DROME:FRU

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Species (Taxon ID)	Drosophila melanogaster (Fruit fly). ([1])
Gene Name(s)	fru (synonyms: BTB-VI)
Protein Name(s)	Sex determination protein fruitless
External Links
EMBL	AF039231 U72492 D84437 D84438 AF220176 AF220177 AF220178 AF220179 AF220180 AF220181 AE014297 AE014297 AE014297 AE014297 AE014297 AE014297 AE014297 AE014297 AE014297 AE014297 AE014297 AE014297 AE014297 BT024450 AY152837 AY152838 U14403
RefSeq	NP_001163648.1 NP_524397.2 NP_732344.1 NP_732345.1 NP_732346.1 NP_732347.1 NP_732348.1 NP_732349.1 NP_732350.1 NP_996234.1 NP_996235.1 NP_996236.1 NP_996237.1 NP_996238.1
UniGene	Dm.4626
ProteinModelPortal	Q8IN81
SMR	Q8IN81
DIP	DIP-17120N
IntAct	Q8IN81
MINT	MINT-773162
STRING	Q8IN81
PRIDE	Q8IN81
EnsemblMetazoa	FBtr0083643
GeneID	42226
KEGG	dme:Dmel_CG14307
UCSC	CG14307-RA
CTD	42226
FlyBase	FBgn0004652
eggNOG	inNOG10394
GeneTree	EMGT00050000002223
InParanoid	Q8IN81
OMA	IDGSKAW
OrthoDB	EOG479CQQ
PhylomeDB	Q8IN81
NextBio	827755
Bgee	Q8IN81
GermOnline	CG14307
GO	GO:0005634 GO:0003677 GO:0003700 GO:0008270 GO:0002118 GO:0016199 GO:0007417 GO:0007620 GO:0048813 GO:0016543 GO:0045433 GO:0046661 GO:0048047 GO:0007517 GO:0007530
InterPro	IPR000210 IPR011333 IPR013069 IPR007087 IPR015880 IPR013087
Gene3D	G3DSA:3.30.710.10 G3DSA:3.30.160.60
Pfam	PF00651
SMART	SM00225 SM00355
SUPFAM	SSF54695
PROSITE	PS50097 PS00028 PS50157

