DROME:MLE

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Species (Taxon ID)	Drosophila melanogaster (Fruit fly). (taxon:7227)
Gene Name(s)	mle ( synonyms: nap )
Protein Name(s)	Dosage compensation regulator ATP-dependent RNA helicase mle Protein male-less Protein maleless Protein no action potential
External Links
UniProt Identifier	MLE_DROME
UniProt Accessions	P24785, Q86NQ4, Q9V9J1,
EMBL	M74121, AE013599, AE013599, BT003785, BT010267,
PIR	B40025,
RefSeq	NP_476641.1, NP_724440.1,
IntAct	P24785,
Pfam	PF00270, PF00035, PF04408, PF00271, PF07717,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect
	GO:0000166	nucleotide binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0547	F
	GO:0000785	chromatin	PMID:8288132^[1]	IDA: Inferred from Direct Assay		C
	GO:0000805	X chromosome	PMID:16079233^[2]	IDA: Inferred from Direct Assay		C
	GO:0000805	X chromosome	PMID:18562276^[3]	IDA: Inferred from Direct Assay		C
	GO:0003676	nucleic acid binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001650	F
	GO:0003676	nucleic acid binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002464	F
	GO:0003676	nucleic acid binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011545	F
	GO:0003682	chromatin binding	PMID:8288132^[1]	IDA: Inferred from Direct Assay		F
	GO:0003723	RNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR014720	F
	GO:0003724	RNA helicase activity	PMID:12717814^[4]	NAS: Non-traceable Author Statement		F
	GO:0003725	double-stranded RNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001159	F
	GO:0004386	helicase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001650	F
	GO:0004386	helicase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR007502	F
	GO:0004386	helicase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0347	F
	GO:0005515	protein binding	PMID:14605208^[5]	IPI: Inferred from Physical Interaction	UniProtKB:Q29QS8	F
	GO:0005515	protein binding	PMID:14605208^[5]	IPI: Inferred from Physical Interaction	UniProtKB:Q7KTI0	F
	GO:0005515	protein binding	PMID:14605208^[5]	IPI: Inferred from Physical Interaction	UniProtKB:Q8SZH8	F
	GO:0005515	protein binding	PMID:14605208^[5]	IPI: Inferred from Physical Interaction	UniProtKB:Q9VPJ7	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001650	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002464	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011545	F
	GO:0005524	ATP binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0067	F
	GO:0005622	intracellular	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001159	C
	GO:0005622	intracellular	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR014720	C
	GO:0005634	nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0539	C
	GO:0005634	nucleus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0191	C
	GO:0005694	chromosome	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0158	C
	GO:0005694	chromosome	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0468	C
	GO:0007549	dosage compensation	PMID:8288132^[1]	IMP: Inferred from Mutant Phenotype		P
	GO:0007549	dosage compensation	PMID:8970731^[6]	TAS: Traceable Author Statement		P
	GO:0008026	ATP-dependent helicase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002464	F
	GO:0008026	ATP-dependent helicase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011545	F
	GO:0008026	ATP-dependent helicase activity	PMID:8288132^[1]	TAS: Traceable Author Statement		F
	GO:0008340	determination of adult lifespan	PMID:16272407^[7]	IMP: Inferred from Mutant Phenotype		P
	GO:0009047	dosage compensation, by hyperactivation of X chromosome	PMID:10648226^[8]	NAS: Non-traceable Author Statement		P
	GO:0009047	dosage compensation, by hyperactivation of X chromosome	PMID:8970731^[6]	NAS: Non-traceable Author Statement		P
	GO:0016456	X chromosome located dosage compensation complex, transcription activating	PMID:10648226^[8]	NAS: Non-traceable Author Statement		C
	GO:0016456	X chromosome located dosage compensation complex, transcription activating	PMID:11178270^[9]	TAS: Traceable Author Statement		C
	GO:0016457	dosage compensation complex assembly involved in dosage compensation by hyperactivation of X chromosome	PMID:12717814^[4]	TAS: Traceable Author Statement		P
	GO:0016787	hydrolase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0378	F
	GO:0045433	male courtship behavior, veined wing generated song production	PMID:9504928^[10]	IGI: Inferred from Genetic Interaction	FB:FBgn0005563	P
	GO:0048675	axon extension	PMID:14960616^[11]	IMP: Inferred from Mutant Phenotype		P
	GO:0000166	nucleotide binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0547	F
	GO:0000785	chromatin	PMID:8288132^[1]	IDA: Inferred from Direct Assay		C
	GO:0000805	X chromosome	PMID:16079233^[2]	IDA: Inferred from Direct Assay		C
	GO:0000805	X chromosome	PMID:18562276^[3]	IDA: Inferred from Direct Assay		C
	GO:0003676	nucleic acid binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001650	F
	GO:0003676	nucleic acid binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002464	F
	GO:0003676	nucleic acid binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011545	F
	GO:0003682	chromatin binding	PMID:8288132^[1]	IDA: Inferred from Direct Assay		F
