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ECOLI:HNS

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Contents

Species (Taxon ID) Escherichia coli (strain K12). (taxon:83333)
Gene Name(s) hns ( synonyms: bglY, cur, drdX, hnsA, msyA, osmZ, pilG, topS )
Protein Name(s)
  • DNA-binding protein H-NS
  • Histone-like protein HLP-II
  • Protein B1
  • Protein H1
External Links
UniProt Identifier HNS_ECOLI
UniProt Accessions P0ACF8, P08936,
EMBL X07688, X59940, X57231, X67326, U00096, AP009048,
PIR S00903,
RefSeq AP_001863.1, NP_415753.1,
PDB 1HNR, 1HNS, 1LR1, 1NI8,
Pfam PF00816,

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0003677

DNA binding

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0238

F

GO:0005622

intracellular

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001801

C

GO:0006355

regulation of transcription, DNA-dependent

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001801

P

GO:0003681

bent DNA binding

PMID:10551881[1]

IDA: Inferred from Direct Assay

F

GO:0045449

regulation of transcription

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0805

P

GO:0003677

DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001801

F

GO:0016020

membrane

PMID:16858726[2]

IDA: Inferred from Direct Assay

C

GO:0006350

transcription

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0804

P

GO:0016481

negative regulation of transcription

PMID:16385041[3]

IDA: Inferred from Direct Assay

P

See Fig 3. The preferential binding to the Py region shows that H-NS down-regulates transcription from Py

complete

GO:0045943

positive regulation of transcription from RNA polymerase I promoter

PMID:10801345[4]

IDA: Inferred from Direct Assay

P

See Fig 5

complete

GO:0016072

negative regulation of rRNA processing

PMID:9632265[5]

IMP: Inferred from Mutant Phenotype

P

see Fig 1 and Fig 2

complete

GO:0003677

DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001801

F

GO:0003677

DNA binding

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0238

F

GO:0005622

intracellular

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001801

C

GO:0006351

transcription, DNA-dependent

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0804

P

GO:0006355

regulation of transcription, DNA-dependent

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001801

P

GO:0006355

regulation of transcription, DNA-dependent

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0805

P

GO:0016020

membrane

PMID:16858726[2]

IDA: Inferred from Direct Assay

C


Notes

References

See Help:References for how to manage references in GONUTS.

  1. Azam TA & Ishihama A (1999) Twelve species of the nucleoid-associated protein from Escherichia coli. Sequence recognition specificity and DNA binding affinity. J Biol Chem 274: 33105-13 PubMed GONUTS page
  2. 2.0 2.1 Lasserre JP et al. (2006) A complexomic study of Escherichia coli using two-dimensional blue native/SDS polyacrylamide gel electrophoresis. Electrophoresis 27: 3306-21 PubMed GONUTS page
  3. Will WR & Frost LS (2006) Characterization of the opposing roles of H-NS and TraJ in transcriptional regulation of the F-plasmid tra operon. J Bacteriol 188: 507-14 PubMed GONUTS page
  4. Schröder O & Wagner R (2000) The bacterial DNA-binding protein H-NS represses ribosomal RNA transcription by trapping RNA polymerase in the initiation complex. J Mol Biol 298: 737-48 PubMed GONUTS page
  5. Afflerbach H et al. (1998) Effects of the Escherichia coli DNA-binding protein H-NS on rRNA synthesis in vivo. Mol Microbiol 28: 641-53 PubMed GONUTS page
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