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ECOLI:MUTS

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Species (Taxon ID) Escherichia coli (strain K12). (83333)
Gene Name(s) mutS (synonyms: fdv)
Protein Name(s) DNA mismatch repair protein MutS
External Links
UniProt P23909
EMBL M64730
U29579
U00096
AP009048
AF004287
AF001987
AF001988
AF001989
AF001990
AF001991
AF001992
AF001993
AF001994
AF001995
AF001996
AF001997
AF001998
AF001999
AF002000
AF002001
AF002002
AF002003
AF002004
AF002005
AF002006
AF002007
AF002008
AF002009
AF002010
PIR I54964
RefSeq NP_417213.1
YP_490942.1
PDB 1E3M
1NG9
1OH5
1OH6
1OH7
1OH8
1W7A
1WB9
1WBB
1WBD
2OK2
2WTU
3K0S
3ZLJ
PDBsum 1E3M
1NG9
1OH5
1OH6
1OH7
1OH8
1W7A
1WB9
1WBB
1WBD
2OK2
2WTU
3K0S
3ZLJ
ProteinModelPortal P23909
SMR P23909
DIP DIP-10287N
IntAct P23909
MINT MINT-1264156
STRING 511145.b2733
SWISS-2DPAGE P23909
PaxDb P23909
PRIDE P23909
EnsemblBacteria AAC75775
BAE76810
GeneID 12932427
947206
KEGG ecj:Y75_p2671
eco:b2733
PATRIC 32120868
EchoBASE EB0620
EcoGene EG10625
eggNOG COG0249
HOGENOM HOG000221407
InParanoid P23909
KO K03555
OMA GFGAHSL
OrthoDB EOG6Q5NPV
PhylomeDB P23909
BioCyc EcoCyc:EG10625-MONOMER
ECOL316407:JW2703-MONOMER
MetaCyc:EG10625-MONOMER
EvolutionaryTrace P23909
PRO PR:P23909
Proteomes UP000000318
UP000000625
Genevestigator P23909
GO GO:0005829
GO:0032300
GO:0032136
GO:0043531
GO:0005524
GO:0016887
GO:0003684
GO:0008301
GO:0008094
GO:0042802
GO:0030983
GO:0006200
GO:0006974
GO:0006298
GO:0000018
Gene3D 3.30.420.110
3.40.1170.10
3.40.50.300
HAMAP MF_00096
InterPro IPR005748
IPR007695
IPR000432
IPR007861
IPR007696
IPR016151
IPR007860
IPR027417
Pfam PF01624
PF05188
PF05192
PF05190
PF00488
SMART SM00534
SM00533
SUPFAM SSF48334
SSF52540
SSF53150
SSF55271
TIGRFAMs TIGR01070
PROSITE PS00486

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0008301

DNA binding, bending

PMID:24101514[1]

ECO:0000317

F

Figure 2

Missing: with/from
CACAO 10663

enables

GO:0043531

ADP binding

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10625
PANTHER:PTN000145832

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10625
PANTHER:PTN000145832

F

Seeded From UniProt

complete

part_of

GO:0032300

mismatch repair complex

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10625
PANTHER:PTN002260779

C

Seeded From UniProt

complete

contributes_to

GO:0032143

single thymine insertion binding

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002260779
UniProtKB:P43246
UniProtKB:P52701

F

Seeded From UniProt

complete

contributes_to

GO:0032137

guanine/thymine mispair binding

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:101816
MGI:MGI:1343961
PANTHER:PTN002260779
SGD:S000001162
SGD:S000002504
SGD:S000005450
UniProtKB:P43246
UniProtKB:P52701

F

Seeded From UniProt

complete

enables

GO:0032136

adenine/cytosine mispair binding

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10625
PANTHER:PTN000145832

F

Seeded From UniProt

complete

enables

GO:0008301

DNA binding, bending

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10625
PANTHER:PTN000145832

F

Seeded From UniProt

complete

enables

GO:0008094

DNA-dependent ATPase activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002260779
SGD:S000001162

F

Seeded From UniProt

complete

involved_in

GO:0006298

mismatch repair

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10625
FB:FBgn0015546
MGI:MGI:101816
MGI:MGI:109519
MGI:MGI:1343961
PANTHER:PTN000145505
PomBase:SPBC19G7.01c
PomBase:SPCC285.16c
SGD:S000000688
SGD:S000001162
SGD:S000002504
SGD:S000005450
TAIR:locus:2095097
UniProtKB:P20585
UniProtKB:P43246
UniProtKB:P52701
WB:WBGene00003418
WB:WBGene00003422

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10625
PANTHER:PTN002260803

C

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10625
PANTHER:PTN002260779
SGD:S000002504
SGD:S000005450
UniProtKB:P43246
UniProtKB:P52701

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10625
PANTHER:PTN002260779
SGD:S000002504
SGD:S000005450

F

Seeded From UniProt

complete

enables

GO:0003684

damaged DNA binding

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:101816
MGI:MGI:109519
MGI:MGI:1343961
PANTHER:PTN002260779
TAIR:locus:2095097
TAIR:locus:2131829
UniProtKB:O04716

