DROME:FOXO

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Species (Taxon ID)	Drosophila melanogaster (Fruit fly). (taxon:7227)
Gene Name(s)	foxo ( synonyms: Afx )
Protein Name(s)	Forkhead box protein O dFOXO Protein FKHR
External Links
UniProt Identifier	FOXO_DROME
UniProt Accessions	Q95V55, Q7KF42, Q95TK1, Q9VFN8,
EMBL	AF426831, AF416728, AE014297, AE014297, AE014297, AE014297, AY058718, AY089542,
RefSeq	NP_001138054.1, NP_650330.2, NP_996204.1, NP_996205.1,
IntAct	Q95V55,
Pfam	PF00250,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0005829	cytosol		EXP: Inferred from Experiment		C	Source: Reactome
	GO:0005634	nucleus		IDA: Inferred from Direct Assay		C	Source: UniProtKB
	GO:0005515	protein binding		IPI: Inferred from Physical Interaction		F	Source: UniProtKB
	GO:0043565	sequence-specific DNA binding		IEA: Inferred from Electronic Annotation		F	Source: InterPro
	GO:0003700	sequence-specific DNA binding transcription factor activity		IMP: Inferred from Mutant Phenotype		F	Source: UniProtKB
	GO:0007049	cell cycle		IEA: Inferred from Electronic Annotation		P	Source: UniProtKB-KW
	GO:0030154	cell differentiation		IEA: Inferred from Electronic Annotation		P	Source: UniProtKB-KW
	GO:0034599	cellular response to oxidative stress		IMP: Inferred from Mutant Phenotype		P	Source: FlyBase
	GO:0009267	cellular response to starvation		IMP: Inferred from Mutant Phenotype		P	Source: FlyBase
	GO:0001745	compound eye morphogenesis		IMP: Inferred from Mutant Phenotype		P	Source: FlyBase
	GO:0008340	determination of adult lifespan		IMP: Inferred from Mutant Phenotype		P	Source: FlyBase
	GO:0042593	glucose homeostasis		IMP: Inferred from Mutant Phenotype		P	Source: UniProtKB
	GO:0005977	glycogen metabolic process		IMP: Inferred from Mutant Phenotype		P	Source: FlyBase
	GO:0008286	insulin receptor signaling pathway		IGI: Inferred from Genetic Interaction		P	Source: FlyBase
	GO:0030308	negative regulation of cell growth		IMP: Inferred from Mutant Phenotype		P	Source: UniProtKB
	GO:0008285	negative regulation of cell proliferation		IMP: Inferred from Mutant Phenotype		P	Source: UniProtKB
	GO:0046627	negative regulation of insulin receptor signaling pathway		IMP: Inferred from Mutant Phenotype		P	Source: UniProtKB
	GO:0040015	negative regulation of multicellular organism growth		IMP: Inferred from Mutant Phenotype		P	Source: FlyBase
	GO:0019216	regulation of lipid metabolic process		IMP: Inferred from Mutant Phenotype		P	Source: UniProtKB
	GO:0016241	regulation of macroautophagy		IMP: Inferred from Mutant Phenotype		P	Source: FlyBase
	GO:0006355	regulation of transcription, DNA-dependent		IMP: Inferred from Mutant Phenotype		P	Source: UniProtKB
	GO:0009617	response to bacterium		IMP: Inferred from Mutant Phenotype		P	Source: FlyBase
	GO:0006974	response to DNA damage stimulus		IMP: Inferred from Mutant Phenotype		P	Source: FlyBase
	GO:0005634	nucleus	17686972	IDA: Inferred from Direct Assay		C	Fig 4A & 4B shows increased nuclear dFoxO localization in DN-Dmp53 expressing cells comparing to cytoplasmic localization in controls	complete
	GO:0005737	cytoplasm	17686972	IDA: Inferred from Direct Assay		C	Fig 4A & 4B shows increased nuclear dFoxO localization in DN-Dmp53 expressing cells comparing to cytoplasmic localization in controls	complete
	GO:0001558	regulation of cell growth	PMID:12893776^[1]	IMP: Inferred from Mutant Phenotype		P
	GO:0001745	compound eye morphogenesis	PMID:15843412^[2]	IMP: Inferred from Mutant Phenotype		P
	GO:0003677	DNA binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0238	F
	GO:0003690	double-stranded DNA binding	GO_REF:0000033		PANTHER:PTHR11829_AN0	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001766	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR018122	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	PMID:12908874^[3]	IMP: Inferred from Mutant Phenotype		F
	GO:0003705	sequence-specific enhancer binding RNA polymerase II transcription factor activity	GO_REF:0000033		PANTHER:PTHR11829_AN0	F
