DROME:HMOC

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Species (Taxon ID)	Drosophila melanogaster (Fruit fly). (taxon:7227)
Gene Name(s)	oc ( synonyms: Otd )
Protein Name(s)	Homeotic protein ocelliless Protein orthodenticle
External Links
UniProt Identifier	HMOC_DROME
UniProt Accessions	P22810, Q59E69, Q6NNU8, Q9W3D0,
EMBL	X58983, AE014298, BT011185,
PIR	A35912,
RefSeq	NP_001014727.2,
IntAct	P22810,
Pfam	PF00046,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0005634	nucleus		IEA: Inferred from Electronic Annotation		C	Source: UniProtKB-SubCell
	GO:0043565	sequence-specific DNA binding		IEA: Inferred from Electronic Annotation		F	Source: InterPro
	GO:0003700	transcription factor activity		IEA: Inferred from Electronic Annotation		F	Source: InterPro
	GO:0007628	adult walking behavior		TAS: Traceable Author Statement		P	Source: FlyBase
	GO:0035288	anterior head segmentation		TAS: Traceable Author Statement		P	Source: FlyBase
	GO:0007355	anterior region determination		TAS: Traceable Author Statement		P	Source: FlyBase
	GO:0035284	brain segmentation		IMP: Inferred from Mutant Phenotype		P	Source: FlyBase
	GO:0001700	embryonic development via the syncytial bla...		IMP: Inferred from Mutant Phenotype		P	Source: FlyBase
	GO:0046552	photoreceptor cell fate commitment		IMP: Inferred from Mutant Phenotype		P	Source: UniProtKB
	GO:0006355	regulation of transcription, DNA-dependent		IEA: Inferred from Electronic Annotation		P	Source: InterPro
	GO:0042052	rhabdomere development		IMP: Inferred from Mutant Phenotype		P	Source: UniProtKB
	GO:0042052	rhabdomere development	PMID:20667913^[1]	IGI: Inferred from Genetic Interaction	UniProtKB:Q8T0V5	P	Fig 1B	complete
	GO:0006350	transcription		IEA: Inferred from Electronic Annotation		P	Source: UniProtKB-KW
	GO:0043565	sequence-specific DNA binding	PMID:20667913^[1]	IDA: Inferred from Direct Assay		F	Fig S6	complete
	GO:0016563	transcription activator activity	PMID:20667913^[1]	IDA: Inferred from Direct Assay		F	Fig 7b	complete
	GO:0045872	positive regulation of rhodopsin gene expression	PMID:20667913^[1]	IDA: Inferred from Direct Assay		P	Fig 7b	complete
	GO:0001700	embryonic development via the syncytial blastoderm	PMID:7576627^[2]	IMP: Inferred from Mutant Phenotype		P
	GO:0001700	embryonic development via the syncytial blastoderm	PMID:8608920^[3]	IMP: Inferred from Mutant Phenotype		P
	GO:0001745	compound eye morphogenesis	PMID:12967559^[4]	IMP: Inferred from Mutant Phenotype		P
	GO:0003677	DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012287	F
	GO:0003677	DNA binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0238	F
	GO:0003677	DNA binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0371	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001356	F
	GO:0005634	nucleus	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017970	C
	GO:0005634	nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0539	C
	GO:0005634	nucleus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0191	C
	GO:0006351	transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0804	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001356	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012287	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017970	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0805	P
	GO:0007275	multicellular organismal development	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0217	P
	GO:0007355	anterior region determination	PMID:12867048^[5]	TAS: Traceable Author Statement		P
	GO:0007417	central nervous system development	PMID:8575625^[6]	IMP: Inferred from Mutant Phenotype		P
	GO:0007628	adult walking behavior	PMID:12490252^[7]	TAS: Traceable Author Statement		P
	GO:0008056	ocellus development	PMID:20580700^[8]	IGI: Inferred from Genetic Interaction	FB:FBgn0019650	P
	GO:0010628	positive regulation of gene expression	PMID:20580700^[8]	IMP: Inferred from Mutant Phenotype		P
	GO:0035284	brain segmentation	PMID:7576627^[2]	IMP: Inferred from Mutant Phenotype		P
	GO:0035288	anterior head segmentation	PMID:15382142^[9]	TAS: Traceable Author Statement		P
	GO:0042051	compound eye photoreceptor development	PMID:14505358^[10]	TAS: Traceable Author Statement		P
	GO:0042051	compound eye photoreceptor development	PMID:20667913^[1]	IMP: Inferred from Mutant Phenotype		P
	GO:0042052	rhabdomere development	PMID:12967559^[4]	IMP: Inferred from Mutant Phenotype		P
	GO:0042052	rhabdomere development	PMID:20667913^[1]	IMP: Inferred from Mutant Phenotype		P
	GO:0042052	rhabdomere development	PMID:8575625^[6]	IMP: Inferred from Mutant Phenotype		P
	GO:0042463	ocellus photoreceptor cell development	PMID:20667913^[1]	IGI: Inferred from Genetic Interaction	FB:FBgn0023489	P
	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001356	F
	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017970	F
	GO:0045893	positive regulation of transcription, DNA-dependent	PMID:20667913^[1]	IDA: Inferred from Direct Assay		P
	GO:0046552	photoreceptor cell fate commitment	PMID:8575625^[6]	IMP: Inferred from Mutant Phenotype		P
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Mishra M et al. (2010) Pph13 and orthodenticle define a dual regulatory pathway for photoreceptor cell morphogenesis and function. Development 137: 2895-904 PubMed GONUTS page
↑ ^2.0 ^2.1 Hirth F et al. (1995) Developmental defects in brain segmentation caused by mutations of the homeobox genes orthodenticle and empty spiracles in Drosophila. Neuron 15: 769-78 PubMed GONUTS page
↑ Eberl DF & Hilliker AJ (1988) Characterization of X-linked recessive lethal mutations affecting embryonic morphogenesis in Drosophila melanogaster. Genetics 118: 109-20 PubMed GONUTS page
↑ ^4.0 ^4.1 Tahayato A et al. (2003) Otd/Crx, a dual regulator for the specification of ommatidia subtypes in the Drosophila retina. Dev Cell 5: 391-402 PubMed GONUTS page
↑ Lynch J & Desplan C (2003) Evolution of development: beyond bicoid. Curr Biol 13: R557-9 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Vandendries ER et al. (1996) orthodenticle is required for photoreceptor cell development in the Drosophila eye. Dev Biol 173: 243-55 PubMed GONUTS page
↑ Strauss R (2002) The central complex and the genetic dissection of locomotor behaviour. Curr Opin Neurobiol 12: 633-8 PubMed GONUTS page
↑ ^8.0 ^8.1 Blanco J et al. (2010) Genetic interactions of eyes absent, twin of eyeless and orthodenticle regulate sine oculis expression during ocellar development in Drosophila. Dev Biol 344: 1088-99 PubMed GONUTS page
↑ Peel A (2004) The evolution of arthropod segmentation mechanisms. Bioessays 26: 1108-16 PubMed GONUTS page
↑ Cook T (2003) Cell diversity in the retina: more than meets the eye. Bioessays 25: 921-5 PubMed GONUTS page

