GONUTS is under stress! The website is currently experiencing long-wait times and frequent time-outs due to the record number of students, groups, and annotations related to CACAO this semester. We are currently working on increasing performance -- please accept our apologies for the technical difficulties.
You can help reduce stress on the server by:
- not reloading pages frequently - this just adds
- opening links in new windows (so you can read the old page)
DROME:HP1
Contents |
| Species (Taxon ID) | Drosophila melanogaster (Fruit fly). ([1]) | |
| Gene Name(s) | Su(var)205 (synonyms: HP1) | |
| Protein Name(s) | Heterochromatin protein 1
HP1 Non-histone chromosomal protein C1A9 antigen | |
| External Links | ||
| EMBL | M57574 M14131 FJ218607 FJ218612 FJ218613 FJ218614 FJ218615 FJ218616 FJ218617 FJ218618 FJ218619 FJ218620 FJ218621 FJ218622 FJ218623 FJ218624 FJ218625 FJ218626 FJ218627 FJ218628 FJ218629 FJ218630 FJ218631 FJ218632 FJ218633 FJ218634 FJ218635 FJ218636 FJ218637 FJ218638 FJ218639 AE014134 AE014134 AY061119 | |
| PIR | A39268 | |
| RefSeq | NP_476755.1 NP_723361.1 | |
| UniGene | Dm.3713 | |
| PDB | 1KNA 1KNE 1Q3L 3P7J | |
| PDBsum | 1KNA 1KNE 1Q3L 3P7J | |
| ProteinModelPortal | P05205 | |
| SMR | P05205 | |
| DIP | DIP-21869N | |
| IntAct | P05205 | |
| MINT | MINT-271388 | |
| STRING | P05205 | |
| EnsemblMetazoa | FBtr0079635 FBtr0079636 | |
| GeneID | 34119 | |
| KEGG | dme:Dmel_CG8409 | |
| CTD | 34119 | |
| FlyBase | FBgn0003607 | |
| eggNOG | inNOG10141 | |
| GeneTree | EMGT00050000005564 | |
| InParanoid | P05205 | |
| OMA | PETENTW | |
| OrthoDB | EOG40CG02 | |
| PhylomeDB | P05205 | |
| NextBio | 786946 | |
| ArrayExpress | P05205 | |
| Bgee | P05205 | |
| GermOnline | CG8409 | |
| GO | GO:0005721 GO:0000780 GO:0005720 GO:0005701 GO:0005703 GO:0035012 GO:0003682 GO:0042393 GO:0003729 GO:0000182 GO:0003696 GO:0030702 GO:0044026 GO:0006343 GO:0034773 GO:0045893 GO:0042981 GO:0031060 GO:0000723 GO:0006351 | |
| InterPro | IPR017984 IPR023780 IPR000953 IPR008251 IPR018125 IPR016197 | |
| Pfam | PF00385 PF01393 | |
| PRINTS | PR00504 | |
| SMART | SM00298 SM00300 | |
| SUPFAM | SSF54160 | |
| PROSITE | PS00598 PS50013 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000182 |
rDNA binding |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0000723 |
telomere maintenance |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0000775 |
chromosome, centromeric region |
NAS: Non-traceable Author Statement |
|
C |
Seeded From UniProt |
|||
| GO:0000775 |
chromosome, centromeric region |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
|||
| GO:0000780 |
condensed nuclear chromosome, centromeric region |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0000781 |
chromosome, telomeric region |
NAS: Non-traceable Author Statement |
|
C |
Seeded From UniProt |
|||
| GO:0000781 |
chromosome, telomeric region |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0000781 |
chromosome, telomeric region |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0000792 |
heterochromatin |
NAS: Non-traceable Author Statement |
|
C |
Seeded From UniProt |
|||
| GO:0000792 |
heterochromatin |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
|||
| GO:0000792 |
heterochromatin |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0000793 |
condensed chromosome |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0003682 |
chromatin binding |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0003696 |
satellite DNA binding |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0003729 |
mRNA binding |
NAS: Non-traceable Author Statement |
|
F |
Seeded From UniProt |
|||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005634 |
nucleus |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005634 |
nucleus |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005634 |
nucleus |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005634 |
nucleus |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0191 |
C |
Seeded From UniProt |
|||
| GO:0005634 |
nucleus |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005694 |
chromosome |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005700 |
polytene chromosome |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005701 |
