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ECOLI:ISCA
Contents |
| Species (Taxon ID) | Escherichia coli (strain K12). ([1]) | |
| Gene Name(s) | iscA (synonyms: yfhF) | |
| Protein Name(s) | Iron-binding protein iscA
Iron-sulfur cluster assembly protein | |
| External Links | ||
| EMBL | U01827 U00096 AP009048 | |
| PIR | G65029 | |
| RefSeq | NP_417023.1 | |
| PDB | 1R94 1R95 1S98 | |
| PDBsum | 1R94 1R95 1S98 | |
| ProteinModelPortal | P0AAC8 | |
| SMR | P0AAC8 | |
| DIP | DIP-35854N | |
| IntAct | P0AAC8 | |
| EnsemblBacteria | EBESCT00000000088 EBESCT00000015130 | |
| GeneID | 946999 | |
| GenomeReviews | AP009048_GR U00096_GR | |
| KEGG | ecj:JW2512 eco:b2528 | |
| EchoBASE | EB2053 | |
| EcoGene | EG12132 | |
| eggNOG | COG0316 | |
| GeneTree | EBGT00050000009093 | |
| HOGENOM | HBG730174 | |
| OMA | NVSSECG | |
| ProtClustDB | PRK09502 | |
| BioCyc | EcoCyc:EG12132-MONOMER | |
| Genevestigator | P0AAC8 | |
| GO | GO:0051537 GO:0008198 GO:0034986 GO:0005515 GO:0005198 GO:0016226 | |
| HAMAP | MF_01429 | |
| InterPro | IPR000361 IPR016092 IPR017870 IPR011302 | |
| Gene3D | G3DSA:2.60.300.12 | |
| Pfam | PF01521 | |
| SUPFAM | SSF89360 | |
| TIGRFAMs | TIGR02011 TIGR00049 | |
| PROSITE | PS01152 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0005198 |
structural molecule activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005506 |
iron ion binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0008198 |
ferrous iron binding |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0016226 |
iron-sulfur cluster assembly |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0016226 |
iron-sulfur cluster assembly |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0016226 |
iron-sulfur cluster assembly |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0016226 |
iron-sulfur cluster assembly |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0034986 |
iron chaperone activity |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0034986 |
iron chaperone activity |
IMP: Inferred from Mutant Phenotype |
|
F |
Seeded From UniProt |
|||
| GO:0046872 |
metal ion binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0051536 |
iron-sulfur cluster binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0051536 |
iron-sulfur cluster binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0051537 |
2 iron, 2 sulfur cluster binding |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0005506 |
iron ion binding |
IMP: Inferred from Mutant Phenotype |
F |
Fig. 1 shows a decrease in iron bonding ability in the absence of IscA. |
complete | |||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Ollagnier-de-Choudens S et al. (2001) Iron-sulfur cluster assembly: characterization of IscA and evidence for a specific and functional complex with ferredoxin. J Biol Chem 276: 22604-7 PubMed GONUTS page
- ↑ Tokumoto U et al. (2002) Network of protein-protein interactions among iron-sulfur cluster assembly proteins in Escherichia coli. J Biochem 131: 713-9 PubMed GONUTS page
- ↑ 3.0 3.1 Ding H & Clark RJ (2004) Characterization of iron binding in IscA, an ancient iron-sulphur cluster assembly protein. Biochem J 379: 433-40 PubMed GONUTS page
- ↑ Takahashi Y & Nakamura M (1999) Functional assignment of the ORF2-iscS-iscU-iscA-hscB-hscA-fdx-ORF3 gene cluster involved in the assembly of Fe-S clusters in Escherichia coli. J Biochem 126: 917-26 PubMed GONUTS page
- ↑ Ding H et al. (2004) IscA mediates iron delivery for assembly of iron-sulfur clusters in IscU under the limited accessible free iron conditions. J Biol Chem 279: 37499-504 PubMed GONUTS page
- ↑ Ding H et al. (2005) Thioredoxin reductase system mediates iron binding in IscA and iron delivery for the iron-sulfur cluster assembly in IscU. J Biol Chem 280: 30432-7 PubMed GONUTS page
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