ECOLI:FPG

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Species (Taxon ID)	Escherichia coli (strain K12). (taxon:83333)
Gene Name(s)	mutM ( synonyms: fpg )
Protein Name(s)	Formamidopyrimidine-DNA glycosylase Fapy-DNA glycosylase DNA-(apurinic or apyrimidinic site) lyase mutM AP lyase mutM
External Links
UniProt Identifier	FPG_ECOLI
UniProt Accessions	P05523, Q2M7U9,
EMBL	M86305, X06036, L10328, U00039, U00096, AP009048, M60670,
PIR	A30254,
RefSeq	AP_004156.1, NP_418092.1,
PDB	1K82,
Pfam	PF01149, PF06831, PF06827,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect
	GO:0003676	nucleic acid binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR010979	F
	GO:0003677	DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR015887	F
	GO:0003677	DNA binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0238	F
	GO:0003684	damaged DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012319	F
	GO:0003684	damaged DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR015886	F
	GO:0003684	damaged DNA binding	PMID:10862773^[1]	IDA: Inferred from Direct Assay		F
	GO:0003824	catalytic activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR010663	F
	GO:0003824	catalytic activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0511	F
	GO:0003906	DNA-(apurinic or apyrimidinic site) lyase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000191	F
	GO:0003906	DNA-(apurinic or apyrimidinic site) lyase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000214	F
	GO:0003906	DNA-(apurinic or apyrimidinic site) lyase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012319	F
	GO:0003906	DNA-(apurinic or apyrimidinic site) lyase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR015886	F
	GO:0003906	DNA-(apurinic or apyrimidinic site) lyase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR015887	F
	GO:0003906	DNA-(apurinic or apyrimidinic site) lyase activity	GO_REF:0000003	IEA: Inferred from Electronic Annotation	EC:4.2.99.18	F
	GO:0003906	DNA-(apurinic or apyrimidinic site) lyase activity	PMID:1731864^[2]	IDA: Inferred from Direct Assay		F
	GO:0003906	DNA-(apurinic or apyrimidinic site) lyase activity	PMID:8473347^[3]	IDA: Inferred from Direct Assay		F
	GO:0004519	endonuclease activity	PMID:1649454^[4]	EXP: Inferred from Experiment		F
	GO:0004519	endonuclease activity	PMID:1731864^[2]	IDA: Inferred from Direct Assay		F
	GO:0004519	endonuclease activity	PMID:2664776^[5]	IDA: Inferred from Direct Assay		F
	GO:0004519	endonuclease activity	PMID:8473347^[3]	IDA: Inferred from Direct Assay		F
	GO:0006281	DNA repair	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000191	P
	GO:0006281	DNA repair	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000214	P
	GO:0006281	DNA repair	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR015887	P
	GO:0006281	DNA repair	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR020629	P
	GO:0006281	DNA repair	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0234	P
	GO:0006284	base-excision repair	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012319	P
	GO:0006289	nucleotide-excision repair	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR015886	P
	GO:0006974	response to DNA damage stimulus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0227	P
	GO:0006974	response to DNA damage stimulus	PMID:1731864^[2]	IDA: Inferred from Direct Assay		P
	GO:0008152	metabolic process	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0326	P
	GO:0008152	metabolic process	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0511	P
	GO:0008270	zinc ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000191	F
	GO:0008270	zinc ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000214	F
	GO:0008270	zinc ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012319	F
	GO:0008270	zinc ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR015886	F
	GO:0008270	zinc ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR015887	F
	GO:0008270	zinc ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR020629	F
	GO:0008270	zinc ion binding	PMID:8473347^[3]	IDA: Inferred from Direct Assay		F
	GO:0008534	oxidized purine base lesion DNA N-glycosylase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000191	F
	GO:0008534	oxidized purine base lesion DNA N-glycosylase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR020629	F
	GO:0008534	oxidized purine base lesion DNA N-glycosylase activity	GO_REF:0000003	IEA: Inferred from Electronic Annotation	EC:3.2.2.23	F
	GO:0016787	hydrolase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0378	F
	GO:0016798	hydrolase activity, acting on glycosyl bonds	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0326	F
	GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000214	F
	GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012319	F
	GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR015886	F
	GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR015887	F
	GO:0016829	lyase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0456	F
	GO:0019104	DNA N-glycosylase activity	PMID:10862773^[1]	IDA: Inferred from Direct Assay		F
	GO:0019104	DNA N-glycosylase activity	PMID:1649454^[4]	EXP: Inferred from Experiment		F
	GO:0019104	DNA N-glycosylase activity	PMID:2664776^[5]	IDA: Inferred from Direct Assay		F
	GO:0019104	DNA N-glycosylase activity	PMID:8473347^[3]	IDA: Inferred from Direct Assay		F
	GO:0046872	metal ion binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0479	F
	GO:0046872	metal ion binding	PMID:8473347^[3]	IDA: Inferred from Direct Assay		F
	GO:0003676	nucleic acid binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR010979	F
	GO:0003677	DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR015887	F
	GO:0003677	DNA binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0238	F
	GO:0003684	damaged DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012319	F