[PMID:20667913-0] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Mishra M et al. (2010) Pph13 and orthodenticle define a dual regulatory pathway for photoreceptor cell morphogenesis and function. Development 137: 2895-904 PubMed GONUTS page

[PMID:7576627-1] 2.0 ^2.1 Hirth F et al. (1995) Developmental defects in brain segmentation caused by mutations of the homeobox genes orthodenticle and empty spiracles in Drosophila. Neuron 15: 769-78 PubMed GONUTS page

[PMID:8608920-2] Eberl DF & Hilliker AJ (1988) Characterization of X-linked recessive lethal mutations affecting embryonic morphogenesis in Drosophila melanogaster. Genetics 118: 109-20 PubMed GONUTS page

[PMID:12967559-3] 4.0 ^4.1 Tahayato A et al. (2003) Otd/Crx, a dual regulator for the specification of ommatidia subtypes in the Drosophila retina. Dev Cell 5: 391-402 PubMed GONUTS page

[PMID:12867048-4] Lynch J & Desplan C (2003) Evolution of development: beyond bicoid. Curr Biol 13: R557-9 PubMed GONUTS page

[PMID:8575625-5] 6.0 ^6.1 ^6.2 Vandendries ER et al. (1996) orthodenticle is required for photoreceptor cell development in the Drosophila eye. Dev Biol 173: 243-55 PubMed GONUTS page

[PMID:12490252-6] Strauss R (2002) The central complex and the genetic dissection of locomotor behaviour. Curr Opin Neurobiol 12: 633-8 PubMed GONUTS page

[PMID:20580700-7] 8.0 ^8.1 Blanco J et al. (2010) Genetic interactions of eyes absent, twin of eyeless and orthodenticle regulate sine oculis expression during ocellar development in Drosophila. Dev Biol 344: 1088-99 PubMed GONUTS page

[PMID:15382142-8] Peel A (2004) The evolution of arthropod segmentation mechanisms. Bioessays 26: 1108-16 PubMed GONUTS page

[PMID:14505358-9] Cook T (2003) Cell diversity in the retina: more than meets the eye. Bioessays 25: 921-5 PubMed GONUTS page

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DROME:HMOC

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