	GO:0005515	protein binding	PMID:16054033^[4]	IPI: Inferred from Physical Interaction	UniProtKB:Q9VS24	F
	GO:0005634	nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0539	C
	GO:0005634	nucleus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0191	C
	GO:0005634	nucleus	PMID:12893776^[1]	IDA: Inferred from Direct Assay		C
	GO:0005667	transcription factor complex	GO_REF:0000033		PANTHER:PTHR11829_AN0	C
	GO:0005737	cytoplasm	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0963	C
	GO:0005737	cytoplasm	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0086	C
	GO:0005737	cytoplasm	PMID:12893776^[1]	IDA: Inferred from Direct Assay		C
	GO:0005737	cytoplasm	PMID:16564014^[5]	IDA: Inferred from Direct Assay		C
	GO:0005829	cytosol	GO_REF:0000033		PANTHER:PTHR11829_AN111	C
	GO:0005829	cytosol	Reactome:REACT_6263	TAS: Traceable Author Statement		C
	GO:0005977	glycogen metabolic process	PMID:17055976^[6]	IMP: Inferred from Mutant Phenotype		P
	GO:0006351	transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0804	P
	GO:0006351	transcription, DNA-dependent	PMID:12908874^[3]	IMP: Inferred from Mutant Phenotype		P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001766	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR018122	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0805	P
	GO:0006355	regulation of transcription, DNA-dependent	PMID:12908874^[3]	IMP: Inferred from Mutant Phenotype		P
	GO:0006974	response to DNA damage stimulus	PMID:19543366^[7]	IMP: Inferred from Mutant Phenotype		P
	GO:0007049	cell cycle	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0131	P
	GO:0007275	multicellular organismal development	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0217	P
	GO:0007389	pattern specification process	GO_REF:0000033		PANTHER:PTHR11829_AN1	P
	GO:0008134	transcription factor binding	GO_REF:0000033		PANTHER:PTHR11829_AN0	F
	GO:0008285	negative regulation of cell proliferation	PMID:12844367^[8]	IMP: Inferred from Mutant Phenotype		P
	GO:0008285	negative regulation of cell proliferation	PMID:12908874^[3]	IMP: Inferred from Mutant Phenotype		P
	GO:0008286	insulin receptor signaling pathway	PMID:12893776^[1]	IGI: Inferred from Genetic Interaction	FB:FBgn0010379	P
	GO:0008286	insulin receptor signaling pathway	PMID:12893776^[1]	IPI: Inferred from Physical Interaction	FB:FBgn0013984	P
	GO:0008286	insulin receptor signaling pathway	PMID:12893776^[1]	IPI: Inferred from Physical Interaction	FB:FBgn0261560	P
	GO:0008301	DNA bending activity	GO_REF:0000033		PANTHER:PTHR11829_AN1	F
	GO:0008340	determination of adult lifespan	PMID:15175753^[9]	IMP: Inferred from Mutant Phenotype		P
	GO:0008340	determination of adult lifespan	PMID:15192154^[10]	IMP: Inferred from Mutant Phenotype		P
	GO:0009267	cellular response to starvation	PMID:12908874^[3]	IMP: Inferred from Mutant Phenotype		P
	GO:0009617	response to bacterium	PMID:17055976^[6]	IMP: Inferred from Mutant Phenotype		P
	GO:0009790	embryo development	GO_REF:0000033		PANTHER:PTHR11829_AN1	P
	GO:0009888	tissue development	GO_REF:0000033		PANTHER:PTHR11829_AN1	P
	GO:0010259	multicellular organismal aging	PMID:15175753^[9]	IMP: Inferred from Mutant Phenotype		P
	GO:0010506	regulation of autophagy	PMID:17363962^[11]	IMP: Inferred from Mutant Phenotype		P
	GO:0016241	regulation of macroautophagy	PMID:17363962^[11]	IMP: Inferred from Mutant Phenotype		P
	GO:0019216	regulation of lipid metabolic process	PMID:18234213^[12]	IMP: Inferred from Mutant Phenotype		P
	GO:0019901	protein kinase binding	GO_REF:0000033		PANTHER:PTHR11829_AN111	F
	GO:0030154	cell differentiation	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0221	P
	GO:0030308	negative regulation of cell growth	PMID:12908874^[3]	IMP: Inferred from Mutant Phenotype		P
	GO:0034599	cellular response to oxidative stress	PMID:12908874^[3]	IMP: Inferred from Mutant Phenotype		P
	GO:0040008	regulation of growth	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0341	P
	GO:0040008	regulation of growth	PMID:18665908^[13]	IGI: Inferred from Genetic Interaction	FB:FBgn0020238	P
