Ambox notice.png

GONUTS is under stress! The website is currently experiencing long-wait times and frequent time-outs due to the record number of students, groups, and annotations related to CACAO this semester. We are currently working on increasing performance -- please accept our apologies for the technical difficulties.

You can help reduce stress on the server by:

  1. not reloading pages frequently - this just adds
  2. opening links in new windows (so you can read the old page)

DROME:TIM

From GONUTS
Jump to: navigation, search

Contents

Species (Taxon ID) Drosophila melanogaster (Fruit fly). ([1])
Gene Name(s) tim
Protein Name(s) Protein timeless
External Links
EMBL U37018
AF032401
AF032400
AE014134
AE014134
AE014134
AE014134
Y09930
Y09931
Y09932
Y09933
Y09934
Y09935
AY058278
BT001424
AF038501
PIR A57655
RefSeq NP_001137780.1
NP_001137781.1
NP_001188687.1
NP_523468.2
NP_722912.2
NP_722913.2
NP_722914.3
ProteinModelPortal P49021
DIP DIP-29425N
MINT MINT-344208
STRING P49021
GeneID 33571
KEGG dme:Dmel_CG3234
UCSC CG3234-RA
CTD 107698
FlyBase FBgn0014396
eggNOG inNOG07043
InParanoid P49021
OrthoDB EOG4X3FG5
NextBio 784249
ArrayExpress P49021
Bgee P49021
GermOnline CG3234
GO GO:0005634
GO:0048471
GO:0043234
GO:0046982
GO:0007620
GO:0008062
GO:0009649
GO:0045475
GO:0007617
GO:0046957
GO:0000122
GO:0009648
GO:0006606
GO:0045187
GO:0042306
GO:0030431
InterPro IPR006906
KO K12074
Pfam PF04821

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000122

negative regulation of transcription from RNA polymerase II promoter

PMID:11178250[1]

TAS: Traceable Author Statement

P

Seeded From UniProt

GO:0000122

negative regulation of transcription from RNA polymerase II promoter

PMID:12015613[2]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

GO:0005515

protein binding

PMID:10417378[3]

IPI: Inferred from Physical Interaction

FB:FBgn0025680

F

Seeded From UniProt

GO:0005515

protein binding

PMID:10417378[3]

IPI: Inferred from Physical Interaction

UniProtKB:O77059

F

Seeded From UniProt

GO:0005634

nucleus

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0539

C

Seeded From UniProt

GO:0005634

nucleus

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0191

C

Seeded From UniProt

GO:0005634

nucleus

PMID:12015613[2]

NAS: Non-traceable Author Statement

C

Seeded From UniProt

GO:0005634

nucleus

PMID:12486701[4]

TAS: Traceable Author Statement

C

Seeded From UniProt

GO:0005634

nucleus

PMID:12944510[5]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0005634

nucleus

PMID:16410523[6]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0005634

nucleus

PMID:17369364[7]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0005737

cytoplasm

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0963

C

Seeded From UniProt

GO:0005737

cytoplasm

PMID:10417378[3]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0005737

cytoplasm

PMID:12015613[2]

NAS: Non-traceable Author Statement

C

Seeded From UniProt

GO:0005737

cytoplasm

PMID:12944510[5]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0005737

cytoplasm

PMID:16410523[6]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0005737

cytoplasm

PMID:17369364[7]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0006606

protein import into nucleus

PMID:12015613[2]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

GO:0007617

mating behavior

PMID:11470898[8]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0007620

copulation

PMID:15324667[9]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0007622

rhythmic behavior

PMID:12486701[4]

TAS: Traceable Author Statement

P

Seeded From UniProt

GO:0007623

circadian rhythm

PMID:11178250[1]

TAS: Traceable Author Statement

P

Seeded From UniProt

GO:0007623

circadian rhythm

PMID:11715043[10]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

GO:0007623

circadian rhythm

PMID:12015613[2]

TAS: Traceable Author Statement

P

Seeded From UniProt

GO:0007623

circadian rhythm

PMID:12154068[11]

TAS: Traceable Author Statement

P

Seeded From UniProt

GO:0007623

circadian rhythm

PMID:12490253[12]

TAS: Traceable Author Statement

P

Seeded From UniProt

GO:0007623

circadian rhythm

PMID:15312644[13]

TAS: Traceable Author Statement

P

Seeded From UniProt

GO:0008062

eclosion rhythm

PMID:11715043[10]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

GO:0008062

eclosion rhythm

PMID:12111533[14]

TAS: Traceable Author Statement

P

Seeded From UniProt

GO:0008062

eclosion rhythm

PMID:12486701[4]

TAS: Traceable Author Statement

P

Seeded From UniProt

GO:0009648

photoperiodism

PMID:17600215[15]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0009649

entrainment of circadian clock

PMID:11178250[1]

TAS: Traceable Author Statement

P

Seeded From UniProt

GO:0030431

sleep

PMID:11715043[10]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

GO:0042306

regulation of protein import into nucleus

PMID:11178250[1]

TAS: Traceable Author Statement

P

Seeded From UniProt

GO:0042749

regulation of circadian sleep/wake cycle

PMID:16938867[16]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0043234

protein complex

PMID:10417378[3]

IPI: Inferred from Physical Interaction

FB:FBgn0025680

C

Seeded From UniProt

GO:0045187

regulation of circadian sleep/wake cycle, sleep

PMID:12015603[17]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0045187

regulation of circadian sleep/wake cycle, sleep

PMID:12486704[18]

