ECOLI:ADA

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Species (Taxon ID)	Escherichia coli (strain K12). (taxon:83333)
Gene Name(s)	ada
Protein Name(s)	Bifunctional transcriptional activator/DNA repair enzyme Ada Regulatory protein of adaptative response Methylphosphotriester-DNA--protein-cysteine S-methyltransferase Methylphosphotriester-DNA methyltransferase Methylated-DNA--protein-cysteine methyltransferase O6-methylguanine-DNA alkyltransferase
External Links
UniProt Identifier	ADA_ECOLI
UniProt Accessions	P06134, Q47032,
EMBL	M10211, M10315, U00008, U00096, AP009048, J02607, M13155, M13828,
PIR	C64991,
RefSeq	AP_002809.1, NP_416717.1,
PDB	1ADN, 1EYF, 1SFE, 1U8B, 1WPK, 1ZGW,
Pfam	PF02805, PF01035, PF02870,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0003677	DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR004026	F
	GO:0003677	DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012287	F
	GO:0003677	DNA binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0238	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR018060	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR018062	F
	GO:0003824	catalytic activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR014048	F
	GO:0003824	catalytic activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0511	F
	GO:0003908	methylated-DNA-(protein)-cysteine S-methyltransferase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001497	F
	GO:0003908	methylated-DNA-(protein)-cysteine S-methyltransferase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008332	F
	GO:0003908	methylated-DNA-(protein)-cysteine S-methyltransferase activity	GO_REF:0000003	IEA: Inferred from Electronic Annotation	[http://ca.expasy.org/cgi-bin/get-entries?EC=2.1.1.*&view=full&num=100 EC:2.1.1.63]	F
	GO:0005622	intracellular	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR018060	C
	GO:0005622	intracellular	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR018062	C
	GO:0006281	DNA repair	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001497	P
	GO:0006281	DNA repair	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR004026	P
	GO:0006281	DNA repair	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008332	P
	GO:0006281	DNA repair	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR014048	P
	GO:0006281	DNA repair	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0234	P
	GO:0006351	transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0804	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR004026	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR018060	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR018062	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0805	P
	GO:0006974	response to DNA damage stimulus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0227	P
	GO:0008152	metabolic process	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0511	P
	GO:0008168	methyltransferase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR004026	F
	GO:0008168	methyltransferase activity	GO_REF:0000003	IEA: Inferred from Electronic Annotation	EC:2.1.1	F
	GO:0008168	methyltransferase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0489	F
	GO:0008270	zinc ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR004026	F
	GO:0008270	zinc ion binding	PMID:1581309^[1]	IDA: Inferred from Direct Assay		F
	GO:0016740	transferase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0808	F
	GO:0032259	methylation	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0489	P
	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR018060	F
	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR018062	F
	GO:0046872	metal ion binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0479	F
	GO:0003908	methylated-DNA-(protein)-cysteine S-methyltransferase activity	PMID:8195077^[2]	IMP: Inferred from Mutant Phenotype		F	The number of spontaneous mutations from G:C to A:T and G:C to C:G increases 4 fold in ada ogt double mutants (Table 2).	complete
	GO:0003677	DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR004026	F
	GO:0003677	DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012287	F
	GO:0003677	DNA binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0238	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR018060	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR018062	F
	GO:0003824	catalytic activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR014048	F
	GO:0003824	catalytic activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0511	F
	GO:0003908	methylated-DNA-(protein)-cysteine S-methyltransferase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001497	F
	GO:0003908	methylated-DNA-(protein)-cysteine S-methyltransferase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008332	F
	GO:0003908	methylated-DNA-(protein)-cysteine S-methyltransferase activity	GO_REF:0000003	IEA: Inferred from Electronic Annotation	[http://ca.expasy.org/cgi-bin/get-entries?EC=2.1.1.*&view=full&num=100 EC:2.1.1.63]	F
	GO:0005622	intracellular	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR018060	C
	GO:0005622	intracellular	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR018062	C
	GO:0006281	DNA repair	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001497	P
	GO:0006281	DNA repair	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR004026	P
	GO:0006281	DNA repair	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008332	P
	GO:0006281	DNA repair	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR014048	P
	GO:0006281	DNA repair	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0234	P
	GO:0006351	transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0804	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR004026	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012287	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR018060	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR018062	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0805	P
	GO:0006974	response to DNA damage stimulus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0227	P
	GO:0008152	metabolic process	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0511	P
	GO:0008168	methyltransferase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR004026	F
	GO:0008168	methyltransferase activity	GO_REF:0000003	IEA: Inferred from Electronic Annotation	EC:2.1.1	F
	GO:0008168	methyltransferase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0489	F
	GO:0008270	zinc ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR004026	F
	GO:0008270	zinc ion binding	PMID:1581309^[1]	IDA: Inferred from Direct Assay		F
	GO:0016740	transferase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0808	F
	GO:0032259	methylation	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0489	P
	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR018060	F
	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR018062	F
	GO:0046872	metal ion binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0479	F
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Myers LC et al. (1992) Zinc binding by the methylation signaling domain of the Escherichia coli Ada protein. Biochemistry 31: 4541-7 PubMed GONUTS page
↑ Mackay WJ et al. (1994) DNA alkylation repair limits spontaneous base substitution mutations in Escherichia coli. J Bacteriol 176: 3224-30 PubMed GONUTS page

[PMID:1581309-0] 1.0 ^1.1 Myers LC et al. (1992) Zinc binding by the methylation signaling domain of the Escherichia coli Ada protein. Biochemistry 31: 4541-7 PubMed GONUTS page

[PMID:8195077-1] Mackay WJ et al. (1994) DNA alkylation repair limits spontaneous base substitution mutations in Escherichia coli. J Bacteriol 176: 3224-30 PubMed GONUTS page

[1]

[2]

ECOLI:ADA

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