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DROME:PER

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Contents

Species (Taxon ID) Drosophila melanogaster (Fruit fly). ([1])
Gene Name(s) per
Protein Name(s) Period circadian protein

Protein clock-6 CLK-6

External Links
EMBL M30114
M30114
M30114
AF033029
X03636
AE014298
AL024485
AL024485
AL024485
AL024485
AY575847
L07817
L07818
L07819
L07821
L07823
L07825
AB029194
AB029195
AB029196
AB029222
AB029223
AB029224
AB029250
AB029251
AB029252
D00009
AF251241
AY047980
AY047981
AY047982
AY047983
AY047984
AY047985
AY047986
AY047987
AY047988
AY047989
AY047990
AY047991
AY047992
AY047993
AY047994
AY047995
AY047996
AY047997
AY047998
AY047999
AY048000
AY048001
AY048002
AY048003
AY048004
AY048005
AY048006
AY048007
AY048008
AY048009
AY048010
AY048011
AY048012
AY048013
AY048014
AY048015
AY048016
AY048017
AY048018
AY048019
AY048020
AY048021
AY048022
AY048023
AY048024
AY048025
AY048026
AY048027
AY048028
AY048029
AY048030
AY048031
AY048032
AY048033
AY048034
AY048035
AY048036
AY048037
AY048038
AY048040
AY048041
AY048042
PIR A23932
A26427
A26588
B26427
C26427
S52943
RefSeq NP_525056.2
UniGene Dm.65
PDB 1WA9
3GEC
PDBsum 1WA9
3GEC
ProteinModelPortal P07663
SMR P07663
DIP DIP-29426N
MINT MINT-1327740
STRING P07663
GeneID 31251
KEGG dme:Dmel_CG2647
CTD 31251
FlyBase FBgn0003068
eggNOG inNOG08244
InParanoid P07663
OrthoDB EOG4V41PZ
NextBio 772671
Bgee P07663
GermOnline CG2647
GO GO:0005634
GO:0048471
GO:0046982
GO:0004871
GO:0003714
GO:0001306
GO:0048148
GO:0007620
GO:0008340
GO:0008062
GO:0043153
GO:0045475
GO:0007616
GO:0045433
GO:0000122
GO:0045187
GO:0009266
InterPro IPR001610
IPR000014
IPR013767
KO K02633
Pfam PF00989
SMART SM00086
SM00091
PROSITE PS50112

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000122

negative regulation of transcription from RNA polymerase II promoter

PMID:11178250[1]

TAS: Traceable Author Statement

P

Seeded From UniProt

GO:0000122

negative regulation of transcription from RNA polymerase II promoter

PMID:12015613[2]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

GO:0000122

negative regulation of transcription from RNA polymerase II promoter

PMID:12486701[3]

TAS: Traceable Author Statement

P

Seeded From UniProt

GO:0001306

age-dependent response to oxidative stress

PMID:20157575[4]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0003712

transcription cofactor activity

PMID:11715043[5]

NAS: Non-traceable Author Statement

F

Seeded From UniProt

GO:0003714

transcription corepressor activity

PMID:12486701[3]

TAS: Traceable Author Statement

F

Seeded From UniProt

GO:0004871

signal transducer activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000014

F

Seeded From UniProt

GO:0005515

protein binding

PMID:11448767[6]

IPI: Inferred from Physical Interaction

UniProtKB:O77059

F

Seeded From UniProt

GO:0005634

nucleus

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0539

C

Seeded From UniProt

GO:0005634

nucleus

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0191

C

Seeded From UniProt

GO:0005634

nucleus

PMID:12015613[2]

NAS: Non-traceable Author Statement

C

Seeded From UniProt

GO:0005634

nucleus

PMID:12486701[3]

TAS: Traceable Author Statement

C

Seeded From UniProt

GO:0005634

nucleus

PMID:12626480[7]

TAS: Traceable Author Statement

C

Seeded From UniProt

GO:0005634

nucleus

PMID:12944510[8]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0005634

nucleus

PMID:15356209[9]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0005634

nucleus

PMID:15930393[10]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0005634

nucleus

PMID:16410523[11]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0005634

nucleus

PMID:17369364[12]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0005737

cytoplasm

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0963

C

Seeded From UniProt

GO:0005737

cytoplasm

PMID:12015613[2]

NAS: Non-traceable Author Statement

C

Seeded From UniProt

GO:0005737

cytoplasm

PMID:12626480[7]

TAS: Traceable Author Statement

C

Seeded From UniProt

GO:0005737

cytoplasm

PMID:12944510[8]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0005737

cytoplasm

PMID:15356209[9]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0005737

cytoplasm

PMID:16410523[11]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0005737

cytoplasm

PMID:17369364[12]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0005737

cytoplasm

PMID:19223210[13]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0006355

regulation of transcription, DNA-dependent

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001610

P

Seeded From UniProt

GO:0006355

regulation of transcription, DNA-dependent

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR013767

P

Seeded From UniProt

GO:0006979

response to oxidative stress

PMID:18627767[14]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0007165

signal transduction

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000014

P

Seeded From UniProt

GO:0007165

signal transduction

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001610

P

Seeded From UniProt

GO:0007616

long-term memory

PMID:15522971[15]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0007617

mating behavior

PMID:11470898[16]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0007619

courtship behavior

PMID:11715043[5]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

GO:0007620

copulation

PMID:15324667[17]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0007622

rhythmic behavior

PMID:12486701[3]

