ECOLI:IDH

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Species (Taxon ID)	Escherichia coli (strain K12). (taxon:83333)
Gene Name(s)	icd ( synonyms: icdA, icdE )
Protein Name(s)	Isocitrate dehydrogenase [NADP] IDH IDP NADP(+)-specific ICDH Oxalosuccinate decarboxylase
External Links
UniProt Identifier	IDH_ECOLI
UniProt Accessions	P08200,
EMBL	J02799, U00096, AP009048, AF017587,
PIR	A28482,
RefSeq	AP_001762.1, NP_415654.1,
PDB	1AI2, 1AI3, 1BL5, 1CW1, 1CW4, 1CW7, 1GRO, 1GRP, 1HJ6, 1IDC, 1IDD, 1IDE, 1IDF, 1IKA, 1ISO, 1P8F, 1PB1, 1PB3, 1SJS, 3ICD, 3LCB, 4ICD, 5ICD, 6ICD, 7ICD, 8ICD, 9ICD,
Pfam	PF00180,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0000287	magnesium ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001804	F
	GO:0000287	magnesium ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR019818	F
	GO:0004450	isocitrate dehydrogenase (NADP+) activity	PMID:3112144^[1]	IDA: Inferred from Direct Assay		F	Table 1	complete
	GO:0004450	isocitrate dehydrogenase (NADP+) activity	GO_REF:0000003	IEA: Inferred from Electronic Annotation	EC:1.1.1.42	F
	GO:0006097	glyoxylate cycle	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0329	P
	GO:0006099	tricarboxylic acid cycle	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR004439	P
	GO:0006099	tricarboxylic acid cycle	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0816	P
	GO:0006099	tricarboxylic acid cycle	PMID:13152052^[2]	IDA: Inferred from Direct Assay		P
	GO:0016491	oxidoreductase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0560	F
	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001804	F
	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR019818	F
	GO:0022900	electron transport chain	PMID:15221231^[3]	IMP: Inferred from Mutant Phenotype		P
	GO:0046872	metal ion binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0479	F
	GO:0051287	NAD binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001804	F
	GO:0051287	NAD binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR019818	F
	GO:0055114	oxidation-reduction process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001804	P
	GO:0055114	oxidation-reduction process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR004439	P
	GO:0055114	oxidation-reduction process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR019818	P
	GO:0055114	oxidation-reduction process	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0560	P
	GO:0000287	magnesium ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001804	F
	GO:0000287	magnesium ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR019818	F
	GO:0004450	isocitrate dehydrogenase (NADP+) activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR004439	F
	GO:0004450	isocitrate dehydrogenase (NADP+) activity	GO_REF:0000003	IEA: Inferred from Electronic Annotation	EC:1.1.1.42	F
	GO:0006097	glyoxylate cycle	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0329	P
	GO:0006099	tricarboxylic acid cycle	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR004439	P
	GO:0006099	tricarboxylic acid cycle	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0816	P
	GO:0006099	tricarboxylic acid cycle	PMID:13152052^[2]	IDA: Inferred from Direct Assay		P
	GO:0016491	oxidoreductase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0560	F
	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001804	F
	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR019818	F
	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR024084	F
	GO:0022900	electron transport chain	PMID:15221231^[3]	IMP: Inferred from Mutant Phenotype		P
	GO:0022900	electron transport chain	PMID:776950^[4]	IMP: Inferred from Mutant Phenotype		P
	GO:0046872	metal ion binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0479	F
	GO:0051287	NAD binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001804	F
	GO:0051287	NAD binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR019818	F
	GO:0055114	oxidation-reduction process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001804	P
	GO:0055114	oxidation-reduction process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR004439	P
	GO:0055114	oxidation-reduction process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR019818	P
	GO:0055114	oxidation-reduction process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR024084	P
	GO:0055114	oxidation-reduction process	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0560	P
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Thorsness PE & Koshland DE Jr (1987) Inactivation of isocitrate dehydrogenase by phosphorylation is mediated by the negative charge of the phosphate. J Biol Chem 262: 10422-5 PubMed GONUTS page
↑ ^2.0 ^2.1 SWIM HE & KRAMPITZ LO (1954) Acetic acid oxidation by Escherichia coli; evidence for the occurrence of a tricarboxylic acid cycle. J Bacteriol 67: 419-25 PubMed GONUTS page
↑ ^3.0 ^3.1 Kabir MM & Shimizu K (2004) Metabolic regulation analysis of icd-gene knockout Escherichia coli based on 2D electrophoresis with MALDI-TOF mass spectrometry and enzyme activity measurements. Appl Microbiol Biotechnol 65: 84-96 PubMed GONUTS page
↑ Lakshmi TM & Helling RB (1976) Selection for citrate synthase deficiency in icd mutants of Escherichia coli. J Bacteriol 127: 76-83 PubMed GONUTS page

[PMID:3112144-0] Thorsness PE & Koshland DE Jr (1987) Inactivation of isocitrate dehydrogenase by phosphorylation is mediated by the negative charge of the phosphate. J Biol Chem 262: 10422-5 PubMed GONUTS page

[PMID:13152052-1] 2.0 ^2.1 SWIM HE & KRAMPITZ LO (1954) Acetic acid oxidation by Escherichia coli; evidence for the occurrence of a tricarboxylic acid cycle. J Bacteriol 67: 419-25 PubMed GONUTS page

[PMID:15221231-2] 3.0 ^3.1 Kabir MM & Shimizu K (2004) Metabolic regulation analysis of icd-gene knockout Escherichia coli based on 2D electrophoresis with MALDI-TOF mass spectrometry and enzyme activity measurements. Appl Microbiol Biotechnol 65: 84-96 PubMed GONUTS page

[PMID:776950-3] Lakshmi TM & Helling RB (1976) Selection for citrate synthase deficiency in icd mutants of Escherichia coli. J Bacteriol 127: 76-83 PubMed GONUTS page

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ECOLI:IDH

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