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DROME:O46034

From GONUTS
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Contents

Species (Taxon ID) Drosophila melanogaster (Fruit fly). (taxon:7227)
Gene Name(s) Cbl ( synonyms: cbl )
Protein Name(s)
  • Cbl protein
  • Cbl, isoform A
  • LD46082p
External Links
UniProt Identifier O46034_DROME
UniProt Accessions O46034,
EMBL AE014296, AY118593, AJ223175,
RefSeq NP_729382.1,
IntAct O46034,
Pfam PF02262, PF02761, PF02762, PF00097,

Annotations

Qualifier GO ID GO term name Reference(s) Evidence Code with/from Aspect Notes Status
GO:0006508

proteolysis

PMID:14570584[1]

TAS: Traceable Author Statement

P

GO:0016874

ligase activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0436

F

GO:0001754

eye photoreceptor cell differentiation

PMID:18197257[2]

IDA: Inferred from Direct Assay

P

GO:0008270

zinc ion binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001841

F

GO:0007175

negative regulation of epidermal growth factor receptor activity

PMID:12648473[3]

TAS: Traceable Author Statement

P

GO:0042127

regulation of cell proliferation

PMID:19306863[4]

IGI: Inferred from Genetic Interaction

FB:FBgn0028734

P

GO:0004871

signal transducer activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR014741

F

GO:0007465

R7 cell fate commitment

PMID:18197257[2]

IDA: Inferred from Direct Assay

P

GO:0005634

nucleus

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR014741

C

GO:0007476

imaginal disc-derived wing morphogenesis

PMID:16648592[5]

IMP: Inferred from Mutant Phenotype

P

GO:0048134

germ-line cyst formation

PMID:19306863[4]

IGI: Inferred from Genetic Interaction

FB:FBgn0028734

P

GO:0005634

nucleus

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR014742

C

GO:0005509

calcium ion binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011992

F

GO:0010941

regulation of cell death

PMID:18197257[2]

IDA: Inferred from Direct Assay

P

GO:0007166

cell surface receptor linked signaling pathway

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003153

P

GO:0005938

cell cortex

PMID:16844358[6]

IDA: Inferred from Direct Assay

C

GO:0007173

epidermal growth factor receptor signaling pathway

PMID:11287200[7]

TAS: Traceable Author Statement

P

GO:0004871

signal transducer activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003153

F

GO:0007298

border follicle cell migration

PMID:16054027[8]

IMP: Inferred from Mutant Phenotype

P

GO:0016874

ligase activity

PMID:14570584[1]

TAS: Traceable Author Statement

F

GO:0007166

cell surface receptor linked signaling pathway

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR014741

P

GO:0004871

signal transducer activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR014742

F

GO:0046872

metal ion binding

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0479

F

GO:0042059

negative regulation of epidermal growth factor receptor signaling pathway

PMID:16844358[6]

IMP: Inferred from Mutant Phenotype

P

GO:0009950

dorsal/ventral axis specification

PMID:11051547[9]

IMP: Inferred from Mutant Phenotype

P

GO:0007175

negative regulation of epidermal growth factor receptor activity

PMID:11051547[9]

IMP: Inferred from Mutant Phenotype

P

GO:0008069

dorsal/ventral axis specification, ovarian follicular epithelium

PMID:11051547[9]

IMP: Inferred from Mutant Phenotype

P

GO:0005634

nucleus

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003153

C

GO:0055131

C3HC4-type RING finger domain binding

PMID:21340027[10]

IDA: Inferred from Direct Assay

F

Table 3 Figure 4

complete

GO:0007166

cell surface receptor linked signaling pathway

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR014742

P

GO:0001754

eye photoreceptor cell differentiation

PMID:18197257[2]

IDA: Inferred from Direct Assay

P

GO:0004871

signal transducer activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003153

F

GO:0004871

signal transducer activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR014741

F

GO:0004871

signal transducer activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR014742

F

GO:0005509

calcium ion binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011992

F

GO:0005634

nucleus

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003153

C

GO:0005634

nucleus

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR014741

C

GO:0005634

nucleus

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR014742

C

GO:0005938

cell cortex

PMID:16844358[6]

IDA: Inferred from Direct Assay

C

GO:0006508

proteolysis

PMID:14570584[1]