polytene chromosome chromocenter |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005701 |
polytene chromosome chromocenter |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005701 |
polytene chromosome chromocenter |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
|||
| GO:0005701 |
polytene chromosome chromocenter |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005701 |
polytene chromosome chromocenter |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005703 |
polytene chromosome puff |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005703 |
polytene chromosome puff |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005703 |
polytene chromosome puff |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
|||
| GO:0005704 |
polytene chromosome band |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005720 |
nuclear heterochromatin |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005721 |
centromeric heterochromatin |
NAS: Non-traceable Author Statement |
|
C |
Seeded From UniProt |
|||
| GO:0006342 |
chromatin silencing |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0006343 |
establishment of chromatin silencing |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0006351 |
transcription, DNA-dependent |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006355 |
regulation of transcription, DNA-dependent |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006355 |
regulation of transcription, DNA-dependent |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0016568 |
chromatin modification |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0030702 |
chromatin silencing at centromere |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0031060 |
regulation of histone methylation |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0034773 |
histone H4-K20 trimethylation |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0035012 |
polytene chromosome, telomeric region |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0035012 |
polytene chromosome, telomeric region |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0035012 |
polytene chromosome, telomeric region |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
|||
| GO:0042393 |
histone binding |
NAS: Non-traceable Author Statement |
|
F |
Seeded From UniProt |
|||
| GO:0042981 |
regulation of apoptosis |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0044026 |
DNA hypermethylation |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0045892 |
negative regulation of transcription, DNA-dependent |
NAS: Non-traceable Author Statement |
|
P |
Seeded From UniProt |
|||
| GO:0045893 |
positive regulation of transcription, DNA-dependent |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
|||
| GO:0000792 |
heterochromatin |
IDA: Inferred from Direct Assay |
C |
Figure 1. Interaction of MU2 and HP1a. |
complete | |||
| GO:0051276 |
chromosome organization |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0005701 |
polytene chromosome chromocenter |
IMP: Inferred from Mutant Phenotype |
C |
Figure 3. Effects of HP1a depletion on focal movement. |
complete | |||
| GO:0010369 |
chromocenter |
IDA: Inferred from Direct Assay |
C |
Figure 4. HP1a is not recruited to IRIF and laser induced breaks. |
complete | |||
| GO:0005657 |
replication fork |
IDA: Inferred from Direct Assay |
C |
Figure 5. MU2 and cH2Av recognize stalled replication forks. |
complete | |||
| GO:0007067 |
mitosis |
IDA: Inferred from Direct Assay |
P |
Fig 7. Treatment of S2 cells with HP1a dsRNA leads to a decrease in the number of cells in S phase and an apparent increase in the number of cells at both G1 and G2/M. |
complete | |||
| GO:0051332 |
S phase of meiotic cell cycle |
IDA: Inferred from Direct Assay |
P |
Figure 7. HP1a depletion affects cell cycle in S2 cells. |
complete | |||
| GO:0042981 |
regulation of apoptosis |
IDA: Inferred from Direct Assay |
P |
Figure 8. Apoptosis and G2/M checkpoint in wing discs. |
complete | |||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Blattes R et al. (2006) Displacement of D1, HP1 and topoisomerase II from satellite heterochromatin by a specific polyamide. EMBO J 25: 2397-408 PubMed GONUTS page
