ECOLI:CRP

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Species (Taxon ID)	Escherichia coli (strain K12). (taxon:83333)
Gene Name(s)	crp ( synonyms: cap, csm )
Protein Name(s)	Catabolite gene activator cAMP receptor protein cAMP regulatory protein
External Links
UniProt Identifier	CRP_ECOLI
UniProt Accessions	P0ACJ8, P03020, Q2M723,
EMBL	J01598, U18997, U00096, AP009048,
PIR	A93416,
RefSeq	AP_004432.1, NP_417816.1,
PDB	1CGP, 1G6N, 1HW5, 1I5Z, 1I6X, 1J59, 1LB2, 1O3Q, 1O3R, 1O3S, 1O3T, 1RUN, 1RUO, 1ZRC, 1ZRD, 1ZRE, 1ZRF, 2CGP, 2GAP, 2GZW, 3FWE, 3HIF, 3IYD, 3KCC, 3N4M,
IntAct	P0ACJ8,
Pfam	PF00027, PF00325,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0016564	transcription repressor activity	PMID:12923087^[1]	IDA: Inferred from Direct Assay		F
	GO:0016564	transcription repressor activity	PMID:11742992^[2]	IDA: Inferred from Direct Assay		F
	GO:0045941	positive regulation of transcription	PMID:15520470^[3]	IDA: Inferred from Direct Assay		P
	GO:0006350	transcription	PMID:10760178^[4]	IDA: Inferred from Direct Assay		P
	GO:0016563	transcription activator activity	PMID:8604346^[5]	IMP: Inferred from Mutant Phenotype		F
	GO:0016481	negative regulation of transcription	PMID:15520470^[3]	IDA: Inferred from Direct Assay		P
	GO:0045941	positive regulation of transcription	PMID:8604346^[5]	IMP: Inferred from Mutant Phenotype		P
	GO:0016563	transcription activator activity	PMID:10760178^[4]	IDA: Inferred from Direct Assay		F
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR018335	F
	GO:0003677	DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012318	F
	GO:0006350	transcription	PMID:16166533^[6]	IDA: Inferred from Direct Assay		P
	GO:0016564	transcription repressor activity	PMID:15520470^[3]	IDA: Inferred from Direct Assay		F
	GO:0045449	regulation of transcription	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0805	P
	GO:0006350	transcription	PMID:12923087^[1]	IDA: Inferred from Direct Assay		P
	GO:0006350	transcription	PMID:11742992^[2]	IDA: Inferred from Direct Assay		P
	GO:0016564	transcription repressor activity	PMID:16166533^[6]	IDA: Inferred from Direct Assay		F
	GO:0016563	transcription activator activity	PMID:7551052^[7]	IDA: Inferred from Direct Assay		F
	GO:0016564	transcription repressor activity	PMID:8604346^[5]	IMP: Inferred from Mutant Phenotype		F
	GO:0016563	transcription activator activity	PMID:12923087^[1]	IDA: Inferred from Direct Assay		F
	GO:0016563	transcription activator activity	PMID:12923087^[1]	IDA: Inferred from Direct Assay		F
	GO:0016564	transcription repressor activity	PMID:8604346^[5]	IMP: Inferred from Mutant Phenotype		F
	GO:0045941	positive regulation of transcription	PMID:11742992^[2]	IDA: Inferred from Direct Assay		P
	GO:0003677	DNA binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0238	F
	GO:0016564	transcription repressor activity	PMID:12923087^[1]	IDA: Inferred from Direct Assay		F
	GO:0006350	transcription	PMID:15520470^[3]	IEP: Inferred from Expression Pattern		P
	GO:0045941	positive regulation of transcription	PMID:12923087^[1]	IDA: Inferred from Direct Assay		P
	GO:0006351	transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR018335	P
	GO:0006350	transcription	PMID:11742992^[2]	IDA: Inferred from Direct Assay		P
	GO:0016563	transcription activator activity	PMID:11742992^[2]	IDA: Inferred from Direct Assay		F
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001808	P
	GO:0016564	transcription repressor activity	PMID:7551052^[7]	IDA: Inferred from Direct Assay		F
	GO:0006350	transcription	PMID:7551052^[7]	IDA: Inferred from Direct Assay		P
	GO:0016481	negative regulation of transcription	PMID:8604346^[5]	IMP: Inferred from Mutant Phenotype		P
	GO:0006350	transcription	PMID:16166533^[6]	IDA: Inferred from Direct Assay		P
	GO:0005515	protein binding	PMID:15690043^[8]	IPI: Inferred from Physical Interaction	UniProtKB:P0A7K2	F
	GO:0016564	transcription repressor activity	PMID:11742992^[2]	IDA: Inferred from Direct Assay		F
	GO:0016563	transcription activator activity	PMID:16166533^[6]	IDA: Inferred from Direct Assay		F
	GO:0016564	transcription repressor activity	PMID:16166533^[6]	IDA: Inferred from Direct Assay		F
	GO:0016563	transcription activator activity	PMID:16166533^[6]	IDA: Inferred from Direct Assay		F
	GO:0006351	transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001808	P
	GO:0016481	negative regulation of transcription	PMID:7551052^[7]	IDA: Inferred from Direct Assay		P
	GO:0045941	positive regulation of transcription	PMID:16166533^[6]	IDA: Inferred from Direct Assay		P
	GO:0006350	transcription	PMID:7551052^[7]	IDA: Inferred from Direct Assay		P
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001808	F
	GO:0005515	protein binding	PMID:15690043^[8]	IPI: Inferred from Physical Interaction	UniProtKB:P0A7K2	F
	GO:0000166	nucleotide binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0547	F
	GO:0016481	negative regulation of transcription	PMID:12923087^[1]	IDA: Inferred from Direct Assay		P
	GO:0016481	negative regulation of transcription	PMID:10760178^[4]	IDA: Inferred from Direct Assay		P
	GO:0016481	negative regulation of transcription	PMID:16166533^[6]	IDA: Inferred from Direct Assay		P
	GO:0016564	transcription repressor activity	PMID:7551052^[7]	IDA: Inferred from Direct Assay		F
	GO:0006350	transcription	PMID:15520470^[3]	IEP: Inferred from Expression Pattern		P
	GO:0045941	positive regulation of transcription	PMID:10760178^[4]	IDA: Inferred from Direct Assay		P
