Ambox notice.png

GONUTS is under stress! The website is currently experiencing long-wait times and frequent time-outs due to the record number of students, groups, and annotations related to CACAO this semester. We are currently working on increasing performance -- please accept our apologies for the technical difficulties.

You can help reduce stress on the server by:

  1. not reloading pages frequently - this just adds
  2. opening links in new windows (so you can read the old page)

DROME:SLIT

From GONUTS
Jump to: navigation, search

Contents

Species (Taxon ID) Drosophila melanogaster (Fruit fly). ([1])
Gene Name(s) sli
Protein Name(s) Protein slit

dSlit Protein slit N-product Protein slit C-product

External Links
EMBL X53959
AF126540
AE013599
AE013599
AE013599
AE013599
AE013599
M23543
PIR A36665
B36665
RefSeq NP_001097333.1
NP_001097334.1
NP_476727.1
NP_476728.1
NP_476729.1
UniGene Dm.4729
PDB 1W8A
PDBsum 1W8A
ProteinModelPortal P24014
SMR P24014
STRING P24014
EnsemblMetazoa FBtr0087303
FBtr0112832
GeneID 36746
KEGG dme:Dmel_CG8355
CTD 36746
FlyBase FBgn0003425
eggNOG inNOG07800
InParanoid P24014
OMA CISSITI
OrthoDB EOG46DJHK
PhylomeDB P24014
Reactome REACT_113552
NextBio 800151
Bgee P24014
GermOnline CG8355
GO GO:0005886
GO:0005578
GO:0071666
GO:0005509
GO:0008201
GO:0048495
GO:0016199
GO:0048813
GO:0007502
GO:0035050
GO:0007427
GO:0008347
GO:0008406
GO:0050929
GO:0008078
GO:0001764
GO:0003151
GO:0022409
GO:2000274
GO:0035385
GO:0007432
InterPro IPR008985
IPR013320
IPR000483
IPR006207
IPR006209
IPR006210
IPR001881
IPR013032
IPR000152
IPR000742
IPR018097
IPR001791
IPR012679
IPR001611
IPR003591
IPR000372
Gene3D G3DSA:2.60.120.200
KO K06839
Pfam PF00008
PF00054
PF00560
PF01463
PF01462
SMART SM00041
SM00181
SM00179
SM00282
SM00369
SM00082
SM00013
SUPFAM SSF49899
PROSITE PS00010
PS01185
PS01225
PS00022
PS01186
PS50026
PS01187
PS50025
PS51450

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0001764

neuron migration

PMID:15296748[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0003151

outflow tract morphogenesis

PMID:18250318[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0005509

calcium ion binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001881

F

Seeded From UniProt

GO:0005509

calcium ion binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR018097

F

Seeded From UniProt

GO:0005515

protein binding

PMID:18359766[3]

IPI: Inferred from Physical Interaction

FB:FBgn0005631

F

Seeded From UniProt

GO:0005576

extracellular region

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0964

C

Seeded From UniProt

GO:0005576

extracellular region

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0243

C

Seeded From UniProt

GO:0005576

extracellular region

PMID:2176636[4]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0005578

proteinaceous extracellular matrix

PMID:7760738[5]