- ↑ Perrini B et al. (2004) HP1 controls telomere capping, telomere elongation, and telomere silencing by two different mechanisms in Drosophila. Mol Cell 15: 467-76 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 Kellum R (2003) Is HP1 an RNA detector that functions both in repression and activation? J Cell Biol 161: 671-2 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Zhimulev IF & Belyaeva ES (2003) Intercalary heterochromatin and genetic silencing. Bioessays 25: 1040-51 PubMed GONUTS page
- ↑ 5.0 5.1 Gonzalez C & Bornens M (2000) Light, flies and cell division. Workshop: regulation of cell division in Drosophila. EMBO Rep 1: 390-3 PubMed GONUTS page
- ↑ Gao G et al. (2010) HipHop interacts with HOAP and HP1 to protect Drosophila telomeres in a sequence-independent manner. EMBO J 29: 819-29 PubMed GONUTS page
- ↑ Dubruille R et al. (2010) Specialization of a Drosophila capping protein essential for the protection of sperm telomeres. Curr Biol 20: 2090-9 PubMed GONUTS page
- ↑ 8.0 8.1 Shaffer CD et al. (2006) The large isoform of Drosophila melanogaster heterochromatin protein 2 plays a critical role in gene silencing and chromosome structure. Genetics 174: 1189-204 PubMed GONUTS page
- ↑ Johansson AM et al. (2007) POF and HP1 bind expressed exons, suggesting a balancing mechanism for gene regulation. PLoS Genet 3: e209 PubMed GONUTS page
- ↑ Christensen TW & Tye BK (2003) Drosophila MCM10 interacts with members of the prereplication complex and is required for proper chromosome condensation. Mol Biol Cell 14: 2206-15 PubMed GONUTS page
- ↑ Badugu R et al. (2003) Novel Drosophila heterochromatin protein 1 (HP1)/origin recognition complex-associated protein (HOAP) repeat motif in HP1/HOAP interactions and chromocenter associations. J Biol Chem 278: 34491-8 PubMed GONUTS page
- ↑ 12.0 12.1 12.2 Seong KH et al. (2011) Inheritance of stress-induced, ATF-2-dependent epigenetic change. Cell 145: 1049-61 PubMed GONUTS page
- ↑ Koch CM et al. (2009) Windei, the Drosophila homolog of mAM/MCAF1, is an essential cofactor of the H3K9 methyl transferase dSETDB1/Eggless in germ line development. PLoS Genet 5: e1000644 PubMed GONUTS page
- ↑ Gause M et al. (2008) Functional links between Drosophila Nipped-B and cohesin in somatic and meiotic cells. Chromosoma 117: 51-66 PubMed GONUTS page
- ↑ 15.0 15.1 15.2 Fanti L et al. (2003) Chromosomal distribution of heterochromatin protein 1 (HP1) in Drosophila: a cytological map of euchromatic HP1 binding sites. Genetica 117: 135-47 PubMed GONUTS page
- ↑ 16.0 16.1 16.2 Piacentini L et al. (2003) Heterochromatin protein 1 (HP1) is associated with induced gene expression in Drosophila euchromatin. J Cell Biol 161: 707-14 PubMed GONUTS page
- ↑ Font-Burgada J et al. (2008) Drosophila HP1c isoform interacts with the zinc-finger proteins WOC and Relative-of-WOC to regulate gene expression. Genes Dev 22: 3007-23 PubMed GONUTS page
- ↑ Shaffer CD et al. (2002) Heterochromatin protein 2 (HP2), a partner of HP1 in Drosophila heterochromatin. Proc Natl Acad Sci U S A 99: 14332-7 PubMed GONUTS page
- ↑ 19.0 19.1 Donaldson KM et al. (2002) Modifiers of terminal deficiency-associated position effect variegation in Drosophila. Genetics 160: 995-1009 PubMed GONUTS page
- ↑ Seum C et al. (2001) Ectopic HP1 promotes chromosome loops and variegated silencing in Drosophila. EMBO J 20: 812-8 PubMed GONUTS page
- ↑ 21.0 21.1 21.2 Liu LP et al. (2005) Sex-specific role of Drosophila melanogaster HP1 in regulating chromatin structure and gene transcription. Nat Genet 37: 1361-6 PubMed GONUTS page
- ↑ Yang H et al. (2008) Preferential dimethylation of histone H4 lysine 20 by Suv4-20. J Biol Chem 283: 12085-92 PubMed GONUTS page
- ↑ Gou D et al. (2010) SETDB1 is involved in postembryonic DNA methylation and gene silencing in Drosophila. PLoS One 5: e10581 PubMed GONUTS page
- ↑ 24.0 24.1 24.2 24.3 24.4 24.5 24.6 Dronamraju R & Mason JM (2011) MU2 and HP1a regulate the recognition of double strand breaks in Drosophila melanogaster. PLoS One 6: e25439 PubMed GONUTS page
- ↑ Demakova OV et al. (2007) The SU(VAR)3-9/HP1 complex differentially regulates the compaction state and degree of underreplication of X chromosome pericentric heterochromatin in Drosophila melanogaster. Genetics 175: 609-20 PubMed GONUTS page