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0002118	aggressive behavior	PMID:18042702^[1]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0003676	nucleic acid binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR013087	F	Seeded From UniProt
	GO:0003677	DNA binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0238	F	Seeded From UniProt
	GO:0003700	sequence-specific DNA binding transcription factor activity	PMID:10648226^[2]	TAS: Traceable Author Statement		F	Seeded From UniProt
	GO:0003700	sequence-specific DNA binding transcription factor activity	PMID:11092827^[3]	NAS: Non-traceable Author Statement		F	Seeded From UniProt
	GO:0003700	sequence-specific DNA binding transcription factor activity	PMID:7938017^[4]	NAS: Non-traceable Author Statement		F	Seeded From UniProt
	GO:0005622	intracellular	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR007087	C	Seeded From UniProt
	GO:0005622	intracellular	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR015880	C	Seeded From UniProt
	GO:0005634	nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0539	C	Seeded From UniProt
	GO:0005634	nucleus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0191	C	Seeded From UniProt
	GO:0005634	nucleus	GO_REF:0000029	NAS: Non-traceable Author Statement		C	Seeded From UniProt
	GO:0006351	transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0804	P	Seeded From UniProt
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0805	P	Seeded From UniProt
	GO:0006355	regulation of transcription, DNA-dependent	PMID:10648226^[2]	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0006355	regulation of transcription, DNA-dependent	PMID:11092827^[3]	NAS: Non-traceable Author Statement		P	Seeded From UniProt
	GO:0006355	regulation of transcription, DNA-dependent	PMID:7938017^[4]	NAS: Non-traceable Author Statement		P	Seeded From UniProt
	GO:0007275	multicellular organismal development	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0217	P	Seeded From UniProt
	GO:0007275	multicellular organismal development	PMID:8978612^[5]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0007417	central nervous system development	PMID:12486700^[6]	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0007417	central nervous system development	PMID:12524343^[7]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0007517	muscle organ development	PMID:10934470^[8]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0007517	muscle organ development	PMID:8978612^[5]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0007530	sex determination	PMID:10934470^[8]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0007530	sex determination	PMID:11092827^[3]	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0007530	sex determination	PMID:11715043^[9]	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0007530	sex determination	PMID:8978612^[5]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0007617	mating behavior	PMID:11291102^[10]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0007618	mating	PMID:8244010^[11]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0007620	copulation	PMID:12000098^[12]	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0007620	copulation	PMID:12486700^[6]	NAS: Non-traceable Author Statement		P	Seeded From UniProt
	GO:0008049	male courtship behavior	PMID:10858821^[13]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0008049	male courtship behavior	PMID:10934470^[8]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0008049	male courtship behavior	PMID:11092827^[3]	NAS: Non-traceable Author Statement		P	Seeded From UniProt
	GO:0008049	male courtship behavior	PMID:11300999^[14]	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0008049	male courtship behavior	PMID:11514448^[15]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0008049	male courtship behavior	PMID:11715043^[9]	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0008049	male courtship behavior	PMID:12350340^[16]	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0008049	male courtship behavior	PMID:12486700^[6]	NAS: Non-traceable Author Statement		P	Seeded From UniProt
	GO:0008049	male courtship behavior	PMID:15959468^[17]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0008049	male courtship behavior	PMID:16179386^[18]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0008049	male courtship behavior	PMID:18167550^[19]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0008049	male courtship behavior	PMID:1821857^[20]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0008049	male courtship behavior	PMID:8244010^[11]	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0008270	zinc ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR007087	F	Seeded From UniProt
	GO:0008270	zinc ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR015880	F	Seeded From UniProt
	GO:0016199	axon midline choice point recognition	PMID:20040498^[21]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0016543	male courtship behavior, orientation prior to leg tapping and wing vibration	PMID:12000098^[12]	NAS: Non-traceable Author Statement		P	Seeded From UniProt
