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DROME:HID

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Contents

Species (Taxon ID) Drosophila melanogaster (Fruit fly). ([1])
Gene Name(s) W (synonyms: Hid)
Protein Name(s) Cell death protein W

Protein head involution defective Protein wrinkled

External Links
EMBL U31226
AE014296
AY075188
RefSeq NP_524136.2
UniGene Dm.5624
DIP DIP-20052N
IntAct Q24106
MINT MINT-824104
STRING Q24106
EnsemblMetazoa FBtr0075133
GeneID 40009
KEGG dme:Dmel_CG5123
NMPDR fig|7227.3.peg.10409
FlyBase FBgn0003997
GeneTree EMGT00050000000406
InParanoid Q24106
OMA CGFFAAR
OrthoDB EOG4905S7
NextBio 816537
ArrayExpress Q24106
Bgee Q24106
GermOnline CG5123
GO GO:0005515
GO:0048800
GO:0046667
GO:0048813
GO:0008630
GO:0035072
GO:0043153
GO:0008258
GO:0035096
GO:0007424
GO:0016567
GO:0043281
GO:0046620
GO:0030162
GO:0046668
GO:0010114

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0001700

embryonic development via the syncytial blastoderm

PMID:11102824[1]

TAS: Traceable Author Statement

P

Seeded From UniProt

GO:0001700

embryonic development via the syncytial blastoderm

PMID:14644196[2]

TAS: Traceable Author Statement

P

Seeded From UniProt

GO:0002165

instar larval or pupal development

PMID:1752422[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0005515

protein binding

PMID:12021769[4]

IPI: Inferred from Physical Interaction

UniProtKB:Q24306

F

Seeded From UniProt

GO:0006915

apoptosis

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0053

P

Seeded From UniProt

GO:0006915

apoptosis

PMID:10511707[5]

TAS: Traceable Author Statement

P

Seeded From UniProt

GO:0006915

apoptosis

PMID:10910336[6]

TAS: Traceable Author Statement

P

Seeded From UniProt

GO:0006915

apoptosis

PMID:20837774[7]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0006917

induction of apoptosis

PMID:10481910[8]

IGI: Inferred from Genetic Interaction

FB:FBgn0010501

P

Seeded From UniProt

GO:0006917

induction of apoptosis

PMID:10481910[8]

IGI: Inferred from Genetic Interaction

FB:FBgn0260635

P

Seeded From UniProt

GO:0006917

induction of apoptosis

PMID:10511707[5]

TAS: Traceable Author Statement

P

Seeded From UniProt

GO:0006917

induction of apoptosis

PMID:11048731[9]

TAS: Traceable Author Statement

P

Seeded From UniProt

GO:0006917

induction of apoptosis

PMID:12919673[10]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0006917

induction of apoptosis

PMID:14644196[2]

TAS: Traceable Author Statement

P

Seeded From UniProt

GO:0006917

induction of apoptosis

PMID:9814703[11]

TAS: Traceable Author Statement

P

Seeded From UniProt

GO:0007275

multicellular organismal development

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0217

P

Seeded From UniProt

GO:0007424

open tracheal system development

PMID:16198330[12]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0008219

cell death

PMID:16280349[13]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0008258

head involution

PMID:1752422[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0008630

DNA damage response, signal transduction resulting in induction of apoptosis

PMID:18688282[14]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0010114

response to red light

PMID:14960620[15]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0012501

programmed cell death

PMID:12006672[16]

TAS: Traceable Author Statement

P

Seeded From UniProt

GO:0012501

programmed cell death

PMID:12072176[17]

TAS: Traceable Author Statement

P

Seeded From UniProt

GO:0012501

programmed cell death

PMID:16168982[18]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0012501

programmed cell death

PMID:7622034[19]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0012501

programmed cell death

PMID:9144202[20]

IGI: Inferred from Genetic Interaction

FB:FBgn0011706

P

Seeded From UniProt

GO:0012501

programmed cell death

PMID:9144202[20]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0012502

induction of programmed cell death

PMID:16485033[21]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0016567

protein ubiquitination

PMID:14644196[2]

TAS: Traceable Author Statement

P

Seeded From UniProt

GO:0030162

regulation of proteolysis

PMID:14644196[2]

TAS: Traceable Author Statement

P

Seeded From UniProt

GO:0035071

salivary gland cell autophagic cell death

PMID:15150408[22]