	GO:0040015	negative regulation of multicellular organism growth	PMID:12844367^[8]	IMP: Inferred from Mutant Phenotype		P
	GO:0040027	negative regulation of vulval development	GO_REF:0000033		PANTHER:PTHR11829_AN217	P
	GO:0042593	glucose homeostasis	PMID:18234213^[12]	IMP: Inferred from Mutant Phenotype		P
	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001766	F
	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR018122	F
	GO:0045792	negative regulation of cell size	PMID:12844367^[8]	IMP: Inferred from Mutant Phenotype		P
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	GO_REF:0000033		PANTHER:PTHR11829_AN111	P
	GO:0046626	regulation of insulin receptor signaling pathway	PMID:12908874^[3]	IGI: Inferred from Genetic Interaction	FB:FBgn0010379	P
	GO:0046626	regulation of insulin receptor signaling pathway	PMID:12908874^[3]	IGI: Inferred from Genetic Interaction	FB:FBgn0013984	P
	GO:0046626	regulation of insulin receptor signaling pathway	PMID:12908874^[3]	IGI: Inferred from Genetic Interaction	FB:FBgn0015279	P
	GO:0046626	regulation of insulin receptor signaling pathway	PMID:12908874^[3]	IGI: Inferred from Genetic Interaction	FB:FBgn0024248	P
	GO:0046626	regulation of insulin receptor signaling pathway	PMID:12908874^[3]	IGI: Inferred from Genetic Interaction	FB:FBgn0026317	P
	GO:0046626	regulation of insulin receptor signaling pathway	PMID:12908874^[3]	IGI: Inferred from Genetic Interaction	FB:FBgn0026379	P
	GO:0046627	negative regulation of insulin receptor signaling pathway	PMID:12893776^[1]	IMP: Inferred from Mutant Phenotype		P
	GO:0046627	negative regulation of insulin receptor signaling pathway	PMID:15175753^[9]	IMP: Inferred from Mutant Phenotype		P
	GO:0051090	regulation of sequence-specific DNA binding transcription factor activity	GO_REF:0000033		PANTHER:PTHR11829_AN0	P
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Puig O et al. (2003) Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathway. Genes Dev 17: 2006-20 PubMed GONUTS page
↑ Goberdhan DC et al. (2005) PAT-related amino acid transporters regulate growth via a novel mechanism that does not require bulk transport of amino acids. Development 132: 2365-75 PubMed GONUTS page
↑ ^3.00 ^3.01 ^3.02 ^3.03 ^3.04 ^3.05 ^3.06 ^3.07 ^3.08 ^3.09 ^3.10 ^3.11 ^3.12 Jünger MA et al. (2003) The Drosophila forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling. J Biol 2: 20 PubMed GONUTS page
↑ Teleman AA et al. (2005) Drosophila Melted modulates FOXO and TOR activity. Dev Cell 9: 271-81 PubMed GONUTS page
↑ Betschinger J et al. (2006) Asymmetric segregation of the tumor suppressor brat regulates self-renewal in Drosophila neural stem cells. Cell 124: 1241-53 PubMed GONUTS page
↑ ^6.0 ^6.1 Dionne MS et al. (2006) Akt and FOXO dysregulation contribute to infection-induced wasting in Drosophila. Curr Biol 16: 1977-85 PubMed GONUTS page
↑ Ravi D et al. (2009) A network of conserved damage survival pathways revealed by a genomic RNAi screen. PLoS Genet 5: e1000527 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Kramer JM et al. (2003) Expression of Drosophila FOXO regulates growth and can phenocopy starvation. BMC Dev Biol 3: 5 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Hwangbo DS et al. (2004) Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body. Nature 429: 562-6 PubMed GONUTS page
↑ Giannakou ME et al. (2004) Long-lived Drosophila with overexpressed dFOXO in adult fat body. Science 305: 361 PubMed GONUTS page
↑ ^11.0 ^11.1 Juhász G et al. (2007) Gene expression profiling identifies FKBP39 as an inhibitor of autophagy in larval Drosophila fat body. Cell Death Differ 14: 1181-90 PubMed GONUTS page
↑ ^12.0 ^12.1 Vihervaara T & Puig O (2008) dFOXO regulates transcription of a Drosophila acid lipase. J Mol Biol 376: 1215-23 PubMed GONUTS page
↑ Nielsen MD et al. (2008) 14-3-3 Epsilon antagonizes FoxO to control growth, apoptosis and longevity in Drosophila. Aging Cell 7: 688-99 PubMed GONUTS page

