DROME:RAD54

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Species (Taxon ID)	Drosophila melanogaster (Fruit fly). (taxon:7227)
Gene Name(s)	okr ( synonyms: RAD54 )
Protein Name(s)	DNA repair and recombination protein RAD54-like DmRAD54 Protein okra RAD54 DNA repair protein
External Links
UniProt Identifier	RAD54_DROME
UniProt Accessions	O76460, B6UXG7, B6UXH8, B6UXJ2, B6UXJ5, P91636, Q7K0T1, Q7KPH9,
EMBL	Y10229, AF069779, AF069780, AE014134, AY069599, FJ219215, FJ219218, FJ219219, FJ219220, FJ219221, FJ219222, FJ219223, FJ219224, FJ219225, FJ219226, FJ219227, FJ219228, FJ219229, FJ219230, FJ219231, FJ219232, FJ219233, FJ219234, FJ219235, FJ219236, FJ219237, FJ219238, FJ219239, FJ219240, FJ219241, FJ219242, FJ219243, FJ219244, FJ219245, FJ219246, FJ219247,
RefSeq	NP_476661.1,
IntAct	O76460,
Pfam	PF00271, PF08658, PF00176,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0071481	cellular response to X-ray	PMID:9315669^[1]	IMP: Inferred from Mutant Phenotype		P	Table 1	complete
	GO:0000166	nucleotide binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0547	F
	GO:0000711	meiotic DNA repair synthesis	PMID:9732269^[2]	IMP: Inferred from Mutant Phenotype		P
	GO:0000724	double-strand break repair via homologous recombination	PMID:15105430^[3]	IMP: Inferred from Mutant Phenotype		P
	GO:0003674	molecular function	GO_REF:0000015	ND: No biological Data available		F
	GO:0003676	nucleic acid binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001650	F
	GO:0003677	DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000330	F
	GO:0003677	DNA binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0238	F
	GO:0004386	helicase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001650	F
	GO:0004386	helicase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0347	F
	GO:0005515	protein binding	PMID:14605208^[4]	IPI: Inferred from Physical Interaction	UniProtKB:Q8T3Y0	F
	GO:0005515	protein binding	PMID:14605208^[4]	IPI: Inferred from Physical Interaction	UniProtKB:Q9VKM7	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000330	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001650	F
	GO:0005524	ATP binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0067	F
	GO:0005634	nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0539	C
	GO:0005634	nucleus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0191	C
	GO:0005634	nucleus	PMID:9732269^[2]	IDA: Inferred from Direct Assay		C
	GO:0006281	DNA repair	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0234	P
	GO:0006281	DNA repair	PMID:10449356^[5]	NAS: Non-traceable Author Statement		P
	GO:0006302	double-strand break repair	PMID:14616073^[6]	TAS: Traceable Author Statement		P
	GO:0006302	double-strand break repair	PMID:9315669^[1]	IMP: Inferred from Mutant Phenotype		P
	GO:0006338	chromatin remodeling	PMID:15105430^[3]	IMP: Inferred from Mutant Phenotype		P
	GO:0006417	regulation of translation	PMID:9642168^[7]	TAS: Traceable Author Statement		P
	GO:0006974	response to DNA damage stimulus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0227	P
	GO:0007049	cell cycle	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0131	P
	GO:0007067	mitosis	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0498	P
	GO:0007126	meiosis	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0469	P
	GO:0007131	reciprocal meiotic recombination	PMID:10021357^[8]	TAS: Traceable Author Statement		P
	GO:0007131	reciprocal meiotic recombination	PMID:10449356^[5]	TAS: Traceable Author Statement		P
	GO:0008298	intracellular mRNA localization	PMID:9642168^[7]	TAS: Traceable Author Statement		P
	GO:0010212	response to ionizing radiation	PMID:14704177^[9]	IMP: Inferred from Mutant Phenotype		P
	GO:0010212	response to ionizing radiation	PMID:9315669^[1]	IMP: Inferred from Mutant Phenotype		P
	GO:0016787	hydrolase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0378	F
	GO:0016817	hydrolase activity, acting on acid anhydrides	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR013967	F
	GO:0030261	chromosome condensation	PMID:10449356^[5]	TAS: Traceable Author Statement		P
	GO:0043150	DNA synthesis involved in double-strand break repair via homologous recombination	PMID:9732269^[2]	IMP: Inferred from Mutant Phenotype		P
	GO:0045003	double-strand break repair via synthesis-dependent strand annealing	PMID:17660539^[10]	IMP: Inferred from Mutant Phenotype		P
	GO:0046843	dorsal appendage formation	PMID:1783295^[11]	IMP: Inferred from Mutant Phenotype		P
	GO:0048477	oogenesis	PMID:10449356^[5]	TAS: Traceable Author Statement		P
	GO:0048477	oogenesis	PMID:1783295^[11]	IMP: Inferred from Mutant Phenotype		P
	GO:0048477	oogenesis	PMID:20522776^[12]	IGI: Inferred from Genetic Interaction	FB:FBgn0039044	P
	GO:0051301	cell division	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0132	P
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Kooistra R et al. (1997) The Drosophila melanogaster RAD54 homolog, DmRAD54, is involved in the repair of radiation damage and recombination. Mol Cell Biol 17: 6097-104 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Ghabrial A et al. (1998) okra and spindle-B encode components of the RAD52 DNA repair pathway and affect meiosis and patterning in Drosophila oogenesis. Genes Dev 12: 2711-23 PubMed GONUTS page
↑ ^3.0 ^3.1 Alexiadis V et al. (2004) A conserved N-terminal motif in Rad54 is important for chromatin remodeling and homologous strand pairing. J Biol Chem 279: 27824-9 PubMed GONUTS page
↑ ^4.0 ^4.1 Giot L et al. (2003) A protein interaction map of Drosophila melanogaster. Science 302: 1727-36 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 van Eeden F & St Johnston D (1999) The polarisation of the anterior-posterior and dorsal-ventral axes during Drosophila oogenesis. Curr Opin Genet Dev 9: 396-404 PubMed GONUTS page
↑ Lee LA & Orr-Weaver TL (2003) Regulation of cell cycles in Drosophila development: intrinsic and extrinsic cues. Annu Rev Genet 37: 545-78 PubMed GONUTS page
↑ ^7.0 ^7.1 Cooperstock RL & Lipshitz HD (1997) Control of mRNA stability and translation during Drosophila development. Semin Cell Dev Biol 8: 541-9 PubMed GONUTS page
↑ Morris J & Lehmann R (1999) Drosophila oogenesis: versatile spn doctors. Curr Biol 9: R55-8 PubMed GONUTS page
↑ Gorski MM et al. (2003) The Drosophila melanogaster DNA Ligase IV gene plays a crucial role in the repair of radiation-induced DNA double-strand breaks and acts synergistically with Rad54. Genetics 165: 1929-41 PubMed GONUTS page
↑ Wei DS & Rong YS (2007) A genetic screen for DNA double-strand break repair mutations in Drosophila. Genetics 177: 63-77 PubMed GONUTS page
↑ ^11.0 ^11.1 Schüpbach T & Wieschaus E (1991) Female sterile mutations on the second chromosome of Drosophila melanogaster. II. Mutations blocking oogenesis or altering egg morphology. Genetics 129: 1119-36 PubMed GONUTS page
↑ Lu WJ et al. (2010) Meiotic recombination provokes functional activation of the p53 regulatory network. Science 328: 1278-81 PubMed GONUTS page