TAS: Traceable Author Statement

C

Seeded From UniProt

GO:0005886

plasma membrane

Reactome:REACT_19122

TAS: Traceable Author Statement

C

Seeded From UniProt

GO:0005886

plasma membrane

Reactome:REACT_19143

TAS: Traceable Author Statement

C

Seeded From UniProt

GO:0005886

plasma membrane

Reactome:REACT_19239

TAS: Traceable Author Statement

C

Seeded From UniProt

GO:0005886

plasma membrane

Reactome:REACT_19250

TAS: Traceable Author Statement

C

Seeded From UniProt

GO:0005886

plasma membrane

Reactome:REACT_19265

TAS: Traceable Author Statement

C

Seeded From UniProt

GO:0005886

plasma membrane

Reactome:REACT_19326

TAS: Traceable Author Statement

C

Seeded From UniProt

GO:0005886

plasma membrane

Reactome:REACT_19384

TAS: Traceable Author Statement

C

Seeded From UniProt

GO:0005886

plasma membrane

Reactome:REACT_19386

TAS: Traceable Author Statement

C

Seeded From UniProt

GO:0005886

plasma membrane

Reactome:REACT_19409

TAS: Traceable Author Statement

C

Seeded From UniProt

GO:0005886

plasma membrane

Reactome:REACT_22362

TAS: Traceable Author Statement

C

Seeded From UniProt

GO:0007275

multicellular organismal development

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0217

P

Seeded From UniProt

GO:0007399

nervous system development

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0524

P

Seeded From UniProt

GO:0007411

axon guidance

PMID:10102267[6]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0007411

axon guidance

PMID:11404414[7]

IGI: Inferred from Genetic Interaction

FB:FBgn0005631

P

Seeded From UniProt

GO:0007411

axon guidance

PMID:11404414[7]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0007411

axon guidance

PMID:12040052[8]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0007427

epithelial cell migration, open tracheal system

PMID:15229181[9]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0007432

salivary gland boundary specification

PMID:15950216[10]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0007502

digestive tract mesoderm development

PMID:21377458[11]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0007509

mesoderm migration involved in gastrulation

PMID:11326102[12]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0007509

mesoderm migration involved in gastrulation

PMID:2176636[4]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0008078

mesodermal cell migration

PMID:10102267[6]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0008201

heparin binding

PMID:17062560[13]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

GO:0008347

glial cell migration

PMID:2176636[4]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0008406

gonad development

PMID:21377458[11]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0010632

regulation of epithelial cell migration

PMID:12397103[14]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0016199

axon midline choice point recognition

PMID:15147761[15]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0016199

axon midline choice point recognition

PMID:17049509[16]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0016199

axon midline choice point recognition

PMID:17121810[17]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0022409

positive regulation of cell-cell adhesion

PMID:16888037[18]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0030154

cell differentiation

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0221

P

Seeded From UniProt

GO:0030182

neuron differentiation

PMID:11688564[19]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0031012

extracellular matrix

PMID:2176636[4]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0035050

embryonic heart tube development

PMID:16360689[20]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0035050

embryonic heart tube development

PMID:16516189[21]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0035050

embryonic heart tube development

PMID:16888037[18]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0035385

Roundabout signaling pathway

PMID:10102267[6]

IGI: Inferred from Genetic Interaction

FB:FBgn0005631

P

Seeded From UniProt

GO:0048495

Roundabout binding

PMID:17062560[13]

