:FBgn0087035 |
F |
From FB |
||
| GO:0005634 |
nucleus |
FB:FBrf0189910 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005737 |
cytoplasm |
FB:FBrf0189910 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005737 |
cytoplasm |
FB:FBrf0207452 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005737 |
cytoplasm |
FB:FBrf0208810 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005737 |
cytoplasm |
FB:FBrf0211387 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005850 |
eukaryotic translation initiation factor 2 complex |
FB:FBrf0105495 |
ISS: Inferred from Sequence or Structural Similarity |
C |
From FB |
|||
| GO:0006342 |
chromatin silencing |
FB:FBrf0189910 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0006402 |
mRNA catabolic process |
FB:FBrf0194513 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0051992 |
P |
From FB |
||
| GO:0006402 |
mRNA catabolic process |
FB:FBrf0194513 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007367 |
segment polarity determination |
FB:FBrf0194224 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0039016 |
P |
From FB |
||
| GO:0007367 |
segment polarity determination |
FB:FBrf0194224 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0087035 |
P |
From FB |
||
| GO:0007416 |
synapse assembly |
FB:FBrf0179908 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0016246 |
RNA interference |
FB:FBrf0156099 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0016442 |
RNA-induced silencing complex |
FB:FBrf0105495 |
ISS: Inferred from Sequence or Structural Similarity |
C |
From FB |
|||
| GO:0019899 |
enzyme binding |
FB:FBrf0179363 |
IPI: Inferred from Physical Interaction |
FB:FBgn0039016 |
F |
From FB |
||
| GO:0030422 |
production of siRNA involved in RNA interference |
FB:FBrf0149162 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0030423 |
targeting of mRNA for destruction involved in RNA interference |
FB:FBrf0149162 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0035195 |
gene silencing by miRNA |
FB:FBrf0179895 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0035195 |
gene silencing by miRNA |
FB:FBrf0190594 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0035196 |
production of miRNAs involved in gene silencing by miRNA |
FB:FBrf0179363 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0035198 |
miRNA binding |
FB:FBrf0194520 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0035279 |
mRNA cleavage involved in gene silencing by miRNA |
FB:FBrf0179363 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0035279 |
mRNA cleavage involved in gene silencing by miRNA |
FB:FBrf0190554 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0048471 |
perinuclear region of cytoplasm |
FB:FBrf0208810 |
IDA: Inferred from Direct Assay |
C |
From FB |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Meyer WJ et al. (2006) Overlapping functions of argonaute proteins in patterning and morphogenesis of Drosophila embryos. PLoS Genet 2: e134 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Grimaud C et al. (2006) RNAi components are required for nuclear clustering of Polycomb group response elements. Cell 124: 957-71 PubMed GONUTS page
- ↑ Reich J et al. (2009) miRNA-dependent translational repression in the Drosophila ovary. PLoS One 4: e4669 PubMed GONUTS page
- ↑ 4.0 4.1 Lee YS et al. (2009) Silencing by small RNAs is linked to endosomal trafficking. Nat Cell Biol 11: 1150-6 PubMed GONUTS page
- ↑ Gehrke S et al. (2010) Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression. Nature 466: 637-41 PubMed GONUTS page
- ↑ 6.0 6.1 Behm-Ansmant I et al. (2006) mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexes. Genes Dev 20: 1885-98 PubMed GONUTS page
- ↑ Murchison EP & Hannon GJ (2004) miRNAs on the move: miRNA biogenesis and the RNAi machinery. Curr Opin Cell Biol 16: 223-9 PubMed GONUTS page
- ↑ Cerutti H (2003) RNA interference: traveling in the cell and gaining functions? Trends Genet 19: 39-46 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 Okamura K et al. (2004) Distinct roles for Argonaute proteins in small RNA-directed RNA cleavage pathways. Genes Dev 18: 1655-66 PubMed GONUTS page
- ↑ 10.0 10.1 Williams RW & Rubin GM (2002) ARGONAUTE1 is required for efficient RNA interference in Drosophila embryos. Proc Natl Acad Sci U S A 99: 6889-94 PubMed GONUTS page
- ↑ Rehwinkel J et al. (2005) A crucial role for GW182 and the DCP1:DCP2 decapping complex in miRNA-mediated gene silencing. RNA 11: 1640-7 PubMed GONUTS page
- ↑ Vagin VV et al. (2006) A distinct small RNA pathway silences selfish genetic elements in the germline. Science 313: 320-4 PubMed GONUTS page
- ↑ Miyoshi K et al. (2005) Slicer function of Drosophila Argonautes and its involvement in RISC formation. Genes Dev 19: 2837-48 PubMed GONUTS page