[PMID:9315669-0] 1.0 ^1.1 ^1.2 Kooistra R et al. (1997) The Drosophila melanogaster RAD54 homolog, DmRAD54, is involved in the repair of radiation damage and recombination. Mol Cell Biol 17: 6097-104 PubMed GONUTS page

[PMID:9732269-1] 2.0 ^2.1 ^2.2 Ghabrial A et al. (1998) okra and spindle-B encode components of the RAD52 DNA repair pathway and affect meiosis and patterning in Drosophila oogenesis. Genes Dev 12: 2711-23 PubMed GONUTS page

[PMID:15105430-2] 3.0 ^3.1 Alexiadis V et al. (2004) A conserved N-terminal motif in Rad54 is important for chromatin remodeling and homologous strand pairing. J Biol Chem 279: 27824-9 PubMed GONUTS page

[PMID:14605208-3] 4.0 ^4.1 Giot L et al. (2003) A protein interaction map of Drosophila melanogaster. Science 302: 1727-36 PubMed GONUTS page

[PMID:10449356-4] 5.0 ^5.1 ^5.2 ^5.3 van Eeden F & St Johnston D (1999) The polarisation of the anterior-posterior and dorsal-ventral axes during Drosophila oogenesis. Curr Opin Genet Dev 9: 396-404 PubMed GONUTS page

[PMID:14616073-5] Lee LA & Orr-Weaver TL (2003) Regulation of cell cycles in Drosophila development: intrinsic and extrinsic cues. Annu Rev Genet 37: 545-78 PubMed GONUTS page

[PMID:9642168-6] 7.0 ^7.1 Cooperstock RL & Lipshitz HD (1997) Control of mRNA stability and translation during Drosophila development. Semin Cell Dev Biol 8: 541-9 PubMed GONUTS page

[PMID:10021357-7] Morris J & Lehmann R (1999) Drosophila oogenesis: versatile spn doctors. Curr Biol 9: R55-8 PubMed GONUTS page

[PMID:14704177-8] Gorski MM et al. (2003) The Drosophila melanogaster DNA Ligase IV gene plays a crucial role in the repair of radiation-induced DNA double-strand breaks and acts synergistically with Rad54. Genetics 165: 1929-41 PubMed GONUTS page

[PMID:17660539-9] Wei DS & Rong YS (2007) A genetic screen for DNA double-strand break repair mutations in Drosophila. Genetics 177: 63-77 PubMed GONUTS page

[PMID:1783295-10] 11.0 ^11.1 Schüpbach T & Wieschaus E (1991) Female sterile mutations on the second chromosome of Drosophila melanogaster. II. Mutations blocking oogenesis or altering egg morphology. Genetics 129: 1119-36 PubMed GONUTS page

[PMID:20522776-11] Lu WJ et al. (2010) Meiotic recombination provokes functional activation of the p53 regulatory network. Science 328: 1278-81 PubMed GONUTS page

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DROME:RAD54

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