F

Seeded From UniProt

complete

involved_in

GO:0000018

regulation of DNA recombination

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10625
PANTHER:PTN000145832

P

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:21666597[3]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P23909

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:11585365[4]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P23909

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:11048711[5]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P23909

F

Seeded From UniProt

complete

enables

GO:0043531

ADP binding

PMID:11048711[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0032300

mismatch repair complex

PMID:6987663[6]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P06722
UniProtKB:P23367

C

Seeded From UniProt

complete

enables

GO:0032136

adenine/cytosine mispair binding

PMID:11237867[7]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0030983

mismatched DNA binding

PMID:3014530[8]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0030983

mismatched DNA binding

PMID:11048711[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0016887

ATPase activity

PMID:10715140[9]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0008301

DNA binding, bending

PMID:14634210[10]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

PMID:11967071[11]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006298

mismatch repair

PMID:6987663[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006298

mismatch repair

PMID:2665076[12]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006298

mismatch repair

PMID:14634210[10]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

PMID:12606120[13]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0000018

regulation of DNA recombination

PMID:2555716[14]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:3014530[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:18304323[15]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000432
InterPro:IPR005748
InterPro:IPR007695
InterPro:IPR007696
InterPro:IPR007860
InterPro:IPR007861
InterPro:IPR016151
InterPro:IPR036678

F

Seeded From UniProt

complete

involved_in

GO:0006298

mismatch repair

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000432
InterPro:IPR005748
InterPro:IPR007695
InterPro:IPR007696
InterPro:IPR007860
InterPro:IPR007861
InterPro:IPR016151
InterPro:IPR017261
InterPro:IPR036678

P

Seeded From UniProt

complete

enables

GO:0030983

mismatched DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000432
InterPro:IPR005748
InterPro:IPR007695
InterPro:IPR007696
InterPro:IPR007860
InterPro:IPR007861
InterPro:IPR016151
InterPro:IPR017261
InterPro:IPR036678

F

Seeded From UniProt

complete

enables

GO:0003684

damaged DNA binding

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000001458

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000001458

F

Seeded From UniProt

complete

involved_in

GO:0006298

mismatch repair

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000001458

P

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0234

P

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0227

P

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Hura, GL et al. (2013) DNA conformations in mismatch repair probed in solution by X-ray scattering from gold nanocrystals. Proc. Natl. Acad. Sci. U.S.A. 110 17308-13 PubMed GONUTS page
  2. 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 2.11 2.12 2.13 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  3. Jiang, Y & Marszalek, PE (2011) Atomic force microscopy captures MutS tetramers initiating DNA mismatch repair. EMBO J. 30 2881-93 PubMed GONUTS page
  4. Mansour, CA et al. (2001) Characterization of functional interactions among the Escherichia coli mismatch repair proteins using a bacterial two-hybrid assay. Mutat. Res. 485 331-8 PubMed GONUTS page
  5. 5.0 5.1 5.2 Lamers, MH et al. (2000) The crystal structure of DNA mismatch repair protein MutS binding to a G x T mismatch. Nature 407 711-7 PubMed GONUTS page
  6. 6.0 6.1 Glickman, BW & Radman, M (1980) Escherichia coli mutator mutants deficient in methylation-instructed DNA mismatch correction. Proc. Natl. Acad. Sci. U.S.A. 77 1063-7 PubMed GONUTS page
  7. Brown, J et al. (2001) Affinity of mismatch-binding protein MutS for heteroduplexes containing different mismatches. Biochem. J. 354 627-33 PubMed GONUTS page
  8. 8.0 8.1 Su, SS & Modrich, P (1986) Escherichia coli mutS-encoded protein binds to mismatched DNA base pairs. Proc. Natl. Acad. Sci. U.S.A. 83 5057-61 PubMed GONUTS page
  9. Bjornson, KP et al. (2000) Modulation of MutS ATP hydrolysis by DNA cofactors. Biochemistry 39 3176-83 PubMed GONUTS page
  10. 10.0 10.1 Wang, H et al. (2003) DNA bending and unbending by MutS govern mismatch recognition and specificity. Proc. Natl. Acad. Sci. U.S.A. 100 14822-7 PubMed GONUTS page
  11. Khil, PP & Camerini-Otero, RD (2002) Over 1000 genes are involved in the DNA damage response of Escherichia coli. Mol. Microbiol. 44 89-105 PubMed GONUTS page
  12. Lahue, RS et al. (1989) DNA mismatch correction in a defined system. Science 245 160-4 PubMed GONUTS page
  13. Junop, MS et al. (2003) In vitro and in vivo studies of MutS, MutL and MutH mutants: correlation of mismatch repair and DNA recombination. DNA Repair (Amst.) 2 387-405 PubMed GONUTS page
  14. Rayssiguier, C et al. (1989) The barrier to recombination between Escherichia coli and Salmonella typhimurium is disrupted in mismatch-repair mutants. Nature 342 396-401 PubMed GONUTS page
  15. Ishihama, Y et al. (2008) Protein abundance profiling of the Escherichia coli cytosol. BMC Genomics 9 102 PubMed GONUTS page