IGI: Inferred from Genetic Interaction

FB:FBgn0011706

P

Seeded From UniProt

GO:0035071

salivary gland cell autophagic cell death

PMID:15150408[22]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0035072

ecdysone-mediated induction of salivary gland cell autophagic cell death

PMID:10882130[23]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

GO:0035072

ecdysone-mediated induction of salivary gland cell autophagic cell death

PMID:11102824[1]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

GO:0035096

larval midgut cell programmed cell death

PMID:15150408[22]

IGI: Inferred from Genetic Interaction

FB:FBgn0011706

P

Seeded From UniProt

GO:0043065

positive regulation of apoptosis

PMID:19100727[24]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0043153

entrainment of circadian clock by photoperiod

PMID:14960620[15]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0043281

regulation of cysteine-type endopeptidase activity involved in apoptotic process

PMID:16485033[21]

IGI: Inferred from Genetic Interaction

FB:FBgn0019972

P

Seeded From UniProt

GO:0043281

regulation of cysteine-type endopeptidase activity involved in apoptotic process

PMID:16485033[21]

IGI: Inferred from Genetic Interaction

FB:FBgn0024252

P

Seeded From UniProt

GO:0043281

regulation of cysteine-type endopeptidase activity involved in apoptotic process

PMID:16485033[21]

IGI: Inferred from Genetic Interaction

FB:FBgn0026404

P

Seeded From UniProt

GO:0043281

regulation of cysteine-type endopeptidase activity involved in apoptotic process

PMID:16485033[21]

IGI: Inferred from Genetic Interaction

FB:FBgn0028381

P

Seeded From UniProt

GO:0043281

regulation of cysteine-type endopeptidase activity involved in apoptotic process

PMID:16485033[21]

IGI: Inferred from Genetic Interaction

FB:FBgn0033051

P

Seeded From UniProt

GO:0046620

regulation of organ growth

PMID:15066286[25]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0046667

compound eye retinal cell programmed cell death

PMID:11735386[26]

TAS: Traceable Author Statement

P

Seeded From UniProt

GO:0046668

regulation of retinal cell programmed cell death

PMID:12547518[27]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

GO:0048800

antennal morphogenesis

PMID:15464574[28]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0048813

dendrite morphogenesis

PMID:16980964[29]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0045476

nurse cell apoptosis

PMID:11139280[30]

TAS: Traceable Author Statement

P

Seeded From UniProt

GO:0045476

nurse cell apoptosis

PMID:12072176[17]

TAS: Traceable Author Statement

P

Seeded From UniProt

GO:0008219

cell death

PMID:7622034[19]