TAS: Traceable Author Statement

P

Seeded From UniProt

GO:0045475

locomotor rhythm

PMID:11715043[10]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

GO:0045475

locomotor rhythm

PMID:17068124[19]

IGI: Inferred from Genetic Interaction

FB:FBgn0031652

P

Seeded From UniProt

GO:0046957

negative phototaxis

PMID:19285485[20]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0046982

protein heterodimerization activity

PMID:11178250[1]

NAS: Non-traceable Author Statement

F

Seeded From UniProt

GO:0046982

protein heterodimerization activity

PMID:15312644[13]

TAS: Traceable Author Statement

F

Seeded From UniProt

GO:0048471

perinuclear region of cytoplasm

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0198

C

Seeded From UniProt

GO:0048511

rhythmic process

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0090

P

Seeded From UniProt

GO:0048512

circadian behavior

PMID:11333398[21]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0071482

cellular response to light stimulus

PMID:9697866[22]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0006351

transcription, DNA-dependent

PMID:9016581[23]

IDA: Inferred from Direct Assay

P

Figure 1. Nucleotide sequences of a tim fragment.

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Hardin PE (2000) From biological clock to biological rhythms. Genome Biol 1: REVIEWS1023 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 2.4 Panda S et al. (2002) Circadian rhythms from flies to human. Nature 417: 329-35 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 Ceriani MF et al. (1999) Light-dependent sequestration of TIMELESS by CRYPTOCHROME. Science 285: 553-6 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 Stanewsky R (2003) Genetic analysis of the circadian system in Drosophila melanogaster and mammals. J Neurobiol 54: 111-47 PubMed GONUTS page
  5. ↑ 5.0 5.1 Ashmore LJ et al. (2003) Novel insights into the regulation of the timeless protein. J Neurosci 23: 7810-9 PubMed GONUTS page
  6. ↑ 6.0 6.1 Meyer P et al. (2006) PER-TIM interactions in living Drosophila cells: an interval timer for the circadian clock. Science 311: 226-9 PubMed GONUTS page
  7. ↑ 7.0 7.1 Fernández MP et al. (2007) Impaired clock output by altered connectivity in the circadian network. Proc Natl Acad Sci U S A 104: 5650-5 PubMed GONUTS page
  8. ↑ Sakai T & Ishida N (2001) Circadian rhythms of female mating activity governed by clock genes in Drosophila. Proc Natl Acad Sci U S A 98: 9221-5 PubMed GONUTS page
  9. ↑ Beaver LM & Giebultowicz JM (2004) Regulation of copulation duration by period and timeless in Drosophila melanogaster. Curr Biol 14: 1492-7 PubMed GONUTS page
  10. ↑ 10.0 10.1 10.2 10.3 Sokolowski MB (2001) Drosophila: genetics meets behaviour. Nat Rev Genet 2: 879-90 PubMed GONUTS page
  11. ↑ Glossop NR & Hardin PE (2002) Central and peripheral circadian oscillator mechanisms in flies and mammals. J Cell Sci 115: 3369-77 PubMed GONUTS page
  12. ↑ Rothenfluh A & Heberlein U (2002) Drugs, flies, and videotape: the effects of ethanol and cocaine on Drosophila locomotion. Curr Opin Neurobiol 12: 639-45 PubMed GONUTS page
  13. ↑ 13.0 13.1 Emery P & Reppert SM (2004) A rhythmic Ror. Neuron 43: 443-6 PubMed GONUTS page
  14. ↑ Stanewsky R (2002) Clock mechanisms in Drosophila. Cell Tissue Res 309: 11-26 PubMed GONUTS page
  15. ↑ Tauber E et al. (2007) Natural selection favors a newly derived timeless allele in Drosophila melanogaster. Science 316: 1895-8 PubMed GONUTS page
  16. ↑ Koh K et al. (2006) A Drosophila model for age-associated changes in sleep:wake cycles. Proc Natl Acad Sci U S A 103: 13843-7 PubMed GONUTS page
  17. ↑ Shaw PJ et al. (2002) Stress response genes protect against lethal effects of sleep deprivation in Drosophila. Nature 417: 287-91 PubMed GONUTS page
  18. ↑ Shaw PJ & Franken P (2003) Perchance to dream: solving the mystery of sleep through genetic analysis. J Neurobiol 54: 179-202 PubMed GONUTS page
  19. ↑ Peschel N et al. (2006) Veela defines a molecular link between Cryptochrome and Timeless in the light-input pathway to Drosophila's circadian clock. Proc Natl Acad Sci U S A 103: 17313-8 PubMed GONUTS page
  20. ↑ Gong Z (2009) Behavioral dissection of Drosophila larval phototaxis. Biochem Biophys Res Commun 382: 395-9 PubMed GONUTS page
  21. ↑ Wang GK et al. (2001) Regulation of the cycling of timeless (tim) RNA. J Neurobiol 47: 161-75 PubMed GONUTS page
  22. ↑ Suri V et al. (1998) Evidence that the TIM light response is relevant to light-induced phase shifts in Drosophila melanogaster. Neuron 21: 225-34 PubMed GONUTS page
  23. ↑ Rosato E et al. (1997) Conceptual translation of timeless reveals alternative initiating methionines in Drosophila. Nucleic Acids Res 25: 455-8 PubMed GONUTS page
Retrieved from "http://gowiki.tamu.edu/wiki/index.php/DROME:TIM"
Personal tools
Namespaces
Variants
Actions
Navigation
Cacao
Journal Clubs
page contributors
Toolbox