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ECOLI:HIPA
Contents |
| Species (Taxon ID) | Escherichia coli (strain K12). (taxon:83333) | |
| Gene Name(s) | hipA | |
| Protein Name(s) |
| |
| External Links | ||
| UniProt Identifier | HIPA_ECOLI | |
| UniProt Accessions | P23874, P76139, P76880, P77507, | |
| EMBL | M61242, U00096, AP009048, | |
| PIR | F64904, | |
| RefSeq | AP_002129.1, NP_416024.1, | |
| PDB | 2WIU, 3DNT, 3DNU, 3DNV, 3FBR, 3HZI, | |
| IntAct | P23874, | |
| Pfam | PF07804, PF07805, | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000287 |
magnesium ion binding |
IDA: Inferred from Direct Assay |
|
F |
||||
| GO:0004674 |
protein serine/threonine kinase activity |
IDA: Inferred from Direct Assay |
|
F |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
|||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
|||||
| GO:0005524 |
ATP binding |
IDA: Inferred from Direct Assay |
|
F |
||||
| GO:0022611 |
dormancy process |
IDA: Inferred from Direct Assay |
|
P |
||||
| GO:0016301 |
kinase activity |
IDA: Inferred from Direct Assay |
F |
Figure 1 shows the structure of the hipA protein, including its binding domains. Figure 1d shows the hipA kinase assay using EF-Tu as a substrate (immunoblot). |
complete | |||
| GO:0000166 |
nucleotide binding |
IEA: Inferred from Electronic Annotation |
F |
|||||
| GO:0000287 |
magnesium ion binding |
IDA: Inferred from Direct Assay |
F |
|||||
| GO:0004674 |
protein serine/threonine kinase activity |
IEA: Inferred from Electronic Annotation |
F |
|||||
| GO:0004674 |
protein serine/threonine kinase activity |
IDA: Inferred from Direct Assay |
F |
|||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
|||||
| GO:0005524 |
ATP binding |
IEA: Inferred from Electronic Annotation |
F |
|||||
| GO:0005524 |
ATP binding |
IDA: Inferred from Direct Assay |
F |
|||||
| GO:0016301 |
kinase activity |
IEA: Inferred from Electronic Annotation |
F |
|||||
| GO:0016310 |
phosphorylation |
IEA: Inferred from Electronic Annotation |
P |
|||||
| GO:0016740 |
transferase activity |
IEA: Inferred from Electronic Annotation |
F |
|||||
| GO:0022611 |
dormancy process |
IDA: Inferred from Direct Assay |
P |
|||||
| GO:0046872 |
metal ion binding |
IEA: Inferred from Electronic Annotation |
F |
| ||||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 Schumacher MA et al. (2009) Molecular mechanisms of HipA-mediated multidrug tolerance and its neutralization by HipB. Science 323: 396-401 PubMed GONUTS page
- ↑ 2.0 2.1 Correia FF et al. (2006) Kinase activity of overexpressed HipA is required for growth arrest and multidrug tolerance in Escherichia coli. J Bacteriol 188: 8360-7 PubMed GONUTS page
- ↑ 3.0 3.1 Butland G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433: 531-7 PubMed GONUTS page
- ↑ Black DS et al. (1994) Autoregulation of hip, an operon that affects lethality due to inhibition of peptidoglycan or DNA synthesis. J Bacteriol 176: 4081-91 PubMed GONUTS page
- ↑ 5.0 5.1 Korch SB & Hill TM (2006) Ectopic overexpression of wild-type and mutant hipA genes in Escherichia coli: effects on macromolecular synthesis and persister formation. J Bacteriol 188: 3826-36 PubMed GONUTS page
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