IMP: Inferred from Mutant Phenotype

P

Figures 1, 3, and 4

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Buszczak M & Segraves WA (2000) Insect metamorphosis: out with the old, in with the new. Curr Biol 10: R830-3 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 Bergmann A et al. (2003) Regulators of IAP function: coming to grips with the grim reaper. Curr Opin Cell Biol 15: 717-24 PubMed GONUTS page
  3. ↑ 3.0 3.1 Abbott MK & Lengyel JA (1991) Embryonic head involution and rotation of male terminalia require the Drosophila locus head involution defective. Genetics 129: 783-9 PubMed GONUTS page
  4. ↑ Ryoo HD et al. (2002) Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1. Nat Cell Biol 4: 432-8 PubMed GONUTS page
  5. ↑ 5.0 5.1 Abrams JM (1999) An emerging blueprint for apoptosis in Drosophila. Trends Cell Biol 9: 435-40 PubMed GONUTS page
  6. ↑ De Laurenzi V & Melino G (2000) Apoptosis. The little devil of death. Nature 406: 135-6 PubMed GONUTS page
  7. ↑ Sandu C et al. (2010) Drosophila IAP antagonists form multimeric complexes to promote cell death. J Cell Biol 190: 1039-52 PubMed GONUTS page
  8. ↑ 8.0 8.1 Wang SL et al. (1999) The Drosophila caspase inhibitor DIAP1 is essential for cell survival and is negatively regulated by HID. Cell 98: 453-63 PubMed GONUTS page
  9. ↑ Meier P et al. (2000) Apoptosis in development. Nature 407: 796-801 PubMed GONUTS page
  10. ↑ DeFalco TJ et al. (2003) Sex-specific apoptosis regulates sexual dimorphism in the Drosophila embryonic gonad. Dev Cell 5: 205-16 PubMed GONUTS page
  11. ↑ Kurada P & White K (1998) Ras promotes cell survival in Drosophila by downregulating hid expression. Cell 95: 319-29 PubMed GONUTS page
  12. ↑ Guha A & Kornberg TB (2005) Tracheal branch repopulation precedes induction of the Drosophila dorsal air sac primordium. Dev Biol 287: 192-200 PubMed GONUTS page
  13. ↑ Werz C et al. (2005) Mis-specified cells die by an active gene-directed process, and inhibition of this death results in cell fate transformation in Drosophila. Development 132: 5343-52 PubMed GONUTS page
  14. ↑ Moon NS et al. (2008) E2F and p53 induce apoptosis independently during Drosophila development but intersect in the context of DNA damage. PLoS Genet 4: e1000153 PubMed GONUTS page
  15. ↑ 15.0 15.1 Klarsfeld A et al. (2004) Novel features of cryptochrome-mediated photoreception in the brain circadian clock of Drosophila. J Neurosci 24: 1468-77 PubMed GONUTS page
  16. ↑ Gorski S & Marra M (2002) Programmed cell death takes flight: genetic and genomic approaches to gene discovery in Drosophila. Physiol Genomics 9: 59-69 PubMed GONUTS page
  17. ↑ 17.0 17.1 Richardson H & Kumar S (2002) Death to flies: Drosophila as a model system to study programmed cell death. J Immunol Methods 265: 21-38 PubMed GONUTS page
  18. ↑ Rodriguez Moncalvo VG & Campos AR (2005) Genetic dissection of trophic interactions in the larval optic neuropil of Drosophila melanogaster. Dev Biol 286: 549-58 PubMed GONUTS page
  19. ↑ 19.0 19.1 Grether ME et al. (1995) The head involution defective gene of Drosophila melanogaster functions in programmed cell death. Genes Dev 9: 1694-708 PubMed GONUTS page
  20. ↑ 20.0 20.1 Zhou L et al. (1997) Cooperative functions of the reaper and head involution defective genes in the programmed cell death of Drosophila central nervous system midline cells. Proc Natl Acad Sci U S A 94: 5131-6 PubMed GONUTS page
  21. ↑ 21.0 21.1 21.2 21.3 21.4 21.5 Leulier F et al. (2006) Systematic in vivo RNAi analysis of putative components of the Drosophila cell death machinery. Cell Death Differ 13: 1663-74 PubMed GONUTS page
  22. ↑ 22.0 22.1 22.2 Yin VP & Thummel CS (2004) A balance between the diap1 death inhibitor and reaper and hid death inducers controls steroid-triggered cell death in Drosophila. Proc Natl Acad Sci U S A 101: 8022-7 PubMed GONUTS page
  23. ↑ Jiang C et al. (2000) A steroid-triggered transcriptional hierarchy controls salivary gland cell death during Drosophila metamorphosis. Mol Cell 5: 445-55 PubMed GONUTS page
  24. ↑ Tanaka-Matakatsu M et al. (2009) Regulation of apoptosis of rbf mutant cells during Drosophila development. Dev Biol 326: 347-56 PubMed GONUTS page
  25. ↑ de la Cova C et al. (2004) Drosophila myc regulates organ size by inducing cell competition. Cell 117: 107-16 PubMed GONUTS page
  26. ↑ Baker NE (2001) Cell proliferation, survival, and death in the Drosophila eye. Semin Cell Dev Biol 12: 499-507 PubMed GONUTS page
  27. ↑ Brachmann CB & Cagan RL (2003) Patterning the fly eye: the role of apoptosis. Trends Genet 19: 91-6 PubMed GONUTS page
  28. ↑ Cullen K & McCall K (2004) Role of programmed cell death in patterning the Drosophila antennal arista. Dev Biol 275: 82-92 PubMed GONUTS page
  29. ↑ Williams DW et al. (2006) Local caspase activity directs engulfment of dendrites during pruning. Nat Neurosci 9: 1234-6 PubMed GONUTS page
  30. ↑ Buszczak M & Cooley L (2000) Eggs to die for: cell death during Drosophila oogenesis. Cell Death Differ 7: 1071-4 PubMed GONUTS page
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