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DROME:PEN2
Contents |
| Species (Taxon ID) | Drosophila melanogaster (Fruit fly). (taxon:7227) | |
| Gene Name(s) | pen-2 | |
| Protein Name(s) |
| |
| External Links | ||
| UniProt Identifier | PEN2_DROME | |
| UniProt Accessions | Q86BE9, A8E6Z8, Q8MUT4, | |
| EMBL | AF512426, AE013599, BT030940, BT030980, | |
| RefSeq | NP_788401.2, | |
| IntAct | Q86BE9, | |
| Pfam | PF10251, | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0016020 |
membrane |
IEA: Inferred from Electronic Annotation |
C |
|||||
| GO:0004175 |
endopeptidase activity |
IDA: Inferred from Direct Assay |
|
F |
||||
| GO:0016021 |
integral to membrane |
IEA: Inferred from Electronic Annotation |
C |
|||||
| GO:0007219 |
Notch signaling pathway |
IMP: Inferred from Mutant Phenotype |
P |
Figure 5 I-M. Knockdown of pen-2 in Drosophila cells via RNAi results in fewer Notch signaling products being released. |
complete | |||
| GO:0016020 |
membrane |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0162 |
C |
||||
| GO:0004175 |
endopeptidase activity |
IDA: Inferred from Direct Assay |
F |
|||||
| GO:0007219 |
Notch signaling pathway |
IEA: Inferred from Electronic Annotation |
P |
|||||
| GO:0016020 |
membrane |
IEA: Inferred from Electronic Annotation |
C |
|||||
| GO:0016020 |
membrane |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0162 |
C |
||||
| GO:0016021 |
integral to membrane |
IEA: Inferred from Electronic Annotation |
C |
| ||||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Takasugi N et al. (2003) The role of presenilin cofactors in the gamma-secretase complex. Nature 422: 438-41 PubMed GONUTS page
- ↑ Francis R et al. (2002) aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation. Dev Cell 3: 85-97 PubMed GONUTS page