IPI: Inferred from Physical Interaction

FB:FBgn0005631

F

Seeded From UniProt

GO:0048813

dendrite morphogenesis

PMID:18817767[22]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0050929

induction of negative chemotaxis

PMID:2176636[4]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0071666

Slit-Robo signaling complex

PMID:17062560[13]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:2000274

regulation of epithelial cell migration, open tracheal system

PMID:12397103[14]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt


edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Kraut R & Zinn K (2004) Roundabout 2 regulates migration of sensory neurons by signaling in trans. Curr Biol 14: 1319-29 PubMed GONUTS page
  2. ↑ Zmojdzian M et al. (2008) Cellular components and signals required for the cardiac outflow tract assembly in Drosophila. Proc Natl Acad Sci U S A 105: 2475-80 PubMed GONUTS page
  3. ↑ Fukuhara N et al. (2008) Structural and functional analysis of slit and heparin binding to immunoglobulin-like domains 1 and 2 of Drosophila Robo. J Biol Chem 283: 16226-34 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 4.4 Rothberg JM et al. (1990) slit: an extracellular protein necessary for development of midline glia and commissural axon pathways contains both EGF and LRR domains. Genes Dev 4: 2169-87 PubMed GONUTS page
  5. ↑ Fessler LI et al. (1994) Drosophila extracellular matrix. Methods Enzymol 245: 271-94 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 Kidd T et al. (1999) Slit is the midline repellent for the robo receptor in Drosophila. Cell 96: 785-94 PubMed GONUTS page
  7. ↑ 7.0 7.1 Battye R et al. (2001) Repellent signaling by Slit requires the leucine-rich repeats. J Neurosci 21: 4290-8 PubMed GONUTS page
  8. ↑ Stevens A & Jacobs JR (2002) Integrins regulate responsiveness to slit repellent signals. J Neurosci 22: 4448-55 PubMed GONUTS page
  9. ↑ Gallio M et al. (2004) Rhomboid 3 orchestrates Slit-independent repulsion of tracheal branches at the CNS midline. Development 131: 3605-14 PubMed GONUTS page
  10. ↑ Kolesnikov T & Beckendorf SK (2005) NETRIN and SLIT guide salivary gland migration. Dev Biol 284: 102-11 PubMed GONUTS page
  11. ↑ 11.0 11.1 Weyers JJ et al. (2011) A genetic screen for mutations affecting gonad formation in Drosophila reveals a role for the slit/robo pathway. Dev Biol 353: 217-28 PubMed GONUTS page
  12. ↑ Kramer SG et al. (2001) Switching repulsion to attraction: changing responses to slit during transition in mesoderm migration. Science 292: 737-40 PubMed GONUTS page
  13. ↑ 13.0 13.1 13.2 Hussain SA et al. (2006) A molecular mechanism for the heparan sulfate dependence of slit-robo signaling. J Biol Chem 281: 39693-8 PubMed GONUTS page
  14. ↑ 14.0 14.1 Englund C et al. (2002) Attractive and repulsive functions of Slit are mediated by different receptors in the Drosophila trachea. Development 129: 4941-51 PubMed GONUTS page
  15. ↑ Orgogozo V et al. (2004) Slit-Robo signalling prevents sensory cells from crossing the midline in Drosophila. Mech Dev 121: 427-36 PubMed GONUTS page
  16. ↑ Simionato E et al. (2007) The Drosophila RNA-binding protein ELAV is required for commissural axon midline crossing via control of commissureless mRNA expression in neurons. Dev Biol 301: 166-77 PubMed GONUTS page
  17. ↑ Garbe DS et al. (2007) beta-Spectrin functions independently of Ankyrin to regulate the establishment and maintenance of axon connections in the Drosophila embryonic CNS. Development 134: 273-84 PubMed GONUTS page
  18. ↑ 18.0 18.1 Santiago-Martínez E et al. (2006) Lateral positioning at the dorsal midline: Slit and Roundabout receptors guide Drosophila heart cell migration. Proc Natl Acad Sci U S A 103: 12441-6 PubMed GONUTS page
  19. ↑ Mehta B & Bhat KM (2001) Slit signaling promotes the terminal asymmetric division of neural precursor cells in the Drosophila CNS. Development 128: 3161-8 PubMed GONUTS page
  20. ↑ Qian L et al. (2005) Slit and Robo control cardiac cell polarity and morphogenesis. Curr Biol 15: 2271-8 PubMed GONUTS page
  21. ↑ MacMullin A & Jacobs JR (2006) Slit coordinates cardiac morphogenesis in Drosophila. Dev Biol 293: 154-64 PubMed GONUTS page
  22. ↑ Dimitrova S et al. (2008) Slit and Robo regulate dendrite branching and elongation of space-filling neurons in Drosophila. Dev Biol 324: 18-30 PubMed GONUTS page
Retrieved from "http://gowiki.tamu.edu/wiki/index.php/DROME:SLIT"
Personal tools
Namespaces
Variants
Actions
Navigation
Cacao
Journal Clubs
page contributors
Toolbox