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ECOLI:MUTS
Contents
Species (Taxon ID) | Escherichia coli (strain K12). (83333) | |
Gene Name(s) | mutS (synonyms: fdv) | |
Protein Name(s) | DNA mismatch repair protein MutS | |
External Links | ||
UniProt | P23909 | |
EMBL | M64730 U29579 U00096 AP009048 AF004287 AF001987 AF001988 AF001989 AF001990 AF001991 AF001992 AF001993 AF001994 AF001995 AF001996 AF001997 AF001998 AF001999 AF002000 AF002001 AF002002 AF002003 AF002004 AF002005 AF002006 AF002007 AF002008 AF002009 AF002010 | |
PIR | I54964 | |
RefSeq | NP_417213.1 YP_490942.1 | |
PDB | 1E3M 1NG9 1OH5 1OH6 1OH7 1OH8 1W7A 1WB9 1WBB 1WBD 2OK2 2WTU 3K0S 3ZLJ | |
PDBsum | 1E3M 1NG9 1OH5 1OH6 1OH7 1OH8 1W7A 1WB9 1WBB 1WBD 2OK2 2WTU 3K0S 3ZLJ | |
ProteinModelPortal | P23909 | |
SMR | P23909 | |
DIP | DIP-10287N | |
IntAct | P23909 | |
MINT | MINT-1264156 | |
STRING | 511145.b2733 | |
SWISS-2DPAGE | P23909 | |
PaxDb | P23909 | |
PRIDE | P23909 | |
EnsemblBacteria | AAC75775 BAE76810 | |
GeneID | 12932427 947206 | |
KEGG | ecj:Y75_p2671 eco:b2733 | |
PATRIC | 32120868 | |
EchoBASE | EB0620 | |
EcoGene | EG10625 | |
eggNOG | COG0249 | |
HOGENOM | HOG000221407 | |
InParanoid | P23909 | |
KO | K03555 | |
OMA | GFGAHSL | |
OrthoDB | EOG6Q5NPV | |
PhylomeDB | P23909 | |
BioCyc | EcoCyc:EG10625-MONOMER ECOL316407:JW2703-MONOMER MetaCyc:EG10625-MONOMER | |
EvolutionaryTrace | P23909 | |
PRO | PR:P23909 | |
Proteomes | UP000000318 UP000000625 | |
Genevestigator | P23909 | |
GO | GO:0005829 GO:0032300 GO:0032136 GO:0043531 GO:0005524 GO:0016887 GO:0003684 GO:0008301 GO:0008094 GO:0042802 GO:0030983 GO:0006200 GO:0006974 GO:0006298 GO:0000018 | |
Gene3D | 3.30.420.110 3.40.1170.10 3.40.50.300 | |
HAMAP | MF_00096 | |
InterPro | IPR005748 IPR007695 IPR000432 IPR007861 IPR007696 IPR016151 IPR007860 IPR027417 | |
Pfam | PF01624 PF05188 PF05192 PF05190 PF00488 | |
SMART | SM00534 SM00533 | |
SUPFAM | SSF48334 SSF52540 SSF53150 SSF55271 | |
TIGRFAMs | TIGR01070 | |
PROSITE | PS00486 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
GO:0008301 |
DNA binding, bending |
ECO:0000317 |
F |
Figure 2 |
Missing: with/from | |||||
enables |
GO:0043531 |
ADP binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG10625 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0042802 |
identical protein binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG10625 |
F |
Seeded From UniProt |
complete | ||
part_of |
GO:0032300 |
mismatch repair complex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG10625 |
C |
Seeded From UniProt |
complete | ||
contributes_to |
GO:0032143 |
single thymine insertion binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002260779 |
F |
Seeded From UniProt |
complete | ||
contributes_to |
GO:0032137 |
guanine/thymine mispair binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:101816 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0032136 |
adenine/cytosine mispair binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG10625 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0008301 |
DNA binding, bending |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG10625 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0008094 |
DNA-dependent ATPase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002260779 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006298 |
mismatch repair |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG10625 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005829 |
cytosol |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG10625 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0005524 |
ATP binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG10625 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0005524 |
ATP binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG10625 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0003684 |
damaged DNA binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:101816 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0000018 |
regulation of DNA recombination |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG10625 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0043531 |
ADP binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0032300 |
mismatch repair complex |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0032136 |
adenine/cytosine mispair binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0030983 |