	GO:0006350	transcription	PMID:8604346^[5]	IMP: Inferred from Mutant Phenotype		P
	GO:0030552	cAMP binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0116	F
	GO:0005622	intracellular	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001808	C
	GO:0006350	transcription	PMID:8604346^[5]	IMP: Inferred from Mutant Phenotype		P
	GO:0016563	transcription activator activity	PMID:8604346^[5]	IMP: Inferred from Mutant Phenotype		F
	GO:0016563	transcription activator activity	PMID:10760178^[4]	IDA: Inferred from Direct Assay		F
	GO:0016564	transcription repressor activity	PMID:10760178^[4]	IDA: Inferred from Direct Assay		F
	GO:0016563	transcription activator activity	PMID:15520470^[3]	IDA: Inferred from Direct Assay		F
	GO:0006350	transcription	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0804	P
	GO:0006350	transcription	PMID:10760178^[4]	IDA: Inferred from Direct Assay		P
	GO:0006350	transcription	PMID:12923087^[1]	IDA: Inferred from Direct Assay		P
	GO:0016481	negative regulation of transcription	PMID:11742992^[2]	IDA: Inferred from Direct Assay		P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR018335	P
	GO:0016563	transcription activator activity	PMID:11742992^[2]	IDA: Inferred from Direct Assay		F
	GO:0016563	transcription activator activity	PMID:7551052^[7]	IDA: Inferred from Direct Assay		F
	GO:0016564	transcription repressor activity	PMID:10760178^[4]	IDA: Inferred from Direct Assay		F
	GO:0005622	intracellular	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR018335	C
	GO:0045941	positive regulation of transcription	PMID:7551052^[7]	IDA: Inferred from Direct Assay		P
	GO:0045449	regulation of transcription	PMID:12591879^[9]	IDA: Inferred from Direct Assay		P	See Fig 4 and Table 2 supports the data of regulation of transcription	complete
	GO:0045449	regulation of transcription	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012318	P
	GO:0000166	nucleotide binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0547	F
	GO:0003677	DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012318	F
	GO:0003677	DNA binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0238	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001808	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR018335	F
	GO:0005515	protein binding	PMID:15690043^[8]	IPI: Inferred from Physical Interaction	UniProtKB:P0A7K2	F
	GO:0005622	intracellular	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001808	C
	GO:0005622	intracellular	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR018335	C
	GO:0006351	transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0804	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001808	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012318	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR018335	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0805	P
	GO:0008270	zinc ion binding	PMID:11985624^[10]	IDA: Inferred from Direct Assay		F
	GO:0030552	cAMP binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0116	F
	GO:0009409	response to cold	PMID:21926233^[11]	IMP: Inferred from Mutant Phenotype		P	Figure 6 shows crp mutants show reduced cell growth compared to the WT at 15C.	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Beatty CM et al. (2003) Cyclic AMP receptor protein-dependent activation of the Escherichia coli acsP2 promoter by a synergistic class III mechanism. J Bacteriol 185: 5148-57 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Wade JT et al. (2001) A simple mechanism for co-dependence on two activators at an Escherichia coli promoter. EMBO J 20: 7160-7 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Zheng D et al. (2004) Identification of the CRP regulon using in vitro and in vivo transcriptional profiling. Nucleic Acids Res 32: 5874-93 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 Belyaeva TA et al. (2000) Transcription activation at the Escherichia coli melAB promoter: the role of MelR and the cyclic AMP receptor protein. Mol Microbiol 36: 211-22 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 Williams RM et al. (1996) Orientation of functional activating regions in the Escherichia coli CRP protein during transcription activation at class II promoters. Nucleic Acids Res 24: 1112-8 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 Wickstrum JR et al. (2005) Cyclic AMP receptor protein and RhaR synergistically activate transcription from the L-rhamnose-responsive rhaSR promoter in Escherichia coli. J Bacteriol 187: 6708-18 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 Ramseier TM & Saier MH Jr (1995) cAMP-cAMP receptor protein complex: five binding sites in the control region of the Escherichia coli mannitol operon. Microbiology 141 ( Pt 8): 1901-7 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Butland G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433: 531-7 PubMed GONUTS page
↑ Starcic M et al. (2003) The cyclic AMP-cyclic AMP receptor protein complex regulates activity of the traJ promoter of the Escherichia coli conjugative plasmid pRK100. J Bacteriol 185: 1616-23 PubMed GONUTS page
↑ Katayama A et al. (2002) Systematic search for zinc-binding proteins in Escherichia coli. Eur J Biochem 269: 2403-13 PubMed GONUTS page
↑ Uppal S et al. (2011) Cyclic AMP receptor protein regulates cspE, an early cold-inducible gene, in Escherichia coli. J Bacteriol 193: 6142-51 PubMed GONUTS page