	GO:0003684	damaged DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR015886	F
	GO:0003684	damaged DNA binding	PMID:10862773^[1]	IDA: Inferred from Direct Assay		F
	GO:0003824	catalytic activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR010663	F
	GO:0003824	catalytic activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0511	F
	GO:0003906	DNA-(apurinic or apyrimidinic site) lyase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000191	F
	GO:0003906	DNA-(apurinic or apyrimidinic site) lyase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000214	F
	GO:0003906	DNA-(apurinic or apyrimidinic site) lyase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012319	F
	GO:0003906	DNA-(apurinic or apyrimidinic site) lyase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR015886	F
	GO:0003906	DNA-(apurinic or apyrimidinic site) lyase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR015887	F
	GO:0003906	DNA-(apurinic or apyrimidinic site) lyase activity	GO_REF:0000003	IEA: Inferred from Electronic Annotation	EC:4.2.99.18	F
	GO:0003906	DNA-(apurinic or apyrimidinic site) lyase activity	PMID:1731864^[2]	IDA: Inferred from Direct Assay		F
	GO:0003906	DNA-(apurinic or apyrimidinic site) lyase activity	PMID:8473347^[3]	IDA: Inferred from Direct Assay		F
	GO:0004519	endonuclease activity	PMID:1649454^[4]	EXP: Inferred from Experiment		F
	GO:0004519	endonuclease activity	PMID:1731864^[2]	IDA: Inferred from Direct Assay		F
	GO:0004519	endonuclease activity	PMID:2664776^[5]	IDA: Inferred from Direct Assay		F
	GO:0004519	endonuclease activity	PMID:8473347^[3]	IDA: Inferred from Direct Assay		F
	GO:0006281	DNA repair	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000191	P
	GO:0006281	DNA repair	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000214	P
	GO:0006281	DNA repair	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR015887	P
	GO:0006281	DNA repair	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR020629	P
	GO:0006281	DNA repair	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0234	P
	GO:0006284	base-excision repair	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012319	P
	GO:0006289	nucleotide-excision repair	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR015886	P
	GO:0006974	response to DNA damage stimulus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0227	P
	GO:0006974	response to DNA damage stimulus	PMID:1731864^[2]	IDA: Inferred from Direct Assay		P
	GO:0008152	metabolic process	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0326	P
	GO:0008152	metabolic process	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0511	P
	GO:0008270	zinc ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000191	F
	GO:0008270	zinc ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000214	F
	GO:0008270	zinc ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012319	F
	GO:0008270	zinc ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR015886	F
	GO:0008270	zinc ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR015887	F
	GO:0008270	zinc ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR020629	F
	GO:0008270	zinc ion binding	PMID:8473347^[3]	IDA: Inferred from Direct Assay		F
	GO:0008534	oxidized purine base lesion DNA N-glycosylase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000191	F
	GO:0008534	oxidized purine base lesion DNA N-glycosylase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR020629	F
	GO:0008534	oxidized purine base lesion DNA N-glycosylase activity	GO_REF:0000003	IEA: Inferred from Electronic Annotation	EC:3.2.2.23	F
	GO:0016787	hydrolase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0378	F
	GO:0016798	hydrolase activity, acting on glycosyl bonds	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0326	F
	GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000214	F
	GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012319	F
	GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR015886	F
	GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR015887	F
	GO:0016829	lyase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0456	F
	GO:0019104	DNA N-glycosylase activity	PMID:10862773^[1]	IDA: Inferred from Direct Assay		F
	GO:0019104	DNA N-glycosylase activity	PMID:1649454^[4]	EXP: Inferred from Experiment		F
	GO:0019104	DNA N-glycosylase activity	PMID:2664776^[5]	IDA: Inferred from Direct Assay		F
	GO:0019104	DNA N-glycosylase activity	PMID:8473347^[3]	IDA: Inferred from Direct Assay		F
	GO:0046872	metal ion binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0479	F
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Hazra TK et al. (2000) Characterization of a novel 8-oxoguanine-DNA glycosylase activity in Escherichia coli and identification of the enzyme as endonuclease VIII. J Biol Chem 275: 27762-7 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Boiteux S et al. (1992) Substrate specificity of the Escherichia coli Fpg protein (formamidopyrimidine-DNA glycosylase): excision of purine lesions in DNA produced by ionizing radiation or photosensitization. Biochemistry 31: 106-10 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 ^3.8 O'Connor TR et al. (1993) Fpg protein of Escherichia coli is a zinc finger protein whose cysteine residues have a structural and/or functional role. J Biol Chem 268: 9063-70 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Michaels ML et al. (1991) MutM, a protein that prevents G.C----T.A transversions, is formamidopyrimidine-DNA glycosylase. Nucleic Acids Res 19: 3629-32 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 O'Connor TR & Laval J (1989) Physical association of the 2,6-diamino-4-hydroxy-5N-formamidopyrimidine-DNA glycosylase of Escherichia coli and an activity nicking DNA at apurinic/apyrimidinic sites. Proc Natl Acad Sci U S A 86: 5222-6 PubMed GONUTS page