mismatched DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0030983 |
mismatched DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0016887 |
ATPase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0008301 |
DNA binding, bending |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006974 |
cellular response to DNA damage stimulus |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006298 |
mismatch repair |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006298 |
mismatch repair |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006298 |
mismatch repair |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0005524 |
ATP binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0000018 |
regulation of DNA recombination |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0005524 |
ATP binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR000432 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006298 |
mismatch repair |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR000432 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0030983 |
mismatched DNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR000432 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0003684 |
damaged DNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000001458 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0005524 |
ATP binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000001458 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006298 |
mismatch repair |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000001458 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006281 |
DNA repair |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006974 |
cellular response to DNA damage stimulus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0003677 |
DNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Hura, GL et al. (2013) DNA conformations in mismatch repair probed in solution by X-ray scattering from gold nanocrystals. Proc. Natl. Acad. Sci. U.S.A. 110 17308-13 PubMed GONUTS page
- ↑ 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 2.11 2.12 2.13 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Jiang, Y & Marszalek, PE (2011) Atomic force microscopy captures MutS tetramers initiating DNA mismatch repair. EMBO J. 30 2881-93 PubMed GONUTS page
- ↑ Mansour, CA et al. (2001) Characterization of functional interactions among the Escherichia coli mismatch repair proteins using a bacterial two-hybrid assay. Mutat. Res. 485 331-8 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Lamers, MH et al. (2000) The crystal structure of DNA mismatch repair protein MutS binding to a G x T mismatch. Nature 407 711-7 PubMed GONUTS page
- ↑ 6.0 6.1 Glickman, BW & Radman, M (1980) Escherichia coli mutator mutants deficient in methylation-instructed DNA mismatch correction. Proc. Natl. Acad. Sci. U.S.A. 77 1063-7 PubMed GONUTS page
- ↑ Brown, J et al. (2001) Affinity of mismatch-binding protein MutS for heteroduplexes containing different mismatches. Biochem. J. 354 627-33 PubMed GONUTS page
- ↑ 8.0 8.1 Su, SS & Modrich, P (1986) Escherichia coli mutS-encoded protein binds to mismatched DNA base pairs. Proc. Natl. Acad. Sci. U.S.A. 83 5057-61 PubMed GONUTS page
- ↑ Bjornson, KP et al. (2000) Modulation of MutS ATP hydrolysis by DNA cofactors. Biochemistry 39 3176-83 PubMed GONUTS page
- ↑ 10.0 10.1 Wang, H et al. (2003) DNA bending and unbending by MutS govern mismatch recognition and specificity. Proc. Natl. Acad. Sci. U.S.A. 100 14822-7 PubMed GONUTS page
- ↑ Khil, PP & Camerini-Otero, RD (2002) Over 1000 genes are involved in the DNA damage response of Escherichia coli. Mol. Microbiol. 44 89-105 PubMed GONUTS page
- ↑ Lahue, RS et al. (1989) DNA mismatch correction in a defined system. Science 245 160-4 PubMed GONUTS page
- ↑ Junop, MS et al. (2003) In vitro and in vivo studies of MutS, MutL and MutH mutants: correlation of mismatch repair and DNA recombination. DNA Repair (Amst.) 2 387-405 PubMed GONUTS page
- ↑ Rayssiguier, C et al. (1989) The barrier to recombination between Escherichia coli and Salmonella typhimurium is disrupted in mismatch-repair mutants. Nature 342 396-401 PubMed GONUTS page
- ↑ Ishihama, Y et al. (2008) Protein abundance profiling of the Escherichia coli cytosol. BMC Genomics 9 102 PubMed GONUTS page
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