	GO:0003723	RNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR014720	F
	GO:0003724	RNA helicase activity	PMID:12717814^[4]	NAS: Non-traceable Author Statement		F
	GO:0003725	double-stranded RNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001159	F
	GO:0004386	helicase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001650	F
	GO:0004386	helicase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR007502	F
	GO:0004386	helicase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0347	F
	GO:0005515	protein binding	PMID:14605208^[5]	IPI: Inferred from Physical Interaction	UniProtKB:Q29QS8	F
	GO:0005515	protein binding	PMID:14605208^[5]	IPI: Inferred from Physical Interaction	UniProtKB:Q7KTI0	F
	GO:0005515	protein binding	PMID:14605208^[5]	IPI: Inferred from Physical Interaction	UniProtKB:Q8SZH8	F
	GO:0005515	protein binding	PMID:14605208^[5]	IPI: Inferred from Physical Interaction	UniProtKB:Q9VPJ7	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001650	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002464	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011545	F
	GO:0005524	ATP binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0067	F
	GO:0005622	intracellular	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001159	C
	GO:0005622	intracellular	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR014720	C
	GO:0005634	nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0539	C
	GO:0005634	nucleus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0191	C
	GO:0005694	chromosome	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0158	C
	GO:0005694	chromosome	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0468	C
	GO:0007549	dosage compensation	PMID:8288132^[1]	IMP: Inferred from Mutant Phenotype		P
	GO:0007549	dosage compensation	PMID:8970731^[6]	TAS: Traceable Author Statement		P
	GO:0008026	ATP-dependent helicase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002464	F
	GO:0008026	ATP-dependent helicase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011545	F
	GO:0008026	ATP-dependent helicase activity	PMID:8288132^[1]	TAS: Traceable Author Statement		F
	GO:0008340	determination of adult lifespan	PMID:16272407^[7]	IMP: Inferred from Mutant Phenotype		P
	GO:0009047	dosage compensation, by hyperactivation of X chromosome	PMID:10648226^[8]	NAS: Non-traceable Author Statement		P
	GO:0009047	dosage compensation, by hyperactivation of X chromosome	PMID:8970731^[6]	NAS: Non-traceable Author Statement		P
	GO:0016456	X chromosome located dosage compensation complex, transcription activating	PMID:10648226^[8]	NAS: Non-traceable Author Statement		C
	GO:0016456	X chromosome located dosage compensation complex, transcription activating	PMID:11178270^[9]	TAS: Traceable Author Statement		C
	GO:0016457	dosage compensation complex assembly involved in dosage compensation by hyperactivation of X chromosome	PMID:12717814^[4]	TAS: Traceable Author Statement		P
	GO:0016787	hydrolase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0378	F
	GO:0045433	male courtship behavior, veined wing generated song production	PMID:9504928^[10]	IGI: Inferred from Genetic Interaction	FB:FBgn0005563	P
	GO:0048675	axon extension	PMID:14960616^[11]	IMP: Inferred from Mutant Phenotype		P
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Bone JR et al. (1994) Acetylated histone H4 on the male X chromosome is associated with dosage compensation in Drosophila. Genes Dev 8: 96-104 PubMed GONUTS page
↑ ^2.0 ^2.1 Kotlikova IV et al. (2006) The Drosophila dosage compensation complex binds to polytene chromosomes independently of developmental changes in transcription. Genetics 172: 963-74 PubMed GONUTS page
↑ ^3.0 ^3.1 Smith ER et al. (2008) Regulation of the transcriptional activity of poised RNA polymerase II by the elongation factor ELL. Proc Natl Acad Sci U S A 105: 8575-9 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Wutz A (2003) RNAs templating chromatin structure for dosage compensation in animals. Bioessays 25: 434-42 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 Giot L et al. (2003) A protein interaction map of Drosophila melanogaster. Science 302: 1727-36 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Williamson A & Lehmann R (1996) Germ cell development in Drosophila. Annu Rev Cell Dev Biol 12: 365-91 PubMed GONUTS page
↑ ^7.0 ^7.1 Fergestad T et al. (2006) Neuropathology in Drosophila membrane excitability mutants. Genetics 172: 1031-42 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Schütt C & Nöthiger R (2000) Structure, function and evolution of sex-determining systems in Dipteran insects. Development 127: 667-77 PubMed GONUTS page
↑ ^9.0 ^9.1 Amrein H (2000) Multiple RNA-protein interactions in Drosophila dosage compensation. Genome Biol 1: REVIEWS1030 PubMed GONUTS page
↑ ^10.0 ^10.1 Peixoto AA & Hall JC (1998) Analysis of temperature-sensitive mutants reveals new genes involved in the courtship song of Drosophila. Genetics 148: 827-38 PubMed GONUTS page
↑ ^11.0 ^11.1 Zhong Y & Wu CF (2004) Neuronal activity and adenylyl cyclase in environment-dependent plasticity of axonal outgrowth in Drosophila. J Neurosci 24: 1439-45 PubMed GONUTS page