	GO:0016545	male courtship behavior, veined wing vibration	PMID:2508613^[22]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0045433	male courtship behavior, veined wing generated song production	PMID:12000098^[12]	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0045433	male courtship behavior, veined wing generated song production	PMID:8978612^[5]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0046661	male sex differentiation	PMID:12486700^[6]	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0046872	metal ion binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0479	F	Seeded From UniProt
	GO:0048047	mating behavior, sex discrimination	PMID:12486700^[6]	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0048047	mating behavior, sex discrimination	PMID:20967276^[23]	IGI: Inferred from Genetic Interaction	FB:FBgn0010329	P	Seeded From UniProt
	GO:0048047	mating behavior, sex discrimination	PMID:20967276^[23]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0048813	dendrite morphogenesis	PMID:21471381^[24]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Chan YB & Kravitz EA (2007) Specific subgroups of FruM neurons control sexually dimorphic patterns of aggression in Drosophila melanogaster. Proc Natl Acad Sci U S A 104: 19577-82 PubMed GONUTS page
↑ ^2.0 ^2.1 Schütt C & Nöthiger R (2000) Structure, function and evolution of sex-determining systems in Dipteran insects. Development 127: 667-77 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Greenspan RJ & Ferveur JF (2000) Courtship in Drosophila. Annu Rev Genet 34: 205-232 PubMed GONUTS page
↑ ^4.0 ^4.1 Zollman S et al. (1994) The BTB domain, found primarily in zinc finger proteins, defines an evolutionarily conserved family that includes several developmentally regulated genes in Drosophila. Proc Natl Acad Sci U S A 91: 10717-21 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Ryner LC et al. (1996) Control of male sexual behavior and sexual orientation in Drosophila by the fruitless gene. Cell 87: 1079-89 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 Emmons SW & Lipton J (2003) Genetic basis of male sexual behavior. J Neurobiol 54: 93-110 PubMed GONUTS page
↑ Song HJ et al. (2002) The fruitless gene is required for the proper formation of axonal tracts in the embryonic central nervous system of Drosophila. Genetics 162: 1703-24 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Usui-Aoki K et al. (2000) Formation of the male-specific muscle in female Drosophila by ectopic fruitless expression. Nat Cell Biol 2: 500-6 PubMed GONUTS page
↑ ^9.0 ^9.1 Sokolowski MB (2001) Drosophila: genetics meets behaviour. Nat Rev Genet 2: 879-90 PubMed GONUTS page
↑ Lee G et al. (2001) New reproductive anomalies in fruitless-mutant Drosophila males: extreme lengthening of mating durations and infertility correlated with defective serotonergic innervation of reproductive organs. J Neurobiol 47: 121-49 PubMed GONUTS page
↑ ^11.0 ^11.1 Castrillon DH et al. (1993) Toward a molecular genetic analysis of spermatogenesis in Drosophila melanogaster: characterization of male-sterile mutants generated by single P element mutagenesis. Genetics 135: 489-505 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Billeter JC et al. (2002) Genes mediating sex-specific behaviors in Drosophila. Adv Genet 47: 87-116 PubMed GONUTS page
↑ Nilsson EE et al. (2000) Fruitless is in the regulatory pathway by which ectopic mini-white and transformer induce bisexual courtship in Drosophila. J Neurogenet 13: 213-32 PubMed GONUTS page
↑ Baker BS et al. (2001) Are complex behaviors specified by dedicated regulatory genes? Reasoning from Drosophila. Cell 105: 13-24 PubMed GONUTS page
↑ Anand A et al. (2001) Molecular genetic dissection of the sex-specific and vital functions of the Drosophila melanogaster sex determination gene fruitless. Genetics 158: 1569-95 PubMed GONUTS page
↑ Christiansen AE et al. (2002) Sex comes in from the cold: the integration of sex and pattern. Trends Genet 18: 510-6 PubMed GONUTS page
↑ Manoli DS et al. (2005) Male-specific fruitless specifies the neural substrates of Drosophila courtship behaviour. Nature 436: 395-400 PubMed GONUTS page
↑ Villella A et al. (2005) Functional analysis of fruitless gene expression by transgenic manipulations of Drosophila courtship. Proc Natl Acad Sci U S A 102: 16550-7 PubMed GONUTS page
↑ Lee HG et al. (2008) Recurring ethanol exposure induces disinhibited courtship in Drosophila. PLoS One 3: e1391 PubMed GONUTS page
↑ Gailey DA et al. (1991) Elements of the fruitless locus regulate development of the muscle of Lawrence, a male-specific structure in the abdomen of Drosophila melanogaster adults. Development 113: 879-90 PubMed GONUTS page
↑ Mellert DJ et al. (2010) Midline crossing by gustatory receptor neuron axons is regulated by fruitless, doublesex and the Roundabout receptors. Development 137: 323-32 PubMed GONUTS page
↑ Wheeler DA et al. (1989) Spectral analysis of courtship songs in behavioral mutants of Drosophila melanogaster. Behav Genet 19: 503-28 PubMed GONUTS page
↑ ^23.0 ^23.1 Certel SJ et al. (2010) Octopamine neuromodulatory effects on a social behavior decision-making network in Drosophila males. PLoS One 5: e13248 PubMed GONUTS page
↑ Goto J et al. (2011) Sexually dimorphic shaping of interneuron dendrites involves the hunchback transcription factor. J Neurosci 31: 5454-9 PubMed GONUTS page