[PMID:12893776-0] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Puig O et al. (2003) Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathway. Genes Dev 17: 2006-20 PubMed GONUTS page

[PMID:15843412-1] Goberdhan DC et al. (2005) PAT-related amino acid transporters regulate growth via a novel mechanism that does not require bulk transport of amino acids. Development 132: 2365-75 PubMed GONUTS page

[PMID:12908874-2] 3.00 ^3.01 ^3.02 ^3.03 ^3.04 ^3.05 ^3.06 ^3.07 ^3.08 ^3.09 ^3.10 ^3.11 ^3.12 Jünger MA et al. (2003) The Drosophila forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling. J Biol 2: 20 PubMed GONUTS page

[PMID:16054033-3] Teleman AA et al. (2005) Drosophila Melted modulates FOXO and TOR activity. Dev Cell 9: 271-81 PubMed GONUTS page

[PMID:16564014-4] Betschinger J et al. (2006) Asymmetric segregation of the tumor suppressor brat regulates self-renewal in Drosophila neural stem cells. Cell 124: 1241-53 PubMed GONUTS page

[PMID:17055976-5] 6.0 ^6.1 Dionne MS et al. (2006) Akt and FOXO dysregulation contribute to infection-induced wasting in Drosophila. Curr Biol 16: 1977-85 PubMed GONUTS page

[PMID:19543366-6] Ravi D et al. (2009) A network of conserved damage survival pathways revealed by a genomic RNAi screen. PLoS Genet 5: e1000527 PubMed GONUTS page

[PMID:12844367-7] 8.0 ^8.1 ^8.2 Kramer JM et al. (2003) Expression of Drosophila FOXO regulates growth and can phenocopy starvation. BMC Dev Biol 3: 5 PubMed GONUTS page

[PMID:15175753-8] 9.0 ^9.1 ^9.2 Hwangbo DS et al. (2004) Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body. Nature 429: 562-6 PubMed GONUTS page

[PMID:15192154-9] Giannakou ME et al. (2004) Long-lived Drosophila with overexpressed dFOXO in adult fat body. Science 305: 361 PubMed GONUTS page

[PMID:17363962-10] 11.0 ^11.1 Juhász G et al. (2007) Gene expression profiling identifies FKBP39 as an inhibitor of autophagy in larval Drosophila fat body. Cell Death Differ 14: 1181-90 PubMed GONUTS page

[PMID:18234213-11] 12.0 ^12.1 Vihervaara T & Puig O (2008) dFOXO regulates transcription of a Drosophila acid lipase. J Mol Biol 376: 1215-23 PubMed GONUTS page

[PMID:18665908-12] Nielsen MD et al. (2008) 14-3-3 Epsilon antagonizes FoxO to control growth, apoptosis and longevity in Drosophila. Aging Cell 7: 688-99 PubMed GONUTS page

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DROME:FOXO

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