[PMID:8288132-0] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Bone JR et al. (1994) Acetylated histone H4 on the male X chromosome is associated with dosage compensation in Drosophila. Genes Dev 8: 96-104 PubMed GONUTS page

[PMID:16079233-1] 2.0 ^2.1 Kotlikova IV et al. (2006) The Drosophila dosage compensation complex binds to polytene chromosomes independently of developmental changes in transcription. Genetics 172: 963-74 PubMed GONUTS page

[PMID:18562276-2] 3.0 ^3.1 Smith ER et al. (2008) Regulation of the transcriptional activity of poised RNA polymerase II by the elongation factor ELL. Proc Natl Acad Sci U S A 105: 8575-9 PubMed GONUTS page

[PMID:12717814-3] 4.0 ^4.1 ^4.2 ^4.3 Wutz A (2003) RNAs templating chromatin structure for dosage compensation in animals. Bioessays 25: 434-42 PubMed GONUTS page

[PMID:14605208-4] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 Giot L et al. (2003) A protein interaction map of Drosophila melanogaster. Science 302: 1727-36 PubMed GONUTS page

[PMID:8970731-5] 6.0 ^6.1 ^6.2 ^6.3 Williamson A & Lehmann R (1996) Germ cell development in Drosophila. Annu Rev Cell Dev Biol 12: 365-91 PubMed GONUTS page

[PMID:16272407-6] 7.0 ^7.1 Fergestad T et al. (2006) Neuropathology in Drosophila membrane excitability mutants. Genetics 172: 1031-42 PubMed GONUTS page

[PMID:10648226-7] 8.0 ^8.1 ^8.2 ^8.3 Schütt C & Nöthiger R (2000) Structure, function and evolution of sex-determining systems in Dipteran insects. Development 127: 667-77 PubMed GONUTS page

[PMID:11178270-8] 9.0 ^9.1 Amrein H (2000) Multiple RNA-protein interactions in Drosophila dosage compensation. Genome Biol 1: REVIEWS1030 PubMed GONUTS page

[PMID:9504928-9] 10.0 ^10.1 Peixoto AA & Hall JC (1998) Analysis of temperature-sensitive mutants reveals new genes involved in the courtship song of Drosophila. Genetics 148: 827-38 PubMed GONUTS page

[PMID:14960616-10] 11.0 ^11.1 Zhong Y & Wu CF (2004) Neuronal activity and adenylyl cyclase in environment-dependent plasticity of axonal outgrowth in Drosophila. J Neurosci 24: 1439-45 PubMed GONUTS page

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DROME:MLE

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References

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