[PMID:18042702-0] Chan YB & Kravitz EA (2007) Specific subgroups of FruM neurons control sexually dimorphic patterns of aggression in Drosophila melanogaster. Proc Natl Acad Sci U S A 104: 19577-82 PubMed GONUTS page

[PMID:10648226-1] 2.0 ^2.1 Schütt C & Nöthiger R (2000) Structure, function and evolution of sex-determining systems in Dipteran insects. Development 127: 667-77 PubMed GONUTS page

[PMID:11092827-2] 3.0 ^3.1 ^3.2 ^3.3 Greenspan RJ & Ferveur JF (2000) Courtship in Drosophila. Annu Rev Genet 34: 205-232 PubMed GONUTS page

[PMID:7938017-3] 4.0 ^4.1 Zollman S et al. (1994) The BTB domain, found primarily in zinc finger proteins, defines an evolutionarily conserved family that includes several developmentally regulated genes in Drosophila. Proc Natl Acad Sci U S A 91: 10717-21 PubMed GONUTS page

[PMID:8978612-4] 5.0 ^5.1 ^5.2 ^5.3 Ryner LC et al. (1996) Control of male sexual behavior and sexual orientation in Drosophila by the fruitless gene. Cell 87: 1079-89 PubMed GONUTS page

[PMID:12486700-5] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 Emmons SW & Lipton J (2003) Genetic basis of male sexual behavior. J Neurobiol 54: 93-110 PubMed GONUTS page

[PMID:12524343-6] Song HJ et al. (2002) The fruitless gene is required for the proper formation of axonal tracts in the embryonic central nervous system of Drosophila. Genetics 162: 1703-24 PubMed GONUTS page

[PMID:10934470-7] 8.0 ^8.1 ^8.2 Usui-Aoki K et al. (2000) Formation of the male-specific muscle in female Drosophila by ectopic fruitless expression. Nat Cell Biol 2: 500-6 PubMed GONUTS page

[PMID:11715043-8] 9.0 ^9.1 Sokolowski MB (2001) Drosophila: genetics meets behaviour. Nat Rev Genet 2: 879-90 PubMed GONUTS page

[PMID:11291102-9] Lee G et al. (2001) New reproductive anomalies in fruitless-mutant Drosophila males: extreme lengthening of mating durations and infertility correlated with defective serotonergic innervation of reproductive organs. J Neurobiol 47: 121-49 PubMed GONUTS page

[PMID:8244010-10] 11.0 ^11.1 Castrillon DH et al. (1993) Toward a molecular genetic analysis of spermatogenesis in Drosophila melanogaster: characterization of male-sterile mutants generated by single P element mutagenesis. Genetics 135: 489-505 PubMed GONUTS page

[PMID:12000098-11] 12.0 ^12.1 ^12.2 Billeter JC et al. (2002) Genes mediating sex-specific behaviors in Drosophila. Adv Genet 47: 87-116 PubMed GONUTS page

[PMID:10858821-12] Nilsson EE et al. (2000) Fruitless is in the regulatory pathway by which ectopic mini-white and transformer induce bisexual courtship in Drosophila. J Neurogenet 13: 213-32 PubMed GONUTS page

[PMID:11300999-13] Baker BS et al. (2001) Are complex behaviors specified by dedicated regulatory genes? Reasoning from Drosophila. Cell 105: 13-24 PubMed GONUTS page

[PMID:11514448-14] Anand A et al. (2001) Molecular genetic dissection of the sex-specific and vital functions of the Drosophila melanogaster sex determination gene fruitless. Genetics 158: 1569-95 PubMed GONUTS page

[PMID:12350340-15] Christiansen AE et al. (2002) Sex comes in from the cold: the integration of sex and pattern. Trends Genet 18: 510-6 PubMed GONUTS page

[PMID:15959468-16] Manoli DS et al. (2005) Male-specific fruitless specifies the neural substrates of Drosophila courtship behaviour. Nature 436: 395-400 PubMed GONUTS page

[PMID:16179386-17] Villella A et al. (2005) Functional analysis of fruitless gene expression by transgenic manipulations of Drosophila courtship. Proc Natl Acad Sci U S A 102: 16550-7 PubMed GONUTS page

[PMID:18167550-18] Lee HG et al. (2008) Recurring ethanol exposure induces disinhibited courtship in Drosophila. PLoS One 3: e1391 PubMed GONUTS page

[PMID:1821857-19] Gailey DA et al. (1991) Elements of the fruitless locus regulate development of the muscle of Lawrence, a male-specific structure in the abdomen of Drosophila melanogaster adults. Development 113: 879-90 PubMed GONUTS page

[PMID:20040498-20] Mellert DJ et al. (2010) Midline crossing by gustatory receptor neuron axons is regulated by fruitless, doublesex and the Roundabout receptors. Development 137: 323-32 PubMed GONUTS page

[PMID:2508613-21] Wheeler DA et al. (1989) Spectral analysis of courtship songs in behavioral mutants of Drosophila melanogaster. Behav Genet 19: 503-28 PubMed GONUTS page

[PMID:20967276-22] 23.0 ^23.1 Certel SJ et al. (2010) Octopamine neuromodulatory effects on a social behavior decision-making network in Drosophila males. PLoS One 5: e13248 PubMed GONUTS page

[PMID:21471381-23] Goto J et al. (2011) Sexually dimorphic shaping of interneuron dendrites involves the hunchback transcription factor. J Neurosci 31: 5454-9 PubMed GONUTS page

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DROME:FRU

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