[PMID:10862773-0] 1.0 ^1.1 ^1.2 ^1.3 Hazra TK et al. (2000) Characterization of a novel 8-oxoguanine-DNA glycosylase activity in Escherichia coli and identification of the enzyme as endonuclease VIII. J Biol Chem 275: 27762-7 PubMed GONUTS page

[PMID:1731864-1] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Boiteux S et al. (1992) Substrate specificity of the Escherichia coli Fpg protein (formamidopyrimidine-DNA glycosylase): excision of purine lesions in DNA produced by ionizing radiation or photosensitization. Biochemistry 31: 106-10 PubMed GONUTS page

[PMID:8473347-2] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 ^3.8 O'Connor TR et al. (1993) Fpg protein of Escherichia coli is a zinc finger protein whose cysteine residues have a structural and/or functional role. J Biol Chem 268: 9063-70 PubMed GONUTS page

[PMID:1649454-3] 4.0 ^4.1 ^4.2 ^4.3 Michaels ML et al. (1991) MutM, a protein that prevents G.C----T.A transversions, is formamidopyrimidine-DNA glycosylase. Nucleic Acids Res 19: 3629-32 PubMed GONUTS page

[PMID:2664776-4] 5.0 ^5.1 ^5.2 ^5.3 O'Connor TR & Laval J (1989) Physical association of the 2,6-diamino-4-hydroxy-5N-formamidopyrimidine-DNA glycosylase of Escherichia coli and an activity nicking DNA at apurinic/apyrimidinic sites. Proc Natl Acad Sci U S A 86: 5222-6 PubMed GONUTS page

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ECOLI:FPG

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