[PMID:12923087-0] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Beatty CM et al. (2003) Cyclic AMP receptor protein-dependent activation of the Escherichia coli acsP2 promoter by a synergistic class III mechanism. J Bacteriol 185: 5148-57 PubMed GONUTS page

[PMID:11742992-1] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Wade JT et al. (2001) A simple mechanism for co-dependence on two activators at an Escherichia coli promoter. EMBO J 20: 7160-7 PubMed GONUTS page

[PMID:15520470-2] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Zheng D et al. (2004) Identification of the CRP regulon using in vitro and in vivo transcriptional profiling. Nucleic Acids Res 32: 5874-93 PubMed GONUTS page

[PMID:10760178-3] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 Belyaeva TA et al. (2000) Transcription activation at the Escherichia coli melAB promoter: the role of MelR and the cyclic AMP receptor protein. Mol Microbiol 36: 211-22 PubMed GONUTS page

[PMID:8604346-4] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 Williams RM et al. (1996) Orientation of functional activating regions in the Escherichia coli CRP protein during transcription activation at class II promoters. Nucleic Acids Res 24: 1112-8 PubMed GONUTS page

[PMID:16166533-5] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 Wickstrum JR et al. (2005) Cyclic AMP receptor protein and RhaR synergistically activate transcription from the L-rhamnose-responsive rhaSR promoter in Escherichia coli. J Bacteriol 187: 6708-18 PubMed GONUTS page

[PMID:7551052-6] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 Ramseier TM & Saier MH Jr (1995) cAMP-cAMP receptor protein complex: five binding sites in the control region of the Escherichia coli mannitol operon. Microbiology 141 ( Pt 8): 1901-7 PubMed GONUTS page

[PMID:15690043-7] 8.0 ^8.1 ^8.2 Butland G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433: 531-7 PubMed GONUTS page

[PMID:12591879-8] Starcic M et al. (2003) The cyclic AMP-cyclic AMP receptor protein complex regulates activity of the traJ promoter of the Escherichia coli conjugative plasmid pRK100. J Bacteriol 185: 1616-23 PubMed GONUTS page

[PMID:11985624-9] Katayama A et al. (2002) Systematic search for zinc-binding proteins in Escherichia coli. Eur J Biochem 269: 2403-13 PubMed GONUTS page

[PMID:21926233-10] Uppal S et al. (2011) Cyclic AMP receptor protein regulates cspE, an early cold-inducible gene, in Escherichia coli. J Bacteriol 193: 6142-51 PubMed GONUTS page

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ECOLI:CRP

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