TAS: Traceable Author Statement

P

Seeded From UniProt

GO:0007623

circadian rhythm

PMID:11092827[18]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

GO:0007623

circadian rhythm

PMID:11178250[1]

TAS: Traceable Author Statement

P

Seeded From UniProt

GO:0007623

circadian rhythm

PMID:11715043[5]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

GO:0007623

circadian rhythm

PMID:12154068[19]

TAS: Traceable Author Statement

P

Seeded From UniProt

GO:0007623

circadian rhythm

PMID:12417656[20]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0007623

circadian rhythm

PMID:12944510[8]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0007623

circadian rhythm

PMID:15312644[21]

TAS: Traceable Author Statement

P

Seeded From UniProt

GO:0007623

circadian rhythm

PMID:16319317[22]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0007623

circadian rhythm

PMID:18666831[23]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0008062

eclosion rhythm

PMID:11264660[24]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0008062

eclosion rhythm

PMID:11715043[5]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

GO:0008062

eclosion rhythm

PMID:12015613[2]

TAS: Traceable Author Statement

P

Seeded From UniProt

GO:0008062

eclosion rhythm

PMID:12111533[25]

TAS: Traceable Author Statement

P

Seeded From UniProt

GO:0008062

eclosion rhythm

PMID:12486701[3]

TAS: Traceable Author Statement

P

Seeded From UniProt

GO:0008062

eclosion rhythm

PMID:12626480[7]

TAS: Traceable Author Statement

P

Seeded From UniProt

GO:0008340

determination of adult lifespan

PMID:20157575[4]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0009266

response to temperature stimulus

PMID:12626480[7]

TAS: Traceable Author Statement

P

Seeded From UniProt

GO:0009416

response to light stimulus

PMID:12626480[7]

TAS: Traceable Author Statement

P

Seeded From UniProt

GO:0009649

entrainment of circadian clock

PMID:16085487[26]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0042745

circadian sleep/wake cycle

PMID:12111533[25]

TAS: Traceable Author Statement

P

Seeded From UniProt

GO:0043153

entrainment of circadian clock by photoperiod

PMID:16361445[27]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0045187

regulation of circadian sleep/wake cycle, sleep

PMID:12015603[28]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0045433

male courtship behavior, veined wing generated song production

PMID:11092827[18]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

GO:0045433

male courtship behavior, veined wing generated song production

PMID:12486700[29]

TAS: Traceable Author Statement

P

Seeded From UniProt

GO:0045475

locomotor rhythm

PMID:11264660[24]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0045475

locomotor rhythm

PMID:11715043[5]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

GO:0045475

locomotor rhythm

PMID:12015613[2]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

GO:0045475

locomotor rhythm

PMID:12626480[7]

TAS: Traceable Author Statement

P

Seeded From UniProt

GO:0045475

locomotor rhythm

PMID:18044989[30]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0046982

protein heterodimerization activity

PMID:11178250[1]

NAS: Non-traceable Author Statement

F

Seeded From UniProt

GO:0046982

protein heterodimerization activity

PMID:15312644[21]

TAS: Traceable Author Statement

F

Seeded From UniProt

GO:0048148

behavioral response to cocaine

PMID:11715043[5]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

GO:0048471

perinuclear region of cytoplasm

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0198

C

Seeded From UniProt

GO:0048511

rhythmic process

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0090

P

Seeded From UniProt

GO:0048512

circadian behavior

PMID:10677013[31]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0048512

circadian behavior

PMID:8134384[32]