TAS: Traceable Author Statement

P

GO:0007166

cell surface receptor linked signaling pathway

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003153

P

GO:0007166

cell surface receptor linked signaling pathway

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR014741

P

GO:0007166

cell surface receptor linked signaling pathway

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR014742

P

GO:0007173

epidermal growth factor receptor signaling pathway

PMID:11287200[7]

TAS: Traceable Author Statement

P

GO:0007175

negative regulation of epidermal growth factor receptor activity

PMID:11051547[9]

IMP: Inferred from Mutant Phenotype

P

GO:0007175

negative regulation of epidermal growth factor receptor activity

PMID:12648473[3]

TAS: Traceable Author Statement

P

GO:0007298

border follicle cell migration

PMID:16054027[8]

IMP: Inferred from Mutant Phenotype

P

GO:0007465

R7 cell fate commitment

PMID:18197257[2]

IDA: Inferred from Direct Assay

P

GO:0007476

imaginal disc-derived wing morphogenesis

PMID:16648592[5]

IMP: Inferred from Mutant Phenotype

P

GO:0008069

dorsal/ventral axis specification, ovarian follicular epithelium

PMID:11051547[9]

IMP: Inferred from Mutant Phenotype

P

GO:0008270

zinc ion binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001841

F

GO:0009950

dorsal/ventral axis specification

PMID:11051547[9]

IMP: Inferred from Mutant Phenotype

P

GO:0010941

regulation of cell death

PMID:18197257[2]

IDA: Inferred from Direct Assay

P

GO:0016874

ligase activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0436

F

GO:0016874

ligase activity

PMID:14570584[1]

TAS: Traceable Author Statement

F

GO:0042059

negative regulation of epidermal growth factor receptor signaling pathway

PMID:16844358[6]

IMP: Inferred from Mutant Phenotype

P

GO:0042127

regulation of cell proliferation

PMID:19306863[4]

IGI: Inferred from Genetic Interaction

FB:FBgn0028734

P

GO:0046872

metal ion binding

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0479

F

GO:0048134

germ-line cyst formation

PMID:19306863[4]

IGI: Inferred from Genetic Interaction

FB:FBgn0028734

P


edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 Ghabrial A et al. (2003) Branching morphogenesis of the Drosophila tracheal system. Annu Rev Cell Dev Biol 19: 623-47 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Wang Y et al. (2008) Drosophila cbl is essential for control of cell death and cell differentiation during eye development. PLoS One 3: e1447 PubMed GONUTS page
  3. ↑ 3.0 3.1 Shilo BZ (2003) Signaling by the Drosophila epidermal growth factor receptor pathway during development. Exp Cell Res 284: 140-9 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 Epstein AM et al. (2009) Drosophila Fragile X protein controls cellular proliferation by regulating cbl levels in the ovary. Dev Biol 330: 83-92 PubMed GONUTS page
  5. ↑ 5.0 5.1 Dworkin I & Gibson G (2006) Epidermal growth factor receptor and transforming growth factor-beta signaling contributes to variation for wing shape in Drosophila melanogaster. Genetics 173: 1417-31 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 6.3 Pai LM et al. (2006) Differential effects of Cbl isoforms on Egfr signaling in Drosophila. Mech Dev 123: 450-62 PubMed GONUTS page
  7. ↑ 7.0 7.1 Hime GR et al. (2001) Dynamic expression of alternate splice forms of D-cbl during embryogenesis. Mech Dev 102: 235-8 PubMed GONUTS page
  8. ↑ 8.0 8.1 Jékely G et al. (2005) Regulators of endocytosis maintain localized receptor tyrosine kinase signaling in guided migration. Dev Cell 9: 197-207 PubMed GONUTS page
  9. ↑ 9.0 9.1 9.2 9.3 9.4 9.5 Pai LM et al. (2000) D-cbl, a negative regulator of the Egfr pathway, is required for dorsoventral patterning in Drosophila oogenesis. Cell 103: 51-61 PubMed GONUTS page
  10. ↑ Wang PY & Pai LM (2011) D-Cbl binding to Drk leads to dose-dependent down-regulation of EGFR signaling and increases receptor-ligand endocytosis. PLoS One 6: e17097 PubMed GONUTS page
Retrieved from "http://gowiki.tamu.edu/wiki/index.php/DROME:O46034"
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