ECOLI:LRP

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Species (Taxon ID)	Escherichia coli (strain K12). (taxon:83333)
Gene Name(s)	lrp ( synonyms: alsB, ihb, livR, oppI )
Protein Name(s)	Leucine-responsive regulatory protein
External Links
UniProt Identifier	LRP_ECOLI
UniProt Accessions	P0ACJ0, P19494,
EMBL	M35869, D11105, U00096, AP009048,
PIR	JH0412,
RefSeq	AP_001519.1, NP_415409.1,
PDB	2GQQ,
IntAct	P0ACJ0,
Pfam	PF01037,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR019885	F
	GO:0043201	response to leucine	PMID:12054800^[1]	IMP: Inferred from Mutant Phenotype		P
	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR019887	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR019888	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000485	F
	GO:0006350	transcription	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0804	P
	GO:0006351	transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR019887	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000485	P
	GO:0006351	transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR019885	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR019885	P
	GO:0006355	regulation of transcription, DNA-dependent	PMID:12374860^[2]	IMP: Inferred from Mutant Phenotype		P
	GO:0043565	sequence-specific DNA binding	PMID:10551881^[3]	IDA: Inferred from Direct Assay		F
	GO:0005622	intracellular	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR019885	C
	GO:0045449	regulation of transcription	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0805	P
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR019885	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR019887	F
	GO:0006351	transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000485	P
	GO:0005515	protein binding	PMID:16606699^[4]	IPI: Inferred from Physical Interaction	UniProtKB:P0A744	F
	GO:0006351	transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR019888	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR019887	P
	GO:0005622	intracellular	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000485	C
	GO:0003677	DNA binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0238	F
	GO:0005622	intracellular	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR019888	C
	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR019888	F
	GO:0005622	intracellular	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR019887	C
	GO:0043201	response to leucine	PMID:1346534^[5]	IMP: Inferred from Mutant Phenotype		P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR019888	P
	GO:0010467	gene expression	PMID:8955316^[6]	EXP: Inferred from Experiment		P	Figure 1B indicates that the induction of of lrp expression in cells entering the stationary phase, grown in a rich medium, is not dependent on the stationary phase sigma factor encoded by rpoS	complete
	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000485	F
	GO:0010467	gene expression	PMID:8955316^[6]	EXP: Inferred from Experiment		P	Table 2 illustrates that Lrp does not play any role in the stationary phase induction of the lrp gene.	complete
	GO:0003677	DNA binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0238	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000485	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR019885	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR019887	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR019888	F
	GO:0005515	protein binding	PMID:16606699^[4]	IPI: Inferred from Physical Interaction	UniProtKB:P0A744	F
	GO:0005622	intracellular	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000485	C
	GO:0005622	intracellular	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR019885	C
	GO:0005622	intracellular	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR019887	C
	GO:0005622	intracellular	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR019888	C
	GO:0006351	transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0804	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000485	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR019885	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR019887	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR019888	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0805	P
	GO:0006355	regulation of transcription, DNA-dependent	PMID:12374860^[2]	IMP: Inferred from Mutant Phenotype		P
	GO:0043201	response to leucine	PMID:12054800^[1]	IMP: Inferred from Mutant Phenotype		P
	GO:0043201	response to leucine	PMID:1346534^[5]	IMP: Inferred from Mutant Phenotype		P
	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000485	F
	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR019885	F
	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR019887	F
	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR019888	F
	GO:0043565	sequence-specific DNA binding	PMID:10551881^[3]	IDA: Inferred from Direct Assay		F
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Chen S & Calvo JM (2002) Leucine-induced dissociation of Escherichia coli Lrp hexadecamers to octamers. J Mol Biol 318: 1031-42 PubMed GONUTS page
↑ ^2.0 ^2.1 Tani TH et al. (2002) Adaptation to famine: a family of stationary-phase genes revealed by microarray analysis. Proc Natl Acad Sci U S A 99: 13471-6 PubMed GONUTS page
↑ ^3.0 ^3.1 Azam TA & Ishihama A (1999) Twelve species of the nucleoid-associated protein from Escherichia coli. Sequence recognition specificity and DNA binding affinity. J Biol Chem 274: 33105-13 PubMed GONUTS page
↑ ^4.0 ^4.1 Arifuzzaman M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res 16: 686-91 PubMed GONUTS page
↑ ^5.0 ^5.1 Ernsting BR et al. (1992) Characterization of the regulon controlled by the leucine-responsive regulatory protein in Escherichia coli. J Bacteriol 174: 1109-18 PubMed GONUTS page
↑ ^6.0 ^6.1 Landgraf JR et al. (1996) Effects of nutrition and growth rate on Lrp levels in Escherichia coli. J Bacteriol 178: 6930-6 PubMed GONUTS page

[PMID:12054800-0] 1.0 ^1.1 Chen S & Calvo JM (2002) Leucine-induced dissociation of Escherichia coli Lrp hexadecamers to octamers. J Mol Biol 318: 1031-42 PubMed GONUTS page

[PMID:12374860-1] 2.0 ^2.1 Tani TH et al. (2002) Adaptation to famine: a family of stationary-phase genes revealed by microarray analysis. Proc Natl Acad Sci U S A 99: 13471-6 PubMed GONUTS page

[PMID:10551881-2] 3.0 ^3.1 Azam TA & Ishihama A (1999) Twelve species of the nucleoid-associated protein from Escherichia coli. Sequence recognition specificity and DNA binding affinity. J Biol Chem 274: 33105-13 PubMed GONUTS page

[PMID:16606699-3] 4.0 ^4.1 Arifuzzaman M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res 16: 686-91 PubMed GONUTS page

[PMID:1346534-4] 5.0 ^5.1 Ernsting BR et al. (1992) Characterization of the regulon controlled by the leucine-responsive regulatory protein in Escherichia coli. J Bacteriol 174: 1109-18 PubMed GONUTS page

[PMID:8955316-5] 6.0 ^6.1 Landgraf JR et al. (1996) Effects of nutrition and growth rate on Lrp levels in Escherichia coli. J Bacteriol 178: 6930-6 PubMed GONUTS page

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ECOLI:LRP

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