IMP: Inferred from Mutant Phenotype

P

Figure 3

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 Hardin PE (2000) From biological clock to biological rhythms. Genome Biol 1: REVIEWS1023 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 2.4 Panda S et al. (2002) Circadian rhythms from flies to human. Nature 417: 329-35 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 3.4 Stanewsky R (2003) Genetic analysis of the circadian system in Drosophila melanogaster and mammals. J Neurobiol 54: 111-47 PubMed GONUTS page
  4. ↑ 4.0 4.1 Krishnan N et al. (2009) The circadian clock gene period extends healthspan in aging Drosophila melanogaster. Aging (Albany NY) 1: 937-48 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 5.4 5.5 Sokolowski MB (2001) Drosophila: genetics meets behaviour. Nat Rev Genet 2: 879-90 PubMed GONUTS page
  6. ↑ Rosato E et al. (2001) Light-dependent interaction between Drosophila CRY and the clock protein PER mediated by the carboxy terminus of CRY. Curr Biol 11: 909-17 PubMed GONUTS page
  7. ↑ 7.0 7.1 7.2 7.3 7.4 7.5 Hendricks JC (2003) Invited review: Sleeping flies don't lie: the use of Drosophila melanogaster to study sleep and circadian rhythms. J Appl Physiol 94: 1660-72; discussion 1673 PubMed GONUTS page
  8. ↑ 8.0 8.1 8.2 Ashmore LJ et al. (2003) Novel insights into the regulation of the timeless protein. J Neurosci 23: 7810-9 PubMed GONUTS page
  9. ↑ 9.0 9.1 Lin Y et al. (2004) The neuropeptide pigment-dispersing factor coordinates pacemaker interactions in the Drosophila circadian system. J Neurosci 24: 7951-7 PubMed GONUTS page
  10. ↑ Cyran SA et al. (2005) The double-time protein kinase regulates the subcellular localization of the Drosophila clock protein period. J Neurosci 25: 5430-7 PubMed GONUTS page
  11. ↑ 11.0 11.1 Meyer P et al. (2006) PER-TIM interactions in living Drosophila cells: an interval timer for the circadian clock. Science 311: 226-9 PubMed GONUTS page
  12. ↑ 12.0 12.1 Fernández MP et al. (2007) Impaired clock output by altered connectivity in the circadian network. Proc Natl Acad Sci U S A 104: 5650-5 PubMed GONUTS page
  13. ↑ Kotwica J et al. (2009) Developmental profiles of PERIOD and DOUBLETIME in Drosophila melanogaster ovary. J Insect Physiol 55: 419-25 PubMed GONUTS page
  14. ↑ Krishnan N et al. (2008) Circadian regulation of response to oxidative stress in Drosophila melanogaster. Biochem Biophys Res Commun 374: 299-303 PubMed GONUTS page
  15. ↑ Sakai T et al. (2004) A clock gene, period, plays a key role in long-term memory formation in Drosophila. Proc Natl Acad Sci U S A 101: 16058-63 PubMed GONUTS page
  16. ↑ Sakai T & Ishida N (2001) Circadian rhythms of female mating activity governed by clock genes in Drosophila. Proc Natl Acad Sci U S A 98: 9221-5 PubMed GONUTS page
  17. ↑ Beaver LM & Giebultowicz JM (2004) Regulation of copulation duration by period and timeless in Drosophila melanogaster. Curr Biol 14: 1492-7 PubMed GONUTS page
  18. ↑ 18.0 18.1 Greenspan RJ & Ferveur JF (2000) Courtship in Drosophila. Annu Rev Genet 34: 205-232 PubMed GONUTS page
  19. ↑ Glossop NR & Hardin PE (2002) Central and peripheral circadian oscillator mechanisms in flies and mammals. J Cell Sci 115: 3369-77 PubMed GONUTS page
  20. ↑ Ceriani MF et al. (2002) Genome-wide expression analysis in Drosophila reveals genes controlling circadian behavior. J Neurosci 22: 9305-19 PubMed GONUTS page
  21. ↑ 21.0 21.1 Emery P & Reppert SM (2004) A rhythmic Ror. Neuron 43: 443-6 PubMed GONUTS page
  22. ↑ Lin JM et al. (2005) In vivo circadian function of casein kinase 2 phosphorylation sites in Drosophila PERIOD. J Neurosci 25: 11175-83 PubMed GONUTS page
  23. ↑ Kivimäe S et al. (2008) Activating PER repressor through a DBT-directed phosphorylation switch. PLoS Biol 6: e183 PubMed GONUTS page
  24. ↑ 24.0 24.1 Blanchardon E et al. (2001) Defining the role of Drosophila lateral neurons in the control of circadian rhythms in motor activity and eclosion by targeted genetic ablation and PERIOD protein overexpression. Eur J Neurosci 13: 871-88 PubMed GONUTS page
  25. ↑ 25.0 25.1 Stanewsky R (2002) Clock mechanisms in Drosophila. Cell Tissue Res 309: 11-26 PubMed GONUTS page
  26. ↑ Glaser FT & Stanewsky R (2005) Temperature synchronization of the Drosophila circadian clock. Curr Biol 15: 1352-63 PubMed GONUTS page
  27. ↑ Collins BH et al. (2005) Disruption of Cryptochrome partially restores circadian rhythmicity to the arrhythmic period mutant of Drosophila. Proc Natl Acad Sci U S A 102: 19021-6 PubMed GONUTS page
  28. ↑ Shaw PJ et al. (2002) Stress response genes protect against lethal effects of sleep deprivation in Drosophila. Nature 417: 287-91 PubMed GONUTS page
  29. ↑ Emmons SW & Lipton J (2003) Genetic basis of male sexual behavior. J Neurobiol 54: 93-110 PubMed GONUTS page
  30. ↑ Picot M et al. (2007) Light activates output from evening neurons and inhibits output from morning neurons in the Drosophila circadian clock. PLoS Biol 5: e315 PubMed GONUTS page
  31. ↑ Kaneko M et al. (2000) Involvement of the period gene in developmental time-memory: effect of the perShort mutation on phase shifts induced by light pulses delivered to Drosophila larvae. J Biol Rhythms 15: 13-30 PubMed GONUTS page
  32. ↑ Edery I et al. (1994) Temporal phosphorylation of the Drosophila period protein. Proc Natl Acad Sci U S A 91: 2260-4 PubMed GONUTS page
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